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Acute-On-Chronic Liver Failure clinical trials

The registry lists 167 studies for Acute-On-Chronic Liver Failure across more than 10 countries. 62 are recruiting or about to start. 124 of them are mainly about Acute-On-Chronic Liver Failure (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12.

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Status

Completed
46
Status unknown
40
Recruiting
32
Not yet recruiting
28
Terminated
8
Withdrawn
6

Phase

Phase 2
25
Phase 1
17
Phase 3
6
Phase 4
6
Early Phase 1
2

Where

India
53
China
48
Germany
16
France
14
Spain
11
Italy
10

Who runs them

Institute of Liver and Biliary Sciences, India (39) · Third Affiliated Hospital, Sun Yat-Sen University (13) · Post Graduate Institute of Medical Education and Research, Chandigarh (11) · Nanfang Hospital, Southern Medical University (9) · Genfit (4) · Assiut University (3) · Qin Ning (3) · Cellaion SA (3)

What is being tested here

Drugs under test in Acute-On-Chronic Liver Failure studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted

DrugOpenPhase 3All
Rifaximin204
Terlipressin213
Lactulose102
Midodrine102
Ascorbic Acid101
Prothrombin complex concentrate101
Enoxaparin101
Tenofovir alafenamide101
Solizmestrocel101
Albumins004

Coming up

3phase 3 studies under way
16studies finish main data collection within a year1 of them phase 3

Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.

The 10 nearest, phase 3 first

Who these studies take

Of the 32 Acute-On-Chronic Liver Failure studies recruiting now, 11 (34%) set no upper age limit and 15 (47%) stop at 75 or younger. 3 (9%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 2 (6%) take healthy volunteers.

Recruiting studies that take each age, of 32
AgeWomenMen
102 (6%)2 (6%)
1831 (97%)31 (97%)
3032 (100%)32 (100%)
4032 (100%)32 (100%)
5032 (100%)32 (100%)
6530 (94%)30 (94%)
7520 (63%)20 (63%)
8511 (34%)11 (34%)

Across all 167 studies, recruiting or not: 60% stop at 75 or younger and 25% at 65; 13% take children; 0% are for women only and 0% for men only; 8% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.

How long Acute-On-Chronic Liver Failure studies take

Of 38 observational studies under Acute-On-Chronic Liver Failure, half reached primary completion within 26 months of starting, counting those still running.

Start to primary completionEvery sponsorIndustryNon-industry
Interventional, no phase29 mo23–50 · 32 studies——
Observational26 mo18–65 · 38 studies——

Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out

What changed recently

From the registry's own updates since Oct 14, 2026.

Started recruiting1

Results posted1

Stopped1

Newly registered2

Studies

Recruiting first, then most recently updated. Showing 50 of 167. Browse all 167 → or search them.