DrugBiological
Prothrombin complex concentrate clinical trials
- studies test it
- 26
- open now
- 5
- in phase 3
- 6
- first study started
- 2005
Keep track of what changes. Save the prothrombin complex concentrate studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Brand
Development codes
Studies by the year they started
26 studies that test it; most in 2008 (2)
| Year | Studies |
|---|---|
| 2005 | 1 |
| 2008 | 2 |
| 2009 | 2 |
| 2010 | 1 |
| 2012 | 1 |
| 2014 | 2 |
| 2015 | 2 |
| 2016 | 2 |
| 2018 | 1 |
| 2019 | 2 |
| 2020 | 2 |
| 2021 | 2 |
| 2023 | 2 |
| 2024 | 1 |
| 2025 | 1 |
| 2026 | 2 |
By phase
A phase 1/2 study counts in both.
- Phase 1
- 3
- Phase 2
- 6
- Phase 3
- 6
- Phase 4
- 8
- No phase
- 3
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 7 · Other 19
CSL Behring (5) · Konkuk University Medical Center (3) · University of Utah (2) · Oregon Health and Science University (1) · Fondation Ophtalmologique Adolphe de Rothschild (1) · Mayo Clinic (1) · Baxalta now part of Shire (1) · Queen Mary University of London (1)
Often tested with
Tested in the same studies.
Four-factor Prothrombin Complex Concentrate (6) · Homo sapiens whole (2) · Human plasma (2) · Profilnine SD (1) · Fibrinogen (1) · Recombinant FVIIa (1)
Studies
Open first, then newest update. How each study uses prothrombin complex concentrate is read from its arms, and is right about nine times in ten.
Testing it · 26
- Very Low-volume Plasma Exchange in ACLFNot yet recruitingNot applicableThird Affiliated Hospital, Sun Yat-Sen UniversityNCT07857434Written as Prothrombin Complex Concentrate (PCC)
- Prothrombin Complex Concentrate vs Fresh Frozen Plasma in Goal-directed Bleeding Management in Cardiac SurgeryRecruitingPhase 4Konkuk University Medical CenterNCT06144125Written as prothrombin complex concentrate
- Fibrinogen Concentrates Versus Cryoprecipitate in Liver Transplant SurgeryNot yet recruitingPhase 4Konkuk University Medical CenterNCT06144112Written as prothrombin complex concentrate
- Liberal or Adhere to Recommendations for PCC Management in Major Bleeding Following TraumaRecruitingNot applicableSecond Affiliated Hospital, School of Medicine, Zhejiang UniversityNCT06627218Written as Prothrombin Complex Concentrate
- Prothrombin Complex Concentrate vs Fresh Frozen Plasma in Goal-directed Bleeding Management in Non-cardiac SurgeryNot yet recruitingPhase 4Konkuk University Medical CenterNCT06144099Written as prothrombin complex concentrate
- Efficacy of Prothrombin Complex Concentrate Reducing Perioperative Blood Loss in Cardiac SurgeryTerminatedPhase 4SHI JiaNCT04244981Written as Prothrombin Complex Concentrate, Human
- Evaluation of BE1116 in Patients With Traumatic Injury and Acute Major Bleeding to Improve Survival ( TAP Study )TerminatedPhase 3CSL BehringNCT05568888Written as BE1116
- Administration of Prothrombin Complex Concentrate vs. Standard Transfusion During/After Heart TransplantationTerminatedPhase 3University of Maryland, BaltimoreNCT03341156Written as Kcentra
- CPP Versus PFC to Correct Coagulation Disorders in Adult Neurosurgical PatientsCompletedPhase 4Fondation Ophtalmologique Adolphe de RothschildNCT02777424Written as Prothrombin Complex Concentrate
- Prehospital Kcentra for Hemorrhagic ShockActive, not recruitingPhase 2Oregon Health and Science UniversityNCT04019015Written as Prothrombin Complex Concentrate, Human
- PCC vs. FFP for Post Cardiopulmonary Bypass Coagulopathy and BleedingCompletedPhase 4Mayo ClinicNCT02557672Written as Prothrombin complex concentrate (Human)
- ZEPLAST- PED: ZEro_PLASma Trial in Small Infants Undergoing Cardiac SurgeryTerminatedPhase 2IRCCS Policlinico S. DonatoNCT04434001Written as Prothrombin Complex Concentrate
- Efficacy and Safety of Prothromplex Total (Prothrombin Complex Concentrate) in Oral Anticoagulant ReversalCompletedPhase 4Baxalta now part of ShireNCT01159210Written as Prothrombin complex concentrate (coagulation factors IX, II, VII and X in combination)
- Trial of PCC Versus FFP in Patients Undergoing Heart SurgeryCompletedPhase 2Queen Mary University of LondonNCT03715348Written as Prothrombin Complex Concentrate (PCC)
- Factor Replacement in SurgeryStatus unknownPhase 2University Health Network, TorontoNCT04114643Written as Prothrombin Complex Concentrate
- REPlaCE- Randomized Trial Evaluating the Use of Prothrombin Complex concEntrate to Improve Survival in Patients With Traumatic CoagulopathyStatus unknownPhase 2Bellal A. Joseph, MD, FACSNCT03981484Written as Prothrombin Complex Concentrate
- A Study to Assess the Effects of 2 Different Prothrombin Complex Concentrates on the Pharmacodynamics of Rivaroxaban in Healthy Adult VolunteersCompletedPhase 1Janssen Research & Development, LLCNCT01656330Written as Beriplex P/N
- FFP Versus PCC in Intracranial HemorrhageWithdrawnNot applicableUniversity of UtahNCT02429453Written as Four Factor Prothrombin Complex Concentrate
- International Normalized Ratio (INR) Normalization in Coumadin Associated Intracerebral HaemorrhageCompletedPhase 4Heidelberg UniversityNCT00928915Written as Prothrombin complex concentrate (PCC); fresh frozen plasma (FFP)
- Reversibility of Apixaban Anticoagulation With the Four Factor Prothrombin Complex Concentrate KcentraCompletedPhase 1Thomas Jefferson UniversityNCT02270918Written as Kcentra
See all 26 studies that test prothrombin complex concentrate →
As the comparator · 2 — what is tested is compared with prothrombin complex concentrate
- Coagulation in CirrhosisRecruitingPhase 4Medical University of ViennaNCT05667805Written as Prothrombin Complex Concentrate
- Study of Octaplex, a Four-factor Prothrombin Complex Concentrate (4F-PCC) and Beriplex® P/N (Kcentra) for the Reversal of Vitamin K Antagonist (VKA) Induced Anticoagulation in Patients Needing Urgent Surgery With Significant Bleeding Risk.CompletedPhase 3OctapharmaNCT02740335Written as Beriplex P/N (Kcentra)