Liver Failure clinical trials
The registry lists 190 studies for Liver Failure across more than 10 countries. 33 are recruiting or about to start. 114 of them are mainly about Liver Failure (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-07. Counting its 4 narrower conditions too, such as Hepatic Encephalopathy: 744 studies, 179 open.
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Who runs them
Sun Yat-sen University (7) · Third Affiliated Hospital, Sun Yat-Sen University (6) · Vital Therapies, Inc. (4) · Assistance Publique - Hôpitaux de Paris (4) · Nanfang Hospital, Southern Medical University (4) · Beijing 302 Hospital (3) · Vantive Health LLC (2) · Cardiox Corporation (2)
What is being tested here
Drugs under test in Liver Failure studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 8
- Nov 2026A Multicenter Prospective Clinical Cohort Study on the Pathogen Spectrum of Severe Hepatitis (Liver Failure) Complicated With Infection · Zhejiang University
- Dec 2026Study of Sacituzumab Govitecan in Participants With Advanced or Metastatic Solid Tumor and Moderate Liver Impairment · Gilead Sciences
- Dec 2026Empagliflozin in Patients With Cirrhosis and Ascites · Yale University
- Dec 2026Safety and Effectiveness of Mesenchymal Stem Cells in Blood Purification for the Treatment of Liver Failure · Kebo Zhong
- Dec 2026A Study on Relationship Between Resected Normal Liver Parenchymal Volume(RNLV)and Post-Hepatectomy Liver Failure (PHLF) · National Natural Science Foundation of China
- Mar 2027Glucocorticoids for Acute Drug Induced Liver Injury With Hyperbilirubinemia · General Hospital of Shenyang Military Region
- May 2027Hypothermic Machine Perfusion for Liver Graft Preservation · University of Sao Paulo General Hospital
- Aug 2027The Microbiota Augmentation to Reestablish Commensal Organisms (MARCO) Trial · University of Chicago
Who these studies take
Of the 22 Liver Failure studies recruiting now, 11 (50%) set no upper age limit and 8 (36%) stop at 75 or younger. 4 (18%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 1 (5%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 3 (14%) | 3 (14%) |
| 18 | 22 (100%) | 22 (100%) |
| 30 | 22 (100%) | 22 (100%) |
| 40 | 22 (100%) | 22 (100%) |
| 50 | 22 (100%) | 22 (100%) |
| 65 | 19 (86%) | 19 (86%) |
| 75 | 14 (64%) | 14 (64%) |
| 85 | 12 (55%) | 12 (55%) |
Across all 190 studies, recruiting or not: 34% stop at 75 or younger and 17% at 65; 18% take children; 0% are for women only and 0% for men only; 11% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Liver Failure studies take
Of 25 interventional studies with no phase under Liver Failure, half reached primary completion within 29 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 29 mo23–49 · 25 studies | — | — |
| Observational | 65 mo29–127 · 25 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
Studies
Recruiting first, then most recently updated. Showing 50 of 190. Browse all 190 → or search them.
- TLI- and ATG-Enabled Minimization Protocol in Liver TransplantationRecruitingNCT07634562Phase 1/21 country
- Empagliflozin in Patients With Cirrhosis and AscitesRecruitingNCT05726032Phase 21 country
- Role of N-Acetylcysteine in Non-Acetaminophen-Induced Liver FailureRecruitingNCT07765823Not applicable1 country
- CT Volumetry and Hepatic Vascular Deformation Mapping to Predict Post-Hepatectomy Liver FailureRecruitingNCT077277591 country
- Study of Sacituzumab Govitecan in Participants With Advanced or Metastatic Solid Tumor and Moderate Liver ImpairmentRecruitingNCT04617522Phase 14 countries
- VitaSmart HOPE System: Bridge to HOPE RegistryEnrolling by invitationNCT075784411 country
- Hypothermic Machine Perfusion for Liver Graft PreservationNot yet recruitingNCT07595627Not applicable1 country
- Personalized Two-stage Regional Citrate Anticoagulation for CRRT in Patients With Citrate Metabolism ImpairmentNot yet recruitingNCT07579663Not applicable
- Safety and Tolerability Study of a Novel Bioartificial Liver in Liver Failure and Small-for-Size SyndromeRecruitingNCT07312864Phase 1/21 country
- Safety and Effectiveness of Mesenchymal Stem Cells in Blood Purification for the Treatment of Liver FailureRecruitingNCT06904755Phase 11 country
- A Study on Relationship Between Resected Normal Liver Parenchymal Volume(RNLV)and Post-Hepatectomy Liver Failure (PHLF)RecruitingNCT063660481 country
- Development of a Cognitive Tool for Rapid and Reliable Screening of Minimal Hepatic Encephalopathy: Pilot StudyRecruitingNCT066191061 country
- Glucocorticoids for Acute Drug Induced Liver Injury With HyperbilirubinemiaRecruitingNCT06922669Not applicable1 country
- The Microbiota Augmentation to Reestablish Commensal Organisms (MARCO) TrialRecruitingNCT06871111Phase 11 country
- National Collaborative Centre for Hepatic Regenerative Medicine (NC-CHRM): Phase I Study on Safety and Efficacy of Mesenchymal Stem-Cell (MSC) Therapy in Non-Viral Acute-on-Chronic Liver Failure (ACLF)Not yet recruitingNCT07131540Phase 1
- CRISPR-Edited HLA Donor Liver Transplant to Reduce RejectionRecruitingNCT07053488Phase 1/21 country
- Perioperative Use of Amino Acids in Recipients of Orthotopic Liver Transplantation as a Renal Protective FactorNot yet recruitingNCT07004387Not applicable1 country
- Efficacy and Safety of Citrate Anticoagulation in CRRT for Patients With Liver Failure/DysfuncTION, the CAUTION Trial! A Retrospective Study on Etiology of Liver Failure and Their ComplicationsRecruitingNCT069087461 country
- The Safety ,Tolerability and Efficacy Study of HepaCure in Chinese Subjects with Acute-On-Chronic Liver FailureRecruitingNCT05989958Phase 1/21 country
- MSC-EVs in Acute/ Acute-on-Chronic Liver Failure After Liver TransplantationNot yet recruitingNCT06825572Phase 11 country
- Study of Oxidized Albumin in Liver Transplant PatientsNot yet recruitingNCT06772298
- Efficacy and Safety of ALSS Treatment for ICIs-LF in Patients With HCCRecruitingNCT05484908Not applicable1 country
- Assessment of the Pharmacokinetic Profile of Tacrolimus Medications and Their Relation to Effectiveness and Safety in Liver Transplant PatientsRecruitingNCT057446352 countries
- Predictive Values of Presepsin Levels in ASciteS in Patients With Chronic Liver FailureRecruitingNCT062240231 country
- Clinical Retrospective Study Analysis of Postoperative Complications Following HepatectomyRecruitingNCT065322141 country
- Fecal Microbiota Transplantation for Liver FailureRecruitingNCT05170971Not applicable1 country
- A Multicenter Prospective Clinical Cohort Study on the Pathogen Spectrum of Severe Hepatitis (Liver Failure) Complicated With InfectionNot yet recruitingNCT06272071
- Throid Dysfunction in Liver Failure and Its Eddects Upon OutcomeRecruitingNCT061793681 country
- Characteristics and Risk Factors for Invasive Fungal Infection With Acute-on-chronic Hepatitis B Liver FailureNot yet recruitingNCT06190002
- Quantitative MRI and Outcomes of Liver ResectionNot yet recruitingNCT06181318
- May the Risk of PHLF be Predicted With Preoperative Liver Gadoxetate MRIRecruitingNCT04692259Not applicable4 countries
- Alterations in Coagulation Factor Levels in Patients With End Stage Liver DiseaseNot yet recruitingNCT060143201 country
- Registry Study for Optimal Management of Liver Failure in the Chinese PopulationRecruitingNCT057406961 country
- Effects of Donor and Recipient Genetic Expression on Heart, Lung, Liver, or Kidney Transplant SurvivalCompletedNCT005319211 country
- Effects of the SGLT2 Inhibitor Empagliflozin in Patients With Euvolemic and Hypervolemic HyponatremiaCompletedNCT04447911Phase 43 countries
- Veliparib, Paclitaxel, and Carboplatin in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery and Liver or Kidney DysfunctionActive, not recruitingNCT01366144Phase 11 country
- TReatment for ImmUne Mediated PathopHysiologyActive, not recruitingNCT04862221Phase 21 country
- Efficacy, Safety and Tolerability of VS-01 in Adult Patients With Acute-on-Chronic Liver Failure and Ascites (UNVEIL-IT)®TerminatedNCT05900050Phase 27 countries
- Bridge to HOPE: Hypothermic Oxygenated Perfusion Versus Cold Storage Prior to Liver TransplantationCompletedNCT05045794Not applicable1 country
- Safety and Clinical Activity of QEL-001 in A2-mismatch Liver Transplant PatientsActive, not recruitingNCT05234190Phase 1/23 countries
- Epidemiology of Complications After Solid Organ Transplantation - EpCOT StudyActive, not recruitingNCT029911051 country
- BRIDGE Device for Post-operative Pain ControlTerminatedNCT03265249Not applicable1 country
- Bidirectional Cohort Study of a Prognosis Model for Acute-on-chronic Liver FailureActive, not recruitingNCT075481901 country
- Ex Vivo Perfusion of Gene-Edited Porcine Livers in Patients With Severe Hepatic FailureActive, not recruitingNCT07519005Early Phase 11 country
- Raltegravir in Patients With End Stage Liver Disease and in Transplant RecipientsCompletedNCT01022476Phase 1/21 country
- Pyrophosphate Homeostasis and Hepatic Expression of ABCC6.Pyro-THCompletedNCT03576859Not applicable1 country
- Single-Cell and Spatial Transcriptomics Analysis of Steatotic Donor Liver Susceptibility to Post-Transplant InjuryCompletedNCT073627451 country
- Quantitative Evaluation of the Progression of Liver Disease, Using ShearWaveTMCompletedNCT020703151 country
- A Non-interventional, Post-Marketing Study to Describe Outcome of Nitisinone Treatment in HT-1 PatientsWithdrawnNCT062274291 country
- Biliary Anastomosis Using Surgical Loupe Versus Microscope in Living Donor Liver TransplantationCompletedNCT04618692Not applicable1 country