An observational study in Hepatitis B and Acute-On-Chronic Liver Failure, sponsored by Third Affiliated Hospital, Sun Yat-Sen University. Recruiting at 1 site in China. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2024-11-29.
Sponsored by Third Affiliated Hospital, Sun Yat-Sen University · Observational
This study is to investigate the long-term outcomes and prognostic risk factors in patients recovered from hepatitis B virus related acute on-chronic liver failure.
Chronic acute liver failure (ACLF) is a systemic multi-organ failure driven by acute liver injury in the basis of chronic liver disease. The main cause of chronic acute liver failure in China is hepatitis b virus infection.Previous studies on the prognosis of acute on-chronic liver failure mainly focused on the short-term survival rate and the follow-up time was relatively short, while the study on the long-term prognosis of patients with spontaneous recovery of chronic acute liver failure was still lack-ing. Thus,this study mainly retrospectively analyzed the clinical data of patients with chronic hepatitis b related acute liver failure admitted to the department of infectious diseases, the third affiliated hospital of sun yat-sen university, and con-ducted telephone follow-up survey to analyze the long-term prognosis of patients with chronic hepatitis b related acute on-chronic liver failure.
1,662 studies on the registry are indexed under Hepatitis B; 192 are open to participants now.
This study's planned enrollment of 300 is below the median of 395 across 410 observational studies indexed under Hepatitis B.
Browse Hepatitis B studies →Third Affiliated Hospital, Sun Yat-Sen University is the lead sponsor of 133 studies on the registry; 35 are open to participants now.
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This study population were patients with hepatitis b-related acute on-chronic liver failure in the department of infectious diseases, the third affiliated hospital of sun yat-sen university.
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Exclusion Criteria:
To investigate the clinical events and prognosis of patients with hepatitis b associated acute on-chronic liver failure
adverse events
Adverse events included decompensated cirrhosis, hepatocellular carcinoma, liver transplantation, and death.
Time frame: 5 years
Plan to share: Yes — Individual participant data that underline the results reported in this article (text, tables, figures and appendices) will be shared.
Supporting information: Study protocol, Statistical analysis plan, Informed consent form, Clinical study report, Analytic code
Time frame: The data will be shared beginning 3 months and ending 5 years following the article publication.
Access criteria: Proposals should be directed to xxx@yyy. To gain access, data requestors need to sign a data access agreement.
No publications or documents are linked to this record.
Started May 2020 (actual). Primary completion is estimated for Dec 2024, 55 months after the start.
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Third Affiliated Hospital, Sun Yat-Sen University →