Acute-On-Chronic Liver Failure: all 173 studies
Page 1 of 2. Open to participants first (59), then studies with results posted, then the rest; newest registration first within each.
- Very Low-volume Plasma Exchange in ACLFNot yet recruitingNCT07857434Not applicable
- Evaluating Novel Scoring Systems to Predict Outcomes in Acute-on-Chronic Liver FailureNot yet recruitingNCT07734896
- Phase 2 Study of 500 mg BID NTZ on Top of Standard of Care in Patients With Acute Decompensation of Liver Cirrhosis at High Risk of Progression to Acute-on-Chronic Liver Failure or Established Acute-on-Chronic Liver FailureNot yet recruitingNCT07694297Phase 2
- Plasma Exchange Half-dose and Extracorporeal Detoxification for ACLFNot yet recruitingNCT07593638Not applicable
- Predictors of Decompensation, Acute-on-chronic Liver Failure and Mortality in Liver CirrhosisRecruitingNCT07438288
- RENEW: Study of Porcine Liver Support in Participants With Acute-on-Chronic Liver FailureNot yet recruitingNCT07429838Phase 1/2
- Efficacy and Safety of Early Initiation of Midodrine for Control and Prevention of Ascites and Its Related Complications in Acute-on-chronic Liver Failure.Not yet recruitingNCT07422948Not applicable
- A Novel Extracorporeal Liver Support Therapy In ALCF and to Evaluate the Efficacy of DIALIVE 2.0, a Liver Dialysis Device.RecruitingNCT07347275Not applicable
- Risk Factors Affecting MSC Efficacy in ACLF PatientsRecruitingNCT07198854
- Vitamin C for Acute Kidney Injury in ACLF With Septic Shock: A Randomized Controlled TrialNot yet recruitingNCT07184866Not applicable
- Double Plasma Separation and Adsorption in Acute-on-Chronic Liver Failure (DPMAS-ACLF Trial)Not yet recruitingNCT07178366Not applicable
- National Collaborative Centre for Hepatic Regenerative Medicine (NC-CHRM): Phase I Study on Safety and Efficacy of Mesenchymal Stem-Cell (MSC) Therapy in Non-Viral Acute-on-Chronic Liver Failure (ACLF)Not yet recruitingNCT07131540Phase 1
- National Collaborative Centre for Hepatic Regenerative Medicine (NC-CHRM): Evaluating Mesenchymal Stem Cell Therapy in Non-viral Acute on Chronic Liver Failure (ACLF) Patient- Phase-II TrialNot yet recruitingNCT07131306Phase 2
- National Collaborative Centre for Hepatic Regenerative Medicine (NC-CHRM): Evaluating Mesenchymal Stem-Cell (MSC) Therapy in Non-viral Acute on Chronic Liver Failure (ACLF) Patients - Phase-III TrialNot yet recruitingNCT07075315Phase 3
- Continuous Renal Replacement Therapy Intensity in HyperammonemiaEnrolling by invitationNCT06987604Not applicable
- Prognosis of Cirrhotic Patients Admitted to the General Intensive Care Unit Between 2014 and 2024: a Regional Retrospective Multicentre Cohort StudyRecruitingNCT06948565
- Chinese Phase II Trail of AS1501 in Acute-on-chronic Liver Failure (ACLF) PatientsRecruitingNCT06916585Phase 2
- A-TANGO Phase 2 StudyRecruitingNCT06890039Phase 2
- Umbilical Cord-derived Mesenchymal Stem Cell Infusion for Treating ACLFNot yet recruitingNCT06884904Phase 2/3
- Single Cell Landscape of HBV-related Acute-on-chronic Liver Failure PatientsRecruitingNCT06865859
- Study About Hepatic Toxins Kinetic and Evaluation of Organ Damage in Acute on Chronic Liver Failure (ACLF) PatientsRecruitingNCT06837766
- Comparison of Blood Products Required Using Two Different ROTEM Cut-offs Before Invasive Procedures in Cirrhosis and Acute on Chronic Liver Failure (ACLF) Patients With Severe CoagulopathyRecruitingNCT06831565Not applicable
- MSC-EVs in Acute/ Acute-on-Chronic Liver Failure After Liver TransplantationNot yet recruitingNCT06825572Phase 1
- Comparison of Efficacy and Safety of Ceftazidime Avibactam Versus Extended Infusions of High Dose Meropenem in Patients of ACLF With Nosocomial Infections.Not yet recruitingNCT06818565Not applicable
- Efficacy and Safety of Continuous Infusion of Terlipressin vs Bolus Terlipressin in ACLF Patients With Acute Esophageal Variceal BleedNot yet recruitingNCT06815770Phase 2/3
- Goal Directed Ammonia Lowering Therapy in Hyperammonemic ACLF Patients With no Overt HE to Reduce Major Adverse Liver Related Outcomes (GOAL Trial)Not yet recruitingNCT06808009Not applicable
- Efficacy and Safety of Cytokine Adsorption and Plasma Exchange in Patients With ACLF and SepsisRecruitingNCT06562803Not applicable
- Safety and Efficacy of Continuous Infusion of Terlipressin With Norepinephrine Versus Norepinephrine Alone in Improving Outcomes of Acute Kidney Injury in Acute on Chronic Liver Failure With Septic ShockNot yet recruitingNCT06556472Not applicable
- Study on Prognosis of Acute-on-chronic Liver Failure Complicated by Bacterial or Fungal InfectionRecruitingNCT06437067
- To Determine the Predictors of Reversibility for Acute-on-Chronic Liver Failure at 6-months.Not yet recruitingNCT06387160
- To Optimize Therapeutic Procedures of DPMAS in ACLF Patients: a Prospective, Sigle Arm and Multicenter StudyNot yet recruitingNCT06377774
- Acute hemodynamiC Response To Carvedilol Predicts Survival in ACLF PatientsNot yet recruitingNCT06298656
- An Open-label Randomized Controlled Trial Comparing the Role of Therapeutic Plasma-exchange in Ameliorating Secondary Organ Dysfunctions in Patients With ACLF and Develop Biomarkers of Treatment ResponseNot yet recruitingNCT06276907Not applicable
- Acute on Chronic Liver Failure in Cirrhotic Patients at Assiut University HospitalsNot yet recruitingNCT06142968
- Individual Nutrition Support in HBV-ACLF Patients at Nutrition RiskRecruitingNCT06128421Not applicable
- Lactate Kinetics as a Predictor of Survival in ACLF With Septic ShockNot yet recruitingNCT06116305
- COOLEY- Study: aCute On chrOnic Liver failurE Using the cYtosorb DeviceRecruitingNCT06079021Not applicable
- Prognostic Significance of Acute Change in Liver and Splenic Stiffness in Patients of Acute on Chronic Liver FailureNot yet recruitingNCT06069284
- SALT for Treatment of Patients With Early ACLFNot yet recruitingNCT06069037Not applicable
- To Study the Role of Plasma Von Willebrand Factor Antigen (vWF) to A Disintegrin-like and Metalloproteinase With Thrombospondin Type-1 Motifs 13 (ADAMTS-13) Activity Ratio as a Predictor of Development of Extrahepatic Organ Failure in Acute on Chronic Liver Failure (ACLF) Patients.Not yet recruitingNCT06066814
- Robotic vs. Laparoscopic vs. Open Living Donor HepatectomyEnrolling by invitationNCT06062706
- The Safety ,Tolerability and Efficacy Study of HepaCure in Chinese Subjects with Acute-On-Chronic Liver FailureRecruitingNCT05989958Phase 1/2
- Human Umbilical Cord Mesenchymal Stem Cell Transplantation for The Treatment of Acute-on-Chronic Liver FailureRecruitingNCT05985863Phase 1/2
- Identification and Verification of Neutrophil Extracellular Trap Net Related Markers in Acute-on-chronic Liver FailureNot yet recruitingNCT05909319
- A Novel COMBinATorial Therapy With Albumin and Enoxaparin in Patients With Decompensated Cirrhosis at High-risk of Poor Outcome (COMBAT Trial).RecruitingNCT05895136Phase 2
- The Efficacy and Safety of Rifaximin TreatmentRecruitingNCT05786859Early Phase 1
- Micro-encapsulated Hepatocyte Intraperitoneal Transplantation in Liver Failure AdultsRecruitingNCT05727722Phase 1
- Point-of-Care Echocardiography to Assess Impact of Dynamic Cardiac Function, Renal and Cardiac Biomarkers in Cirrhosis With Refractory AscitesRecruitingNCT05700708
- F573 for Injection for the Treatment of Liver Injury/FailureRecruitingNCT05689645Phase 2
- Immune Profile, Neuronal Dysfunction, Metabolomics and Ammonia in Therapeutic Response of HE in ACLFRecruitingNCT05421351
- Prognosis of Patients With Acute-on-chronic Liver FailureRecruitingNCT05393453
- CytOSorb TreatMent Of Critically Ill PatientS RegistryRecruitingNCT05146336
- The Effects of Double Plasma Molecular Adsorption System in Acute on Chronic Liver Failure PatientsRecruitingNCT05030571Not applicable
- Characterization and Pathogenesis of ACLFRecruitingNCT04975490
- Liver Transplantation in Patients With CirrHosis and Severe Acute-on-Chronic Liver Failure: iNdications and outComEsRecruitingNCT04613921
- Combination of DPMAS and Low Volume PE for Patients With HBV Related ACLFRecruitingNCT04597164
- Predicting Acute-on-Chronic Liver Failure After Surgical Intervention in Chronic Liver DiseaseRecruitingNCT04578301
- Long-term Prognosis of Patients With Hepatitis B Related Acute-on-chronic Liver FailureRecruitingNCT04310787
- Three Types of Nucleotide/Nucleoside Analogues Treatment in HBV Related ACLFRecruitingNCT03920618Not applicable
- Efficacy, Safety and Tolerability of VS-01 in Adult Patients With Acute-on-Chronic Liver Failure and Ascites (UNVEIL-IT)®TerminatedNCT05900050Phase 2Results posted
- TAK-242 in Patients With Acute Alcoholic HepatitisTerminatedNCT04620148Phase 2Results posted
- Short-term Survival of Subjects With Acute-on-chronic Liver Failure After Plasma Exchange With Human Serum Albumin 5%TerminatedNCT03702920Phase 3Results posted
- Chinese CLIF-C Acute-on-Chronic Liver Disease and Liver Failure StudyCompletedNCT02457637Results posted
- The Relationship Between Novel Virological Indicators and Treatment With Different Nucleotide Analogues and the Prognosis of HBV-ACLF PatientsCompletedNCT07815418
- PT-MSCs Exosome Injection in the Treatment of Chronic-to-acute Liver FailureActive, not recruitingNCT07409259Early Phase 1
- Pharmacokinetic Study on G1090N (Nitazoxanide) Capsules in Healthy VolunteersCompletedNCT07110441Phase 1
- Phase I Trial of QH-1A Hybrid Bio-Artificial Liver With Ex Vivo Blood-Purifying MSCs in Acute-on-Chronic Liver FailureActive, not recruitingNCT06996392Phase 1
- A Study to See if an Investigational Medicine Called VS-01 Can Help and How Safe it is in the Treatment of Patients With Overt Hepatic EncephalopathyTerminatedNCT06987968Phase 2
- Plasma Proteomics Study of End-Stage Liver Disease Patients Based on Olink TechnologyActive, not recruitingNCT06865898
- Validation of New Prognostic Biomarkers in Patients With Decompensated CirrhosisCompletedNCT06855056
- Efficacy and Safety of BMSCs (CG-BM1) for ACLF PatientsCompletedNCT06740149Phase 1/2
- Feasibility Pilot Study to Evaluate the Safety and Performance of the MEX-CD1 Medical Device in ACLFCompletedNCT06340269Not applicable
- miroliverELAP® for the Treatment of Acute Liver Failure: A Phase 1 TrialCompletedNCT06285253Phase 1
- The Safety and Efficacy of MSC-EVs in Acute/Acute-on-Chronic Liver FailureWithdrawnNCT05940610Phase 1/2
- MSC-EV in Acute-on-Chronic Liver Failure After Liver TransplantationWithdrawnNCT05881668Phase 1
- S100A8/A9 and Innate Immunity in Liver DiseaseStatus unknownNCT05793983
- Characterization of Metabolomic Fingerprints in Patients With Acute Liver Failure and Acute-on-chronic Liver Failure With Hepatic EncephalopathyWithdrawnNCT05772585
- Albumin Infusion in Inpatients With Decompensated CirrhosisStatus unknownNCT05719051
- Intravenous BCAA for HE in ACLF (BCAA-HE-ACLF)CompletedNCT05700695Phase 1
- To Compare Relaxed Rotational Thromboelastometry Cut-offs With Standard Cut-offs for Guiding Blood Product Use Before Invasive Procedures in Cirrhosis and Acute on Chronic Liver Failure PatientsStatus unknownNCT05672589Not applicable
- Role of Bilirubin Molecular Species in Hepatic Encephalopathy and Acute-on-chronic Liver FailureStatus unknownNCT05566548
- The Renal Safety of Tenofovir Alafenamide in HBV-related Acute-on-chronic Liver Failure: Real-World StudyCompletedNCT05453448Not applicable
- 20% Albumin vs. Balanced Salt Solution as Resuscitation Fluid in Cirrhosis With Sepsis Induced HypotensionStatus unknownNCT05441878Phase 4
- Point-of-Care Echocardiography to Assess Impact of Dynamic Cardiac Function, Renal and Cardiac Biomarkers in Cirrhosis With Hepatorenal Syndrome-Acute Kidney InjuryStatus unknownNCT05434286
- Efficacy and Safety of Avatrombopag for Treating TCP in HBV-ACLF Patients Receiving ALSS TreatmentStatus unknownNCT05382013Phase 4
- Acute Hemodynamic Response to Carvedilol in Predicting Survival in Acute on Chronic Liver Failure Patients - A Pilot Study.Status unknownNCT05180292Not applicable
- CytoSorb® in Patients With Acute on Chronic Liver FailureWithdrawnNCT05131230
- Precise Profiling of Liver Disease Patients With DPMAS Therapy, Treating Optimal Patients and Achieving Hard Endpoint (PADSTONE Study)Active, not recruitingNCT05129904
- Goal-Directed Hemostatic Resuscitation Trial in ACLF Induced CoagulopathyCompletedNCT05124041Not applicable
- Intravenous NAC Use in ACLF PatientsStatus unknownNCT05089981Not applicable
- Volume Resuscitation in Cirrhosis With Sepsis Induced HypotensionCompletedNCT05059795
- Transplantation for EASL-CLIF and APASL ACLF Patients: a Retrospective Cohort StudyStatus unknownNCT05036031
- Cytokine Adsorption in Acute-on-chronic Liver FailureStatus unknownNCT05019352Not applicable
- Utility of Liver and Splenic Stiffness in Predicting Esophageal Varices in Patients With Acute on Chronic Liver FailureCompletedNCT04983108
- Incidence and Predictors of Bleeding Diathesis Development Due to DIC in Cirrhosis and ACLF Patients Undergoing CRRTStatus unknownNCT04960163
- Citrate Pharmacokinetics in Critically Ill Liver Failure Patients Receiving CRRTCompletedNCT04959110Not applicable
- Safety of UC-MSC Transfusion for ACLF PatientsStatus unknownNCT04822922Phase 2
- Acute-On-Chronic Liver Failure In Cirrhotic PatientsCompletedNCT04790435
- Thromboelastography Guides a Multicentre Cluster Controlled Study of Plasma Exchange for Hepatitis B Associated Acute-on-chronic Liver FailureStatus unknownNCT04747106Not applicable
- Role of Fecal Microbiota in Predicting Graft Rejection and Sepsis Among Recipients of Living Donor Liver Transplant in First Year.Status unknownNCT04621812