Mania clinical trials

The registry lists 166 studies for Mania across more than 10 countries. 13 are recruiting or about to start. 50 of them are mainly about Mania (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10.

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Breast cancer · Recruiting: 2 came in, 3 changed

What changed in your saved searches, Oct 31 – Nov 6:

A study of drug A after surgery for early breast cancer

Came in · now Recruiting

Drug B with hormone therapy in advanced breast cancer

Changed

· Sites: 4 added, including Seoul and Busan

· Enrollment: 300 → 450 participants

Exercise during chemotherapy

Now Active, not recruiting

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Status

Completed: 129
Recruiting: 11
Status unknown: 10
Terminated: 10
Withdrawn: 3
Not yet recruiting: 2

Phase

Phase 3: 54
Phase 4: 38
Phase 2: 24
Phase 1: 4

Where

United States: 94
Ukraine: 15
Poland: 13
Russian Federation: 11
Bulgaria: 10
Canada: 10

Who runs them

Massachusetts General Hospital (13) · Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (13) · AstraZeneca (10) · Otsuka Pharmaceutical Development & Commercialization, Inc. (8) · National Institute of Mental Health (NIMH) (8) · Mclean Hospital (7) · University of Texas Southwestern Medical Center (6) · Forest Laboratories (5)

What is being tested here

Drugs under test in Mania studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted

Drug	Open	Phase 3	All
Xanomeline	4	4	4
Trospium	4	4	4
Trospium chloride	1	1	1
Direclidine	1	0	1
Quetiapine	0	3	9
Risperidone	0	7	9
Lithium	0	3	8
Valproic Acid	0	4	8
Aripiprazole	0	3	5
Cariprazine	0	4	5

Drug classes tested here Antimuscarinics 4 open · Antipsychotics 40 · SSRIs 3

Coming up

4phase 3 studies under way

5studies finish main data collection within a year3 of them phase 3

Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.

All 5, phase 3 first

Nov 2026A Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder · Phase 3 · Bristol-Myers Squibb
Nov 2026A Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder (BALSAM-2) · Phase 3 · Bristol-Myers Squibb
Jun 2027A Study to Evaluate the Efficacy and Safety of Adjunctive KarXT for the Treatment of Mania, With or Without Mixed Features, in Participants With Bipolar-I Disorder Taking Lithium, Valproate, or Lamotrigine · Phase 3 · Bristol-Myers Squibb
Mar 2027A Novel Blood Test as a Biomarker in Mental Health · Fraser Health
May 2027Combining mHealth and Nurse-delivered Care to Improve the Outcomes of People With Serious Mental Illness in West Africa · University of Washington

Who these studies take

Of the 11 Mania studies recruiting now, 5 (45%) set no upper age limit and 6 (55%) stop at 75 or younger. 0 (0%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 2 (18%) take healthy volunteers.

Recruiting studies that take each age, of 11
Age	Women	Men
10	0 (0%)	0 (0%)
18	9 (82%)	9 (82%)
30	11 (100%)	11 (100%)
40	11 (100%)	11 (100%)
50	11 (100%)	11 (100%)
65	11 (100%)	11 (100%)
75	5 (45%)	5 (45%)
85	5 (45%)	5 (45%)

Across all 166 studies, recruiting or not: 79% stop at 75 or younger and 68% at 65; 28% take children; 2% are for women only and 1% for men only; 11% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.

Studies

Recruiting first, then most recently updated. Showing 50 of 166. Browse all 166 → or search them.