Mania clinical trials
The registry lists 97 studies for Mania across more than 10 countries. 10 are recruiting or about to start. Per ClinicalTrials.gov, last updated 2026-09-24.
Status
- Completed
- 74
- Recruiting
- 9
- Terminated
- 6
- Status unknown
- 3
- Withdrawn
- 2
- Suspended
- 1
Phase
- Phase 3
- 33
- Phase 4
- 30
- Phase 2
- 11
- Phase 1
- 1
Where
- United States
- 50
- Ukraine
- 10
- Germany
- 8
- Poland
- 7
- Canada
- 7
- China
- 7
Who runs them
Massachusetts General Hospital (10) · AstraZeneca (10) · University of Texas Southwestern Medical Center (5) · Otsuka Pharmaceutical Development & Commercialization, Inc. (5) · Bristol-Myers Squibb (4) · Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (4) · Forest Laboratories (3) · Novartis Pharmaceuticals (3)
Studies
Recruiting first, then most recently updated. Showing 50 of 97 — search for more.
- A Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder (BALSAM-2)RecruitingNCT06951711Phase 311 countries
- A Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I DisorderRecruitingNCT06951698Phase 39 countries
- A Study to Assess the Long-term Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder (BALSAM-3)RecruitingNCT06929273Phase 320 countries
- An Assessment of Efficacy, Safety, and Pharmacokinetics of NBI-1117568 in Adults With Bipolar I Disorder With Current ManiaRecruitingNCT07288320Phase 21 country
- A Study to Evaluate the Efficacy and Safety of Adjunctive KarXT for the Treatment of Mania, With or Without Mixed Features, in Participants With Bipolar-I Disorder Taking Lithium, Valproate, or LamotrigineRecruitingNCT07140913Phase 313 countries
- Immune Mechanisms of Antipsychotic Treatment ResponseRecruitingNCT066876941 country
- LHC-CIDI-5 in Hong KongRecruitingNCT068045251 country
- A Novel Blood Test as a Biomarker in Mental HealthRecruitingNCT068561611 country
- Feasibility and Preliminary Results of the Efficacy of Blue-Blocking Glasses on Manic Symptoms in Bipolar DisorderRecruitingNCT07194278Not applicable1 country
- Effect of Blue Light Blocking on Reducing Manic Symptoms in Bipolar DisorderNot yet recruitingNCT06748716Not applicable1 country
- Study Evaluating the Efficacy and Safety of RAP-219 in Adult Participants With Bipolar I DisorderActive, not recruitingNCT07046494Phase 21 country
- LRFN5 and OLFM4 in Bipolar DisorderCompletedNCT074344141 country
- Aripiprazole Pharmacokinetics (PK) and Tolerability Study in Children and AdolescentsCompletedNCT00102479Phase 1
- Ketosis Impact on Signs & Symptoms of Schizophrenia and Bipolar disorderSCompletedNCT06426134Not applicable1 country
- Long-acting Injectable Antipsychotics for Mental Ill-Health in Pregnancy and PostpartumCompletedNCT057660071 country
- A Study of Spoken Language in ManiaCompletedNCT05956340Not applicable1 country
- Clocks in Sync - Circadian Rhythm and Bipolar ManiaCompletedNCT06504342Not applicable1 country
- A Probiotic Intervention to Prevent Relapse Following Hospitalization for ManiaCompletedNCT03383874Phase 31 country
- BHV-7000 Open-Label Extension Bipolar Mania StudyTerminatedNCT06423794Phase 21 country
- BHV-7000 Acute Treatment of Bipolar ManiaCompletedNCT06419582Phase 2/31 country
- Causal Lesion Network Guided Treatment of Bipolar Mania With Transcranial Electrical StimulationCompletedNCT05445466Not applicable1 country
- Quetiapine for Bipolar Disorder and Alcohol DependenceCompletedNCT00457197Phase 41 country
- CBT for Problematic Impulsive Behaviours in Bipolar Disorder: A Case Series / CBT-PIBSuspendedNCT06129500Not applicable1 country
- Ottawa Sunglasses at Night for Mania StudyCompletedNCT05206747Not applicable1 country
- Feasibility of a Novel Process-based Treatment for Patients With PsychosisCompletedNCT04874974Not applicable1 country
- Effect of tDCS Combined With Pharmacological Treatments for Bipolar ManiaStatus unknownNCT05622552Not applicable1 country
- Ziprasidone And Olanzapine's Outcomes In ManiaTerminatedNCT00329108Phase 45 countries
- Impact of Duration of Untreated Manic Episodes on Clinical OutcomeStatus unknownNCT045639101 country
- A Trial to Evaluate the Safety and Tolerability of Brexpiprazole in the Treatment of Participants With Bipolar I Disorder.CompletedNCT03287869Phase 36 countries
- Inositol and Omega-3 Fatty Acids in Pediatric ManiaCompletedNCT01396486Phase 41 country
- Brain Voxel-based Morphometry in Bipolar ManiaCompletedNCT031816981 country
- A Trial to Assess Brexpiprazole Versus Placebo for the Treatment of Acute Manic Episodes, Associated With Bipolar I DisorderCompletedNCT03257865Phase 33 countries
- A Trial to Assess Brexpiprazole Versus Placebo for the Treatment of Acute Manic Episodes Associated With Bipolar I DisorderCompletedNCT03259555Phase 34 countries
- Neurochemical Effects of Omega-3 Fatty Acids in Adolescents at Risk for ManiaCompletedNCT00917501Phase 21 country
- Allopurinol Maintenance Study for Bipolar DisorderTerminatedNCT00732251Phase 41 country
- Allopurinol Add-on Treatment for Refractory ManiaCompletedNCT00643123Phase 41 country
- Clinical Trial of Lamotrigine to Reverse Cognitive Impairment in Chronic Corticosteroid-Treated PatientsCompletedNCT00223262Phase 41 country
- Effects of Pentazocine Versus Lorazepam on Manic SymptomsCompletedNCT00431184Phase 21 country
- Treatment of Alcohol Dependence and Comorbid Bipolar DisorderCompletedNCT01015586Phase 41 country
- Treatment of Bipolar Mania in Older AdultsCompletedNCT00254488Phase 42 countries
- Comparison of Combination Olanzapine+Lithium or Chlorpromazine+Lithium in Treatment of First Manic Episode With Psychotic FeaturesCompletedNCT00202293Phase 41 country
- A Study of Aerobic Exercise for Adolescents With Subthreshold Mood SyndromesCompletedNCT03300778Not applicable1 country
- Open-Label Study of Latuda for the Treatment of Mania in Children and Adolescents 6-17 Years OldWithdrawnNCT01932541Phase 41 country
- Seroquel in the Treatment of Dysphoric Hypomania in Bipolar IICompletedNCT00186043Phase 41 country
- Safety and Efficacy of Cariprazine for ManiaCompletedNCT01058096Phase 32 countries
- Study Evaluating Cariprazine (RGH-188) in the Treatment of Patients With Acute ManiaCompletedNCT00488618Phase 21 country
- Safety and Efficacy of Cariprazine for Bipolar I DisorderCompletedNCT01058668Phase 36 countries
- Open Label Extension Study of Licarbazepine in the Treatment of Manic Episodes of Bipolar I DisorderCompletedNCT00139594Phase 413 countries
- An Open-label Extension Study to Evaluate the Safety and Tolerability of Licarbazepine 750-2000 mg/d in the Treatment of Manic Episodes of Bipolar I DisorderCompletedNCT00238485Phase 3
- Study of Licarbazepine in the Treatment of Manic Episodes of Bipolar DisorderCompletedNCT00107939Phase 31 country