Status Epilepticus clinical trials
The registry lists 124 studies for Status Epilepticus across more than 10 countries. 37 are recruiting or about to start. 96 of them are mainly about Status Epilepticus (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-05.
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· Enrollment: 300 → 450 participants
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Who runs them
University Hospital, Basel, Switzerland (5) · Assistance Publique - Hôpitaux de Paris (5) · Sohag University (5) · Marinus Pharmaceuticals (4) · Versailles Hospital (4) · University Hospital Marburg (3) · Assiut University (3) · Supernus Pharmaceuticals, Inc. (3)
What is being tested here
Drugs under test in Status Epilepticus studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Ketamine | 3 | 5 | 6 |
| Levetiracetam | 2 | 4 | 13 |
| Phenobarbital | 1 | 1 | 3 |
| Midazolam | 1 | 0 | 2 |
| Perampanel | 1 | 0 | 2 |
| Lorazepam | 0 | 8 | 10 |
| Valproic Acid | 0 | 2 | 5 |
| Fosphenytoin | 0 | 2 | 3 |
| Ganaxolone | 0 | 2 | 3 |
| Clonazepam | 0 | 2 | 2 |
Drug classes tested here Anxiolytics 10
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest
- Dec 2026Rapid-Response EEG in Children With Suspected Status Epilepticus · Children's Hospital at Montefiore
- Dec 2026The STatus Epilepticus Prognosis Study · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
- Feb 2027KD Treatment for Super-refractory Status Epilepticus · Xuanwu Hospital, Beijing
- Mar 2027Patient-reported Outcome and Patient-reported Experience After Status Epilepticus · Versailles Hospital
- Mar 2027Improving Status Epilepticus Treatment Times · Nationwide Children's Hospital
- Apr 2027Lacosamide Intravenous Injection for Emergency Termination of Status Epilepticus · Second Affiliated Hospital of Guangzhou Medical University
- May 2027PeRampanel fOr Status ePilEpticus pRophylaxis Post-cardiac Arrest · University of California, San Francisco
- Jul 2027Ketamine for the Treatment of Refractory Status Epilepticus · Thomas Jefferson University
- Jul 2027EEG Monitoring for Refractory Status Epilepticus · Barts & The London NHS Trust
- Sep 2027The Role of Imaging in the Diagnosis, Management and Prognosis of Possible Non-convulsive Status Epilepticus · Universitaire Ziekenhuizen KU Leuven
Who these studies take
Of the 29 Status Epilepticus studies recruiting now, 16 (55%) set no upper age limit and 8 (28%) stop at 75 or younger. 14 (48%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 2 (7%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 10 (34%) | 10 (34%) |
| 18 | 23 (79%) | 23 (79%) |
| 30 | 21 (72%) | 21 (72%) |
| 40 | 21 (72%) | 21 (72%) |
| 50 | 21 (72%) | 21 (72%) |
| 65 | 21 (72%) | 21 (72%) |
| 75 | 21 (72%) | 21 (72%) |
| 85 | 18 (62%) | 18 (62%) |
Across all 124 studies, recruiting or not: 35% stop at 75 or younger and 33% at 65; 51% take children; 0% are for women only and 0% for men only; 8% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Status Epilepticus studies take
Of 22 interventional studies with no phase under Status Epilepticus, half reached primary completion within 42 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 42 mo9–65 · 22 studies | — | — |
| Observational | 35 mo14–… · 20 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
Studies
Recruiting first, then most recently updated. Showing 50 of 124. Browse all 124 → or search them.
- Predictors of Outcomes of Convulsive Status EpilepticusNot yet recruitingNCT07853391
- Ketamine add-on Therapy for Established Status Epilepticus Treatment Trial (KESETT)RecruitingNCT06907173Phase 31 country
- EEG Monitoring for Refractory Status EpilepticusRecruitingNCT04170491Not applicable1 country
- COMparison Between Anakinra and Tocilizumab in NORSE - "COMBAT-NORSE"Not yet recruitingNCT07281027Phase 37 countries
- Application of tDCS Stimulation in Controlling Refractory Status EpilepticusRecruitingNCT06344338Not applicable1 country
- buRst-supprESsion TO Stop Refractory Status Epilepticus Post-cardiac ArrestRecruitingNCT05851391Phase 21 country
- PeRampanel fOr Status ePilEpticus pRophylaxis Post-cardiac ArrestRecruitingNCT06401707Phase 21 country
- Patient-reported Outcome and Patient-reported Experience After Status EpilepticusRecruitingNCT061009781 country
- Treatment of ELectroencephalographic STatus Epilepticus After Cardiopulmonary Resuscitation-2 (TELSTAR-2)RecruitingNCT06549426Not applicable2 countries
- Improving Outcomes for Patients With Life-Threatening Neurologic IllnessRecruitingNCT041894711 country
- Simulation Trial of Telemedical Support for ParamedicsRecruitingNCT06441760Not applicable1 country
- Electrographic Seizure Management and Neurobehavioral Outcomes in Critically Ill ChildrenRecruitingNCT034192601 country
- De-identified UNMH EEG Corpus Database Creation With Fully De-identified Clinical InformationRecruitingNCT051402651 country
- Status Epilepticus Population Study (STEPS)RecruitingNCT042048631 country
- Recovery Trajectory for Coma and Disorders of ConsciousnessRecruitingNCT076140741 country
- Use of Cognitive Aid Methods in the Management of Status EpilepticusNot yet recruitingNCT07603843Not applicable
- Study of Pathophysiology of Status Epilepticus and Dysimmune EncephalitisRecruitingNCT04421846Not applicable1 country
- KD Treatment for Super-refractory Status EpilepticusRecruitingNCT07496749Not applicable1 country
- Fast Acute Sedation at Intensive Care vs. High-dose i.v. Anti-seizure Medication for Treatment of Non-convulsive Status Epilepticus (FAST-trial)RecruitingNCT05263674Phase 31 country
- Improving Status Epilepticus Treatment TimesRecruitingNCT06194747Not applicable1 country
- Augmented Renal Clearance in Neurocritical CareRecruitingNCT074106242 countries
- Targeted Hypothermia Versus Targeted Normothermia After Convulsive Refractory Status EpilepticusNot yet recruitingNCT07383779Phase 31 country
- Melatonin for the Treatment of DEE-SWASNot yet recruitingNCT07221968Phase 2
- Ketamine for the Treatment of Refractory Status EpilepticusNot yet recruitingNCT07177235Phase 41 country
- Prehospital Early Administration of Ketamine for Status Epilepticus in Epileptic Kids (PEAK-SEEK)RecruitingNCT07095842Phase 2/31 country
- Levetiracetam Versus Phenobarbital in Benzodiazepines Unresponsive Paediatric Prolonged SeizuresRecruitingNCT07098728Not applicable1 country
- Ketamine and Levetiracetam as Second-line Antiseizure Medication for Status Epilepticus in ChildrenRecruitingNCT07046611Phase 2/31 country
- Lacosamide Intravenous Injection for Emergency Termination of Status EpilepticusNot yet recruitingNCT069668301 country
- Study of Patients with Electrical Status Epilepticus in SleepRecruitingNCT067923961 country
- The Role of Imaging in the Diagnosis, Management and Prognosis of Possible Non-convulsive Status EpilepticusRecruitingNCT06017973Not applicable1 country
- Exogenous Ketone Esters for Refractory Status EpilepticsRecruitingNCT05674552Phase 2/31 country
- The STatus Epilepticus Prognosis StudyRecruitingNCT065908831 country
- Assessment of Adults Epidemiological Characteristics of Status Epilepticus in the French West Indies and in French GuianaRecruitingNCT052465661 country
- Rapid-Response EEG in Children With Suspected Status EpilepticusRecruitingNCT065646621 country
- Cardiac Injury With Convulsive Status EpilepticusNot yet recruitingNCT06119919
- Sustained Effort Network for Treatment of Status Epilepticus/European Academy of Neurology Registry on Refractory Status Epilepticus (SENSE-II/AROUSE)RecruitingNCT058394188 countries
- Status Epilepticus in the Critically Ill PatientsRecruitingNCT034578311 country
- Training Program to Improve EEG CompetenceCompletedNCT07689084Not applicable1 country
- The Efficacy and Safety of Levetiracetam Versus Fosphenytoin in Convulsive Status EpilepticusCompletedNCT06403150Phase 41 country
- Efficacy of Epidiolex in Patients With Electrical Status Epilepticus of Sleep (ESES).CompletedNCT04721691Phase 11 country
- Dual Anti-glutamate Therapy in Super-refractory Status Epilepticus After Cardiac ArrestCompletedNCT057566211 country
- A Study to Evaluate Efficacy and Safety of Vatiquinone for Treating Mitochondrial Disease in Participants With Refractory EpilepsyTerminatedNCT04378075Phase 2/39 countries
- Status Epilepticus in Men and Women: Clinical Presentation, Management, and OutcomesCompletedNCT07443241
- Study of Antiepileptic Drug in Generalised Convulsive Status EpilepticusCompletedNCT01150331Phase 31 country
- Efficacy and Safety of Perampanel in the Treatment of Refractory Status EpilepticusTerminatedNCT05684978Phase 41 country
- A Study With SAGE-547 for Super-Refractory Status EpilepticusCompletedNCT02477618Phase 316 countries
- Multicenter Retrospective Study of Isoflurane in Refractory and Super-Refractory Status EpilepticusCompletedNCT058308641 country
- An Open Label, Expanded Access Protocol With SAGE-547 for Super-Refractory Status EpilepticusNo longer availableNCT02433314
- Study to Evaluate SAGE-547 Injection as Adjunctive Therapy for the Treatment of Super-Refractory Status EpilepticusCompletedNCT02052739Phase 1/21 country
- Comparison of Intravenous Brivaracetam Versus Levetiracetam in the Management of Status EpilepticusCompletedNCT07163572Not applicable1 country