Muscular Atrophy clinical trials
The registry lists 413 studies for Muscular Atrophy across more than 10 countries. 77 are recruiting or about to start. 172 of them are mainly about Muscular Atrophy (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12. Counting its narrower condition Sarcopenia too: 1,681 studies, 482 open.
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A study of drug A after surgery for early breast cancer
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· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
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Status
Who runs them
Novartis Pharmaceuticals (13) · University of Nottingham (11) · McMaster University (9) · Maastricht University Medical Center (8) · University of Erlangen-Nürnberg Medical School (6) · University of Utah (6) · Bispebjerg Hospital (6) · United States Army Research Institute of Environmental Medicine (6)
What is being tested here
Drugs under test in Muscular Atrophy studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Nov 2026Long-Term Safety & Efficacy of Apitegromab in Patients With SMA Who Completed Previous Trials of Apitegromab · Phase 3 · Scholar Rock, Inc.
- Nov 2026Role of Metformin on Muscle Health of Older Adults · University of Utah
- Dec 2026Neuromuscular Electrical Stimulation in Critically Ill Patients Aged 80 and Over · Universidad de La Frontera
- Dec 2026Essential Amino Acid Supplementation for Femoral Fragility Fractures · Michael C Willey
- Dec 2026The Role of Blood Flow Restriction Therapy in Postoperative Elderly Patients With Hip Fracture · University of Alabama at Birmingham
- Dec 2026Protein Supplementation During Luteal Phase to Stop Protein Degradation · Sam Houston State University
- Dec 2026Testing LiverWatch, a Home-Based Remote-Monitoring Intervention for Advanced Liver Disease · University of Pennsylvania
- Dec 2026Stromal Vascular Fraction Cell Therapy to Improve the Repair of Rotator Cuff Tears · Hospital for Special Surgery, New York
- Dec 2026Changes in Skeletal Muscle Thickness in Patients With Acute Heart Failure · Tufts Medical Center
- Dec 2026Improved Muscle Metabolism by Combination of Muscle Activation and Protein Substitution ( IMEMPRO ) · Technical University of Munich
Who these studies take
Of the 51 Muscular Atrophy studies recruiting now, 24 (47%) set no upper age limit and 13 (25%) stop at 75 or younger. 4 (8%) take children under 18. 3 (6%) are for women only and 1 (2%) for men only; 17 (33%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 3 (6%) | 3 (6%) |
| 18 | 33 (65%) | 30 (59%) |
| 30 | 36 (71%) | 33 (65%) |
| 40 | 36 (71%) | 34 (67%) |
| 50 | 38 (75%) | 37 (73%) |
| 65 | 43 (84%) | 42 (82%) |
| 75 | 40 (78%) | 39 (76%) |
| 85 | 32 (63%) | 31 (61%) |
Across all 412 studies, recruiting or not: 38% stop at 75 or younger and 29% at 65; 9% take children; 6% are for women only and 11% for men only; 42% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Muscular Atrophy studies take
Of 19 phase 2 interventional studies under Muscular Atrophy, half reached primary completion within 40 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 2 | 40 mo22–43 · 19 studies | — | — |
| Interventional, no phase | 22 mo9–37 · 174 studies | — | 22 mo9–41 · 168 studies |
| Observational | 35 mo18–66 · 38 studies | — | 33 mo18–66 · 36 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Started recruiting1
- Mortality and Muscle Mass Loss in Critically Ill Patients.Oct 19, 2026NCT07280039
Newly registered3
- Electrical Muscle Stimulation (EMS) Versus Standard Physiotherapy for Quadriceps Recovery Following Total Knee ReplacementNov 12, 2026NCT07932821
- The Aim of the Study is to Decipher the Alterations in Signalling Pathways of Skeletal Muscle Stem Cells (Satellite Cells (SCs)) in Individuals With COPD, as Well as to Examine the Effect of Exercise Training on SCs.Nov 6, 2026NCT07923656
- Neuromuscular Electrical Stimulation to Improve the Muscle Health of Individuals With Acute Kidney InjuryNov 4, 2026NCT07915713
Studies
Recruiting first, then most recently updated. Showing 50 of 413. Browse all 413 → or search them.
- Electrical Muscle Stimulation (EMS) Versus Standard Physiotherapy for Quadriceps Recovery Following Total Knee ReplacementRecruitingNCT07932821Not applicable1 country
- A Long-term Safety Study in Brazilian Patients With a Diagnosis of Spinal Muscular Atrophy Treated With ZolgensmaRecruitingNCT060196371 country
- The Effect of Repeated Whole-body NMES Sessions With or Without Protein Intake on Muscle Protein Synthesis During 3 Days of Bed Rest in Healthy Young VolunteersRecruitingNCT07062562Not applicable1 country
- The Aim of the Study is to Decipher the Alterations in Signalling Pathways of Skeletal Muscle Stem Cells (Satellite Cells (SCs)) in Individuals With COPD, as Well as to Examine the Effect of Exercise Training on SCs.Not yet recruitingNCT07923656Not applicable1 country
- Neuromuscular Electrical Stimulation to Improve the Muscle Health of Individuals With Acute Kidney InjuryNot yet recruitingNCT07915713Not applicable1 country
- Changes in Skeletal Muscle Thickness in Patients With Acute Heart FailureRecruitingNCT062531041 country
- Characterization and Longitudinal Monitoring of Muscular Phenotype in Patients Admitted to Intensive Care for SepsisRecruitingNCT07074028Not applicable1 country
- Mortality and Muscle Mass Loss in Critically Ill Patients.RecruitingNCT072800391 country
- Essential Amino Acid Supplementation for Femoral Fragility FracturesRecruitingNCT06050668Phase 21 country
- Weaning Assessment by Peripheral Muscle UltrasonographyNot yet recruitingNCT07860879
- Heat Therapy During Reduced Physical ActivityRecruitingNCT07847424Not applicable1 country
- Protein Supplementation During Luteal Phase to Stop Protein DegradationRecruitingNCT07843095Not applicable1 country
- Ultrasound and Shear Wave Elastography for Assessment of the Quality of Rotator Cuff MusclesNot yet recruitingNCT07837583
- C-Protein in Fatigue and AgingRecruitingNCT05926219Not applicable1 country
- Impact of NMES and HPRO on Recovery After SAH- Pilot StudyRecruitingNCT03201094Not applicable1 country
- Ultrasound Detection of Body Composition in Critical CareRecruitingNCT067287221 country
- HMB Plus Vitamin D to Preserve Muscle in Older Adults Starting SemaglutideNot yet recruitingNCT07760948Phase 21 country
- Resistance Exercise, IL-7 and Immune Phenotypes in Prostate CancerNot yet recruitingNCT07724080Not applicable1 country
- CALM-AF-AI: Counteracting Age-related Loss of Muscle With AAV-Follistatin Combined With Angiogenesis-Inducing VEGF Plasmid Gene TherapyRecruitingNCT07443826Phase 1/21 country
- Effect of Knee Position on Muscle Loss During Leg ImmobilizationNot yet recruitingNCT07690150Not applicable
- Postoperative Electrical Muscle Stimulation TwoRecruitingNCT06964438Not applicable1 country
- Effects of Dietary Supplementation With omega3-fatty Acids (Fish Oil) and Progressive Resistance Training on Skeletal Muscle Status in Gynaecological, Gastrointestinal and Urological Cancer PatientsRecruitingNCT07643558Not applicable1 country
- Muscle Ultrasound for Sarcopenia Assessment in Kidney Transplant RecipientsNot yet recruitingNCT076072361 country
- NLRP3 Inflammasome and Physical Therapy in ICU-Acquired WeaknessRecruitingNCT07017517Not applicable1 country
- Intertrochanteric Femur Fracture Patients Who Receive Metformin With a PlaceboEnrolling by invitationNCT07179042Early Phase 11 country
- Combatting Muscle Loss in Obese Adult Patients on GLP-1 Medications Through Dietary Counseling and Exercise During Treatment Evaluates Whether a 12-week Exercise and Individualized Nutrition Program Can Reduce Muscle and Bone Loss and Improve Strength, Fitness, and Function in Obese Adults on GLP-1Not yet recruitingNCT07554417Phase 41 country
- Exercise Training in Women With Metastatic Breast CancerNot yet recruitingNCT07521826Not applicable1 country
- Exercise for the Treatment of Cancer-Related SarcopeniaNot yet recruitingNCT07498985Not applicable1 country
- Electromyostimulation (EMS) of Astronauts in Spaceflight (Easymotion-2)Enrolling by invitationNCT06492057Not applicable1 country
- Post Operative Use of Neuromuscular Electrical Stimulation (NMES) Device for ACLR PatientsEnrolling by invitationNCT07171346Not applicable1 country
- Improved Muscle Metabolism by Combination of Muscle Activation and Protein Substitution ( IMEMPRO )RecruitingNCT05919940Not applicable2 countries
- Clinical Safety Evaluation and Preliminary Efficacy Study of Subcutaneous Myografts TransplantationNot yet recruitingNCT07426068Early Phase 11 country
- A Study of the Effect of (S)-Pindolol Benzoate (ACM-001.1) on Lean Body Mass (LBM) in Obese Patents During (PROACT 1), and Post-semaglutide Therapy (PROACT 2)RecruitingNCT07101939Phase 21 country
- Testing the Efficacy, Safety, and PK of 20E in Patients With Obesity Who Are Starting Treatment With the GLP-1 Agonist Semaglutide for Weight Loss.Not yet recruitingNCT07411378Phase 2
- Flexi Band Resistance Training Versus EMS Exercise in Patients With the Diagnosis of Malignant DiseasesRecruitingNCT04067167Not applicable1 country
- Preventing Muscle Loss After Bariatric Surgery: Protein-Collagen Supplementation and Resistance ExerciseRecruitingNCT07303543Not applicable1 country
- Metformin and Muscle RecoveryRecruitingNCT06185179Early Phase 11 country
- A SkeleTal Muscle Recovery Intervention With Dietary Protein in Heart FailureRecruitingNCT05627440Not applicable1 country
- MuScle WastIng and DysphaGia iN CriticAlly IlL Patients (SIGNAL)RecruitingNCT070765241 country
- Identifying Fundamental Mechanisms of Skeletal Muscle Ageing in Older Men Undergoing Androgen Deprivation Therapy: a Feasibility StudyNot yet recruitingNCT07134439
- Neuromuscular Electrical Stimulation in Critically Ill Patients Aged 80 and OverNot yet recruitingNCT07127991Not applicable1 country
- Continuous Passive Motion to Prevent Ankle Contracture and Muscle Atrophy in Ventilated PatientsNot yet recruitingNCT07032051Not applicable1 country
- Plant vs Animal-based Protein Sources as an Anabolic and Metabolic-protective Options for SO in Older AdultsNot yet recruitingNCT07030738Not applicable1 country
- Food Intake of Hospitalized Elderly and Its Influence on Muscular and Clinical OutcomesRecruitingNCT069402841 country
- Impacts of Mechanistic Target of Rapamycin (mTOR) Inhibition on Aged Human Muscle (Rapamune)RecruitingNCT05414292Not applicable1 country
- The Role of Surgical Approach on Residual Limping After Total Hip ArthroplastyRecruitingNCT05216666Not applicable1 country
- Achilles Tendon for the Treatment of Gluteus Medius InsufficiencyRecruitingNCT05206838Not applicable1 country
- Resistance Training, Detraining, and Retraining Study 2024 (TraDeRe2024)RecruitingNCT06573086Not applicable1 country
- The Role of Type 2 Diabetes on Skeletal Muscle Atrophy and Recovery Following Bed Rest in Older AdultsRecruitingNCT03761446Not applicable1 country
- Effects of L-ARGinine and Liposomal Vitamin C Supplementation On Physical PerformanceRecruitingNCT06865261Not applicable1 country