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Constipation clinical trials

The registry lists 1,046 studies for Constipation across more than 10 countries. 161 are recruiting or about to start. 768 of them are mainly about Constipation (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10. Counting its narrower condition Opioid-Induced Constipation too: 1,104 studies, 166 open.

ClinicalTrials.gov finds 1,259 studies for Constipation. How that becomes 1,044 here

This page counts the studies the registry files under Constipation, and those it files under no condition that list Constipationthemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count

  1. 1,259Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
  2. −58Filed under a narrower condition, counted on its own pageOpioid-Induced Constipation 55
  3. −71List Constipation as a condition, but the registry did not file them under itMost often written as “Functional Constipation” (16), “Constipation - Functional” (14), and “Irritable Bowel Syndrome With Constipation” (8). The registry filed them under other conditions only, most often Irritable Bowel Syndrome (19) and Gastroesophageal Reflux (5).
  4. −86Match it another way67 name it in the title, 12 in a keyword, and 7 by a synonym or other text the search reads.
  5. 1,044The count on this page237 of them list Constipation in their own words; the registry filed them under no condition.

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Status

Completed
675
Status unknown
100
Recruiting
98
Not yet recruiting
58
Terminated
54
Withdrawn
27

Phase

Phase 2
169
Phase 3
150
Phase 4
105
Phase 1
54
Early Phase 1
8

Where

United States
345
China
109
Turkey
71
United Kingdom
61
Canada
50
France
42

Who runs them

Bausch Health Americas, Inc. (21) · Movetis (19) · Braintree Laboratories (16) · Mayo Clinic (14) · Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) (12) · Augusta University (12) · Cairo University (11) · Novartis (10)

What is being tested here

Drugs under test in Constipation studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted

DrugOpenPhase 3All
Polyethylene glycol 33502324
Probiotic2014
Sennosides139
Electrolytes113
Tenapanor112
Inulin102
Naldemedine102
Fluoxetine102
Fecal microbiota102
Pyridostigmine102

Drug classes tested here SSRIs 2 open · Cholinesterase inhibitors 1 open · Serotonin receptor agonists 33 · Opioid antagonists 27 · Opioids 8

Coming up

9phase 3 studies under way
60studies finish main data collection within a year5 of them phase 3

Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.

The 10 nearest, phase 3 first

Who these studies take

Of the 98 Constipation studies recruiting now, 32 (33%) set no upper age limit and 51 (52%) stop at 75 or younger. 16 (16%) take children under 18. 12 (12%) are for women only and 1 (1%) for men only; 28 (29%) take healthy volunteers.

Recruiting studies that take each age, of 98
AgeWomenMen
1012 (12%)12 (12%)
1870 (71%)61 (62%)
3080 (82%)70 (71%)
4084 (86%)73 (74%)
5077 (79%)70 (71%)
6572 (73%)67 (68%)
7554 (55%)50 (51%)
8538 (39%)34 (35%)

Across all 1,046 studies, recruiting or not: 52% stop at 75 or younger and 38% at 65; 21% take children; 9% are for women only and 1% for men only; 26% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.

How long Constipation studies take

Of 41 phase 2 interventional studies under Constipation, half reached primary completion within 20 months of starting, counting those still running.

Start to primary completionEvery sponsorIndustryNon-industry
Phase 121 mo10–38 · 13 studies——
Phase 220 mo10–42 · 41 studies19 mo10–29 · 24 studies—
Phase 321 mo10–37 · 36 studies21 mo10–37 · 28 studies—
Phase 425 mo9–39 · 34 studies——
Interventional, no phase14 mo6–30 · 314 studies11 mo5–16 · 71 studies17 mo7–35 · 243 studies
Observational26 mo13–46 · 52 studies—26 mo12–46 · 42 studies

Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out

What changed recently

From the registry's own updates since Oct 11, 2026.

Started recruiting1

Newly registered9

Show 4 more

Studies

Recruiting first, then most recently updated. Showing 50 of 1,046. Browse all 1,046 → or search them.