Anhedonia clinical trials

The registry lists 134 studies for Anhedonia across more than 10 countries. 50 are recruiting or about to start. 45 of them are mainly about Anhedonia (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10.

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Status

Completed: 70
Recruiting: 43
Terminated: 5
Not yet recruiting: 4
Withdrawn: 3
Enrolling by invitation: 3

Phase

Phase 2: 15
Phase 1: 8
Phase 3: 7
Phase 4: 6

Where

United States: 76
Germany: 11
United Kingdom: 9
Sweden: 8
Belgium: 7
China: 7

Who runs them

University of North Carolina, Chapel Hill (5) · University of California, Los Angeles (5) · Mclean Hospital (5) · Emory University (4) · Janssen Research & Development, LLC (4) · Florida State University (4) · University of Oxford (4) · Region Skane (4)

What is being tested here

Drugs under test in Anhedonia studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted

Drug	Open	Phase 3	All
Psilocybin	2	0	4
Pramipexole	1	3	3
Levodopa	1	0	2
Carbidopa	1	0	2
Baricitinib	1	0	1
Estradiol	1	0	1
Progesterone	1	0	1
Tocilizumab	1	0	1
Toludesvenlafaxine	1	0	1
Escitalopram	1	0	1

Drug classes tested here Serotonin receptor agonists 2 open

Coming up

1phase 3 study under way

19studies finish main data collection within a year

Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.

The 10 nearest

Dec 2026Multisite rTMS for Mood, Cognitive Impairment and Other Symptoms of Depression · Jakub Antczak
Dec 2026Developing Brain Imaging Analysis Expertise for Personalizing Transcranial Electric Stimulation in Anhedonia Treatment of Patients With Bipolar Depression · The University of Texas Health Science Center, Houston
Dec 2026Evaluation of Anhedonia and Emotional Eating in Individuals Using GLP-1 Receptor Agonists · TC Erciyes University
Dec 2026Get ActivE Study for At-risk Youth · University of Pittsburgh
Dec 2026Long-term Follow-up of Depressive Disorders in Psychiatric Care · Region Skane
Dec 2026Examining the Effects of Estradiol on Neural and Molecular Response to Reward · University of North Carolina, Chapel Hill
Dec 2026A Digitally Assisted Risk Reduction Platform for Youth at High Risk for Suicide · Ksana Health
Jan 2027Dopaminergic Therapy for Anhedonia - 2 · Emory University
Jan 2027Olfactory and Brain Stimulations in Treatment-resistant Depression · Hôpital le Vinatier
Apr 2027Neuromodulation of Motivation and Reward Oscillations · Florida State University

Who these studies take

Of the 43 Anhedonia studies recruiting now, 8 (19%) set no upper age limit and 33 (77%) stop at 75 or younger. 8 (19%) take children under 18. 2 (5%) are for women only and 0 (0%) for men only; 14 (33%) take healthy volunteers.

Recruiting studies that take each age, of 43
Age	Women	Men
10	0 (0%)	0 (0%)
18	35 (81%)	34 (79%)
30	35 (81%)	34 (79%)
40	33 (77%)	32 (74%)
50	32 (74%)	30 (70%)
65	22 (51%)	21 (49%)
75	12 (28%)	11 (26%)
85	9 (21%)	8 (19%)

Across all 134 studies, recruiting or not: 81% stop at 75 or younger and 72% at 65; 13% take children; 5% are for women only and 0% for men only; 36% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.

How long Anhedonia studies take

Of 12 phase 2 interventional studies under Anhedonia, half reached primary completion within 22 months of starting, counting those still running.

Start to primary completion	Every sponsor	Industry	Non-industry
Phase 2	22 mo17–35 · 12 studies	—	—
Interventional, no phase	26 mo14–46 · 65 studies	—	26 mo15–46 · 58 studies

Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out

What changed recently

From the registry's own updates since Oct 13, 2026.

Studies

Recruiting first, then most recently updated. Showing 50 of 134. Browse all 134 → or search them.