Drug
Midazolam clinical trials
Also written Versed, Dormicum, USL261 and SHP615.
How each study uses Midazolam is sorted by a rule, right about nine times in ten. Readers can ask us to read every study one by one.Ask us to read each study
Get an email when these change. Save the Midazolam studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
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Approvals
The first approval found in each region, with its record
- United States
- 20 Dec 1985 · VERSED · NDA 018654 (FDA, Drugs@FDA)
- European Union
- 4 Sept 2011 · Buccolam · EMEA/H/C/002267 (EMA)
From FDA's Drugs@FDA and Purple Book (through openFDA) and the European Medicines Agency, files of Sept 2026 and 27 Oct 2026. National approvals in Europe and other countries are not included. How this is worked out
How studies write it
Studies that test it under each name
Studies by the year they started
423 studies that test it; most in 2017 (27)
| Year | Studies |
|---|---|
| 1996 | 1 |
| 2000 | 1 |
| 2001 | 1 |
| 2003 | 2 |
| 2004 | 3 |
| 2005 | 7 |
| 2006 | 9 |
| 2007 | 11 |
| 2008 | 14 |
| 2009 | 14 |
| 2010 | 13 |
| 2011 | 17 |
| 2012 | 13 |
| 2013 | 21 |
| 2014 | 18 |
| 2015 | 25 |
| 2016 | 18 |
| 2017 | 27 |
| 2018 | 24 |
| 2019 | 23 |
| 2020 | 16 |
| 2021 | 27 |
| 2022 | 27 |
| 2023 | 22 |
| 2024 | 20 |
| 2025 | 25 |
| 2026 | 24 |
By phase
A phase 1/2 study counts in both.
What it is tested for
Each study’s main condition, where its own words name it, so a study counts once.
Who runs them
Industry 96 · Other 327
Assiut University (10) · Ain Shams University (8) · Seoul National University Hospital (8) · Tanta University (7) · Pfizer (7) · Eli Lilly and Company (7) · Boehringer Ingelheim (7) · Zagazig University (6)
Often tested with
Tested in the same studies.
Dexmedetomidine (84) · Propofol (52) · Ketamine (38) · Fentanyl (33) · Omeprazole (13) · Caffeine (11) · Remifentanil (10) · Sevoflurane (9)
Related medicines
As reviewed, each with the page that says it.
- One of Anesthetics, Intravenous source
- One of Hypnotics and Sedatives source
- One of Benzodiazepines source
Coming up
From the study records. Dates are the sponsors’ own estimates and often move.
Tested against it · 8 phase 3 studies under way
Midazolam is the comparator. A study of two new drugs counts under both.
- 3Dexmedetomidine · University Hospital, Tours, Post Graduate Institute of Medical Education and Research, Chandigarh · next primary completion Dec 2027
- 2Ketamine · Abraham Nunes, Theresa Jacob, PhD, MPH · next primary completion Sep 2027
- 1Nitrous Oxide · Women's College Hospital · next primary completion Feb 2027
- 1Remimazolam · Guy's and St Thomas' NHS Foundation Trust
Reaching primary completion within a year · 25, 4 in phase 3
Studies that test Midazolam, phase 3 first.
- Nov 2026Equivalence of Oral Melatonin and Oral Midazolam in Preoperative Anxiolysis for Pediatric Fast-Track Cardiac SurgeryPhase 2/3 · Ain Shams University
- May 2027Lactium Versus Midazolam Premedication on Postoperative Negative Behavioral ChangesPhase 2/3 · Tanta University
- Jun 2027REMIMID-ICU: Remimazolam vs Midazolam for Deep Sedation in Hemodynamically Unstable, Mechanically Ventilated AdultsPhase 3 · Yancheng First People's Hospital
- Oct 2027Effect of Sedative and Anxiolytic Premedication on Children Experience After General AnesthesiaPhase 3 · University Hospital, Montpellier
- Nov 2026Safety of Driving After Minor Surgery With Monitored Anesthesia CarePhase 4 · Rush University Medical Center
- Nov 2026The Effect of Dormicum-Ketamine Versus Dexmedetomidine on Emergence Delirium During Deep Sedation in Paediatric Burn PatientsPhase 2 · Ain Shams University
- Nov 2026A Study to Assess the Potential CYP3A Induction Effect of Brensocatib on the Pharmacokinetics (PK) of Midazolam in Healthy ParticipantsPhase 1 · Insmed Incorporated
- Nov 2026Comparative Evaluation of Intranasal Atomized Midazalom Combined With Nitrous Oxide Versus Nitrous Oxide MonotherapyNot applicable · Shaheed Zulfiqar Ali Bhutto Medical University
- Dec 2026Dexmedetomidine-Midazolam vs. Ketamine-Midazolam on Emergence DeliriumPhase 4 · Kasr El Aini Hospital
- Dec 2026Evaluating the Pharmacokinetics of Oregano and Potential Oregano-drug Interactions Using a Drug Cocktail ApproachEarly Phase 1 · Washington State University
Studies
Open first, then newest update. How each study uses Midazolam is read from its arms, and is right about nine times in ten. Ask us to read each study. These are the studies that list it as an intervention; a search of ClinicalTrials.gov also finds studies that mention it only in a description, such as earlier treatment.
Testing it · 423
- Lactium Versus Midazolam Premedication on Postoperative Negative Behavioral ChangesNot yet recruitingPhase 2/3Tanta UniversityNCT07928947Written as Midazolam
- Effect of Midazolam Given at Induction on Recall of Propofol Injection PainNot yet recruitingPhase 4Atlas UniversityNCT07912567Written as Midazolam
- Comparative Evaluation of Intranasal Atomized Midazalom Combined With Nitrous Oxide Versus Nitrous Oxide MonotherapyRecruitingNot applicableShaheed Zulfiqar Ali Bhutto Medical UniversityNCT07876024Written as Midazolam (Intranasal)
- The Effects of Midazolam, Dexmedetomidine, and Esketamine on Bispectral Index and Raw Electroencephalogram in Patients Under Propofol-Remifentanil Baseline AnesthesiaRecruitingNot applicableChina-Japan Friendship HospitalNCT07699523Written as Midazolam
- Exploration of Appropriate BIS Range and Propofol Effect-site Concentration During Total Intravenous Anesthesia With Concomitant Adjuvants.RecruitingNot applicableChina-Japan Friendship HospitalNCT07736352Written as Propofol + Remifentanil +Midazolam
- Conscious Sedation Versus General Anesthesia for Pulsed Field Ablation in Paroxysmal Atrial FibrillationRecruitingNot applicableChina National Center for Cardiovascular DiseasesNCT07877519Written as Midazolam
- A Study of Single and Multiple Doses of LY5625573 in Healthy Participants, Including Japanese and Chinese Populations, and Participants With Inflammation (High C-Reactive Protein)Not yet recruitingPhase 1Eli Lilly and CompanyNCT07867340Written as Midazolam
- A Drug-drug Interaction Study to Evaluate the Effects of Pelabresib on the Pharmacokinetics of Repaglinide, Midazolam, and Combined Oral Contraceptive in Patients With Advanced MalignanciesRecruitingPhase 1Novartis PharmaceuticalsNCT07340190Written as midazolam
- A Study of LY4355756 in Healthy ParticipantsRecruitingPhase 1Eli Lilly and CompanyNCT07765498Written as Midazolam
- A Study to Assess the Potential CYP3A Induction Effect of Brensocatib on the Pharmacokinetics (PK) of Midazolam in Healthy ParticipantsNot yet recruitingPhase 1Insmed IncorporatedNCT07859007Written as Midazolam
- Efficacy of Intravenous Midazolam-Ketamine Combination Versus Placebo for Prevention of Post-Spinal Shivering in Elective Cesarean SectionNot yet recruitingPhase 4Assiut UniversityNCT07855523Written as Midazolam and Ketamine
- Effect of Sedative and Anxiolytic Premedication on Children Experience After General AnesthesiaRecruitingPhase 3University Hospital, MontpellierNCT05681572Written as Midazolam
- A Study to Investigate the Safety and PK of VH4770359 in Healthy ParticipantsRecruitingPhase 1ViiV HealthcareNCT07525544Written as Midazolam
- Comparing Sedatives for Intracranial Pressure Control in Traumatic Brain InjuryNot yet recruitingNot applicableAswan UniversityNCT07678216Written as midazolam
- Induction in the DarkRecruitingPhase 4Medical University of South CarolinaNCT06144177Written as Preoperative midazolam
- Timing Of Midazolam İn Children Undergoing Adenotonsillectomy: Effects On Stress, Cortisol, And RecoveryNot yet recruitingNot applicableErzurum City HospitalNCT07622641Written as Midazolam (Oral)
- Evaluating the Pharmacokinetics of Oregano and Potential Oregano-drug Interactions Using a Drug Cocktail ApproachRecruitingEarly Phase 1Washington State UniversityNCT06693960Written as Drug cocktail
- Patient Quality of Recovery After TAVR With Different Sedation RegimensRecruitingPhase 4David LyubashevskyNCT07556523Written as Midazolam
- Comparative Study Between Different Additives to Lidocaine 2٪ for Peribulbar Block in Vitreoretinal SurgeryNot yet recruitingNot applicableSohag UniversityNCT07519694Written as · Group M (Midazolam):
- The Effect of Dormicum-Ketamine Versus Dexmedetomidine on Emergence Delirium During Deep Sedation in Paediatric Burn PatientsRecruitingPhase 2Ain Shams UniversityNCT07519863Written as Midazolam + Ketamine
See all 423 studies that test Midazolam →
Given beside what is tested · 287 — Midazolam is usual care or a partner of the new treatment
- A Study to Investigate Safety, Tolerability, PK, and PD of AZD4248 in Healthy Participants, Participants With CKD and Type 2 Diabetes, Assess Home Measurements of Creatinine in a Non-Interventional Cohort, and Assess the Effect of AZD4248 on the PK of Midazolam and Metformin in Healthy ParticipantsRecruitingPhase 1AstraZenecaNCT07024823Written as Midazolam
- The RECAP2 Study: Midazolam and PsilocybinRecruitingPhase 1University of Wisconsin, MadisonNCT06692192Written as Midazolam
- An Open-Label Study to Evaluate PF-07994525 in Participants With Advanced CancersRecruitingPhase 1PfizerNCT07426757Written as Midazolam
- A Study Evaluating the Efficacy and Safety of Inavolisib Plus Fulvestrant Compared With Alpelisib Plus Fulvestrant in Participants With HR-Positive, HER2-Negative, PIK3CA Mutated, Locally Advanced or Metastatic Breast Cancer Post CDK4/6i and Endocrine Combination TherapyRecruitingPhase 3Hoffmann-La RocheNCT05646862Written as Midazolam
- A Phase I Study of the Interaction of D-2570 With Other Drugs in Healthy AdultsNot yet recruitingPhase 1InventisBio Co., LtdNCT07875842Written as Midazolam
- DDI Study of ECC0509 With Metformin, Midazolam, and CaffeineNot yet recruitingPhase 1EccogeneNCT07873229Written as Midazolam
- A Clinical Trial of MK-6916 With Midazolam and Rosuvastatin in Healthy Participants (MK-6916-012)Not yet recruitingPhase 1Merck Sharp & Dohme LLCNCT07862621Written as Midazolam
- A Drug-Drug Interaction Study Between NTQ5082 Capsules and Midazolam Oral SolutioNot yet recruitingPhase 1The Third Xiangya Hospital of Central South UniversityNCT07745439Written as Midazolam
- A Phase 1, First-in-human Study of VX-433RecruitingPhase 1Vertex Pharmaceuticals IncorporatedNCT07584434Written as Midazolam
- Intravenous Acetaminophen and Ketorolac for Pain Management During Extracorporeal Shockwave LithotripsyEnrolling by invitationPhase 4Horizon Health NetworkNCT07368738Written as IV midazolam
- Phase III Trial of Anlotinib, Catequentinib in Advanced Alveolar Soft Part Sarcoma, Leiomyosarcoma, Synovial Sarcoma (APROMISS)RecruitingPhase 3Advenchen Laboratories, LLCNCT03016819Written as Midazolam 2 mg for CYP3A4 phenotyping
- Effect of Dexamethasone on CYP Enzyme Activity in Healthy Male SubjectsNot yet recruitingPhase 1Min Kyu ParkNCT07426042Written as CYP Probe Cocktail
- A First-in-human Trial of GRT7041 in Healthy ParticipantsRecruitingPhase 1Grünenthal GmbHNCT07289776Written as Midazolam
- An Open-Label Drug Interaction Clinical Study to Evaluate Itraconazole, Rifampin, Midazolam and SIM0270 in Chinese Healthy Adult ParticipantsRecruitingPhase 1Jiangsu Simcere Pharmaceutical Co., Ltd.NCT07357610Written as midazolam
- A Drug-Drug Interaction Study of HDM1002 and Metformin, Empagliflozin, Midazolam, Valsartan, and WarfarinRecruitingPhase 1Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.NCT07331389Written as Midazolam
- Prehospital Early Administration of Ketamine for Status Epilepticus in Epileptic Kids (PEAK-SEEK)RecruitingPhase 2/3Sohag UniversityNCT07095842Written as Midazolam
- Organ Protective Effect of Cetirizine In Patients With Severe BurnsRecruitingPhase 1/2Ruijin HospitalNCT06126991Written as Midazolam and Fentanyl
- Quelling of Excitotoxicity in Acute Stroke With KetamineNot yet recruitingPhase 2/3Lower Merion Neurology Research FoundationNCT03223220Written as Midazolam injection
- Sedation of Ventilated Traumatic Brain Injury Patients With Midazolam Alone Versus Combination With Dexmedetomidine or Magnesium Sulfate; Monitored by Ultrasonograghic Optic Nerve Sheath DiameterNot yet recruitingPhase 3Assiut UniversityNCT05340803Written as midazolam
- A Study to Test Different Doses of BI 1823911 Alone and Combined With Other Medicines in People With Different Types of Advanced Cancer With KRAS MutationActive, not recruitingPhase 1Boehringer IngelheimNCT04973163Written as Midazolam
Showing 20 of 287.
As the comparator · 158 — what is tested is compared with Midazolam
- A Comparison of Pulsed Field Ablation (PFA) vs Cryoablation for Atrial Fibrillation Under Deep SedationRecruitingNot applicableEast Sussex Healthcare NHS TrustNCT07900685Written as Sedation with midazolam and fentanyl
- Impact on Delirium of the Use of DEXmedetomidine as First-line Sedation in PEDIAtric Intensive CareNot yet recruitingPhase 3University Hospital, ToursNCT07542990Written as Midazolam
- Pediatric DeliriumEnrolling by invitationPhase 4University of Massachusetts, WorcesterNCT04669457Written as Oral Midazolam
- Ketamine for Combined Depression and Alcohol Use DisorderRecruitingPhase 1/2University Hospital of North NorwayNCT06090422Written as Midazolam Hydrochloride
- Intranasal Dexmedetomidine vs Oral Midazolam for Premedication in Pediatric SurgeryRecruitingNot applicableSaglik Bilimleri Universitesi Gazi Yasargil Training and Research HospitalNCT07565116Written as Midazolam
- Nebulized Ketamine for the Treatment of Major Depressive DisorderRecruitingPhase 3Theresa Jacob, PhD, MPHNCT06752759Written as nebulized midazolam
- Safety and Efficacy of Dexmedetomidate vs. Midazolam for Procedural Sedation During Medical ThoracoscopyRecruitingPhase 3Post Graduate Institute of Medical Education and Research, ChandigarhNCT07184801Written as Midazolam
- Efficacy of Dexmedetomidine Versus Midazolam Sedation on Extubation Time in Mechanically Ventilated Preterm InfantsRecruitingPhase 3Assistance Publique - Hôpitaux de ParisNCT06878703Written as Midazolam
- The Effectiveness of Binaural Beats on Midazolam Requirement During Cesarean Section With Spinal AnesthesiaNot yet recruitingNot applicableYonsei UniversityNCT07386054Written as Midazolam
- Sustained Mood Improvement With Laughing Gas ExposureNot yet recruitingPhase 3Women's College HospitalNCT07262008Written as inhalation of %100 oxygen + intravenous midazolam
- Evaluating the Benefit of Hypnoanalgesia Versus Neuroleptanalgesia During Hand SurgeryRecruitingNot applicableGCS Ramsay Santé pour l'Enseignement et la RechercheNCT06185829Written as Neuroleptanalgesic treatment
- Remimazolam vs Midazolam to Reduce Delirium in Adults ≥65 Undergoing CPB Valve SurgeryNot yet recruitingPhase 4Yonsei UniversityNCT07265128Written as Midazolam
- Administration of Intranasal Midazolam for Anxiety in Palliative CareRecruitingPhase 2Insel Gruppe AG, University Hospital BernNCT06330584Written as Midazolam Nasal Spray 0.45 mg/spray
- Inhaled Isoflurane for Sedation of Invasively Ventilated Patients With Cardiogenic Shock on Extracorporeal Membrane OxygenationNot yet recruitingPhase 3Assistance Publique - Hôpitaux de ParisNCT07099014Written as Propofol, midazolam
- Anxiolytic Effect of Virtual Reality Immersion Versus Midazolam Premedication in Patients Undergoing Dacryocystorhinostomy SurgeryRecruitingNot applicableCairo UniversityNCT07050095Written as Midazolam Group
- Ciprofol's Impact on Oxygenator Function in Extracorporeal Membrane Oxygenation (ECMO) PatientsNot yet recruitingPhase 4First Affiliated Hospital of Wannan Medical CollegeNCT06934811Written as Midazolam
- Remimazolam for Cataract SurgeryRecruitingPhase 4University of California, Los AngelesNCT05980117Written as Midazolam
- Remimazolam Versus Midazolam for Sedation During Upper GI Endoscopy: a Randomized Controlled TrialRecruitingPhase 4Koen MuntersNCT06614036Written as Midazolam
- Sedative Effect and Safety of Remimazolam Besylate in ARDS PatientsRecruitingPhase 4Zhiming JiangNCT05758597Written as midazolam
- Trial Evaluating the Efficacy of Remimazolam in Endobronchial Ultrasound Guided Transbronchial Needle AspirationNot yet recruitingPhase 2Yeungnam University HospitalNCT06275594Written as Midazolam
Showing 20 of 158.
What changed recently
From the registry's own updates since Oct 15, 2026.
Started recruiting3
- Comparative Evaluation of Intranasal Atomized Midazalom Combined With Nitrous Oxide Versus Nitrous Oxide MonotherapyNov 3, 2026NCT07876024
- The Effects of Midazolam, Dexmedetomidine, and Esketamine on Bispectral Index and Raw Electroencephalogram in Patients Under Propofol-Remifentanil Baseline AnesthesiaOct 28, 2026NCT07699523
- Exploration of Appropriate BIS Range and Propofol Effect-site Concentration During Total Intravenous Anesthesia With Concomitant Adjuvants.Oct 28, 2026NCT07736352
Results posted1
- Ketamine Versus Midazolam for Recurrence of Suicidality in AdolescentsOct 15, 2026NCT04592809
Newly registered5
- Lactium Versus Midazolam Premedication on Postoperative Negative Behavioral ChangesNov 10, 2026NCT07928947
- Effect of Midazolam Given at Induction on Recall of Propofol Injection PainNov 3, 2026NCT07912567
- Equivalence of Oral Melatonin and Oral Midazolam in Preoperative Anxiolysis for Pediatric Fast-Track Cardiac SurgeryOct 28, 2026NCT07900321
- Conscious Sedation Versus General Anesthesia for Pulsed Field Ablation in Paroxysmal Atrial FibrillationOct 16, 2026NCT07877519
- Comparative Evaluation of Intranasal Atomized Midazalom Combined With Nitrous Oxide Versus Nitrous Oxide MonotherapyOct 15, 2026NCT07876024
Codes
What other systems call Midazolam · ClinicalTrials.gg INT007834
- MeSH (NLM) D008874MidazolamConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) R60L0SM5BCMIDAZOLAMConfirmed FDA, NLM, Wikidata
- RxNorm 6960Confirmed FDA, Wikidata
- Wikidata Q423071midazolamConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C62049MidazolamOne source FDA
- DrugBank DB00683One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D008874 | Midazolam | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | R60L0SM5BC | MIDAZOLAM | Confirmed FDA, NLM, Wikidata |
| RxNorm | 6960 | — | Confirmed FDA, Wikidata |
| Wikidata | Q423071 | midazolam | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C62049 | Midazolam | One source FDA |
| DrugBank | DB00683 | — | One source Wikidata |
Also registered as midazolam hydrochloride (UNII W7TTW573JJ · RxNorm 203128) and midazolam maleate (UNII 77520S18SE · RxNorm 142441).
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.