Drug
Fluorouracil clinical trials
Also written 5-FU, Ro 2-9757, Carac and Adrucil.
- studies test it
- 820
- open now
- 101
- in phase 3
- 170
- first study started
- 1990
Keep track of what changes. Save the Fluorouracil studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Brand
Other names
Studies by the year they started
810 studies that test it; most in 2006 (39); 1 more planned to start later
| Year | Studies |
|---|---|
| 1990 | 2 |
| 1991 | 1 |
| 1993 | 4 |
| 1994 | 3 |
| 1995 | 3 |
| 1996 | 9 |
| 1997 | 18 |
| 1998 | 22 |
| 1999 | 24 |
| 2000 | 29 |
| 2001 | 33 |
| 2002 | 29 |
| 2003 | 33 |
| 2004 | 30 |
| 2005 | 27 |
| 2006 | 39 |
| 2007 | 32 |
| 2008 | 28 |
| 2009 | 29 |
| 2010 | 25 |
| 2011 | 34 |
| 2012 | 26 |
| 2013 | 17 |
| 2014 | 27 |
| 2015 | 26 |
| 2016 | 24 |
| 2017 | 26 |
| 2018 | 29 |
| 2019 | 23 |
| 2020 | 23 |
| 2021 | 26 |
| 2022 | 21 |
| 2023 | 19 |
| 2024 | 25 |
| 2025 | 22 |
| 2026 | 22 |
By phase
A phase 1/2 study counts in both.
- Early Phase 1
- 8
- Phase 1
- 188
- Phase 2
- 483
- Phase 3
- 170
- Phase 4
- 29
- No phase
- 33
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 131 · Other 689
National Cancer Institute (NCI) (50) · M.D. Anderson Cancer Center (22) · ImmunityBio, Inc. (19) · Memorial Sloan Kettering Cancer Center (18) · Fudan University (15) · Alliance for Clinical Trials in Oncology (14) · Sanofi (14) · European Organisation for Research and Treatment of Cancer - EORTC (13)
Often tested with
Tested in the same studies.
Oxaliplatin (271) · Leucovorin (263) · Cisplatin (171) · Irinotecan (136) · Docetaxel (102) · Paclitaxel (99) · Capecitabine (77) · Bevacizumab (75)
Studies
Open first, then newest update. How each study uses Fluorouracil is read from its arms, and is right about nine times in ten.
Testing it · 820
- Ramucirumab and Paclitaxel or FOLFIRI in Advanced Small Bowel CancersRecruitingPhase 2SWOG Cancer Research NetworkNCT04205968Written as Fluorouracil
- Individual Response to Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Treatment of Peritoneal Carcinomatosis From Peritoneal Mesothelioma or Atypical Mesothelial Proliferation or From Ovarian, Colorectal, or Appendiceal HistologiesRecruitingPhase 1National Cancer Institute (NCI)NCT04847063Written as 5-Fluorouracil
- A Study of Novel Agents or Combinations as Perioperative Treatment in Participants With Locally Advanced Resectable Gastroesophageal AdenocarcinomaRecruitingPhase 2AstraZenecaNCT07069712Written as 5-Fluorouracil (5-FU)
- Testing the Addition of an Anti-Cancer Drug, Abemaciclib, to the Usual Chemotherapy Treatment (5-Fluorouracil) for Metastatic, Refractory Colorectal CancerRecruitingPhase 1National Cancer Institute (NCI)NCT06654037Written as Fluorouracil
- Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening TrialRecruitingPhase 2National Cancer Institute (NCI)NCT05564377Written as Fluorouracil
- A Solid Tumor Study for Long Term Treatment of Cancer Patients Who Participated in Adagrasib StudiesRecruitingPhase 2Mirati Therapeutics Inc.NCT07415031Written as Fluorouracil
- A Clinical Trial of MK-2010 Alone and With Other Treatments in Participants With Advanced Solid Tumors (MK-2010-002)Not yet recruitingPhase 2Merck Sharp & Dohme LLCNCT07793942Written as 5-Fluorouracil
- NBTXR3, Chemotherapy, and Radiation Therapy for the Treatment of Esophageal CancerRecruitingPhase 1M.D. Anderson Cancer CenterNCT04615013Written as Fluorouracil
- DCE-MRI for Neoadjuvant Treatment Assessment in Patients With Borderline Resectable Pancreatic CancerRecruitingPhase 1/2Ohio State University Comprehensive Cancer CenterNCT07705919Written as Fluorouracil
- A Pilot Clinical Trial Comparing Topical Fluorouracil to Fluorouracil Plus Calcipotriene Field Treatments in Patients With Multiple Actinic KeratosesRecruitingPhase 3M.D. Anderson Cancer CenterNCT06851507Written as Fluorouracil/Calcipotriene
- Preoperative Hypofractionated Radiotherapy With FOLFOX for Esophageal or Gastroesophageal Junction AdenocarcinomaRecruitingPhase 2Mayo ClinicNCT06078709Written as Fluorouracil
- Testing Safe Doses of Anti-Cancer Medicines, 5-Flurouracil (5-FU) and Tretinoin (ATRA), Added to the Usual Cancer Treatment of EpendymomaNot yet recruitingPhase 1/2Children's Oncology GroupNCT07848568Written as Fluorouracil
- Pan Tumor Rollover StudyRecruitingPhase 2Bristol-Myers SquibbNCT03899155Written as Fluorouracil
- NALIRIFOX Before Surgery for the Treatment of Borderline Resectable Pancreatic Ductal Adenocarcinoma, Nectar TrialRecruitingPhase 2Roswell Park Cancer InstituteNCT06821997Written as Fluorouracil
- Sintilimab Plus NALIRIFOX or Gemcitabine-Cisplatin as First-Line Treatment for Metastatic Biliary Tract CancerRecruitingPhase 2The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical SchoolNCT07831993Written as Fluorouracil
- GAIA-102 Intraperitoneal Administration in Patients With Advanced Gastrointestinal Cancer of Microsatellite Stable With Malignant AscitesRecruitingPhase 1/2Kyushu UniversityNCT05438459Written as Fluorouracil
- Nivolumab, Fluorouracil, and Interferon Alpha 2B for the Treatment of Unresectable Fibrolamellar CancerRecruitingPhase 1/2M.D. Anderson Cancer CenterNCT04380545Written as Fluorouracil
- A Prospective, Open-Label, Randomized Controlled Clinical Study Comparing Hepatic Arterial Infusion Chemotherapy (HAIC) With Capecitabine as Adjuvant Therapy After Radical Surgery for Malignant Biliary Tract TumorsRecruitingPhase 4Zhai WenlongNCT07790445Written as Oxaliplatin + 5-Fluorouracil/Leucovorin
- A Clinical Study of SHR-A1811 in Combination With Chemotherapy and Bevacizumab Versus Standard Therapy as First-Line Treatment for Advanced Colorectal CancerRecruitingPhase 3Suzhou Suncadia Biopharmaceuticals Co., Ltd.NCT07676162Written as SHR-A1811, Oxaliplatin, Levo-leucovorin, Fluorouracil and Bevacizumab
- Ivonescimab and ADG126, Alone, and in Combination With Leucovorin and Fluorouracil or FOLFIRI Regimen for the Treatment of Microsatellite Stable Advanced/Metastatic Colorectal CancerNot yet recruitingPhase 1City of Hope Medical CenterNCT07363408Written as Fluorouracil
See all 820 studies that test Fluorouracil →
Given in every arm · 635 — Fluorouracil is usual care beside what is tested
- Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients Receiving the Usual Chemotherapy Treatment for Bladder Cancer, ARCHER StudyRecruitingPhase 3NRG OncologyNCT07097142Written as Fluorouracil
- A Study of ASP2138 Together With Chemotherapy and Pembrolizumab in Adults With Gastric CancerRecruitingPhase 3Astellas Pharma Global Development, Inc.NCT07673887Written as 5-FU
- A Study of Zolbetuximab Together With Pembrolizumab and Chemotherapy in Adults With Gastric CancerRecruitingPhase 3Astellas Pharma Global Development, Inc.NCT06901531Written as 5-fluorouracil (5-FU)
- A Clinical Study of MK-2870 Alone or With Other Treatments to Treat Gastrointestinal Cancers (MK-9999-02A)RecruitingPhase 1/2Merck Sharp & Dohme LLCNCT06428409Written as Fluorouracil (5-FU)
- SKB500 Combinations in Patients With Esophageal Squamous Cell CarcinomaRecruitingPhase 2Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd.NCT07700667Written as 5 - FU
- The FLOTILLA Study: Providing Continued Access to The Study Medicines Encorafenib and Binimetinib for Participants in Prior Clinical TrialsRecruitingPhase 4PfizerNCT05203172Written as 5-Fluorouracil
- A Study to Evaluate the Adverse Events, and Efficacy of Intravenous (IV) of Telisotuzumab Adizutecan in Combination With IV Oxaliplatin, Fluorouracil, Folinic Acid/Leucovorin, Bevacizumab, Panitumumab in Adult Participants With Metastatic Colorectal CancerRecruitingPhase 2AbbVieNCT06820463Written as Fluorouracil
- FOLFOX8 Versus mFOLFOX6 With Bevacizumab or Cetuximab for First-Line Unresectable Metastatic Colorectal Cancer (Phase II)Not yet recruitingPhase 2Sun Yat-sen UniversityNCT07621497Written as 5-Fluorouracil
- A Study of Neoadjuvant-adjuvant Durvalumab and FLOT Chemotherapy Followed by Adjuvant Durvalumab in Chinese Patients With Resectable GC/GEJC.Not yet recruitingPhase 3AstraZenecaNCT07877818Written as FLOT Chemotherapy
- Substudy 06E: Umbrella Study of Combination Therapies in Esophageal Cancer (MK-3475-06E/KEYMAKER-U06)RecruitingPhase 1/2Merck Sharp & Dohme LLCNCT06780111Written as 5-Fluorouracil (5-FU)
- A Phase Ⅲ Study of Rilvegostomig in Combination With Fluoropyrimidine and Trastuzumab Deruxtecan as the First-line Treatment for HER2-positive Gastric CancerRecruitingPhase 3AstraZenecaNCT06764875Written as 5-fluorouracil
- A Study to Evaluate Efficacy and Safety of Tislelizumab Plus Chemotherapy for Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Adenocarcinoma and Esophageal Squamous Cell Carcinoma in Racial and Ethnic Minority Patients in the United StatesRecruitingPhase 2BeOne MedicinesNCT07554521Written as 5-fluorouracil (5-FU)
- A Study of Olomorasib (LY3537982) in Participants With Advanced Colorectal Cancer and a KRAS G12C MutationNot yet recruitingPhase 2Eli Lilly and CompanyNCT07814417Written as 5-fluorouracil
- A Study of ASP3082 in Adults With Advanced Solid TumorsRecruitingPhase 1Astellas Pharma IncNCT05382559Written as Fluorouracil
- A Study to Investigate Tislelizumab Administered as Subcutaneous Injection Versus Intravenous Infusion Plus Chemotherapy in Patients With Unresectable or Metastatic Gastric or Gastroesophageal Junction AdenocarcinomaRecruitingPhase 3BeOne MedicinesNCT07043400Written as 5-fluorouracil (5-FU)
- A Study Investigating Alternate Schedules of Tislelizumab Plus Chemotherapy in Japanese Patients With First-line Advanced ESCCRecruitingPhase 2BeOne MedicinesNCT07733180Written as 5-fluorouracil (5-FU)
- Hyperthermia With Chemoradiotherapy in Rectal CancerRecruitingNot applicableUniversity Hospital TuebingenNCT06831981Written as Chemotherapy with 5-fluorouracil
- A Study of Pembrolizumab With Trastuzumab and Chemotherapy in People With Esophagogastric CancerRecruitingPhase 2Memorial Sloan Kettering Cancer CenterNCT06123338Written as 5-Fluorouracil
- Study of Zoldonrasib + Chemo of Investigator's Choice vs Placebo + Chemo of Investigator's Choice as First-line Treatment in Metastatic KRAS G12D-mutated Pancreatic Adenocarcinoma ( RASolute 305 )RecruitingPhase 3Revolution Medicines, Inc.NCT07621718Written as 5-Fluorouracil
- A Study to Assess Intravenous (IV) Telisotuzumab Adizutecan in Combination With Fluorouracil, Folinic Acid, and Oxaliplatin (FOLFOX) Compared to Standard of Care in Adult Participants With First-Line Metastatic Pancreatic Ductal AdenocarcinomaRecruitingPhase 2/3AbbVieNCT07490301Written as Fluorouracil
Showing 20 of 635.
As the comparator · 107 — what is tested is compared with Fluorouracil
- Testing the Addition of the Immunotherapy Drug, Pembrolizumab, to Radiation Therapy Compared to the Usual Chemotherapy Treatment During Radiation Therapy for Bladder Cancer, PARRC TrialRecruitingPhase 2National Cancer Institute (NCI)NCT06770582Written as Fluorouracil
- Enfortumab Vedotin in Combination With Pembrolizumab vs. Concurrent Chemoradiotherapy (cCRT) in People With Muscle Invasive Bladder Cancer (EV-309)RecruitingPhase 3Astellas Pharma Global Development, Inc.NCT07566156Written as Fluorouracil
- Sonesitatug Vedotin in Combination With Capecitabine With or Without Rilvegostomig in Participants With Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma Expressing Claudin18.2RecruitingPhase 3AstraZenecaNCT07431281Written as 5-Fluorouracil
- A Study to Assess Adverse Events, Change in Disease Activity and Optimal Dose of Intravenous (IV) Telisotuzumab Adizutecan With IV Pembrolizumab for First-Line Treatment of Adult Participants With Recurrent or Metastatic Head and Neck Squamous Cell CarcinomaRecruitingPhase 2AbbVieNCT07744126Written as Fluorouracil
- Glufosfamide Versus 5-FU in Second Line Metastatic Pancreatic CancerRecruitingPhase 3Eleison Pharmaceuticals LLC.NCT01954992Written as Fluorouracil
- A Study of Amivantamab Monotherapy and in Addition to Standard-of-Care Chemotherapy in Participants With Advanced or Metastatic Colorectal CancerRecruitingPhase 1/2Janssen Research & Development, LLCNCT05379595Written as Fluorouracil
- First-line Treatment With RC48 Plus Sintilimab and S-1 in Advanced Gastric Cancer (RCTS2)RecruitingPhase 2Qilu Hospital of Shandong UniversityNCT06730373Written as 5-FU
- Re-Radiochemotherapy and Pembrolizumab vs. Immuno(Chemo)Therapy for Locoregionally Recurrent PD-L1 Positive (CPS≥1) HNSCCRecruitingPhase 3Universität des SaarlandesNCT07026474Written as cisplatin + 5-fluorouracil (5FU)
- Gemcitabine Plus Nab-paclitaxel as Switch Maintenance Versus Continuation of Modified FOLFIRINOX as 1st Line Chemotherapy in Patients With Advanced Pancreatic Cancer.RecruitingPhase 3Gruppo Oncologico del Nord-OvestNCT06897644Written as 5-FU (5-fluorouracil)
- A Study to Compare the Efficacy and Safety of YL201 With Standard Chemotherapy in Patients With Metastatic Pancreatic Cancer After Failure of Gemcitabine-Based Systemic ChemotherapyNot yet recruitingPhase 3MediLink Therapeutics (Suzhou) Co., Ltd.NCT07803783Written as 5 Fluorouracil
- Paclitaxel, Ramucirumab and Tislelizumab Switch Maintenance in Advanced HER2-negative and PD-L1 TAP Score of 5 or More Advanced Gastroesophageal AdenocarcinomaNot yet recruitingPhase 3Gruppo Oncologico del Nord-OvestNCT07763171Written as CDDP, 5 Fu
- A Study of BL-M07D1 Versus Physician's Choice of Chemotherapy in Patients With HER2-expressing Locally Advanced or Metastatic Biliary Tract Cancer After Platinum-containing Chemotherapy FailureRecruitingPhase 3Sichuan Baili Pharmaceutical Co., Ltd.NCT07606599Written as Fluorouracil
- A Study Comparing BL-B01D1 With Treatment of Physician's Choice in Patients With Locally Advanced or Metastatic Biliary Tract Cancer After Failure of Platinum-based Chemotherapy(PANKU-BTC01)RecruitingPhase 3Sichuan Baili Pharmaceutical Co., Ltd.NCT07582315Written as Fluorouracil
- A Study of ZG006 for Injection Versus Investigator-Selected Chemotherapy in Participants With Advanced Neuroendocrine CarcinomaNot yet recruitingPhase 3Suzhou Zelgen Biopharmaceuticals Co.,LtdNCT07595913Written as 5-fluorouracil, Calcium folinate and Irinotecan
- Neoadjuvant/Adjuvant AK104 in Microsatellite Instability-high or Mismatch Repair-deficient, Resectable Colon CancerRecruitingPhase 3AkesoNCT07412613Written as 5- Fluorouracil
- Efficacy and Safety of TT-00420 (Tinengotinib) Tablets Versus Chemotherapy in Patients With Advanced Intrahepatic Cholangiocarcinoma Harboring FGFR2 Fusions/Rearrangements or MutationsNot yet recruitingPhase 3TransThera Sciences (Nanjing), Inc.NCT07328919Written as Oxaliplatin, fluorouracil, calcium folinate, irinotecan, capecitabine
- 5-Fluorouracil and Calcipotriene for Treatment of Low Grade Skin CancerRecruitingPhase 2/3Boston UniversityNCT05381597Written as 5-fluorouracil cream
- A Study of ASP-1929 Photoimmunotherapy in Combination With Pembrolizumab in First-line Treatment of Locoregional Recurrent Squamous Cell Carcinoma of the Head and Neck With No Distant MetastasesRecruitingPhase 3Rakuten Medical, Inc.NCT06699212Written as 5-fluorouracil
- Combination Therapy of 5-Fluorouracil and CALcipotriol Versus 5-Fluorouracil in the Treatment of Actinic KeratosisRecruitingPhase 4Maastricht University Medical CenterNCT06499415Written as 5-FU 50 MG/ML Topical Cream
- Liposomal Irinotecan + Oxaliplatin + Bevacizumab Versus Liposomal Irinotecan + 5-FU/LVRecruitingPhase 1/2Dai, GuanghaiNCT06782685Written as 5-FU
Showing 20 of 107.
Codes
What other systems call Fluorouracil · ClinicalTrials.gg INT007511
- MeSH (NLM) D005472FluorouracilConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) U3P01618RTFLUOROURACILConfirmed FDA, NLM, Wikidata
- RxNorm 4492Confirmed FDA, Wikidata
- Wikidata Q238512fluorouracilConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C505FluorouracilOne source FDA
- DrugBank DB00544One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D005472 | Fluorouracil | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | U3P01618RT | FLUOROURACIL | Confirmed FDA, NLM, Wikidata |
| RxNorm | 4492 | — | Confirmed FDA, Wikidata |
| Wikidata | Q238512 | fluorouracil | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C505 | Fluorouracil | One source FDA |
| DrugBank | DB00544 | — | One source Wikidata |
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.