Rectal Neoplasms clinical trials
The registry lists 1,758 studies for Rectal Neoplasms across more than 10 countries. 518 are recruiting or about to start. Per ClinicalTrials.gov, last updated 2026-09-25.
Status
- Completed
- 641
- Recruiting
- 361
- Status unknown
- 291
- Not yet recruiting
- 147
- Active, not recruiting
- 132
- Terminated
- 127
Phase
- Phase 2
- 537
- Phase 1
- 192
- Phase 3
- 161
- Phase 4
- 18
- Early Phase 1
- 13
Where
- United States
- 444
- China
- 391
- France
- 109
- Italy
- 80
- Spain
- 75
- United Kingdom
- 68
Who runs them
National Cancer Institute (NCI) (67) · Sun Yat-sen University (36) · Fudan University (35) · Sixth Affiliated Hospital, Sun Yat-sen University (34) · Memorial Sloan Kettering Cancer Center (25) · City of Hope Medical Center (21) · M.D. Anderson Cancer Center (18) · Peking University Cancer Hospital & Institute (16)
Studies
Recruiting first, then most recently updated. Showing 50 of 1,758 — search for more.
- Preoperative Short-course Radiation Followed by Envafolimab Plus CAPEOX for MSS Locally Advanced Rectal AdenocarcinomaRecruitingNCT05752136Phase 31 country
- Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid TumorsRecruitingNCT06128551Phase 1/27 countries
- A Study of Botensilimab and Balstilimab for Colorectal Cancer With ctDNA+ After Surgery and ChemotherapyRecruitingNCT07227636Phase 21 country
- Local Methylene Blue Injection for Prevention of Anastomotic Leakage and Permanent Stoma After Low Anterior Resection for Rectal CancerRecruitingNCT07833319Phase 21 country
- A Clinical Study of Calderasib (MK-1084) With Targeted Therapy and Chemotherapy in People With Colorectal Cancer (MK-1084-012/KANDLELIT-012)RecruitingNCT06997497Phase 329 countries
- Neoadjuvant Chemoradiotherapy Followed by Chemotherapy With or Without Tislelizumab for Resectable Ultra-low Rectal Cancer: The RELIEVE-02 StudyRecruitingNCT07132463Phase 31 country
- A First-in-Human Trial of BLU-924 (SAR449336) in Advanced Solid Tumors Harboring KRAS MutationsRecruitingNCT07629960Phase 1/22 countries
- ABCSG R07 Rectal Cancer RegistryNot yet recruitingNCT077803051 country
- Neoadjuvant Radiotherapy Combined With NALIRIFOX and Adebrelimab in pMMR/MSS Locally Advanced Rectal Cancer: A Prospective, Randomized, Phase II Clinical TrialRecruitingNCT07622771Phase 21 country
- Establishing a ctDNA Biomarker to Improve Organ Preserving Strategies in Patients With Rectal CancerRecruitingNCT050810241 country
- A Study to Investigate the Safety and Preliminary Efficacy of GSK5460025 Alone or in Combination With Other Anti-cancer Agents in Participants With Solid TumorsRecruitingNCT07213609Phase 1/29 countries
- Study of Induction PD-1 Blockade in Subjects With Locally Advanced Mismatch Repair Deficient Solid TumorsRecruitingNCT04165772Phase 21 country
- Safety of Mid and Low Rectal Cancer Surgery Without Dissection of the No.253 Lymph Node (S-M-O-O-T-H)RecruitingNCT06146946Not applicable1 country
- EQUITY GI: A Prospective Study to Enhance Quality, Inclusivity, and Trial Participation in Black Patients With Gastrointestinal Cancer.RecruitingNCT06263088Not applicable1 country
- Multidimensional Study Designed to Develop a Methodological Framework Based on MRI Data to Predict Pathological Complete Response (pCR) in Patients With Locally Advanced Rectal Cancer After Neoadjuvant TreatmentNot yet recruitingNCT074042281 country
- ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy EvaluationRecruitingNCT050594445 countries
- mFOLFOXIRI Plus Bevacizumab for Organ Preservation in Locally Advanced Rectal CancerNot yet recruitingNCT07817888Phase 2
- Evaluating Novel Therapies in ctDNA Positive GI CancersRecruitingNCT05482516Phase 31 country
- Contribution of Preserving the Superior Left Colic Artery to the Vascularization of the Descending Colon Prior to Colorectal Anastomosis During Left-Sided or Rectal Resections for Colorectal or Ovarian Cancer. (Revascularisation Colique)RecruitingNCT07098182Not applicable1 country
- Examination of Rectal Blood Supply During Rectal Cancer Surgery Using Laser Speckle Contrast ImagingNot yet recruitingNCT07799740Not applicable1 country
- HDR Endorectal Brachytherapy With 3D-Printed Guidance and Local Shielding for Rectal Cancer Organ PreservationRecruitingNCT07786493Not applicable1 country
- Resilience and Equity in Aging, Cancer, and Health (REACH)RecruitingNCT04674267Not applicable1 country
- A Phase 1 Study of DEM301 in Participants With Metastatic Colorectal CancerNot yet recruitingNCT07805369Phase 1
- Leveraging Digital Health Solutions to Collect Patient-Reported Outcomes in Rectal CancerNot yet recruitingNCT078111281 country
- Total Neoadjuvant mFOLFOX6 Plus Suvemcitug and Enlonstobart With Selective Omission of Pelvic Radiotherapy for High-Risk Mid-Rectal Locally Advanced Rectal CancerNot yet recruitingNCT07810114Phase 21 country
- 16-Hour Fasting Plus Serplulimab and CAPEOX as Neoadjuvant Therapy in pMMR/MSS Advanced Mid-to-Low Rectal CancerNot yet recruitingNCT07779694Phase 2
- Neoadjuvant Radiotherapy vs Upfront Surgery in Locally Advanced Proximal Rectal CancerRecruitingNCT07802197Not applicable1 country
- Five or Ten Year Colonoscopy for 1-2 Non-Advanced Adenomatous PolypsRecruitingNCT05080673Not applicable2 countries
- PRE-ISPY Phase I/II Oncology Platform ProgramRecruitingNCT05868226Phase 1/21 country
- Study Evaluating the Tailored Management of Locally-advanced Rectal CarcinomaRecruitingNCT04749108Phase 2/31 country
- Ovarian-Sparing Adaptive Radiotherapy in Young Adult WomenRecruitingNCT069043651 country
- Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation RatesRecruitingNCT07292298Phase 21 country
- Family Communications After Genetic TestingRecruitingNCT07143487Not applicable2 countries
- Studying the PAGODA Algorithm for Chemotherapy Dose Changes to Prevent Unplanned Treatment DelaysRecruitingNCT07283939Not applicable3 countries
- Post-Market Study of the Signia Circular Stapler With Tri-Staple Technology in Left-sided Colon, Sigmoid, and Rectal ResectionsRecruitingNCT07351071Not applicable1 country
- Evaluation of Quality of Life and Utilities Following Surgical Treatment of Stage I-IV Rectal CancerRecruitingNCT021071051 country
- Machine Learning-based Surgical Guidance System for Robot-assisted Rectal SurgeryRecruitingNCT05652361Not applicable1 country
- Use of a Novel Camera to Check the Bowel After Polyp or Tumour RemovalNot yet recruitingNCT073411261 country
- Neoadjuvant Chemoradiotherapy and Consolidation Chemotherapy for Rectal Cancer: A Randomized Controlled TrialRecruitingNCT05496491Not applicable1 country
- Improving Colorectal Cancer Screening Uptake Through Education and Stool-Based Testing OutreachNot yet recruitingNCT07781774Not applicable1 country
- Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12V Variant of Mutated RAS in HLA-A*11:01 PatientsRecruitingNCT03190941Phase 1/21 country
- TES RCT Fleet Enema vs Oral Mechanical Bowel PrepRecruitingNCT05148494Phase 41 country
- ColoSeal™ ICD System Anastomotic Protection Pivotal StudyRecruitingNCT07429110Not applicable2 countries
- Trial of the Efficacy and Safety of Short and Long Course Radiation Therapy With/Without BMX-001RecruitingNCT05254327Phase 21 country
- Radiotherapy Combined With Capeox Chemotherapy, Sintilimab and Suvemcitug in Locally Advanced pMMR Rectal Cancer:a Prospective Clinical TrialNot yet recruitingNCT07774754Phase 21 country
- Biomarkers for Predicting Neoadjuvant Chemoradio-resistance for Middle-low Advanced Rectal CancerRecruitingNCT035737911 country
- RECTIFY-1: Neoadjuvant Botensilimab + Balstilimab in MSS/pMMR Early Rectal CancerRecruitingNCT07735624Phase 21 country
- NCT + PD1 + Ketogenic Diet and/or Vitamin C for LARCNot yet recruitingNCT07765667Phase 21 country
- Quality of Life of Patients After Rectal Cancer Resection .Not yet recruitingNCT07764120
- Randomized Controlled Trial of the SurgDiff Model for Predicting Surgical Difficulty to Help Choose Approach in Mid-Low Rectal CancerNot yet recruitingNCT07761169Not applicable