Rectal Neoplasms clinical trials
The registry lists 2,400 studies for Rectal Neoplasms across more than 10 countries. 587 are recruiting or about to start. 1,456 of them are mainly about Rectal Neoplasms (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10. Counting its 2 narrower conditions too, such as Anus Neoplasms: 2,654 studies, 658 open.
ClinicalTrials.gov finds 8,540 studies for Rectal Neoplasms. How that becomes 2,398 here
This page counts the studies the registry files under Rectal Neoplasms, and those it files under no condition that list Rectal Neoplasmsthemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count
- 8,540Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
- −238Filed under a narrower condition, counted on its own pageAnus Neoplasms 237 · Anal Canal Carcinoma 1
- −205List Rectal Neoplasms as a condition, but the registry did not file them under itMost often written as “Colo-rectal Cancer” (170), “Colon Rectal Cancer” (8), and “Rectal Cancer Surgery” (6). The registry filed them under other conditions only, most often Colonic Neoplasms (184) and Colorectal Neoplasms (38).
- −5,700Match it another way147 name it in the title, 11 in a keyword, and 5,542 by a synonym or other text the search reads.
- 2,397Counted here and found by its search155 of them list Rectal Neoplasms in their own words; the registry filed them under no condition.
- +1
Counted here, but its search does not find them
- 2,398The count on this page
Get an email when these change. Save the Rectal Neoplasms studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
See an example email
Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
One email a week for all your saved searches. Stop any time.
Status
Who runs them
National Cancer Institute (NCI) (91) · Memorial Sloan Kettering Cancer Center (54) · Fudan University (42) · Sixth Affiliated Hospital, Sun Yat-sen University (41) · Sun Yat-sen University (39) · Alliance for Clinical Trials in Oncology (37) · M.D. Anderson Cancer Center (27) · City of Hope Medical Center (27)
What is being tested here
Drugs under test in Rectal Neoplasms studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Capecitabine | 13 | 18 | 126 |
| Oxaliplatin | 9 | 34 | 145 |
| Sintilimab | 8 | 1 | 13 |
| Tislelizumab | 8 | 1 | 9 |
| Bevacizumab | 6 | 11 | 79 |
| Xelox | 6 | 2 | 16 |
| Serplulimab | 6 | 1 | 6 |
| Balstilimab | 4 | 0 | 6 |
| Botensilimab | 4 | 0 | 6 |
| Cetuximab | 3 | 9 | 59 |
Drug classes tested here Immune checkpoint inhibitors 60 open · Antimetabolites 19 open · Angiogenesis inhibitors 6 open · Tyrosine kinase inhibitors (TKIs) 3 open · Antibody-drug conjugates (ADCs) 3 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Nov 2026Preoperative Short-course Radiation Followed by Envafolimab Plus CAPEOX for MSS Locally Advanced Rectal Adenocarcinoma · Phase 3 · Sir Run Run Shaw Hospital
- Dec 2026Standard Dose Versus High Dose of Radiotherapy in Rectal Preservation With Chemo-radiotherapy in Rectal Cancer Patients · Phase 3 · Vejle Hospital
- Dec 2026Comparison of Transanal Irrigation and Glycerol Suppositories in Treatment of Low Anterior Resection Syndrome · Phase 3 · University of Aarhus
- Dec 2026Non Inferiority Study of Preoperative Chemotherapy Without Pelvic Irradiation for Rectal Cancer · Phase 3 · Assistance Publique - Hôpitaux de Paris
- Apr 2027Antegrade Intestinal Fluid Reinfusion for Prevention of Low Anterior Resection Syndrome After Low Anterior Resection: a Single-Center, Prospective Randomized Controlled Trial. · Phase 3 · Pei-Rong Ding
- Jun 2027Neoadjuvant Radiotherapy for Rectal Adenocarcinoma With Capecitabine Versus TAS-102 (Neo-REACT): A Multi-center, Randomized, Phase III Trial · Phase 3 · Shandong Cancer Hospital and Institute
- Jul 2027Personalized Long-course Radiotherapy Plus Chemotherapy With or Without Immunotherapy for LARC: PALACE Study · Phase 3 · West China Hospital
- Aug 2027Can we Save the Rectum by Watchful Waiting or TransAnal Surgery Following (Chemo)Radiotherapy Versus Total Mesorectal Excision for Early REctal Cancer? · Phase 3 · University of Birmingham
- Oct 2027Neoadjuvant Chemoradiotherapy Combined With Immunotherapy and Anti-angiogenesis in Treating Locally Advanced Rectal Cancer · Phase 3 · Changhai Hospital
- Oct 2027Total Neoadjuvant Treatment ±Immunotherapy for High Risk Locally Advanced Rectal Cancer (TNTi) · Phase 3 · Peking University Cancer Hospital & Institute
Who these studies take
Of the 404 Rectal Neoplasms studies recruiting now, 210 (52%) set no upper age limit and 142 (35%) stop at 75 or younger. 19 (5%) take children under 18. 5 (1%) are for women only and 2 (<1%) for men only; 16 (4%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 12 (3%) | 12 (3%) |
| 18 | 381 (94%) | 380 (94%) |
| 30 | 394 (98%) | 393 (97%) |
| 40 | 394 (98%) | 393 (97%) |
| 50 | 397 (98%) | 395 (98%) |
| 65 | 395 (98%) | 393 (97%) |
| 75 | 372 (92%) | 368 (91%) |
| 85 | 237 (59%) | 233 (58%) |
Across all 2,400 studies, recruiting or not: 21% stop at 75 or younger and 2% at 65; 7% take children; 1% are for women only and 1% for men only; 4% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Rectal Neoplasms studies take
Of 241 phase 2 interventional studies under Rectal Neoplasms, half reached primary completion within 46 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 1 | 42 mo33–57 · 71 studies | — | 41 mo33–56 · 52 studies |
| Phase 1/2 | 75 mo36–106 · 37 studies | — | — |
| Phase 2 | 46 mo31–75 · 241 studies | — | 46 mo32–80 · 227 studies |
| Phase 3 | 59 mo37–95 · 81 studies | — | 76 mo38–104 · 73 studies |
| Interventional, no phase | 51 mo23–78 · 336 studies | — | 51 mo23–78 · 329 studies |
| Observational | 45 mo24–116 · 228 studies | — | 47 mo24–116 · 213 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Started recruiting3
- ABCSG R07 Rectal Cancer RegistryOct 30, 2026NCT07780305
- Concordance Between Large Language Model and Multidisciplinary Team Recommendations in Rectal CancerOct 15, 2026NCT07595107
- A Phase 1 Study of DEM301 in Participants With Metastatic Colorectal CancerOct 15, 2026NCT07805369
Results posted1
Stopped1
- ctDNA and Organ Preservation/Pathologic CR in Rectal CancerWithdrawnNov 4, 2026NCT05629442
Newly registered11
- Oral B-Complex Vitamin (B6, B9 and B12) Prevents Low Anterior Resection Syndrome in Rectal Cancer Patients With HyperhomocysteinemiaNov 10, 2026NCT07928180
- Single Versus Double Stapling and Two Purse-String Techniques in Rectal Cancer SurgeryNov 10, 2026NCT07929415
- Pre- and On-treatment Multi-omics Profiling of Locally Advanced Rectal CancerNov 6, 2026NCT07920770
- Outcomes of Knife-Assisted Full-Thickness Resection for Rectal Lesions: A Multicenter StudyNov 6, 2026NCT07923682
- Indocyanine Green Lymphatic Mapping in Minimally Invasive Sigmoid and Rectal Cancer SurgeryNov 4, 2026NCT07916532
Show 6 moreShow fewer
- Dose-Escalated Short-Course Proton Therapy for Locally Advanced Rectal CancerOct 29, 2026NCT07903883
- Modified Short-Course Radiotherapy Combined With Tislelizumab and CAPOX for pMMR/MSS Rectal CancerOct 28, 2026NCT07900061
- T1 Colorectal Cancer After Local Excision: Decision Between Surgery and Active Surveillance (T1LDA Trial)Oct 28, 2026NCT07900620
- Purse-String Versus Linear Closure After Ileostomy ReversalOct 23, 2026NCT07892404
- SCRT + Fruquintinib + Tislelizumab + CAPOX Versus SCRT + Tislelizumab + CAPOX as Neoadjuvant Therapy for Locally Advanced Low Rectal CancerOct 22, 2026NCT07888309
- Follow-up After Oncological Resection by Endoscopic Colorectal ESD (Endoscopic Submucosal Dissection)Oct 13, 2026NCT07871227
Studies
Recruiting first, then most recently updated. Showing 50 of 2,400. Browse all 2,400 → or search them.
- Short-course Radiotherapy Followed by Sequential Chemotherapy With or Without PD-1 Monoclonal Antibody and Bevacizumab as Total Neoadjuvant Therapy in pMMR/MSS Locally Advanced Rectal Cancer (SPARK)RecruitingNCT07005570Phase 21 country
- Oral B-Complex Vitamin (B6, B9 and B12) Prevents Low Anterior Resection Syndrome in Rectal Cancer Patients With HyperhomocysteinemiaNot yet recruitingNCT07928180Not applicable1 country
- Single Versus Double Stapling and Two Purse-String Techniques in Rectal Cancer SurgeryRecruitingNCT07929415Not applicable1 country
- The Effects of Kegel Exercise Combined With Biofeedback Therapy on Bowel Function Recovery, Emotional Distress, and Quality of Life in Patients Following Low Anterior Resection for Rectal CancerEnrolling by invitationNCT07253298Not applicable1 country
- Outcomes of Knife-Assisted Full-Thickness Resection for Rectal Lesions: A Multicenter StudyRecruitingNCT079236821 country
- Multidimensional Study Designed to Develop a Methodological Framework Based on MRI Data to Predict Pathological Complete Response (pCR) in Patients With Locally Advanced Rectal Cancer After Neoadjuvant TreatmentNot yet recruitingNCT074042281 country
- Pre- and On-treatment Multi-omics Profiling of Locally Advanced Rectal CancerRecruitingNCT079207701 country
- Improving Colorectal Cancer Screening Uptake Through Education and Stool-Based Testing OutreachNot yet recruitingNCT07781774Not applicable1 country
- Short Course Radiation Therapy and Combination Chemotherapy for the Treatment of Stage II-III Rectal CancerRecruitingNCT04703101Phase 11 country
- A Clinical Study of Calderasib (MK-1084) With Targeted Therapy and Chemotherapy in People With Colorectal Cancer (MK-1084-012/KANDLELIT-012)RecruitingNCT06997497Phase 329 countries
- Sintilimab Combined With LCCRT Followed by Capeox Chemotherapy in pMMR/MSS/MSI-L Locally Advanced Rectal CancerNot yet recruitingNCT07917468Phase 31 country
- Gemcitabine, Cisplatin, Nab-paclitaxel (GAP) and Cemiplimab for Locally Advanced Biliary Tract Cancer (BTC)RecruitingNCT07433673Phase 21 country
- Studying the PAGODA Algorithm for Chemotherapy Dose Changes to Prevent Unplanned Treatment DelaysRecruitingNCT07283939Not applicable3 countries
- Study of Induction PD-1 Blockade in Subjects With Locally Advanced Mismatch Repair Deficient Solid TumorsRecruitingNCT04165772Phase 21 country
- Five or Ten Year Colonoscopy for 1-2 Non-Advanced Adenomatous PolypsRecruitingNCT05080673Not applicable2 countries
- Distance-Based Exercise to Preserve Function and Prevent DisabilityRecruitingNCT07059884Not applicable1 country
- Oncolytic Virotherapy to Enhance PReoperative IMmunotherapy Efficacy in Patients With Proficient Mismatch Repair (pMMR) Rectal CancerRecruitingNCT07687875Phase 11 country
- Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12V Variant of Mutated RAS in HLA-A*11:01 PatientsRecruitingNCT03190941Phase 1/21 country
- Phase Ib/II Trial of Serine/Glycine-Restricted Diet With Chemoradiotherapy for Rectal CancerNot yet recruitingNCT07912463Phase 1/2
- Arginine-Restricted Diet Combined With Chemoradiotherapy in Neoadjuvant Rectal Cancer: A Phase Ib/II TrialNot yet recruitingNCT07912346Phase 1/2
- RECTIFY-1: Neoadjuvant Botensilimab + Balstilimab in MSS/pMMR Early Rectal CancerRecruitingNCT07735624Phase 21 country
- Family Communications After Genetic TestingRecruitingNCT07143487Not applicable2 countries
- ABCSG R07 Rectal Cancer RegistryRecruitingNCT077803051 country
- Exploratory Study of Short-Course Radiotherapy Followed by Adebrelimab Combined With Chemotherapy for Organ Preservation in Locally Advanced Rectal CancerNot yet recruitingNCT07905950Phase 21 country
- Dose-Escalated Short-Course Proton Therapy for Locally Advanced Rectal CancerNot yet recruitingNCT07903883Not applicable1 country
- Adaptive Radiotherapy for Safe HypofractionationNot yet recruitingNCT07516210Phase 21 country
- PET/MRI in Rectal CancerNot yet recruitingNCT06057831Phase 2
- Brachytherapy Followed by Nivolumab Prior to Surgery in Rectal CancerRecruitingNCT07645118Phase 21 country
- A Phase 1 Study of DEM301 in Participants With Metastatic Colorectal CancerRecruitingNCT07805369Phase 11 country
- Modified Short-Course Radiotherapy Combined With Tislelizumab and CAPOX for pMMR/MSS Rectal CancerNot yet recruitingNCT07900061Phase 3
- T1 Colorectal Cancer After Local Excision: Decision Between Surgery and Active Surveillance (T1LDA Trial)Not yet recruitingNCT07900620Not applicable1 country
- Combining DCSZ11 With Radiation and Chemotherapy as Neoadjuvant Treatment for pMMR Locally Advanced Rectal CancerNot yet recruitingNCT07580339Phase 21 country
- NeoCSR-Omics Trial: CAPOX + Serplulimab Before vs. After Short-course RT in LARCRecruitingNCT07898865Phase 21 country
- Efficacy of a Novel High Intensive Percutaneous Tibial Nerve Stimulation on Faecal Incontinence in Patients With Low Anterior Resection Cancer Syndrome After Rectal Cancer SurgeryNot yet recruitingNCT07862673Not applicable1 country
- FAPI in Rectal Cancer TNTRecruitingNCT061574631 country
- SCRT + Fruquintinib + Tislelizumab + CAPOX Versus SCRT + Tislelizumab + CAPOX as Neoadjuvant Therapy for Locally Advanced Low Rectal CancerRecruitingNCT07888309Phase 21 country
- Reinforced Versus Conventional Anastomosis in Laparoscopic Low Rectal Cancer Resection: A Comparative StudyEnrolling by invitationNCT07346534Not applicable1 country
- Evaluation of the Safety and Efficacy of Treatment w/High Dose Melphalan Given Directly Into the Liver Followed by Treatment w/Approved Cancer Treatment or Approved Cancer Treatment Alone in Patients w/ Metastatic Colorectal Cancer w/Liver Dominant DiseaseRecruitingNCT06607458Phase 29 countries
- Neoadjuvant Chemoradiotherapy Plus PD-1 Blockade ± CTLA-4 Blockade for Low/Intermediate-Risk Locally Advanced Rectal Cancer (pMMR/MSS): A National Multicenter, Prospective, Randomized Controlled TrialNot yet recruitingNCT07879599Phase 2/3
- Neoadjuvant Chemoradiotherapy Plus PD-1 Blockade ± CTLA-4 Blockade for High-Risk Locally Advanced Rectal Cancer (pMMR/MSS): A National Multicenter, Prospective, Randomized Controlled TrialNot yet recruitingNCT07879586Phase 2/3
- Neoadjuvant Botensilimab and Balstilimab for the Treatment of Advanced Resectable Colorectal Cancer NEST3RecruitingNCT07595874Phase 21 country
- Follow-up After Oncological Resection by Endoscopic Colorectal ESD (Endoscopic Submucosal Dissection)Not yet recruitingNCT078712271 country
- Radiotherapy Dose Escalation for Non-operative Management of Unresectable Locally Recurrent Rectal Cancer (STEP-UP)RecruitingNCT07721181Not applicable1 country
- Dose Escalation and Dose Expansion Study of MDX2001 in Patients With Advanced Solid TumorsRecruitingNCT06239194Phase 1/21 country
- A Phase 1 Dose Escalation and Dose Expansion Trial of KST-6051 in Participants With Advanced Solid Tumors With Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) MutationRecruitingNCT07458347Phase 11 country
- Concordance Between Large Language Model and Multidisciplinary Team Recommendations in Rectal CancerRecruitingNCT075951071 country
- Neoadjuvant Radiotherapy for Rectal Adenocarcinoma With Capecitabine Versus TAS-102 (Neo-REACT): A Multi-center, Randomized, Phase III TrialRecruitingNCT06850090Phase 31 country
- Stigma and Psychological profilE in REctal-anal caNcer pAtientsRecruitingNCT063668411 country
- Hyperthermia With Chemoradiotherapy in Rectal CancerRecruitingNCT06831981Not applicable1 country
- A Prospective, Single-center, Phase II Study of Neoadjuvant Serplulimab Plus XELOX and Bevacizumab in Locally Advanced Rectal CancerNot yet recruitingNCT07854964Not applicable