A Phase 2 interventional study of Adagrasib and Pembrolizumab in Solid Tumors, sponsored by Mirati Therapeutics Inc.. Recruiting at 101 sites in 21 countries. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-10-27.
Sponsored by Mirati Therapeutics Inc. (part of Bristol-Myers Squibb) · Phase 2, Interventional, and Treatment
This is an open-label, solid tumor, continuation, rollover trial which enrolls participants from ongoing BMS parent studies that evaluated adagrasib (MRTX849, BMS-986503) either as monotherapy or in combination with other cancer therapies in patients with non-small cell lung cancer (NSCLC), colorectal cancer (CRC) and other advanced solid tumors.
Mirati Therapeutics Inc. is the lead sponsor of 51 studies on the registry; 3 are open to participants now.
Of its 20 completed or terminated interventional studies of FDA-regulated products, 4 (20%) have results posted.
First submitted after Mirati Therapeutics Inc. became part of Bristol-Myers Squibb.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Other protocol defined inclusion/exclusion criteria applies.
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Able to become pregnant: from the first period until menopause, unless permanently unable to through surgery (removal of the womb, or of both ovaries or both fallopian tubes).
Criteria for people of childbearing potential usually ask for a negative pregnancy test and for contraception during the study and for a time after it.
Ways of preventing pregnancy. “Highly effective” methods fail less than 1% of the time a year when used correctly — for example an IUD or an implant.
Criteria usually say which methods count and how long to keep using them after the last dose, sometimes for male participants too. Some studies accept a partner’s vasectomy if it was confirmed successful and that person is the participant’s only sexual partner.
Childbearing potential
Able to become pregnant: from the first period until menopause, unless permanently unable to through surgery (removal of the womb, or of both ovaries or both fallopian tubes).
Criteria for people of childbearing potential usually ask for a negative pregnancy test and for contraception during the study and for a time after it.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Contraception
Ways of preventing pregnancy. “Highly effective” methods fail less than 1% of the time a year when used correctly — for example an IUD or an implant.
Criteria usually say which methods count and how long to keep using them after the last dose, sometimes for male participants too. Some studies accept a partner’s vasectomy if it was confirmed successful and that person is the participant’s only sexual partner.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Drug: Adagrasib
Drug: Adagrasib
Drug: Adagrasib · Drug: Pembrolizumab
Drug: Adagrasib · Drug: Pembrolizumab
Drug: Adagrasib · Drug: Cetuximab
Drug: Adagrasib · Drug: Pembrolizumab · Drug: Pemetrexed
Drug: Pembrolizumab
Drug: Docetaxel
Drug: Irinotecan · Drug: Leucovorin · Drug: Fluorouracil
Drug: Leucovorin · Drug: Oxaliplatin · Drug: Fluorouracil
Specified dose on specified days
Also known as: BMS-986503
Specified dose on specified days
Specified dose on specified days
Specified dose on specified days
Specified dose on specified days
Specified dose on specified days
Specified dose on specified days
Also known as: Folinic acid
Specified dose on specified days
Specified dose on specified days
Number of Participants With Adverse Events (AEs)
Time frame: Up to 90 days from last dose or study discontinuation
Number of Participants With AEs Leading to Treatment Discontinuation
Time frame: Up to 90 days from last dose or study discontinuation
Number of Participants With Serious Adverse Events (SAEs)
Time frame: Up to 90 days from last dose or study discontinuation
Number of Participants With AEs Leading to Death
Time frame: Up to 90 days from last dose or study discontinuation
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Showing the first 100 of 101 sites across 21 countries. Choose a country and city above to see the rest.
Plan to share: Yes — BMS will provide access to individual anonymized participant data upon request from qualified researchers, and subject to certain criteria. Additional information regarding Bristol Myer Squibb's data sharing policy and process can be found at https://www.bms.com/researchers-and-partners/clinical-trials-and-research.html
Supporting information: Study protocol, Statistical analysis plan, Clinical study report
Time frame: See Plan Description
Access criteria: See Plan Description
Data sharing details ↗ · www.bms.com
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
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Studies of the drug tested here: Adagrasib