Keratosis, Actinic clinical trials
The registry lists 343 studies for Keratosis, Actinic across more than 10 countries. 29 are recruiting or about to start. 322 of them are mainly about Keratosis, Actinic (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-04.
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Who runs them
LEO Pharma (31) · Peplin (21) · Almirall, S.A. (14) · DUSA Pharmaceuticals, Inc. (10) · Galderma R&D (10) · Graceway Pharmaceuticals, LLC (8) · Maastricht University Medical Center (7) · University of California, Davis (7)
What is being tested here
Drugs under test in Keratosis, Actinic studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Fluorouracil | 3 | 8 | 18 |
| Imipramine | 2 | 0 | 2 |
| Aminolevulinic Acid | 1 | 5 | 28 |
| Imiquimod | 1 | 9 | 23 |
| Tirbanibulin | 1 | 4 | 8 |
| Calcipotriene | 1 | 0 | 5 |
| Niacinamide | 1 | 0 | 3 |
| Drugs, Investigational | 1 | 0 | 1 |
| Ingenol mebutate | 0 | 12 | 43 |
| LEO 43204 | 0 | 5 | 12 |
Drug classes tested here Antimitotic agents 1 open · NSAIDs 12 · COX-2 inhibitors 4
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 10, phase 3 first
- Jan 2027Study of Reformulated Levulan Kerastick Plus PDT for Actinic Keratosis on Face and Scalp · Phase 3 · Sun Pharmaceutical Industries, Inc.
- Jan 2027Study of Reformulated Levulan Kerastick Plus PDT for Actinic Keratosis on Upper Extremities · Phase 3 · Sun Pharmaceutical Industries, Inc.
- Dec 2026A Phase 2 Study of HW211026 · Hubei Bio-Pharmaceutical Industrial Technological Institute Inc.
- Dec 2026An Open-Label Pharmacokinetic Study for Patients With Actinic Keratosis on the Upper Extremities or the Face · Sun Pharmaceutical Industries Limited
- Feb 2027Testing the Efficacy of Topical Calcipotriene Plus 5-Fluorouracil Combination to Activate the Immune System Against Precancerous Skin Lesions in Organ Transplant Recipients · University of Arizona
- Apr 2027SYsteMatical Trained learnIng aLgorithms for Oral carcInogenesiS Interpretation by Optical Coherence Tomography · University of Palermo
- May 2027A Randomized Controlled Trial of Topical 5% Niacinamide for Skin Cancer Prevention in Transplant Recipients · Marissa Lobl
- Jul 2027A Study of Tirbanibulin Ointment and Diclofenac Sodium Gel for the Treatment of Adult Participants With Actinic Keratosis on the Face or Scalp · Almirall, S.A.
- Jul 2027Actinic Keratoses Treated With 5-fluorouracil Plus Aluminum · West Virginia University
- Sep 20275-Fluorouracil and Calcipotriene for Field Treatment of Actinic Keratoses · Cedars-Sinai Medical Center
Who these studies take
Of the 21 Keratosis, Actinic studies recruiting now, 16 (76%) set no upper age limit and 1 (5%) stop at 75 or younger. 0 (0%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 2 (10%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 18 (86%) | 18 (86%) |
| 30 | 18 (86%) | 18 (86%) |
| 40 | 18 (86%) | 18 (86%) |
| 50 | 18 (86%) | 18 (86%) |
| 65 | 20 (95%) | 20 (95%) |
| 75 | 20 (95%) | 20 (95%) |
| 85 | 20 (95%) | 20 (95%) |
Across all 343 studies, recruiting or not: 5% stop at 75 or younger and 2% at 65; 3% take children; 1% are for women only and 1% for men only; 15% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Keratosis, Actinic studies take
Of 26 phase 3 interventional studies under Keratosis, Actinic, half reached primary completion within 13 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 2 | 10 mo9–18 · 18 studies | — | — |
| Phase 3 | 13 mo7–22 · 26 studies | — | — |
| Phase 4 | 12 mo8–30 · 19 studies | — | — |
| Interventional, no phase | 19 mo12–33 · 33 studies | — | — |
| Observational | 22 mo11–36 · 17 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 14, 2026.
Started recruiting1
- Basal Cell Carcinoma Chemoprevention TrialOct 19, 2026NCT05212246
Studies
Recruiting first, then most recently updated. Showing 50 of 343. Browse all 343 → or search them.
- Study of Reformulated Levulan Kerastick Plus PDT for Actinic Keratosis on Face and ScalpRecruitingNCT07144345Phase 31 country
- Study of Reformulated Levulan Kerastick Plus PDT for Actinic Keratosis on Upper ExtremitiesRecruitingNCT07144852Phase 31 country
- Basal Cell Carcinoma Chemoprevention TrialRecruitingNCT05212246Phase 31 country
- Therapeutic Induction of Dermal Remodeling in Veterans to Prevent Actinic Neoplasia Caused by Chronic Environmental Exposure to Ultraviolet RadiationNot yet recruitingNCT07648407Not applicable1 country
- 5-Fluorouracil and Calcipotriene for Field Treatment of Actinic KeratosesNot yet recruitingNCT07794059Phase 11 country
- Multimodal Laser Treatment of Photodamaged SkinRecruitingNCT07789002Not applicable1 country
- The Effect of Topical Imipramine on Pain and Effectiveness of Topical Photodynamic TherapyRecruitingNCT05688904Phase 11 country
- An Open-Label Pharmacokinetic Study for Patients With Actinic Keratosis on the Upper Extremities or the FaceRecruitingNCT07729579Phase 11 country
- Effectiveness of Fractionated Laser Resurfacing to Protect Geriatric Skin From Actinic NeoplasiaRecruitingNCT03906253Not applicable1 country
- The Preventive Role of Fractionated Laser Resurfacing Against Actinic Neoplasia in an At-Risk Geriatric PopulationRecruitingNCT06428721Not applicable1 country
- A Phase 2 Study of HW211026Not yet recruitingNCT07513454Phase 21 country
- Efficacy and Safety of Cryotherapy Versus 5-Fluorouracil in the Treatment of Actinic KeratosisEnrolling by invitationNCT06461442Phase 41 country
- PDT vs Peels for Treatment of Actinic KeratosesNot yet recruitingNCT04429308Phase 21 country
- Outcomes Associated With Tirbanibulin for Large Field Application on the Face in the U.S (CLEAR)RecruitingNCT076579881 country
- A Randomized Controlled Trial of Topical 5% Niacinamide for Skin Cancer Prevention in Transplant RecipientsRecruitingNCT07286318Early Phase 11 country
- Efficacy and Safety of Cryotherapy Followed by Tirbanibulin Ointment for Actinic Keratosis on the Scalp and ForeheadNot yet recruitingNCT07273656Phase 3
- Actinic Keratoses Treated With 5-fluorouracil Plus AluminumRecruitingNCT07401277Phase 11 country
- Study of the Photoprotection and Prevention of Actinic Damage With Anthelios Fluide 100 KA+ UVMune 400 in Patients With Multiple Actinic KeratosesRecruitingNCT07335003Not applicable1 country
- A Phase Ib Study of HW211026 Ointment in Patients With Actinic Keratosis.RecruitingNCT07318675Phase 11 country
- The Effect of Topical Imipramine on Photodynamic Therapy-Mediated Immunosuppression on Forearms or Face on US VeteransRecruitingNCT06778434Phase 21 country
- Phase 3 - Evaluation of Veregen® 10% Ointment as New Herbal Topical Treatment for Actinic KeratosisRecruitingNCT07137819Phase 31 country
- Investigation of the Effect of Lipikar Baume AP+MRecruitingNCT06385340Not applicable1 country
- Investigation of the Efficacy and Tolerability of Topical Applied Tirbanibulin on Actinic Keratoses With Downward-directed Proliferation PatternsRecruitingNCT066484471 country
- SYsteMatical Trained learnIng aLgorithms for Oral carcInogenesiS Interpretation by Optical Coherence TomographyRecruitingNCT063210031 country
- Efficacy of Topical 5-Fluorouracil Vs Calcipotriol As Photodynamic Therapy Pre-treatment for Field Actinic KeratosesNot yet recruitingNCT06685588Not applicable
- Efficacy And Safety Of Illumination Dose Reduction In Red Light Photodynamic Therapy For Actinic KeratosesNot yet recruitingNCT06545396Not applicable
- Stratification of Cutaneous Squamous Cell Carcinomas According to Its Transcriptomic, Metabolic and Inflammatory CharacteristicsRecruitingNCT06476964Not applicable1 country
- Effect of Lipikar Urea 30% Before Actinic Keratoses TreatmentRecruitingNCT06274320Not applicable1 country
- Aminolevulinic Acid-photodynamic Therapy for Facial Actinic Keratosis Treatment and PreventionRecruitingNCT03642535Phase 41 country
- A Pilot Clinical Trial Comparing Topical Fluorouracil to Fluorouracil Plus Calcipotriene Field Treatments in Patients With Multiple Actinic KeratosesActive, not recruitingNCT06851507Phase 31 country
- Combination Therapy of 5-Fluorouracil and CALcipotriol Versus 5-Fluorouracil in the Treatment of Actinic KeratosisCompletedNCT06499415Phase 41 country
- Cryotherapy in Combination With Red Light PDT for Actinic Keratosis of Full FaceActive, not recruitingNCT06745999Phase 41 country
- Study to Evaluate the Safety, Tolerability and Efficacy of BF-200 ALA (Ameluz®) in the Field-directed Treatment of Actinic Keratosis (AK) on the Extremities and Neck/Trunk With Photodynamic Therapy (PDT) Using a RhodoLED LampCompletedNCT05662202Phase 31 country
- Evaluate RLS-1496 Topical Cream for Actinic KeratosisActive, not recruitingNCT07340697Phase 1/21 country
- Methyl Aminolevulinate 8% and 16% Incubated by 1 and 3 for Actinic Keratoses TreatmentCompletedNCT06507644Not applicable1 country
- Photodynamic Therapy Incubation Times for Actinic KeratosisCompletedNCT03066843Not applicable1 country
- A Study to Evaluate the Efficacy and Safety of Tirbanibulin Ointment in Adult Participants With Actinic KeratosisCompletedNCT06135415Phase 35 countries
- Study of Metabolic Changes in the Transformation Malignant Precancerous Skin LesionsCompletedNCT04389112Not applicable1 country
- Evaluating the Device FLEXITHERALIGHT Compared to the Conventional Photodynamic TherapyCompletedNCT03076918Not applicable1 country
- Evaluating an Artificial Intelligence Tool to Help Primary Care Doctors Diagnose Skin Conditions.CompletedNCT074289411 country
- Imaging Techniques to Monitor Photosensitizer and sO2 Levels During Photodynamic Therapy of Actinic KeratosesCompletedNCT05923060Phase 21 country
- Trial to Investigate GZ21T in Healthy VolunteersCompletedNCT06888362Phase 11 country
- Activation of Ameluz With BBL HEROic for the Treatment of Actinic Keratoses and PhotodamageCompletedNCT07053852Phase 11 country
- Indoor Daylight Photodynamic Therapy is an Effective, First-line Treatment for AK, But Its Feasibility is Limited by the Time Required for the Illumination (2 Hours). Our Objective Was to Evaluate the Efficacy of Idl-PDT With an Illumination Time of 1 Hour Versus 2 Hours in the Treatment of Scalp AKCompletedNCT07290959Not applicable1 country
- Portable Measurement of Protoporphyrin IX in the SkinCompletedNCT042235701 country
- Short Contact Protocols to Reduce Pain During 10% ALA Gel Red-light Photodynamic Therapy of Actinic KeratosesCompletedNCT06027619Phase 21 country
- Testing the Efficacy of Topical Calcipotriene Plus 5-Fluorouracil Combination to Activate the Immune System Against Precancerous Skin Lesions in Organ Transplant RecipientsActive, not recruitingNCT05699603Phase 21 country
- Comparison of Nicotinamide Treatments for Actinic KeratosisCompletedNCT07049068Phase 11 country
- Actinic Keratoses Treatment With Metvix® in Combination With LightCompletedNCT02373371Phase 31 country
- Study on the Safety and Efficacy of Bimiralisib Gel in Participants Suffering From Actinic KeratosisCompletedNCT06319794Phase 21 country