Drug

Donepezil clinical trials

Also written Aricept, E2020 and Aricept 10 mg.

studies test it: 184
open now: 7
in phase 3: 31
first study started: 1999

How each study uses Donepezil is sorted by a rule, right about nine times in ten. Readers can ask us to read every study one by one.Ask us to read each study

Get an email when these change. Save the Donepezil studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.

Watch these studies

See an example email

Example · made-up studies

Breast cancer · Recruiting: 2 came in, 3 changed

What changed in your saved searches, Oct 31 – Nov 6:

A study of drug A after surgery for early breast cancer

Came in · now Recruiting

Drug B with hormone therapy in advanced breast cancer

Changed

· Sites: 4 added, including Seoul and Busan

· Enrollment: 300 → 450 participants

Exercise during chemotherapy

Now Active, not recruiting

One email a week for all your saved searches. Stop any time.

Approvals

The first approval found in each region, with its record

United States: 25 Nov 1996 · ARICEPT · NDA 020690 (FDA, Drugs@FDA)
European Union: Not in EMA's list of EU-wide authorisations

From FDA's Drugs@FDA and Purple Book (through openFDA) and the European Medicines Agency, files of Sept 2026 and 27 Oct 2026. National approvals in Europe and other countries are not included. How this is worked out

How studies write it

Studies that test it under each name

Name

Donepezil: 106
Donepezil hydrochloride: 34
Donepezil HCl: 7
Donepezil (Aricept): 6
Donepezil TDS: 5

Brand

Aricept: 68
Aricept 10 mg: 2

Development codes

E2020: 8
MK-0000: 1
DKF-310: 1
THN 201: 1

Studies by the year they started

180 studies that test it; most in 2007 (17); 1 more planned to start later

Studies that test Donepezil, by start year
Year	Studies
1999	3
2000	2
2001	3
2002	7
2003	8
2004	6
2005	10
2006	10
2007	17
2008	16
2009	11
2010	5
2011	13
2012	8
2013	7
2014	10
2015	7
2016	7
2017	5
2018	5
2019	2
2020	4
2021	3
2022	3
2023	2
2024	2
2025	3
2026	1

By phase

A phase 1/2 study counts in both.

Early Phase 1: 5
Phase 1: 45
Phase 2: 43
Phase 3: 31
Phase 4: 49
No phase: 14

What it is tested for

Each study’s main condition, where its own words name it, so a study counts once.

Alzheimer Disease: 51
Parkinson Disease: 12
Cognitive Dysfunction: 6
Down Syndrome: 5
Stroke: 5
Dementia: 4
Autistic Disorder: 3
Delirium: 3
Dementia, Vascular: 3
Brain Neoplasms: 2
Ischemic Stroke: 2
Sleep Apnea, Obstructive: 2

Who runs them

Industry 82 · Other 102

Eisai Inc. (20) · Eisai Co., Ltd. (11) · Corium, Inc. (6) · Pfizer (6) · Wake Forest University Health Sciences (5) · Merck Sharp & Dohme LLC (4) · Eisai Korea Inc. (4) · Oregon Health and Science University (4)

Often tested with

Tested in the same studies.

Memantine (5) · Galantamine (5) · Venlafaxine (3) · Gabapentin (3) · Duloxetine (3) · Citalopram (2) · Vitamin E (2) · Modafinil (2)

Related medicines

As reviewed, each with the page that says it.

One of Cholinesterase inhibitors source

Coming up

From the study records. Dates are the sponsors’ own estimates and often move.

Reaching primary completion within a year · 1

Studies that test Donepezil.

Sep 2027Effect of Acetylcholinesterase Inhibitors on Bone MetabolismPhase 2 · Duke University

Studies

Open first, then newest update. How each study uses Donepezil is read from its arms, and is right about nine times in ten. Ask us to read each study. These are the studies that list it as an intervention; a search of ClinicalTrials.gov also finds studies that mention it only in a description, such as earlier treatment.

Testing it · 184

See all 184 studies that test Donepezil →

Given beside what is tested · 29 — Donepezil is usual care or a partner of the new treatment

Showing 20 of 29.

As the comparator · 30 — what is tested is compared with Donepezil

Showing 20 of 30.

What changed recently

From the registry's own updates since Oct 16, 2026.

Stopped1

The Efficacy and Safety Study of High Dose Donepezil in Parkinson's Disease With DementiaTerminatedNov 10, 2026NCT02415062

Codes

What other systems call Donepezil · ClinicalTrials.gg INT006678

MeSH (NLM) D000077265DonepezilConfirmed ClinicalTrials.gov, NLM, Wikidata
UNII (FDA) 8SSC91326PDONEPEZILConfirmed FDA, NLM, Wikidata
RxNorm 135447Confirmed FDA, Wikidata
Wikidata Q415081donepezilConfirmed FDA, NLM, Wikidata
NCI Thesaurus C66874DonepezilOne source FDA
DrugBank DB00843One source Wikidata

System	Code	Name there	Checked by
MeSH (NLM)	D000077265	Donepezil	Confirmed ClinicalTrials.gov, NLM, Wikidata
UNII (FDA)	8SSC91326P	DONEPEZIL	Confirmed FDA, NLM, Wikidata
RxNorm	135447	—	Confirmed FDA, Wikidata
Wikidata	Q415081	donepezil	Confirmed FDA, NLM, Wikidata
NCI Thesaurus	C66874	Donepezil	One source FDA
DrugBank	DB00843	—	One source Wikidata

Also registered as donepezil hydrochloride (UNII 3O2T2PJ89D · RxNorm 236559).

“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.