Down Syndrome clinical trials
The registry lists 432 studies for Down Syndrome across more than 10 countries. 103 are recruiting or about to start. Per ClinicalTrials.gov, last updated 2026-09-23.
Status
- Completed
- 243
- Recruiting
- 78
- Status unknown
- 40
- Terminated
- 23
- Not yet recruiting
- 18
- Active, not recruiting
- 17
Phase
- Phase 2
- 40
- Phase 3
- 19
- Phase 1
- 16
- Phase 4
- 6
Where
- United States
- 198
- Pakistan
- 50
- France
- 39
- Spain
- 34
- Canada
- 25
- Egypt
- 23
Who runs them
Riphah International University (48) · Cairo University (13) · University of Colorado, Denver (12) · Institut Jerome Lejeune (10) · Sequenom, Inc. (8) · University of Kansas Medical Center (8) · Children's Oncology Group (8) · Natera, Inc. (7)
Studies
Recruiting first, then most recently updated. Showing 50 of 432 — search for more.
- An Open-Label Phase II Feasibility Study for the Use of Ublituximab in Adults With Down Syndrome Regression DisorderNot yet recruitingNCT07812181Phase 21 country
- Escalating Doses of Memantine in Down Syndrome (MEDS-123)Not yet recruitingNCT07531940Phase 11 country
- Treatment of Obstructive Sleep Apnea With Personalized Surgery in Children With Down Syndrome (TOPS-DS)RecruitingNCT05508971Not applicable1 country
- Hematological Profile in Children With Numerical Chromosomal DisordersNot yet recruitingNCT07807540
- Specimen Collection From Pregnant Women at Increased Risk for Fetal AneuploidyRecruitingNCT014293892 countries
- A Study to Evaluate Mivelsiran in Adult Participants With Early-Stage Down Syndrome-Associated Alzheimer's Disease (DS-AD)RecruitingNCT07636811Phase 22 countries
- Endotype DIrected Treatment for OSA in Down SyndromeRecruitingNCT07280468Phase 41 country
- Modulation of the Immune System in Down Syndrome for Improved Outcomes and Neurodevelopment - 1RecruitingNCT07598643Phase 21 country
- A Study to Compare Blinatumomab Alone to Blinatumomab With Nivolumab in Patients Diagnosed With First Relapse B-Cell Acute Lymphoblastic Leukemia (B-ALL)RecruitingNCT04546399Phase 24 countries
- Executive Function Play Opportunities for Children With Down SyndromeNot yet recruitingNCT07792382Not applicable2 countries
- Pilot Evaluation of the Developed Syntactic-Semantic Visual Configuration Intervention for Children With Language ImpairmentNot yet recruitingNCT07786545Not applicable1 country
- A Study to Learn More About the Health of Persons With Down Syndrome After Treatment for Acute LeukemiaRecruitingNCT057026452 countries
- Effect of Sensory Integration on Gross and Balance on Children With Down SyndromeRecruitingNCT07785011Not applicable1 country
- Vestibular Stimulation Versus Foot Intrinsic Muscle Exercises in Children With Down SyndromeNot yet recruitingNCT07778654Not applicable
- Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)RecruitingNCT042784042 countries
- NAD Augmentation to Prevent or Reverse Alzheimer's Disease in People With Down SyndromeNot yet recruitingNCT07278492Phase 11 country
- Self-Supporting Nasopharyngeal Airway (ssNPA) Treating Upper Airway Obstruction in HypotoniaRecruitingNCT05527652Not applicable1 country
- Cooking Skills to Improve Long-Term Weight Loss in Young Adults With Intellectual DisabilitiesRecruitingNCT06961591Not applicable1 country
- The Neurocognitive Bases of Trust in Intellectual DisabilityRecruitingNCT074340371 country
- Adapting RDAD for DSRecruitingNCT07425769Not applicable1 country
- Harness-based Mobility Intervention for Infants With Down SyndromeRecruitingNCT06219863Not applicable1 country
- Non-Invasive Brain Stimulation to Improve Language in Down Syndrome.RecruitingNCT07044804Not applicable1 country
- Metric-Optimized Spectacle Prescriptions for Children With Down SyndromeRecruitingNCT07490444Phase 21 country
- Natural History of Dysregulation and Aging of the Immune System in People With Trisomy 21 With and Without ThymectomyRecruitingNCT074162011 country
- A VIRTUAL Three-month Intervention Study of the Effects of a Smartphone Application (HippoCamera) on Memory in Teens and Young Adults With Down SyndromeRecruitingNCT07008989Not applicable1 country
- Parent and Infant Inter(X)Action Intervention (PIXI)Enrolling by invitationNCT03836300Not applicable1 country
- A Study to Assess the Effects of ACI-24.060 in Alzheimer's Disease and in Down Syndrome (ABATE Study)RecruitingNCT05462106Phase 1/23 countries
- Cholinergic Integrity in Down Syndrome in Association With Aging, Alzheimer's Disease Pathology, and CognitionRecruitingNCT05231798Phase 21 country
- Effects of a Pacifier on Obstructive Sleep Apnea and Its Repercussions in Infants With Down SyndromeNot yet recruitingNCT07658053Not applicable1 country
- How Simplified Language Affects Comprehension and Learning in Young Children With Down SyndromeRecruitingNCT06951516Not applicable1 country
- The ADVANCE (Assay Development and Validation for Pre-Natal and Obstetric Conditions) Study is the Largest U.S.-Based Prospective Study Demonstrating a Circulating Fetal Cell (CFC) Based Approach to Non-invasive Fetal Risk AssessmentRecruitingNCT076438961 country
- tDCS for Catatonic Depression in Down Syndrome: A Pilot StudyRecruitingNCT06866925Not applicable1 country
- Home and Community Use of a Suspension Walker in Pre-Walking Infants With Down SyndromeNot yet recruitingNCT07631130Not applicable
- Vascular Function in Adults With Down SyndromeRecruitingNCT076302071 country
- Collaboration for Down Syndrome Progress (CDP)RecruitingNCT076255791 country
- Drumming Lessons' Influence on Children With Down SyndromeRecruitingNCT07156318Not applicable1 country
- Trial-Ready Cohort-Down Syndrome (TRC-DS)RecruitingNCT041651095 countries
- Amyloid Lowering for Alzheimer's in Down's With Donanemab InvestigationNot yet recruitingNCT06911944Phase 4
- Animal Fun Program and Kinesthetic Development in Down SyndromeRecruitingNCT07579559Not applicable1 country
- Effects of Bean Bag Tossing Game on Balance and Gait in Children With Down Syndrome.RecruitingNCT07578922Not applicable1 country
- Exploring Sympathetic Nervous System Function in Individuals With Down SyndromeRecruitingNCT07238465Phase 31 country
- Patterns of Neurodevelopmental DisordersRecruitingNCT062130901 country
- Qualitative Effects of AEF0217 in Down Syndrome PeopleEnrolling by invitationNCT074132241 country
- AEF0217 in Participants With Down SyndromeRecruitingNCT07334912Phase 23 countries
- Oro-myofunctional Characteristics and Obstructive Sleep Apnea in Infants With Down SyndromeRecruitingNCT071952531 country
- Gamma Frequency Stimulation in Individuals With Down SyndromeRecruitingNCT05196984Not applicable1 country
- Intensive Multimodal Neurorehabilitation Targeting Neuroplasticity in Pediatric Neurodevelopmental and Chromosomal DisordersRecruitingNCT074930961 country
- Sleep Intervention and Quality of Life in Down SyndromeRecruitingNCT06783725Not applicable1 country
- Effects of the Otago Exercise Program on Balance, Endurance, and Motor Coordination in Children With Down SyndromeRecruitingNCT07484464Not applicable1 country
- Brain Outcomes With Lifestyle Change in Down SyndromeRecruitingNCT05985486Not applicable1 country