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Down Syndrome clinical trials

The registry lists 438 studies for Down Syndrome across more than 10 countries. 99 are recruiting or about to start. 342 of them are mainly about Down Syndrome (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10.

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Breast cancer · Recruiting: 2 came in, 3 changed

What changed in your saved searches, Oct 31 – Nov 6:

A study of drug A after surgery for early breast cancer

Came in · now Recruiting

Drug B with hormone therapy in advanced breast cancer

Changed

· Sites: 4 added, including Seoul and Busan

· Enrollment: 300 → 450 participants

Exercise during chemotherapy

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Status

Completed
254
Recruiting
75
Status unknown
40
Terminated
23
Not yet recruiting
18
Active, not recruiting
17

Phase

Phase 2
39
Phase 3
17
Phase 1
16
Phase 4
6

Where

United States
204
Pakistan
50
France
40
Spain
36
Canada
23
Egypt
21

Who runs them

Riphah International University (48) · University of Colorado, Denver (12) · Cairo University (12) · Institut Jerome Lejeune (10) · University of Sao Paulo (8) · University of Kansas Medical Center (8) · Sequenom, Inc. (8) · Natera, Inc. (8)

What is being tested here

Drugs under test in Down Syndrome studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted

DrugOpenPhase 3All
Oxygen202
Memantine104
Tofacitinib103
Blinatumomab112
Methylphenidate102
AEF0217102
Ublituximab101
MIB-626101
Donanemab101
Abrocitinib101

Drug classes tested here JAK inhibitors 2 open · Tyrosine kinase inhibitors (TKIs) 2 open · Cholinesterase inhibitors 7 · Antimetabolites 4

Coming up

7phase 3 studies under way
21studies finish main data collection within a year1 of them phase 3

Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.

The 10 nearest, phase 3 first

Who these studies take

Of the 75 Down Syndrome studies recruiting now, 14 (19%) set no upper age limit and 58 (77%) stop at 75 or younger. 61 (81%) take children under 18. 2 (3%) are for women only and 1 (1%) for men only; 19 (25%) take healthy volunteers.

Recruiting studies that take each age, of 75
AgeWomenMen
1043 (57%)43 (57%)
1838 (51%)36 (48%)
3029 (39%)27 (36%)
4024 (32%)22 (29%)
5024 (32%)22 (29%)
6518 (24%)16 (21%)
7517 (23%)15 (20%)
8517 (23%)15 (20%)

Across all 438 studies, recruiting or not: 74% stop at 75 or younger and 73% at 65; 70% take children; 12% are for women only and 1% for men only; 29% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.

How long Down Syndrome studies take

Of 21 phase 2 interventional studies under Down Syndrome, half reached primary completion within 36 months of starting, counting those still running.

Start to primary completionEvery sponsorIndustryNon-industry
Phase 236 mo26–61 · 21 studies——
Interventional, no phase11 mo3–35 · 165 studies—11 mo3–35 · 163 studies
Observational34 mo19–80 · 55 studies—31 mo23–71 · 40 studies

Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out

What changed recently

From the registry's own updates since Oct 13, 2026.

Newly registered2

Studies

Recruiting first, then most recently updated. Showing 50 of 438. Browse all 438 → or search them.