Vaso-Occlusive Crises clinical trials
The registry lists 104 studies for Vaso-Occlusive Crises across more than 10 countries. 31 are recruiting or about to start. 68 of them are mainly about Vaso-Occlusive Crises (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10.
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Who runs them
Assistance Publique - Hôpitaux de Paris (12) · Novartis Pharmaceuticals (5) · Pfizer (4) · Duke University (3) · Centre Hospitalier Universitaire de la Guadeloupe (3) · Boston Children's Hospital (3) · St. Jude Children's Research Hospital (2) · Anthera Pharmaceuticals (2)
What is being tested here
Drugs under test in Vaso-Occlusive Crises studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
8studies finish main data collection within a year1 of them phase 3
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 8, phase 3 first
- Jun 2027A Study of Intravenous L-Citrulline in Patients Aged 6-21 Years Old With Sickle Cell Disease Presenting to Emergency Departments in Acute Vaso-Occlusive Crisis · Phase 3 · Asklepion Pharmaceuticals, LLC
- Nov 2026Effect of Virtual Reality Technology for Pain Management of Vaso-Occlusive Crisis in Patients With Sickle Cell Disease · St. Jude Children's Research Hospital
- Nov 2026Inflammation, Platelets and Sickle Cell Disease · University Hospital, Toulouse
- Feb 2027Impact of Regional Anesthesia on Inflammatory Mechanisms During Vaso-occlusive Crisis in Sickle Cell Patients · Centre Hospitalier Universitaire de la Guadeloupe
- Jul 2027Ketorolac for Acute Vaso-Occlusive Crisis in Pediatric Sickle Cell Disease · Children's Blood and Cancer Center at Dell Children's Medical Center
- Oct 2027Outcomes of Vaso-occlusive Crisis in Pediatric Sickle Cell Disease · Assiut University
- Oct 2027Safety, Efficacy, and Pharmacokinetics of CSL889 in Adults and Adolescents With Sickle Cell Disease During Vaso-Occlusive Crisis · CSL Behring
- Nov 2027Lipid Balance in Adult Sickle Cell Patients · Centre Hospitalier Universitaire de la Guadeloupe
Who these studies take
Of the 17 Vaso-Occlusive Crises studies recruiting now, 7 (41%) set no upper age limit and 6 (35%) stop at 75 or younger. 10 (59%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 1 (6%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 7 (41%) | 7 (41%) |
| 18 | 17 (100%) | 17 (100%) |
| 30 | 13 (76%) | 13 (76%) |
| 40 | 12 (71%) | 12 (71%) |
| 50 | 12 (71%) | 12 (71%) |
| 65 | 11 (65%) | 11 (65%) |
| 75 | 11 (65%) | 11 (65%) |
| 85 | 11 (65%) | 11 (65%) |
Across all 104 studies, recruiting or not: 47% stop at 75 or younger and 43% at 65; 63% take children; 0% are for women only and 0% for men only; 8% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
What changed recently
From the registry's own updates since Oct 13, 2026.
Started recruiting1
- Virtual Reality for SCD VOCOct 16, 2026NCT07674277
Studies
Recruiting first, then most recently updated. Showing 50 of 104. Browse all 104 → or search them.
- A Study to Investigate the Efficacy and Safety of Crizanlizumab (5 mg/kg) Compared With Placebo in Adolescent and Adult Sickle Cell Disease Patients Who Experience Frequent Vaso-Occlusive Crises (SPARKLE)RecruitingNCT06439082Phase 35 countries
- Efficacy of Liberal Versus Restricted IV Fluid Approach in the Management of Sickle Cell Vaso-Occlusive CrisisRecruitingNCT07188766Not applicable1 country
- Buprenorphine for the Management of Pain in Children With Sickle Cell DiseaseNot yet recruitingNCT07799571Phase 11 country
- Safety of Anumigilimab (CSL324) in Adults With Sickle Cell Disease (SCD)RecruitingNCT07224360Phase 27 countries
- Hypoxic Red Blood Cells in Sickle Cell AnemiaNot yet recruitingNCT06743113Not applicable1 country
- Virtual Reality for SCD VOCRecruitingNCT07674277Not applicable1 country
- Safety, Efficacy, and Pharmacokinetics of CSL889 in Adults and Adolescents With Sickle Cell Disease During Vaso-Occlusive CrisisRecruitingNCT06699849Phase 23 countries
- Adaptive Platform Trial for Pain Management in Sickle Cell Vaso-Occlusive CrisisNot yet recruitingNCT07826988Phase 4
- Lidocaine for Opioid Sparing in Vaso-occlusive Crisis of Sickle Cell DiseaseRecruitingNCT07274254Phase 32 countries
- Sub-dissociative Dose Ketamine in Treatment of Vaso-occlusive Pain Event in Children and Young AdultsRecruitingNCT07369024Phase 21 country
- Pleuropulmonary Ultrasound Imaging in Patients With Sickle Cell Disease in a Vaso-occlusive Crisis. "ECHODREP"Not yet recruitingNCT07782489
- Standard of Care Comparative Arm of Phase 1/2 Gene Therapy Trial DREPAMIR" in Severe Sickle Cell Disease PatientsNot yet recruitingNCT07752043Not applicable1 country
- Rollover Study for Patients With Sickle Cell Disease Who Have Completed a Prior Novartis-Sponsored Crizanlizumab StudyRecruitingNCT04657822Phase 411 countries
- Effect of Virtual Reality Technology for Pain Management of Vaso-Occlusive Crisis in Patients With Sickle Cell DiseaseRecruitingNCT03353584Not applicable1 country
- Evaluation of the Efficacy of Iloprost in the Management of Vaso-occlusive Crises in Adult Patients With Sickle Cell DiseaseNot yet recruitingNCT07498309Phase 31 country
- Morphine Clearance and Glomerular Filtration in Sickle Cell Patients in Crisis in Intensive CareRecruitingNCT07246265Not applicable1 country
- Optimal Timing of Ketamine Initiation for SCD PainNot yet recruitingNCT07450430Phase 31 country
- Efficacy Safety Study of Gene Therapy for Sickle Cell DiseaseSCD Using Autologous CD34+ Cells Transduced ex Vivo, Carrying a Corrected Globin Gene and a Silencing RNA.RecruitingNCT07432867Phase 1/21 country
- Outcomes of Vaso-occlusive Crisis in Pediatric Sickle Cell DiseaseNot yet recruitingNCT072008691 country
- Impact of Regional Anesthesia on Inflammatory Mechanisms During Vaso-occlusive Crisis in Sickle Cell PatientsRecruitingNCT070011891 country
- Effect of EMDR for Reduction of Pain Interference in Children With Sickle Cell DiseaseRecruitingNCT07001631Not applicable1 country
- A Study of Intravenous L-Citrulline in Patients Aged 6-21 Years Old With Sickle Cell Disease Presenting to Emergency Departments in Acute Vaso-Occlusive CrisisNot yet recruitingNCT06989567Phase 31 country
- Analgesic Effect of Parecoxib Versus Morphine in SCD Patients Presenting to the Emergency DepartmentNot yet recruitingNCT06315920Phase 3
- Pilot Study on the Value of Bedside Pleuropulmonary Ultrasound in Patients With Sickle Cell Disease Presenting With Vaso-occlusive CrisisNot yet recruitingNCT06755385
- Investigation Into the Use of BAH243 Lentiviral Vector for Gene Therapy in Treating Sickle Cell DiseaseRecruitingNCT06399107Phase 1/21 country
- Ketorolac for Acute Vaso-Occlusive Crisis in Pediatric Sickle Cell DiseaseNot yet recruitingNCT06579703Phase 4
- Intranasal Sufentanil for Analgesia of Severe Sickle Cell Vaso-occlusive Pain Crisis in the PediatricNot yet recruitingNCT06181695Phase 3
- Lidocaine Intravenous in the Emergency Department For Sickle Cell CrisisNot yet recruitingNCT04614610Phase 21 country
- Sickle Cell Improvement: Enhancing Care in the Emergency DepartmentRecruitingNCT05373771Not applicable1 country
- Hyperbaric-oxygen Therapy (HBOT) Versus Placebo for Treating Vaso-Occlusive Crisis (VOC) in Sickle Cell Disease (SCD)RecruitingNCT05289700Phase 32 countries
- Study of Erythrocyte Parameters and Hypercoagulability in Sickle Cell Disease (SCD-TGA)RecruitingNCT053760461 country
- Study of Two Doses of Crizanlizumab Versus Placebo in Adolescent and Adult Sickle Cell Disease PatientsActive, not recruitingNCT03814746Phase 321 countries
- Oral Ketamine for Treatment of Vaso-Occlusive PainCompletedNCT05378555Phase 11 country
- Hyperbaric Oxygen Therapy in Sickle Cell PainCompletedNCT03412045Not applicable1 country
- Evaluation of the Efficacy of Intra-nasal Sufentanil for Analgesia of Vaso-occlusive Crisis in Sickle-cell Adults.TerminatedNCT04076748Phase 33 countries
- A Study to Learn About Sickle Cell Disease In Adult PatientsCompletedNCT054078051 country
- A Study of Etavopivat in Adults and Adolescents With Sickle Cell Disease (HIBISCUS)Active, not recruitingNCT04624659Phase 317 countries
- Inflammation, Platelets and Sickle Cell DiseaseActive, not recruitingNCT056468881 country
- Non Invasive Positive Pressure Ventilation for Prevention of Acute Chest Syndrome in Sickle Cell DiseaseTerminatedNCT01501643Not applicable1 country
- Nitrous Oxide Analgesia Vaso-occlusive CrisisCompletedNCT01891812Phase 21 country
- A Study to Evaluate the Long-term Safety of Inclacumab Administered to Participants With Sickle Cell DiseaseTerminatedNCT05348915Phase 310 countries
- A Study of Etavopivat in Patients With Thalassemia or Sickle Cell DiseaseCompletedNCT04987489Phase 26 countries
- Lipid Balance in Adult Sickle Cell PatientsActive, not recruitingNCT05780775Not applicable1 country
- A Study to Assess the Safety and Efficacy of Inclacumab in Participants With Sickle Cell Disease Experiencing Vaso-occlusive CrisesCompletedNCT04935879Phase 312 countries
- Interest of Famotidine in Children With Sickle Cell DiseaseCompletedNCT05084521Phase 2/31 country
- An Indian Multi-centric Phase IV Study to Assess the Safety of Crizanlizumab in Sickle Cell Disease PatientsCompletedNCT04662931Phase 41 country
- Observational Prospective Study Measuring the Impact of the Use of a Hypnotic Script Associated With Virtual Reality on the Pain of the Child's Sickle Cell During a Vaso-occlusive CrisisCompletedNCT04917120Not applicable1 country
- Sex Hormones and Inflammatory Biomarkers in Patients With Sickle Cell DiseaseCompletedNCT063456381 country
- Ketamine for Acute Painful Crisis in Sickle Cell Disease PatientsCompletedNCT03431285Not applicable1 country
- Efficacy and Safety of Rivipansel (GMI-1070) in the Treatment of Vaso-Occlusive Crisis in Hospitalized Subjects With Sickle Cell DiseaseCompletedNCT02187003Phase 32 countries