Scleroderma, Diffuse clinical trials
The registry lists 528 studies for Scleroderma, Diffuse across more than 10 countries. 115 are recruiting or about to start. Per ClinicalTrials.gov, last updated 2026-09-25.
Status
- Completed
- 263
- Recruiting
- 79
- Status unknown
- 65
- Terminated
- 49
- Not yet recruiting
- 31
- Withdrawn
- 20
Phase
- Phase 2
- 147
- Phase 1
- 72
- Phase 3
- 55
- Phase 4
- 13
- Early Phase 1
- 8
Where
- United States
- 188
- France
- 92
- United Kingdom
- 58
- Italy
- 51
- Canada
- 46
- Germany
- 45
Who runs them
University of Michigan (16) · Assistance Publique - Hôpitaux de Paris (12) · Assiut University (10) · University Hospital, Strasbourg, France (9) · Johns Hopkins University (9) · Lady Davis Institute (9) · Actelion (8) · Duke University (6)
Studies
Recruiting first, then most recently updated. Showing 50 of 528 — search for more.
- Home-based Exercise for Improving Health-related Quality of Life in Systemic SclerosisNot yet recruitingNCT07840430Not applicable1 country
- The Effect of Progressive Muscle Relaxation Exercises on Fatigue, Dyspnea, and Respiratory Function in Patients With Systemic SclerosisRecruitingNCT07842133Not applicable1 country
- EncompaSSc: Evaluation of MTX-474 in Participants With Diffuse Cutaneous Systemic Sclerosis (dcSSc)RecruitingNCT07287670Phase 210 countries
- Study of Diosmin for the Treatment of Digital Ulcers in Systemic SclerosisRecruitingNCT06256575Not applicable1 country
- A Study to Investigate the Safety and Preliminary Efficacy of ALLO-329, an Allogeneic CAR T-cell Therapy, in Adults With Autoimmune DiseaseRecruitingNCT07085104Phase 12 countries
- A Clinical Study to Evaluate Ianalumab in Participants With Diffuse Cutaneous Systemic SclerosisRecruitingNCT06470048Phase 225 countries
- A Study to Investigate the Long-term Safety and Efficacy of Belimumab in Adults With Interstitial Lung Disease (ILD) Associated With Systemic Sclerosis (SSc) and Other Connective Tissue Diseases (CTD) (BLISSconneCTD-OLE)RecruitingNCT06716606Phase 311 countries
- A Study of the Efficacy and Safety of Belimumab in Adults With Systemic Sclerosis Associated Interstitial Lung DiseaseRecruitingNCT05878717Phase 2/318 countries
- A Phase 1/2 Study of PRO-203 in Healthy Volunteers and Participants With Systemic Sclerosis.RecruitingNCT07641634Phase 1/24 countries
- A Safety and Efficacy Study Evaluating CTX112 in Adult Subjects With Refractory Autoimmune DiseaseRecruitingNCT06925542Phase 13 countries
- Controlling Hyperactive Immunity With Long-lived LymphocytesRecruitingNCT07473154Phase 1/23 countries
- Periodontal Microbiota in Systemic SclerosisRecruitingNCT06182293Not applicable1 country
- Platform Clinical Study for Conquering SclerodermaRecruitingNCT06195072Phase 21 country
- RESET-SSc: An Open-Label Study to Evaluate the Safety and Efficacy of CABA-201, a CD19-CAR T Cell Therapy, in Subjects With Systemic SclerosisRecruitingNCT06328777Phase 2/31 country
- Autologous Stem Cell Transplantation in Patients With Systemic SclerosisRecruitingNCT03630211Phase 21 country
- DERMATOMICS: Identifying Regulators of Skin HomeostasisRecruitingNCT068946541 country
- Efficacy and Safety of HN2301 in Autoimmune Diseases（AIDs）RecruitingNCT06801119Phase 11 country
- A Phase 1/2 Study of NKX019 in Subjects With Immune-Mediated Diseases (Ntrust-2)RecruitingNCT06733935Phase 1/23 countries
- A Phase 1 Open-label Study to Evaluate Safety in Healthy Participants and Participants With Autoimmune DiseasesRecruitingNCT07284797Phase 11 country
- AlloNK®, an Allogeneic Non-genetically Modified, Cord Blood-derived NK Cell Therapy, in Combination With Rituximab, Studied in Relapsing Forms of B-cell Dependent Rheumatologic Diseases.RecruitingNCT06991114Phase 211 countries
- Diffuse Cutaneous Scleroderma (DSSc) SFDI StudyRecruitingNCT07090226Not applicable1 country
- A Study of Healthy Donor CD19-targeted Allogeneic CAR T Cells in Participants With Severe, Refractory Autoimmune DiseasesRecruitingNCT07115745Phase 110 countries
- Preventive Effect of Clopidogrel on the Systemic Sclerosis Development RiskRecruitingNCT05098704Phase 2/31 country
- TL1A Inhibition in Systemic Sclerosis-Related Skin Fibrosis and Immunological Alterations: A Proof-of-Concept In Vitro Study (FIBROSTOP)Not yet recruitingNCT076422971 country
- US Zamto-cel Autoimmune DiseasesRecruitingNCT06708845Phase 11 country
- Allogeneic CD19/BCMA-Targeted CAR-γδT Cell Therapy: Safety and Preliminary Pharmacodynamics in Relapsed/Refractory Autoimmune DiseasesNot yet recruitingNCT07490275Phase 1
- Skeletal Muscle Function in Interstitial Lung DiseaseRecruitingNCT03800017Not applicable1 country
- Elastography Ultrasound in Localized Scleroderma (Morphea) StudyEnrolling by invitationNCT068477501 country
- A Study of Nemolizumab for the Treatment of Adults With Systemic SclerosisRecruitingNCT07047690Phase 22 countries
- Clinico-biological Collection to Investigate the Physiopathology of Systemic Autoimmune DiseasesRecruitingNCT052514151 country
- Clinico-biological Collection of Autoimmune, Dysimmune or Auto-inflammatory Dermatological DiseasesRecruitingNCT063876541 country
- Clinical Study of EVM18001 in the Treatment of Refractory Autoimmune DiseasesRecruitingNCT07470151Not applicable1 country
- YTS109 in Pediatric Relapsed/Refractory Autoimmune DiseasesNot yet recruitingNCT07439029Phase 11 country
- Rheumatology Patient Registry and BiorepositoryRecruitingNCT044020861 country
- Transcriptomic Study of Cutaneous Fibroblasts in SclerodermaRecruitingNCT072564181 country
- The Apollo Device in Systemic Sclerosis for the Management of fatiguE, Raynaud Phenomenon and qualiTy of LifeRecruitingNCT06675344Not applicable1 country
- Maternal Autoimmune Disease Research Alliance (MADRA) RegistryRecruitingNCT032769231 country
- Investigating the Effectiveness of the Biopsychosocial Model-Based Exercise Approach in Children and Adults Diagnosed With SclerodermaRecruitingNCT07292961Not applicable1 country
- Scleroderma Registry & Repository at the Hospital for Special SurgeryRecruitingNCT016564471 country
- Sildenafil for Early Pulmonary Vascular Disease in SclerodermaRecruitingNCT04797286Phase 21 country
- Comparative Autoantibody and Immunologic Cell Marker StudyEnrolling by invitationNCT024228751 country
- Patients Diagnosed With Scleroderma: Physical Performance and FunctionalityRecruitingNCT071830721 country
- Patients Diagnosed With Scleroderma and Their Chewing and Swallowing PerformanceRecruitingNCT071829811 country
- Cultural Adaptation, Validity, and Reliability of the Turkish Version of The PASTUL QuestionnaireRecruitingNCT071829681 country
- Mesenchymal Stromal Cells as Treatment for Digital Ulcers in Systemic SclerosisRecruitingNCT03211793Phase 1/21 country
- Cohort of Patients With Systemic Sclerosis Within the Framework of the RESO Reference CentreRecruitingNCT04265144Not applicable1 country
- PPI Refractory - GERD Mechanisms in Systemic SclerosisNot yet recruitingNCT07022912
- Pathogenic Mechanisms Involved in the Initiation and Progression of Systemic SclerosisNot yet recruitingNCT07015060Not applicable
- Medical Follow-up of New Cases of Polyarthritis in Children and Young AdultsRecruitingNCT070009161 country
- Clinical Study on the Treatment of Systemic Sclerosis With UTAA91 Injection.Not yet recruitingNCT06982534Early Phase 11 country