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Scleroderma, Systemic clinical trials

The registry lists 610 studies for Scleroderma, Systemic across more than 10 countries. 218 are recruiting or about to start. 363 of them are mainly about Scleroderma, Systemic (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10. Counting its narrower condition Scleroderma, Diffuse too: 769 studies, 254 open.

ClinicalTrials.gov finds 823 studies for Scleroderma, Systemic. How that becomes 607 here

This page counts the studies the registry files under Scleroderma, Systemic, and those it files under no condition that list Scleroderma, Systemicthemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count

  1. 823Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
  2. −159Filed under a narrower condition, counted on its own pageScleroderma, Diffuse 159
  3. −11List Scleroderma, Systemic as a condition, but the registry did not file them under itMost often written as “SSc-Systemic Sclerosis” (4), “Lung Disease With Systemic Sclerosis” (2), and “Systemic Sclerosis Patients With Digital Ulcers” (1). The registry filed them under other conditions only, most often Lupus Erythematosus, Systemic (5) and Lung Diseases, Interstitial (3).
  4. −46Match it another way13 name it in the title, 3 in a keyword, and 30 by a synonym or other text the search reads.
  5. 607The count on this page12 of them list Scleroderma, Systemic in their own words; the registry filed them under no condition.

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Status

Completed
250
Recruiting
144
Not yet recruiting
64
Status unknown
59
Terminated
39
Active, not recruiting
24

Phase

Phase 2
166
Phase 1
106
Phase 3
52
Early Phase 1
28
Phase 4
18

Where

United States
165
France
132
China
81
United Kingdom
56
Germany
51
Italy
48

Who runs them

Assistance Publique - Hôpitaux de Paris (23) · University Hospital, Lille (13) · University of Michigan (10) · Lady Davis Institute (9) · Actelion (9) · University Hospital, Strasbourg, France (8) · Assiut University (8) · University Hospital, Bordeaux (7)

What is being tested here

Drugs under test in Scleroderma, Systemic studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted

DrugOpenPhase 3All
Cyclophosphamide4514
Rituximab338
Tocilizumab345
Anti-CD19 CAR T Cells Preparation304
UTAA91303
YTS109303
Fludarabine228
Mycophenolic Acid218
Treprostinil206
Nintedanib234

Drug classes tested here Alkylating agents 4 open · Tyrosine kinase inhibitors (TKIs) 3 open · Antimetabolites 2 open · JAK inhibitors 1 open · Endothelin receptor antagonists 15

Coming up

13phase 3 studies under way
60studies finish main data collection within a year1 of them phase 3

Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.

The 10 nearest, phase 3 first

Who these studies take

Of the 144 Scleroderma, Systemic studies recruiting now, 82 (57%) set no upper age limit and 49 (34%) stop at 75 or younger. 19 (13%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 16 (11%) take healthy volunteers.

Recruiting studies that take each age, of 144
AgeWomenMen
1017 (12%)17 (12%)
18143 (99%)143 (99%)
30142 (99%)142 (99%)
40142 (99%)142 (99%)
50142 (99%)142 (99%)
65137 (95%)137 (95%)
75103 (72%)103 (72%)
8589 (62%)89 (62%)

Across all 610 studies, recruiting or not: 32% stop at 75 or younger and 15% at 65; 10% take children; 3% are for women only and <1% for men only; 13% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.

How long Scleroderma, Systemic studies take

Of 48 phase 2 interventional studies under Scleroderma, Systemic, half reached primary completion within 37 months of starting, counting those still running.

Start to primary completionEvery sponsorIndustryNon-industry
Phase 129 mo17–60 · 44 studies——
Phase 237 mo24–83 · 48 studies——
Phase 325 mo21–36 · 17 studies——
Interventional, no phase23 mo10–38 · 100 studies—22 mo8–38 · 94 studies
Observational44 mo15–80 · 61 studies—55 mo15–80 · 59 studies

Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out

What changed recently

From the registry's own updates since Oct 11, 2026.

Started recruiting5

Stopped2

Newly registered7

Show 2 more

Studies

Recruiting first, then most recently updated. Showing 50 of 610. Browse all 610 → or search them.