Scleroderma, Systemic clinical trials
The registry lists 686 studies for Scleroderma, Systemic across more than 10 countries. 222 are recruiting or about to start. Per ClinicalTrials.gov, last updated 2026-09-25.
Status
- Completed
- 295
- Recruiting
- 145
- Status unknown
- 68
- Not yet recruiting
- 67
- Terminated
- 50
- Active, not recruiting
- 23
Phase
- Phase 2
- 180
- Phase 1
- 113
- Phase 3
- 63
- Early Phase 1
- 29
- Phase 4
- 19
Where
- United States
- 205
- France
- 131
- China
- 77
- United Kingdom
- 61
- Italy
- 53
- Germany
- 52
Who runs them
Assistance Publique - Hôpitaux de Paris (21) · University of Michigan (17) · University Hospital, Lille (14) · Assiut University (14) · University Hospital, Strasbourg, France (10) · Actelion (9) · Lady Davis Institute (9) · University Hospital, Bordeaux (7)
Studies
Recruiting first, then most recently updated. Showing 50 of 686 — search for more.
- Combined Growth Differentiation Factor-15 (GDF-15) and Lung Ultrasound for ILD Screening in Rheumatoid Arthritis and Systemic SclerosisNot yet recruitingNCT07839221
- The Effect of Progressive Muscle Relaxation Exercises on Fatigue, Dyspnea, and Respiratory Function in Patients With Systemic SclerosisRecruitingNCT07842133Not applicable1 country
- Home-based Exercise for Improving Health-related Quality of Life in Systemic SclerosisNot yet recruitingNCT07840430Not applicable1 country
- Obinutuzumab in Systemic SclerosisNot yet recruitingNCT07842523Phase 21 country
- A Study to Assess the Efficacy and Safety of Efgartigimod PH20 SC in Adults With Systemic SclerosisRecruitingNCT06655155Phase 224 countries
- Investigation of Type I Interferon Excess in Patients With Systemic Autoimmune Diseases and Genetic Type I InterferonopathiesNot yet recruitingNCT07837986Not applicable1 country
- Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVORecruitingNCT03816345Phase 12 countries
- Safety and Efficacy of Universal CAR-T Cells (UWD-CD19) Combined With Immunosuppressants in the Treatment of Refractory Autoimmune DiseasesNot yet recruitingNCT06821659Phase 1/2
- Clinical Study of BCT301 Cell Injection Therapy for Refractory Autoimmune DiseasesRecruitingNCT07301164Early Phase 11 country
- Clinical Cohort Study of Systemic SclerosisRecruitingNCT078363611 country
- Safety and Efficacy of Universal CD19-targeting CAR-γδT Cells in Refractory Autoimmune DiseasesRecruitingNCT06828042Phase 1/21 country
- A Study of ATG-201 in Adult Participants With Autoimmune DiseasesNot yet recruitingNCT07732309Phase 11 country
- A Study to Compare the Efficacy and Safety of BMS-986353 (Zolacabtagene- Autoleucel / Zola-cel), CD19-CAR T Cells, Versus Standard of Care in Participants With Active Systemic SclerosisNot yet recruitingNCT07335562Phase 310 countries
- Rituximab vs Placebo for Maintenance in Systemic Sclerosis - Interstitial Lung DiseaseNot yet recruitingNCT07827742Phase 21 country
- A Study to Test Whether Nerandomilast Helps People With Systemic SclerosisRecruitingNCT07497087Phase 345 countries
- Hyperpolarized Xenon MRI in Adults With Pulmonary Hypertension in Interstitial Lung Disease and Systemic SclerosisNot yet recruitingNCT07821398Phase 2
- Subcutaneous Injection of Sodium Thiosulfate for Ectopic Calcifications or Ossifications. A Pilot StudyRecruitingNCT03582800Phase 21 country
- A Study to Learn About a Medicine Called PF-08154225 in Participants With Autoimmune DiseasesNot yet recruitingNCT07782450Phase 1/2
- Study of Diosmin for the Treatment of Digital Ulcers in Systemic SclerosisRecruitingNCT06256575Not applicable1 country
- A Study to Investigate the Safety and Preliminary Efficacy of ALLO-329, an Allogeneic CAR T-cell Therapy, in Adults With Autoimmune DiseaseRecruitingNCT07085104Phase 12 countries
- Nebulized UC-EVs for Recurrent or Refractory IMIDs With Lung InvolvementNot yet recruitingNCT07806045Early Phase 11 country
- A Study of the Efficacy and Safety of Belimumab in Adults With Systemic Sclerosis Associated Interstitial Lung DiseaseRecruitingNCT05878717Phase 2/318 countries
- A Phase 1/2 Study of PRO-203 in Healthy Volunteers and Participants With Systemic Sclerosis.RecruitingNCT07641634Phase 1/24 countries
- Study Investigating the Safety of Anti-CD19 CAR-T Cells Therapy Produced at Gustave Roussy for Adults With Severe and Refractory Systemic Autoimmune Rheumatic DiseasesNot yet recruitingNCT07544225Phase 11 country
- FT839 in Autoimmune DiseasesRecruitingNCT07800871Phase 1/21 country
- A Safety and Efficacy Study Evaluating CTX112 in Adult Subjects With Refractory Autoimmune DiseaseRecruitingNCT06925542Phase 13 countries
- Mass Spectrometry-based Immune Profiling in Autoimmune DiseasesEnrolling by invitationNCT071882851 country
- A Study to Test CRT-402 in Refractory Autoimmune DiseaseNot yet recruitingNCT07778446Phase 1/21 country
- Controlling Hyperactive Immunity With Long-lived LymphocytesRecruitingNCT07473154Phase 1/23 countries
- Characterization of Autoreactive b Lymphocytes in Autoimmune Diseases and Immune DeficienciesRecruitingNCT072511791 country
- Platform Clinical Study for Conquering SclerodermaRecruitingNCT06195072Phase 21 country
- Efficacy of A Non-Invasive Botulinum Toxin Microneedle Pad for the Treatment of Secondary Raynaud's PhenomenonNot yet recruitingNCT07759557Phase 3
- RESET-SSc: An Open-Label Study to Evaluate the Safety and Efficacy of CABA-201, a CD19-CAR T Cell Therapy, in Subjects With Systemic SclerosisRecruitingNCT06328777Phase 2/31 country
- Autologous Stem Cell Transplantation in Patients With Systemic SclerosisRecruitingNCT03630211Phase 21 country
- DERMATOMICS: Identifying Regulators of Skin HomeostasisRecruitingNCT068946541 country
- Safety and Preliminary Efficacy of HN2302 in Patients With Autoimmune DiseasesNot yet recruitingNCT07523282Phase 11 country
- Inflammatory Disease Biobank for Immunophenotyping and Cardiovascular ResearchNot yet recruitingNCT07737470
- A Phase 1/2 Study of NKX019 in Subjects With Immune-Mediated Diseases (Ntrust-2)RecruitingNCT06733935Phase 1/23 countries
- Mycophenolate After Stem Cell Transplant for Systemic SclerosisNot yet recruitingNCT07734012Phase 21 country
- A Study of LIQ861 (Inhaled Treprostinil) in Adults With Systemic Sclerosis Who Have Symptomatic Raynaud's Phenomenon AttacksNot yet recruitingNCT07748000Phase 2
- A Phase II Study of TollB-001 Tablets in Systemic SclerosisNot yet recruitingNCT07745725Phase 21 country
- A Phase 1 Open-label Study to Evaluate Safety in Healthy Participants and Participants With Autoimmune DiseasesRecruitingNCT07284797Phase 11 country
- AlloNK®, an Allogeneic Non-genetically Modified, Cord Blood-derived NK Cell Therapy, in Combination With Rituximab, Studied in Relapsing Forms of B-cell Dependent Rheumatologic Diseases.RecruitingNCT06991114Phase 211 countries
- Objective Assessment of Skin Damage Using ADHELASKIN in Patients With Systemic SclerosisRecruitingNCT07543679Not applicable1 country
- CD19-BCMA CART Cell Therapy for Refractory SLE-LN, SSc, and pSS-PAHRecruitingNCT06947460Phase 1/21 country
- BAFF CAR-T Cells (LMY-922) for Treatment of Refractory Autoimmune DiseaseNot yet recruitingNCT07729995Phase 11 country
- A Study of AZD0120 in Autoimmune DiseasesRecruitingNCT07295847Phase 16 countries
- Finger Versus Earlobe Pulse Oximetry During the 6-Minute Walk Test in Interstitial Lung DiseaseRecruitingNCT077238721 country
- Diffuse Cutaneous Scleroderma (DSSc) SFDI StudyRecruitingNCT07090226Not applicable1 country
- Extracellular Vesicle Dynamics Predicting Vascular Complications and Treatment Response in Systemic SclerosisNot yet recruitingNCT07717060Not applicable