Osteoporosis clinical trials
The registry lists 1,601 studies for Osteoporosis across more than 10 countries. 209 are recruiting or about to start. 1,024 of them are mainly about Osteoporosis (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10. Counting its narrower condition Osteoporosis, Postmenopausal too: 1,810 studies, 225 open.
ClinicalTrials.gov finds 1,914 studies for Osteoporosis. How that becomes 1,601 here
This page counts the studies the registry files under Osteoporosis, and those it files under no condition that list Osteoporosisthemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count
- 1,914Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
- −209Filed under a narrower condition, counted on its own pageOsteoporosis, Postmenopausal 207
- −30List Osteoporosis as a condition, but the registry did not file them under itMost often written as “Osteopenia, Osteoporosis” (6), “Osteoporosis Fracture” (5), and “Osteoporosis Risk” (4). The registry filed them under other conditions only, most often Bone Diseases, Metabolic (10) and Fractures, Bone (5).
- −74Match it another way69 name it in the title and 5 in a keyword.
- 1,601The count on this page45 of them list Osteoporosis in their own words; the registry filed them under no condition.
Get an email when these change. Save the Osteoporosis studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Status
Who runs them
Amgen (34) · National Taiwan University Hospital (32) · Eli Lilly and Company (23) · Merck Sharp & Dohme LLC (21) · GlaxoSmithKline (19) · Novartis Pharmaceuticals (19) · Massachusetts General Hospital (16) · University of Aarhus (15)
What is being tested here
Drugs under test in Osteoporosis studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Denosumab | 7 | 22 | 59 |
| Romosozumab | 5 | 4 | 19 |
| Teriparatide | 3 | 13 | 62 |
| Zoledronic Acid | 2 | 26 | 62 |
| Alendronate | 2 | 15 | 51 |
| Ibandronic Acid | 2 | 5 | 15 |
| Metformin | 2 | 0 | 2 |
| Cholecalciferol | 1 | 4 | 21 |
| Vitamin D | 1 | 1 | 13 |
| Abaloparatide | 1 | 4 | 8 |
Drug classes tested here GLP-1 receptor agonists 2 open · SERMs 13 · Estrogens 10 · Aromatase inhibitors 7 · Statins 7
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Jan 2027A Comparative Study to Valuating the Efficacy and Safety of QL1206 and Prolia® · Phase 3 · Qilu Pharmaceutical Co., Ltd.
- Apr 2027Quanduzhong Capsules for Primary Osteoporosis · Phase 3 · Shanghai University of Traditional Chinese Medicine
- May 2027To Evaluate the Efficacy and Safety of Abaloparatide Injection (QLG2128) in the Treatment of Postmenopausal Women With Osteoporosis and at High Risk of Fracture · Phase 3 · Qilu Pharmaceutical Co., Ltd.
- Nov 2026Metabolic Determinants of DXA-Measured Bone Mineral Density · Mardin Artuklu University
- Nov 2026A Study Evaluating the Performance of Using AI Software and Chest X-rays to Screen for Osteoporosis as Compared to Standard DXA Scans in Patients 50 Years and Older · Promedius Inc
- Dec 2026A Trial Evaluating Efficacy of AGA2118 in PostMenopausal Women wIth Low Bone MasS (ARTEMIS) · Angitia Biopharmaceuticals
- Dec 2026Fragility Fracture Liaison Service and Anti-osteoporosis Medication Monitoring Service Study · National Taiwan University Hospital
- Dec 2026Assessment of Mineral and Bone Disorders in Kidney Transplant Recipients · Grigore T. Popa University of Medicine and Pharmacy
- Dec 2026Continuous Mobility and Physical Activity in Vertebroplasty vs Sham for Osteoporotic Vertebral Fracture · Spine Centre of Southern Denmark
- Dec 2026Impact of Allo-HSCT on Bone Remodeling: Evolution of Bone Mineral Density and Architecture Measured by Bone Densitometry · University Hospital, Caen
Who these studies take
Of the 132 Osteoporosis studies recruiting now, 76 (58%) set no upper age limit and 20 (15%) stop at 75 or younger. 9 (7%) take children under 18. 33 (25%) are for women only and 1 (1%) for men only; 36 (27%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 9 (7%) | 5 (4%) |
| 18 | 45 (34%) | 37 (28%) |
| 30 | 64 (48%) | 54 (41%) |
| 40 | 71 (54%) | 60 (45%) |
| 50 | 103 (78%) | 78 (59%) |
| 65 | 120 (91%) | 92 (70%) |
| 75 | 115 (87%) | 92 (70%) |
| 85 | 106 (80%) | 87 (66%) |
Across all 1,601 studies, recruiting or not: 29% stop at 75 or younger and 19% at 65; 15% take children; 42% are for women only and 5% for men only; 33% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Osteoporosis studies take
Of 65 phase 4 interventional studies under Osteoporosis, half reached primary completion within 46 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 1 | 13 mo4–22 · 30 studies | — | — |
| Phase 2 | 47 mo29–65 · 42 studies | — | 60 mo34–65 · 33 studies |
| Phase 3 | 37 mo21–57 · 45 studies | 24 mo20–46 · 35 studies | — |
| Phase 4 | 46 mo29–71 · 65 studies | — | 46 mo31–71 · 55 studies |
| Interventional, no phase | 26 mo9–50 · 238 studies | — | 22 mo8–49 · 219 studies |
| Observational | 51 mo24–97 · 125 studies | — | 53 mo24–113 · 114 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Started recruiting2
- The Effect of Digital Education for Osteoporosis Patients on Fracture Risk and Related Health Outcomes.Nov 10, 2026NCT06603545
- Post-osteoporotic Fracture Exercise ProgramNov 10, 2026NCT07595991
Results posted2
- Muscle Impact of Treating OsteoporosisOct 27, 2026NCT05666310
- A Study of Romosozumab (EVENITY®) in Postmenopausal Women in India With Osteoporosis at a High Risk of Fracture.Oct 21, 2026NCT06079476
Newly registered2
Studies
Recruiting first, then most recently updated. Showing 50 of 1,601. Browse all 1,601 → or search them.
- The Effect of Digital Education for Osteoporosis Patients on Fracture Risk and Related Health Outcomes.RecruitingNCT06603545Not applicable1 country
- Post-osteoporotic Fracture Exercise ProgramRecruitingNCT07595991Not applicable1 country
- A Clinical Study to Collect Real-wordt Data on Safety and Clinical Performance of the VCFix Spinal System for Treatment of Vertebral Compression Fractures of (Suspected) Osteoporotic Origin.RecruitingNCT079204841 country
- Assessment and Comparison of Osteoporosis Risk Factors After StrokeRecruitingNCT072286111 country
- GRACE II (General Retrospective Analysis of Commercial Experience With AGN1 LOEP)Enrolling by invitationNCT075946391 country
- Glucocorticoid-induced Osteoporosis in Patients With Chronic Inflammatory Rheumatic Diseases or PsoriasisRecruitingNCT027193141 country
- Exercise and Fall Prevention for Fracture ReductionNot yet recruitingNCT07897929Not applicable1 country
- Surgeon-Initiated Bone Health Referral Pathway in Patients Undergoing Lower Extremity ArthroplastyRecruitingNCT05845021Not applicable1 country
- A Natural History Study of Bone and Mineral DisordersRecruitingNCT000248041 country
- Quanduzhong Capsules for Primary OsteoporosisEnrolling by invitationNCT07895082Phase 31 country
- A Study Evaluating the Performance of Using AI Software and Chest X-rays to Screen for Osteoporosis as Compared to Standard DXA Scans in Patients 50 Years and OlderRecruitingNCT074217132 countries
- Combined Anabolic TherapyRecruitingNCT06558188Phase 41 country
- Study of the Impact of Mother-of-pearl Nutritional Supplementation on the Prevention of Post-menopausal OsteoporosisRecruitingNCT05571514Not applicable1 country
- Osteoporosis & Renal Disease: Research in Primary Health Care ServicesNot yet recruitingNCT078484901 country
- Controlled Reduction of AO Spine B3 Fractures in Ankylosing Spinal Disorders Using an Inflatable Positioning Device: Technical Note and Retrospective Single-centre Case SeriesNot yet recruitingNCT07847320
- Clinical Study on a New Diagnostic Strategy for Osteoporosis and Sarcopenia in Chronic Kidney Disease Patients Based on MRI-FFEnrolling by invitationNCT076457941 country
- Preserving Geriatric Muscle With an Osteoporosis MedicationRecruitingNCT06118905Phase 41 country
- Effect of Acetylcholinesterase Inhibitors on Bone MetabolismRecruitingNCT06041789Phase 21 country
- Evaluation of the Role of Luteinizing Hormone (LH) and Human Chorionic Gonadotropin (hCG) in Adult Patients Undergoing Assessment for Endocrine DisordersRecruitingNCT078241021 country
- Pharmacokinetics of Zoledronic Acid in Patients on DialysisNot yet recruitingNCT07741136Phase 11 country
- Patient Education in Osteoporosis (RCT-PATOS)RecruitingNCT07367776Not applicable1 country
- Effect of Postural Correction Exercises on Pelvic Floor Dysfunction in Postmenopausal Osteoporotic WomenNot yet recruitingNCT07806968Not applicable1 country
- GLP-1R Actions on Muscle and the SkeletonRecruitingNCT07154719Phase 41 country
- Full-Spectrum Cannabis Extract for Chronic Pain and Bone Health Biomarkers in WomenNot yet recruitingNCT07783295Phase 21 country
- The Comparison of Ibandronate and Zoledronic Acid After Denosumab DiscontinuationRecruitingNCT07406685Phase 41 country
- The Relationship Between Lipedema and OsteoporosisNot yet recruitingNCT07779603
- OSTEOPOROSIS EDUCATION AND ITS IMPACT ON OSTEOPOROSIS HEALTH BELIEFS AND AWARENESS IN WOMEN AT RISK OF OSTEOPOROSISEnrolling by invitationNCT07486076Not applicable1 country
- Sequential Treatment With Romosozumab Followed by Denosumab vs. Zoledronic Acid for Gains in HIP BMDNot yet recruitingNCT07772609Phase 41 country
- Dynamics in Bone Turnover Markers During and After Short-term Glucocorticoid Treatment in Patients With an Inflammatory Joint DiseaseRecruitingNCT063958831 country
- OSTEOMICS: Identifying Regulators of Bone HomeostasisRecruitingNCT057328701 country
- EFFECTIVENESS AND CLINICAL OPTIMIZATION OF A STANDARDIZED PHYSIOTHERAPY EXERCISE PROGRAM TARGETING BALANCE-POSTURE INTERACTION AND FALL RISK IN OSTEOPOROSIS: A RANDOMIZED CONTROLLED TRIALNot yet recruitingNCT07763717Not applicable1 country
- Calcium-Rich Food Versus Calcium Carbonate for Bone HealthNot yet recruitingNCT07763509Not applicable1 country
- Romosozumab Versus Denosumab In Glucocorticoid-induced Osteoporosis: An Extended Observation Of a Clinical Trial at 6 YearsNot yet recruitingNCT07757373Phase 41 country
- Comparing Implant Retention Versus Removal for MRONJ at Implant SitesRecruitingNCT07435259Not applicable1 country
- 25(OH)-Vitamin D and Its Association With Structural and Functional Parameters in Hospitalized Patients With Neurological DiseasesRecruitingNCT06791044Not applicable1 country
- Blackcurrants Modify Gut Microbiota and Reduce Osteoporosis Risk in Postmenopausal FemalesRecruitingNCT07365514Phase 11 country
- The Effect of Osteoporotic Medications on Vertebral Bone Quality ScoreEnrolling by invitationNCT07587775Phase 21 country
- U.S. Prospective Evaluation of EPIONE Device for Percutaneous MSK ProceduresRecruitingNCT07325578Not applicable1 country
- Osteoporotic Fracture and Lidocaine Plaster 5% for Neuropathic Pain preventioNNot yet recruitingNCT07691359Phase 41 country
- The Optimised Use of Romozosumab StudyRecruitingNCT06059222Phase 41 country
- Functional Muscle-Bone Incongruity Index (FKUI): A Prospective Observational StudyRecruitingNCT076770331 country
- Can Serum Lumican Level Identify a Hidden Fragility Phenotype Beyond Bone Mineral Density in Postmenopausal Women?RecruitingNCT076770721 country
- Safety and Efficacy Clinical Trial of the Vessel-X® Bone Filling Container SystemRecruitingNCT07665424Not applicable1 country
- Effects of Cycle Therapy vs Sequential Therapy With Romosozumab and Denosumab in Postmenopausal Osteoporosis PatientsRecruitingNCT06938152Phase 41 country
- Link Between ASCorbemia Level and OsteoporosisNot yet recruitingNCT07660484Not applicable1 country
- A Clinical Study Evaluating the Safety and Efficacy of the VCFix Spinal System for Treatment of Vertebral Compression FracturesRecruitingNCT07301749Not applicable2 countries
- Radiographic Cortical Thickness of the Humerus in Detecting Post-Stroke Regional Bone LossRecruitingNCT076513061 country
- Robot Assisted Minimally Invasive Treatment Versus Conventional Surgery for FFP3-4 Fragility Fractures of the Pelvis in Elderly PatientsNot yet recruitingNCT07639619Not applicable1 country
- Bone, Exercise, Alendronate, and Caloric RestrictionRecruitingNCT05764733Phase 41 country
- Contribution of Bone to Urine CitrateEnrolling by invitationNCT068113631 country