An observational study in Osteoporosis and Bone Mineral Density, sponsored by Mardin Artuklu University. Active, not recruiting at 1 site in Turkey (Türkiye). Open to participants aged 40 Years and older. Per ClinicalTrials.gov, last updated 2026-09-23.
Sponsored by Mardin Artuklu University · Observational
Among 67 studies in Osteoporosis with a site in Turkey — 14 open to participants now, 17 under way, none of them phase 3. Osteoporosis · Turkey.
Among the 67 studies in Osteoporosis with a site in Turkey, this one has the largest planned enrollment of the 36 observational ones, is one of 10 that started in 2026, is one of 36 observational ones, reaches primary completion later than 12 of the 16 other live ones, and was the 66th registered.
1,601 studies on the registry are indexed under Osteoporosis; 209 are open to participants now.
This study's planned enrollment of 750 is above the median of 160 across 455 observational studies indexed under Osteoporosis.
Browse Osteoporosis studies →14 of the 67 studies in Osteoporosis with a site in Turkey are open now, in 1 country. Each count lists the studies.
Of the 132 Osteoporosis studies recruiting now, 76 (58%) set no upper age limit and 20 (15%) stop at 75 or younger; 9 take children under 18; 36 take healthy volunteers.
This study: 40 Years and older · all sexes · no healthy volunteers.
The full table on the hub →67 studies; the count open now beside each. This study's row is marked.
First in 2001; this study’s year is marked. 10 started in 2026.
Median enrollment 60 across the 31 interventional studies, 107 across the 36 observational. Of the 44 that completed or were terminated, 2 (5%) have results posted.
4 of 67 have an industry lead sponsor. The 10 most frequent:
Mardin Artuklu University is the lead sponsor of 34 studies on the registry; 15 are open to participants now.
Mardin Artuklu University has 1 study filed under Osteoporosis — fewer than ten, so there is no comparison to draw.
5 of the studies in Osteoporosis with a site in Turkey that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07836868Mardin Artuklu UniversityMetabolic Determinants of DXA-Measured Bone Mineral Density | 2026-11-01 |
| NCT07228611Ankara Etlik City HospitalAssessment and Comparison of Osteoporosis Risk Factors After Stroke | 2026-12-01 |
| NCT07677072Kanuni Sultan Suleyman Training and Research HospitalCan Serum Lumican Level Identify a Hidden Fragility Phenotype Beyond Bone Mineral Density in Postmenopausal Women? | 2026-12-01 |
| NCT07486076Bartın UnıversityOSTEOPOROSIS EDUCATION AND ITS IMPACT ON OSTEOPOROSIS HEALTH BELIEFS AND AWARENESS IN WOMEN AT RISK OF OSTEOPOROSIS | 2027-01-20 |
| NCT07677033Kanuni Sultan Suleyman Training and Research HospitalFunctional Muscle-Bone Incongruity Index (FKUI): A Prospective Observational Study | 2027-05-01 |
Among the 67 studies in Osteoporosis with a site in Turkey, from their registry updates:
This retrospective observational study will examine bone mineral density measurements and their metabolic and clinical determinants in adults aged 40 years and older. Existing medical records of approximately 300 patients who underwent dual-energy X-ray absorptiometry (DXA) of the lumbar spine and femoral neck will be reviewed.
The researchers will examine the relationships between DXA measurements and available clinical and laboratory findings. Differences between lumbar spine and femoral neck T-scores, bone mineral density discordance, fracture history, and FRAX fracture risk will also be evaluated. No additional examination, laboratory test, treatment, or intervention will be performed as part of the study.
Background: Bone mineral density measured at the lumbar spine and femoral neck may differ because these regions have different bone structures and may be affected differently by aging, metabolic factors, and degenerative changes. These differences may influence the diagnosis of osteoporosis and the assessment of fracture risk.
Objective: This study aims to investigate the metabolic and clinical factors associated with bone mineral density parameters measured by DXA. It will also evaluate lumbar spine-femoral neck T-score differences, bone mineral density discordance, fragility fractures, and FRAX fracture risk.
Method: This retrospective observational study will include adults aged 40 years and older who underwent DXA examination of the lumbar spine and femoral neck. Existing hospital records, DXA results, laboratory findings, and clinical information will be reviewed. The study will examine lumbar vertebral and femoral neck T-scores, the T-score difference between these regions, and concordant or discordant bone mineral density categories. Available metabolic and clinical variables will be analyzed. Previous and newly recorded fragility fractures and FRAX risk estimates will also be evaluated. No new tests or interventions will be performed.
Adults aged 40 years and older who underwent lumbar spine and femoral neck DXA examination at Mardin Training and Research Hospital will be identified from existing hospital records. Patients with eligible DXA measurements and available clinical and laboratory data will be included. The study population may include individuals with normal bone mineral density, osteopenia, or osteoporosis. No healthy control group will be recruited separately.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Malignancy means cancer. Criteria about another or earlier malignancy ask whether you have had a different cancer, usually within a set number of years.
Some are commonly allowed, such as treated skin cancers other than melanoma and early cancers removed completely — check the exceptions this study lists.
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
Cancer (malignancy)
Malignancy means cancer. Criteria about another or earlier malignancy ask whether you have had a different cancer, usually within a set number of years.
Some are commonly allowed, such as treated skin cancers other than melanoma and early cancers removed completely — check the exceptions this study lists.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Corticosteroids (steroids)
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Adults aged 40 years and older who underwent DXA examination of the lumbar spine and femoral neck will be included. Existing DXA measurements, clinical information, laboratory findings, fracture records, and FRAX estimates will be reviewed retrospectively. No treatment, examination, or intervention will be assigned as part of the study.
Lumbar Spine-Femoral Neck T-Score Gradient
The lumbar spine-femoral neck T-score gradient will be calculated by subtracting the femoral neck T-score from the mean lumbar spine T-score obtained from eligible L1-L4 vertebrae. T-scores represent the number of standard deviations by which bone mineral density differs from the young-adult reference mean. T-scores and the calculated gradient do not have predefined minimum or maximum values. Higher positive gradient values indicate a relatively higher lumbar spine T-score compared with the femoral neck, while more negative values indicate a relatively lower lumbar spine T-score. The relationships between the gradient and metabolic and clinical variables will be evaluated.
Time frame: Baseline
Lumbar Spine-Femoral Neck Bone Mineral Density Discordance
Lumbar spine and femoral neck T-scores will be classified as normal (T-score ≥ -1.0), osteopenic (T-score \< -1.0 and \> -2.5), or osteoporotic (T-score ≤ -2.5). Participants will be classified as concordant when the lumbar spine and femoral neck are in the same diagnostic category and discordant when they are in different diagnostic categories. This is a categorical outcome reported as concordant or discordant and is not a numerical scale; therefore, it has no minimum or maximum score, and higher values do not represent a better or worse outcome.
Time frame: Baseline
Prevalent Fragility Fracture
The presence of a fragility fracture before or at the time of the index DXA examination will be identified from medical records, radiology reports, and available imaging. Vertebral, hip, distal radius, and proximal humerus fractures caused by low-energy trauma will be included.
Time frame: Before or at the index DXA examination
Incident Fragility Fracture
New fragility fractures occurring after the index DXA examination will be identified from medical records, radiology reports, and available imaging. Vertebral, hip, distal radius, and proximal humerus fractures caused by low-energy trauma will be included.
Time frame: From the index DXA examination to the date of record review, up to 10 years
FRAX 10-Year Major Osteoporotic Fracture Probability
The 10-year probability of a major osteoporotic fracture will be calculated using the Turkey-specific Fracture Risk Assessment Tool model, with femoral neck bone mineral density and available clinical risk factors. Major osteoporotic fracture includes clinical vertebral, hip, forearm, or proximal humerus fracture. The probability is reported from 0% to 100%, with higher percentages indicating a greater 10-year risk of major osteoporotic fracture.
Time frame: Baseline
FRAX 10-Year Hip Fracture Probability
The 10-year probability of hip fracture will be calculated using the Turkey-specific Fracture Risk Assessment Tool model, with femoral neck bone mineral density and available clinical risk factors. The probability is reported from 0% to 100%, with higher percentages indicating a greater 10-year risk of hip fracture.
Time frame: Baseline
Plan to share: No
Started Jul 2026 (actual). Primary completion is estimated for Nov 2026, 4 months after the start.
How these figures are worked out, and which studies are left out of them.
This study is active, not recruiting, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
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Mardin Artuklu University