An observational study in Tumor Induced Osteomalcia, Osteomalacia and Familial Tumoral Calcinosis, sponsored by National Institute of Dental and Craniofacial Research (NIDCR). Recruiting at 1 site in United States. Open to participants aged 1 Day to 100 Years. Per ClinicalTrials.gov, last updated 2026-10-26.
Sponsored by National Institute of Dental and Craniofacial Research (NIDCR) · Observational
This study has four objectives: 1) to provide investigators the opportunity to study bone specimens from patients with various skeletal diseases; 2) to treat patients with skeletal diseases at the NIH; 3) to expose NIH trainees to certain skeletal diseases; and 4) to gain more knowledge about skeletal diseases and stimulate further study of bone biology.
Anyone with a disease that affects the skeleton may be eligible for this study.
All evaluations, tests, procedures and treatments given study participants are used in the standard care of skeletal diseases. No experimental evaluations or treatments are offered. Patient evaluations include a medical history, review of medical records and routine physical examination. Based on the findings, other procedures may be recommended, including blood tests, urine tests, and imaging tests, such as X-rays, bone densitometry, bone scan, computed tomography (CT) and magnetic resonance imaging (MRI).
Bone specimens from participants will be collected for research use. Specimens will be obtained from bone removed during a patient s planned surgical procedure performed for medical care, or patients may be requested to have a bone biopsy removal of a small piece of bone tissue as part of the patient evaluation procedure.
Study Description:
To evaluate participants with bone and mineral disorders at the NIH Clinical Center and obtain tissue and clinical specimens from outside institutions
Objectives:
Primary Objective:
Provide a protocol within which participants with common and rare disorders of bone and mineral metabolism can be studied, evaluated and treated at NIH.
Secondary Objectives:
To obtain tissue and clinical specimens (including but not limited to blood, urine, nucleic acids, skin and bone) and data collected at outside institutions and the NIH Clinical Center from participants with various bone and mineral disorders.
Tertiary/Exploratory Objective:
Generate a pool of participants with bone and mineral disorders, from which research questions could arise and future clinical research studies may be generated.
Endpoints:
Primary Endpoint:
Medical evaluation with clinical assessments performed at time points specific to each participant s diagnosis. Analysis of research and participant outcome data will be performed.
Secondary Endpoint:
Genetic and/or biochemical assessments of surgical waste material from the NIH Clinical Center or other medical facilities.
Tertiary/Exploratory Endpoint:
Development of a database containing information from enrolled participants with bone and mineral disorders and annotated specimens and data.
34 studies on the registry are indexed under Osteomalacia; 3 are open to participants now.
This study's planned enrollment of 1,000 is above the median of 65 across 14 observational studies indexed under Osteomalacia.
Browse Osteomalacia studies →National Institute of Dental and Craniofacial Research (NIDCR) is the lead sponsor of 94 studies on the registry; 9 are open to participants now.
Of its 8 completed or terminated interventional studies of FDA-regulated products, 5 (63%) have results posted.
Counted across the registry records on this site, refreshed daily.
Subjects with known or suspected bone disease and disorder of mineral metabolism.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
The study population will include participants with known or suspected bone disease and/or with a known or suspected disorder of mineral metabolism. To be eligible to participate in this study, an individual must meet all of the following criteria:
EXCLUSION CRITERIA:
1. Participants unwilling or unable to abide by the procedures of the protocol.
Subjects with known or suspected bone disease and disorder of mineral metabolism.
Collection of clinical and research specimens
Specimens will be collected for creating better understanding of the disorders seen and for generating future research studies.
Time frame: 10 years
Plan to share: No — As this study enrolls participants with a myriad of disorders and research specimens are not collected in a systematic manner, sharing of IPD is not meaningful.
Started Nov 2001 (actual).
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
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National Institute of Dental and Craniofacial Research (NIDCR) →