An interventional study of Estrogen replacement therapy and General advice in Osteoporosis and Postmenopausal, sponsored by Cairo University. Not yet recruiting at 1 site in Egypt. Open to female participants aged 55 Years to 65 Years. Per ClinicalTrials.gov, last updated 2026-09-08.
Sponsored by Cairo University · Not applicable, Interventional, and Treatment
Among 10 studies in Osteoporosis by Cairo University — 2 open to participants now, 2 under way, none of them phase 3. Osteoporosis · Cairo University.
Among the 10 studies in Osteoporosis by Cairo University, this one is the only one that started in 2026, is one of 7 with no phase, and was the 10th registered.
1,601 studies on the registry are indexed under Osteoporosis; 209 are open to participants now.
This study's planned enrollment of 60 is below the median of 88 across 1,084 interventional studies indexed under Osteoporosis.
Browse Osteoporosis studies →2 of the 10 studies in Osteoporosis by Cairo University are open now, in 1 country. Each count lists the studies.
Of the 132 Osteoporosis studies recruiting now, 76 (58%) set no upper age limit and 20 (15%) stop at 75 or younger; 9 take children under 18; 36 take healthy volunteers.
This study: 55 Years to 65 Years · female · no healthy volunteers.
The full table on the hub →10 studies; the count open now beside each. This study's row is marked.
First in 2015; this study’s year is marked. 1 started in 2026.
Median enrollment 60 across the 7 interventional studies, 70 across the 3 observational. Of the 8 that completed or were terminated, 0 (0%) have results posted.
Cairo University is the lead sponsor of 4,941 studies on the registry; 1,458 are open to participants now.
Of its 37 completed or terminated interventional studies of FDA-regulated products, 5 (14%) have results posted.
1 of the studies in Osteoporosis by Cairo University that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07806968Cairo UniversityEffect of Postural Correction Exercises on Pelvic Floor Dysfunction in Postmenopausal Osteoporotic Women | 2027-03-20 |
Among the 10 studies in Osteoporosis by Cairo University, from their registry updates:
Nothing recorded among them since 2026-09-25.
This study aimed to investigate the effect of postural correction exercises on pelvic floor dysfunction in postmenopausal osteoporotic women
Osteoporosis is a progressive musculoskeletal disease that significantly affects postmenopausal women, leading not only to reduced bone density but also to altered spinal and pelvic alignment, which negatively impacts functional capacity and quality of life. These postural deviations are associated with changes in pelvic biomechanics and increased prevalence of pelvic floor muscle (PFM) dysfunction.
Pelvic floor dysfunction in postmenopausal women is a major health concern, manifesting as urinary incontinence, pelvic discomfort, and reduced core stability. Recent evidence suggests a strong relationship between pelvic tilt, lumbar lordosis, and pelvic floor muscle function, indicating that abnormal posture may compromise pelvic floor support and contribute to dysfunction and symptomatic severity. This highlights the biomechanical interdependence between posture and pelvic floor activity.
Emerging evidence suggests a potential association between osteoporosis and pelvic floor dysfunction (PFD). Studies have demonstrated that reduced bone strength and low bone mineral density are associated with a higher prevalence of pelvic floor symptoms among postmenopausal women.
Pelvic floor muscle training (PFMT) is widely recognized as a first-line conservative treatment for pelvic floor dysfunction (PFD) However, emerging evidence suggests that PFMT alone may not be sufficient to fully address symptoms in all individuals, especially when underlying biomechanical and postural factors are present. Recent studies have highlighted the importance of lumbopelvic alignment and postural control in optimizing pelvic floor muscle function, as alterations in spinal curvature and pelvic tilt can influence muscle activation and intra-abdominal pressure distribution.
Interventions that target postural correction may therefore play a crucial role in optimizing pelvic floor function. A clinical study demonstrated that posture correction therapy, including postural alignment and behavioral modifications, significantly influenced pelvic floor muscle activity as measured by electromyography in women suggesting that addressing postural deviations may enhance pelvic floor rehabilitation outcomes.
Furthermore, postural and stabilization exercises focusing on spinal alignment have been shown to improve pelvic floor muscle strength, core stability, urinary symptoms, and quality of life in women with functional pelvic disorders such as overactive bladder.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Periods have stopped for good: usually no period for 12 months in a row without another medical reason, sometimes confirmed by a blood test (FSH).
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Postmenopausal
Periods have stopped for good: usually no period for 12 months in a row without another medical reason, sometimes confirmed by a blood test (FSH).
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The participants will receive estrogen replacement therapy and general advice for 3 months
Drug: Estrogen replacement therapy · Other: General advice
The participants will receive postural correction exercise program, in addition to estrogen replacement therapy and general advice for 3 months
Drug: Estrogen replacement therapy · Other: General advice · Other: Postural correction exercise program
The participants will receive estrogen replacement therapy for 3 months to enhance postmenopausal symptoms and their quality of life
Postmenopausal women will be instructed to maintain a neutral spinal alignment during sitting, standing, and daily activities, avoid prolonged slouched sitting, and use supportive seating to encourage correct posture. Light to moderate physical activity, such as daily walking, will be encouraged to reduce sedentary behavior and maintain overall physical function. women will also receive guidance on healthy bowel and bladder habits, including avoiding straining during bowel movements and unnecessary frequent urination, as increased intra-abdominal pressure can worsen pelvic floor dysfunction.
The participants will follow a structured postural correction exercise program, 3 times per week for 12 weeks, each session lasting 45-60 minutes.
Pelvic Floor Muscle Assessment
Pelvic floor muscle function will be assessed using surface electromyographic (EMG) to measure muscle activation patterns. For the measurement, women will be placed in a supine position with knees flexed. A vaginal surface probe electrode will be gently inserted to record pelvic floor muscle (PFM) activity, and a reference electrode will be placed on a bony landmark such as the anterior superior iliac spine to reduce electrical noise. Participants will be instructed to contract their pelvic floor muscles as if stopping urine flow, holding each contraction for 5 seconds, followed by 10 seconds of relaxation. Each contraction will be repeated three times, and the highest root mean square RMS amplitude of the three contractions will be used for analysis. EMG signals will be processed to calculate RMS amplitude and normalized to maximum voluntary contraction for inter-individual comparisons
Time frame: 12 weeks
Kyphotic angle
Formetric System will be used to evaluate spinal alignment parameters including thoracic kyphosis before and after treatment The system is a non-invasive, radiation-free optical imaging technology that projects a light grid onto the back surface and captures the reflected pattern using a high-resolution digital camera. Using surface topography, the software reconstructs a three-dimensional model of the back allowing precise calculation of spinal angles. Thoracic kyphosis angle is measured as the angle between tangent lines at the upper and lower thoracic vertebrae.
Time frame: 12 weeks
Lumbar lordotic angle
Formetric System will be used to evaluate spinal alignment parameters including lumbar lordosis before and after treatment The system is a non-invasive, radiation-free optical imaging technology that projects a light grid onto the back surface and captures the reflected pattern using a high-resolution digital camera. Using surface topography, the software reconstructs a three-dimensional model of the back allowing precise calculation of spinal angles. Lumbar lordosis angle as the angle between tangent lines at the upper lumbar and sacral vertebrae.
Time frame: 12 weeks
Menopause-specific quality of life questionnaire
The MENQOL is self-administered and consists of a total of 29 items in a Likert-scale format. Each item assesses the impact of one of four domains of menopausal symptoms, as experienced over the last month: vasomotor (items 1-3), psychosocial (items 4-10), physical (items 11-26), and sexual (items 27-29). Items pertaining to a specific symptom are rated as present or not present, and if present, how bothersome on a zero (not bothersome) to six (extremely bothersome) scale
Time frame: 12 Weeks
Start is estimated for Sep 2026; primary completion for Mar 2027, 6 months later.
Of 219 non-industry interventional studies with no phase under Osteoporosis, half reached primary completion within 22 months of starting (the median), counting those still running; a quarter within 8 and three quarters within 49. This study's planned 6 months is below that.
Counting every sponsor, half of 238 studies reached it within 26 months; a quarter within 9 and three quarters within 50.
How these figures are worked out, and which studies are left out of them.
This study is not yet recruiting, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
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