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Osteonecrosis clinical trials

The registry lists 286 studies for Osteonecrosis across more than 10 countries. 45 are recruiting or about to start. 102 of them are mainly about Osteonecrosis (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-02. Counting its 2 narrower conditions too, such as Femur Head Necrosis: 353 studies, 61 open.

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Status

Completed
112
Terminated
57
Active, not recruiting
38
Status unknown
25
Recruiting
23
Not yet recruiting
12

Phase

Phase 4
29
Phase 2
20
Phase 1
14
Phase 3
10
Early Phase 1
3

Where

United States
105
United Kingdom
33
France
28
Germany
27
Canada
20
Italy
18

Who runs them

Zimmer Biomet (46) · DePuy International (17) · MicroPort Orthopedics Inc. (15) · Medacta International SA (11) · Biomet Orthopedics, LLC (9) · DePuy Orthopaedics (9) · Smith & Nephew, Inc. (7) · Corin (5)

What is being tested here

Drugs under test in Osteonecrosis studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted

DrugOpenPhase 3All
Alendronate102
Oxygen101
Sulfur Hexafluoride101
Zoledronic Acid005
Pentoxifylline012
Tocopherols012
Ferrosoferric Oxide001
Gabapentin001
Celecoxib001
Ketorolac Tromethamine001

Coming up

1phase 3 study under way
16studies finish main data collection within a year

Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.

The 10 nearest

Who these studies take

Of the 23 Osteonecrosis studies recruiting now, 14 (61%) set no upper age limit and 4 (17%) stop at 75 or younger. 2 (9%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 2 (9%) take healthy volunteers.

Recruiting studies that take each age, of 23
AgeWomenMen
101 (4%)1 (4%)
1819 (83%)19 (83%)
3022 (96%)22 (96%)
4022 (96%)22 (96%)
5022 (96%)22 (96%)
6520 (87%)20 (87%)
7520 (87%)20 (87%)
8517 (74%)17 (74%)

Across all 286 studies, recruiting or not: 30% stop at 75 or younger and 13% at 65; 16% take children; 1% are for women only and <1% for men only; 8% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.

How long Osteonecrosis studies take

Of 59 observational studies under Osteonecrosis, half reached primary completion within 141 months of starting, counting those still running.

Start to primary completionEvery sponsorIndustryNon-industry
Interventional, no phase52 mo29–91 · 45 studies——
Observational141 mo93–184 · 59 studies——

Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out

What changed recently

From the registry's own updates since Oct 12, 2026.

Results posted1

Studies

Recruiting first, then most recently updated. Showing 50 of 286. Browse all 286 → or search them.