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Enrolling by invitationNCT05329558SULVOUpdated Apr 5, 2024

Local and Systemic Changes in Osteonecrosis of the Jawbone

An observational study in Osteonecrosis of the Jaw, sponsored by Medical University of Graz. Enrolling by invitation at 1 site in Austria. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-04-05.

Sponsored by Medical University of Graz · Observational

From the registry’s dates

  • Primary completion was expected by Jan 2026, 10 months ago, but the record still lists the study as enrolling by invitation.
Study type
Observational
Model
Case-control
Time perspective
Prospective
Enrollment
100
Ages
18 Years and older
Sex
All
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Study summary

Osteonecrosis of the Jawbone (ONJ) is a serious complication of antiresorptive therapies (ARTs), for example with bisphosphonates or Denosumab. Especially long term treatment with intravenous antiresorptive agents causing lesions and, less frequent, also oral administration. This study aims at elucidating local and systemic changes in patients with ONJ.

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Conditions studied

  • Osteonecrosis of the Jaw

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03

In context

Osteonecrosis

286 studies on the registry are indexed under Osteonecrosis; 45 are open to participants now.

This study's planned enrollment of 100 is below the median of 121 across 127 observational studies indexed under Osteonecrosis.

Browse Osteonecrosis studies →

Lead sponsor

Medical University of Graz is the lead sponsor of 471 studies on the registry; 98 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

Patients at the Department of Oral Surgery and Radiology, University Clinic for Oral and Maxillofacial Medicine, Graz, Austria

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • 18 years or older
  • with/without ART
  • with/without MRONJ

Exclusion criteria

Exclusion Criteria:

  • smoker (>10 cigarettes/day)
  • pregnancy
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Study design

Observational model
Case-control
Time perspective
Prospective
Enrollment
100 participants (estimated)
Patient registry
No
Biospecimen retention
Samples with dna

Groups and cohorts

  • Healthy Controls
  • Patients with ART without MRONJ
  • Patients with oral ART with MRONJ
  • Patients with intravenous ART with MRONJ
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What researchers measure

Primary outcomes

  1. target gene expression

    differences in gene expression recorded by qPCR will be assessed

    Time frame: through study completion, an average of 1 year

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Study locations

1 site
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Apr 5, 2024, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT05329558
Responsible party
Foessl, Ines, MSc (Investigator, Medical University of Graz) — Principal investigator
First posted
Apr 15, 2022
Start date
Mar 1, 2018
Primary completion
Jan 1, 2026 (estimated)
Completion
Dec 1, 2026 (estimated)
Last update
Apr 5, 2024

Study contacts

Stephan Acham
principal investigator · Medical University of Graz

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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No contact was published for this record. The registry link below has the sponsor’s details.

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