Bone Diseases clinical trials
The registry lists 177 studies for Bone Diseases across more than 10 countries. 38 are recruiting or about to start. 40 of them are mainly about Bone Diseases (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-06. Counting its 68 narrower conditions too, such as Osteoporosis: 8,512 studies, 1,676 open.
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Status
Who runs them
Alexion Pharmaceuticals, Inc. (12) · BioMarin Pharmaceutical (10) · QED Therapeutics, a BridgeBio company (8) · Amgen (6) · Northwestern University (4) · National Institute of Dental and Craniofacial Research (NIDCR) (4) · National Heart, Lung, and Blood Institute (NHLBI) (4) · Hospices Civils de Lyon (3)
What is being tested here
Drugs under test in Bone Diseases studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Infigratinib | 3 | 2 | 5 |
| Colchicine | 1 | 0 | 1 |
| Testosterone 17 beta-cypionate | 1 | 1 | 1 |
| Testosterone | 1 | 1 | 1 |
| Finasteride | 1 | 1 | 1 |
| Apixaban | 1 | 0 | 1 |
| Narlumosbart | 1 | 1 | 1 |
| Transdermal Estrogen | 1 | 0 | 1 |
| Progesterone | 1 | 0 | 1 |
| Apple cider vinegar | 1 | 0 | 1 |
Drug classes tested here Tyrosine kinase inhibitors (TKIs) 3 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 10, phase 3 first
- Jan 2027An Interventional Study of Infigratinib in Children With Hypochondroplasia · Phase 3 · QED Therapeutics, a BridgeBio company
- Nov 2026Musculoskeletal Cancers Remote Monitoring and Care · Case Comprehensive Cancer Center
- Dec 2026Clinical Validation of BoneMRI in the Spine · MRIguidance B.V.
- Dec 2026A Natural History Study in Children With a Type II Collagen Disorder With Short Stature · Innoskel
- Jan 2027European Transplant Registry of Senior Renal Transplant Recipients on Advagraf · Klemens Budde
- Jan 2027Estrogen Supplementation and Bone Health in Women With CF · Johns Hopkins University
- Mar 2027A Study of Vosoritide in Children With Noonan Syndrome With Inadequate Growth During or After Human Growth Hormone Treatment · BioMarin Pharmaceutical
- Apr 2027BASUN - Risks for Malnutrition, Metabolic Bone Disease and Impaired Oral Health After Obesity Treatment · Göteborg University
- Sep 2027mFFE MRI Versus CT for Cortical Bone Evaluation in Knee Osteoarthritis · Assiut University
- Nov 2027Extended Prophylactic Anticoagulation Following Spinal Surgery for Metastatic Disease · James Bayley
Who these studies take
Of the 26 Bone Diseases studies recruiting now, 10 (38%) set no upper age limit and 9 (35%) stop at 75 or younger. 12 (46%) take children under 18. 1 (4%) are for women only and 1 (4%) for men only; 2 (8%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 9 (35%) | 8 (31%) |
| 18 | 18 (69%) | 18 (69%) |
| 30 | 19 (73%) | 19 (73%) |
| 40 | 19 (73%) | 19 (73%) |
| 50 | 19 (73%) | 19 (73%) |
| 65 | 19 (73%) | 19 (73%) |
| 75 | 16 (62%) | 16 (62%) |
| 85 | 15 (58%) | 15 (58%) |
Across all 177 studies, recruiting or not: 38% stop at 75 or younger and 32% at 65; 37% take children; 12% are for women only and 6% for men only; 16% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Bone Diseases studies take
Of 19 phase 2 interventional studies under Bone Diseases, half reached primary completion within 43 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 2 | 43 mo29–66 · 19 studies | — | — |
| Interventional, no phase | 22 mo10–54 · 25 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
Studies
Recruiting first, then most recently updated. Showing 50 of 177. Browse all 177 → or search them.
- A First-in-human Study of KK8123 in Adults With X-linked HypophosphatemiaRecruitingNCT06525636Phase 1/25 countries
- A Study of MACI in Patients Aged 17 to 65 Years With Symptomatic Chondral or Osteochondral Defects of the AnkleRecruitingNCT06915233Phase 31 country
- REducing Systemic Inflammation With LOw-dose Colchicine to ImproVE Cardiovascular Calcification in Chronic Kidney Disease: A Pilot Randomized Open-Label TrialNot yet recruitingNCT07654231Phase 21 country
- Extension Study of Infigratinib in Children With Achondroplasia (ACH)Enrolling by invitationNCT05145010Phase 210 countries
- A Natural History Study of Bone and Mineral DisordersRecruitingNCT000248041 country
- Study to Evaluate the Efficacy and Safety of BMN 333 Versus Vosoritide in Children With AchondroplasiaRecruitingNCT07441876Phase 2/39 countries
- Clinical Validation of BoneMRI in the SpineRecruitingNCT067457914 countries
- mFFE MRI Versus CT for Cortical Bone Evaluation in Knee OsteoarthritisNot yet recruitingNCT07827443
- Autologous Bone Marrow Aspirate Treatment for Early-Stage OsteonecrosisRecruitingNCT06123481Not applicable1 country
- Open-Label, Long-Term, Extension Study of Infigratinib in Children With HypochondroplasiaEnrolling by invitationNCT07393373Phase 210 countries
- OSTEOMICS: Identifying Regulators of Bone HomeostasisRecruitingNCT057328701 country
- Musculoskeletal Cancers Remote Monitoring and CareRecruitingNCT07129226Not applicable1 country
- Testosterone Therapy With or Without Finasteride After Spinal Cord Injury: TRT-SCI TrialNot yet recruitingNCT07742553Phase 2/31 country
- Extended Prophylactic Anticoagulation Following Spinal Surgery for Metastatic DiseaseNot yet recruitingNCT07713875Phase 41 country
- An Interventional Study of Infigratinib in Children With HypochondroplasiaEnrolling by invitationNCT06873035Phase 2/310 countries
- Prospective Clinical Assessment Study in Children With HypochondroplasiaRecruitingNCT0641097610 countries
- Interventional Study of Infigratinib in Children < 3 Years Old With Achondroplasia (ACH)RecruitingNCT07169279Phase 27 countries
- Proximal FEmur Reconstruction or Internal Fixation fOR Metastases (PERFORM) TrialRecruitingNCT06863129Not applicable4 countries
- Clinico-biological Collection of Bone, Calcium and Growth Plate PathologiesRecruitingNCT064445031 country
- Evaluation of the Effectiveness of Odontogenic Grafts Obtained From Human Teeth on Bone FormationEnrolling by invitationNCT075737611 country
- Prospective Evaluation of Interventional Studies on Bone Metastases - the PRESENT CohortRecruitingNCT023564971 country
- Prospective Observational Cohort Study of Cardiac Structure and Function in Children and Adults With Osteogenesis ImperfectaRecruitingNCT072872411 country
- Estrogen Supplementation and Bone Health in Women With CFRecruitingNCT05704036Phase 41 country
- Akkermansia Muciniphilia and Metabolic Side Effects of ADTRecruitingNCT05802121Early Phase 11 country
- Characterization of Familial Myopathy and Paget Disease of BoneRecruitingNCT011668541 country
- Multicenter Prospective Cohort Study on Current Treatments of Legg-Calvé-Perthes DiseaseEnrolling by invitationNCT0204071415 countries
- BASUN - Risks for Malnutrition, Metabolic Bone Disease and Impaired Oral Health After Obesity TreatmentRecruitingNCT031526171 country
- Digital Diagnostics and Intervention Services for Parkinson's DiseaseNot yet recruitingNCT06534177
- Sarcopenia, Fall and Osteoporosis in Chronic Kidney DiseaseRecruitingNCT045153421 country
- Interest of the SPECT-CT Scan SUVspect in the New Generation of Gamma-cameras With SemiconductorRecruitingNCT034140211 country
- Narlumosbart Compared With Denosumab in Patients With Multiple Myeloma Bone DiseaseNot yet recruitingNCT06314698Phase 3
- Biomarkers Related to Bone in Pediatric Gaucher DiseaseRecruitingNCT061160711 country
- Deep Phenotyping of Bone Disease in Type 2 Diabetes and Relations to Diabetic NeuropathyRecruitingNCT056421431 country
- 18F-sodium Fluoride (NaF) PET to Replace Bone Scintigraphy: Safety and Efficacy AssessmentRecruitingNCT04842071Phase 31 country
- A Natural History Study in Children With a Type II Collagen Disorder With Short StatureRecruitingNCT054087152 countries
- Evaluation of Osteopathic Care After Rupture of the Antero-external Cruciate Ligament of the Knee (DIDT OSTEO)RecruitingNCT05875766Not applicable1 country
- Monocytes as Predictors of Cystic Fibrosis-related Bone DiseaseRecruitingNCT048772231 country
- European Transplant Registry of Senior Renal Transplant Recipients on AdvagrafNot yet recruitingNCT02558452
- Stereophotogrammetry of the Torso in Healthy Individuals and Patients With Scoliosis, Chest Wall Deformations, or ObesityCompletedNCT013529491 country
- A Study of Vosoritide in Children With Noonan Syndrome With Inadequate Growth During or After Human Growth Hormone TreatmentActive, not recruitingNCT06668805Phase 27 countries
- Image Quality: Ultra-Low Dose Scanner Versus Standard Dose Conventional Scanner for Thoraco-abdominopelvic ScansCompletedNCT05840003Not applicable1 country
- Calcitriol Monotherapy for X-Linked HypophosphatemiaCompletedNCT03748966Early Phase 11 country
- Fully Constrained Acetabular Liner vs. Dual Mobility Hip Joint in the Surgical Treatment of Metastatic Bone Disease of the HipActive, not recruitingNCT05461313Not applicable1 country
- Prospective Clinical Assessment Study in Children With Achondroplasia (ACH)CompletedNCT0403581111 countries
- Assessment of Femoral Failure Load and Fracture Risk in Rare Bone Disorders Using MEKANOS Tool. Case Study of Fibrous Dysplasia of Bone/McCune Albright SyndromeActive, not recruitingNCT075079421 country
- Using Radiation-free Ultrasound for Screening Scoliosis Among Female School Children in Hong Kong to Reduce Unnecessary X-ray ExposureCompletedNCT06828068Not applicable1 country
- Thumb Ossification Composite Index (TOCI) to Predict Skeletal Maturity and Curve Progression in AISCompletedNCT039049141 country
- A Study to Evaluate the Efficacy and Safety of Infigratinib in Children and Adolescents With AchondroplasiaCompletedNCT06164951Phase 310 countries
- A Study to Evaluate Long-Term Safety, Tolerability, & Efficacy of BMN 111 in Children With Achondroplasia (ACH)Active, not recruitingNCT02724228Phase 24 countries
- An Extension Study to Evaluate Safety and Efficacy of BMN 111 in Children With AchondroplasiaActive, not recruitingNCT03989947Phase 24 countries