Orthostatic Intolerance clinical trials
The registry lists 64 studies for Orthostatic Intolerance across more than 10 countries. 12 are recruiting or about to start. 9 of them are mainly about Orthostatic Intolerance (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10. Counting its 4 narrower conditions too, such as Hypotension, Orthostatic: 406 studies, 108 open.
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Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Who runs them
Vanderbilt University (9) · Vanderbilt University Medical Center (8) · New York Medical College (5) · Hvidovre University Hospital (3) · Rigshospitalet, Denmark (2) · Satish R. Raj (2) · Lund University (2) · Copenhagen University Hospital, Hvidovre (2)
What is being tested here
Drugs under test in Orthostatic Intolerance studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Pyridostigmine | 1 | 0 | 2 |
| Guanfacine | 1 | 0 | 1 |
| Cromolyn | 1 | 0 | 1 |
| Naltrexone | 1 | 0 | 1 |
| Propranolol | 0 | 0 | 4 |
| Phenylephrine | 0 | 0 | 3 |
| Isoproterenol | 0 | 0 | 2 |
| Droxidopa | 0 | 1 | 2 |
| Saline Solution | 0 | 0 | 1 |
| Sodium Chloride | 0 | 0 | 1 |
Drug classes tested here Cholinesterase inhibitors 1 open · Beta blockers 5
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 9
- Nov 2026Breathing Device in Postural Orthostatic Tachycardia Syndrome (POTS) · Alfredo Gamboa
- Dec 2026Modafinil and Cognitive Function in POTS · Vanderbilt University Medical Center
- Dec 2026Aldosterone & Sodium Regulation in Postural Tachycardia Syndrome - Screening · Vanderbilt University
- Jan 2027Association Between Sarcopenia, Fatigue and Orthostatic Intolerance in Geriatric Patients: A Case Control Study · Ain Shams University
- Feb 2027Autoimmune Basis for Postural Tachycardia Syndrome · Vanderbilt University Medical Center
- May 2027Postural Sway and Counterpressure Maneuvers for Pediatric Syncope · Simon Fraser University
- Jun 2027Continuous and Non-invasive Measurements by Task Force® CORE/CARDIO in Autonomic Function Testing (AFT) · CNSystems Medizintechnik GmbH
- Sep 2027LIFT: Life Improvement Trial · Brigham and Women's Hospital
- Sep 2027Paediatric Syncope in the Emergency Department · Dr. Victoria Claydon
Who these studies take
Of the 9 Orthostatic Intolerance studies recruiting now, 3 (33%) set no upper age limit and 5 (56%) stop at 75 or younger. 2 (22%) take children under 18. 1 (11%) are for women only and 0 (0%) for men only; 1 (11%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 2 (22%) | 2 (22%) |
| 18 | 8 (89%) | 8 (89%) |
| 30 | 7 (78%) | 6 (67%) |
| 40 | 6 (67%) | 6 (67%) |
| 50 | 6 (67%) | 6 (67%) |
| 65 | 5 (56%) | 5 (56%) |
| 75 | 4 (44%) | 4 (44%) |
| 85 | 4 (44%) | 4 (44%) |
Across all 64 studies, recruiting or not: 59% stop at 75 or younger and 55% at 65; 20% take children; 9% are for women only and 0% for men only; 39% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
What changed recently
From the registry's own updates since Oct 13, 2026.
Newly registered1
- Adverse Events During Physical Therapy in Neurocritical ICU PatientsOct 28, 2026NCT07901140
Studies
Recruiting first, then most recently updated. Showing 50 of 64. Browse all 64 → or search them.
- LIFT: Life Improvement TrialRecruitingNCT06366724Phase 21 country
- Guanfacine and Cromolyn Sodium for POTS: The DBPOTS TrialNot yet recruitingNCT07757555Early Phase 11 country
- The Effect of Physical Activity on Postural Orthostatic Tachycardia SyndromeRecruitingNCT05554107Not applicable1 country
- Effects of Breathing Retraining Exercises in Pregnant Females With Postural Orthostatic Tachycardia Syndrome.RecruitingNCT07579026Not applicable1 country
- Hypercapnia and Orthostatic Tolerance in Postural Orthostatic Tachycardia SyndromeRecruitingNCT04271878Not applicable1 country
- Association Between Sarcopenia, Fatigue and Orthostatic Intolerance in Geriatric Patients: A Case Control StudyNot yet recruitingNCT075648301 country
- Effects of Age, Sex and Isometric Exercise on Ventricular-Vascular Interactions During Cardiac UnloadingRecruitingNCT06939153Not applicable1 country
- Paediatric Syncope in the Emergency DepartmentRecruitingNCT05555771Not applicable1 country
- Postural Sway and Counterpressure Maneuvers for Pediatric SyncopeRecruitingNCT05633693Not applicable1 country
- Continuous and Non-invasive Measurements by Task Force® CORE/CARDIO in Autonomic Function Testing (AFT)Not yet recruitingNCT05977335
- The STAND-UP StudyRecruitingNCT07195903Not applicable1 country
- Autonomic Dysfunction in Patients Following Bariatric Surgery: The ADiPOSE StudyRecruitingNCT062894131 country
- Autoimmune Basis for Postural Tachycardia SyndromeActive, not recruitingNCT02725060Not applicable1 country
- Adverse Events During Physical Therapy in Neurocritical ICU PatientsActive, not recruitingNCT079011401 country
- Acute Salt Handling in Orthostatic IntoleranceActive, not recruitingNCT00581633Not applicable1 country
- Assessment of Antibodies and Inflammatory Markers in Postural Tachycardia SyndromeActive, not recruitingNCT021963761 country
- Intravenous (IV) Saline and Exercise in Postural Tachycardia Syndrome (POTS)Active, not recruitingNCT01000350Not applicable1 country
- Sleep Actigraphy in Postural Tachycardia Syndrome (POTS)Active, not recruitingNCT006924711 country
- Pathophysiology of Orthostatic IntoleranceActive, not recruitingNCT00608725Not applicable1 country
- Long COVID Immune ProfilingActive, not recruitingNCT060272551 country
- Study of Natriuretic Peptide Receptor 1 (NPR1) Antagonist in Adult Patients With Postural Orthostatic Tachycardia Syndrome (POTS)CompletedNCT06593600Phase 22 countries
- Modafinil and Cognitive Function in POTSActive, not recruitingNCT01988883Early Phase 11 country
- Aldosterone & Sodium Regulation in Postural Tachycardia Syndrome - ScreeningActive, not recruitingNCT01783288Not applicable1 country
- Breathing Device in Postural Orthostatic Tachycardia Syndrome (POTS)Active, not recruitingNCT00962728Not applicable1 country
- The Renin-Aldosterone Axis in Postural Tachycardia SyndromeCompletedNCT00962949Phase 11 country
- Northera Improves Postural Tachycardia Syndrome (POTS) and Postural Vasovagal Syncope (VVS)TerminatedNCT02558972Phase 21 country
- Mechanisms of Vasovagal SyncopeCompletedNCT01791816Early Phase 11 country
- Effect of Stellate Ganglion Block on ME/CFSCompletedNCT05664711Phase 11 country
- Orthostatic Intolerance After Bariatric SurgeryTerminatedNCT03808740Phase 11 country
- The Effects of Medication Induced Blood Pressure Reduction on Cerebral Hemodynamics in Hypertensive Frail ElderlyCompletedNCT055291471 country
- Cardiovascular Effects of Exercise in Patients With Parkinson's DiseaseActive, not recruitingNCT03343574Not applicable1 country
- POTS-CFS Study: Orthostatic Intolerance in the Context of Pediatric ME/CFSCompletedNCT060549581 country
- Influence of RIC on the Orthostatic Competence of the MicrocirculationActive, not recruitingNCT05990907Not applicable1 country
- Vitamin D Deficiency and DysautonomiaCompletedNCT03032328Not applicable1 country
- Cardiovagal Baroreflex Deficits Impair Neurovascular Coupling and Cognition in POTSCompletedNCT03261570Early Phase 11 country
- Postoperative Orthostatic Intolerance and Hypotension in Unilateral TKACompletedNCT037431161 country
- Melatonin and Zinc Administration on Cardinal Symptoms in Myalgic Encephalomyelitis/Chronic Fatigue SyndromeStatus unknownNCT05454683Not applicable1 country
- Long-term Effects of Transcutaneous Vagal Nerve Stimulation on Postural Orthostatic Tachycardia Syndrome (POTS)Status unknownNCT04632134Not applicable1 country
- Technology Assisted Solutions for the Recognition of Objective Physiological Indicators of Post-Coronavirus-19 FatigueCompletedNCT050277241 country
- Treatment of Orthostatic HypotensionTerminatedNCT00581477Phase 2/31 country
- Dietary Salt in Postural Tachycardia SyndromeCompletedNCT01547117Not applicable1 country
- Dietary Sodium's Effect on Urinary Sodium and Dopamine Excretion in Patients With Postural Tachycardia SyndromeCompletedNCT01563107Not applicable1 country
- Peripheral Dopamine in Postural Tachycardia SyndromeCompletedNCT00685919Phase 2/31 country
- Physical Activity as a Complementary Treatment in POTSWithdrawnNCT04702217Not applicable1 country
- Orthostatic Intolerance and Hypotension After Administration of Morphine in Patients Prior to Hip or Knee ArthroplastyStatus unknownNCT049022221 country
- Local Vasoconstriction in Postural Tachycardia SyndromeCompletedNCT01210430Early Phase 11 country
- Reducing Orthostatic Intolerance With Oral Rehydration in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome PatientsStatus unknownNCT02854683Phase 11 country
- The Pathophysiology of Orthostatic HypotensionCompletedNCT00748059Phase 11 country
- Lower Body Muscle Pre-activation in Initial Orthostatic HypotensionStatus unknownNCT03970551Not applicable1 country
- Pathophysiologic Hemodynamics After Primary Unilateral Total Hip Arthroplasty in Patients Receiving ACEIs and ARBsStatus unknownNCT048420581 country