An observational study in Critical Illness, Brain Injury and Stroke, sponsored by Hospital H+ Queretaro. Active, not recruiting at 2 sites in Mexico. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-10-28.
Sponsored by Hospital H+ Queretaro · Observational
The goal of this observational study is to identify the clinical, neurological, hemodynamic, and respiratory variables associated with the occurrence of adverse events during physical therapy interventions in adult neurocritical patients admitted to the Intensive Care Unit (ICU).
The main questions it aims to answer are:
What clinical, neurological, hemodynamic, and respiratory factors are associated with adverse events during physical therapy in neurocritical patients? What is the incidence and type of adverse events that occur most frequently during physical therapy in this patient population? Researchers will compare clinical and physiological data between patients who experienced adverse events during physical therapy and those who did not, to determine risk factors associated with these complications. Participants' data will be retrospectively collected from medical records without performing new clinical interventions.
2,127 studies on the registry are indexed under Brain Injuries; 386 are open to participants now.
This study's planned enrollment of 47 is below the median of 100 across 692 observational studies indexed under Brain Injuries.
Browse Brain Injuries studies →Hospital H+ Queretaro is the lead sponsor of 13 studies on the registry; 6 are open to participants now.
Compared within Brain Injuries, this study's primary condition as ClinicalTrials.gg classifies it; the registry's first condition term is Critical Illness. The counts are of registry records indexed under each term, refreshed daily. How we classify →
Medical records of adult neurocritical patients admitted to the Intensive Care Unit (ICU) at a tertiary hospital in Querétaro, Mexico, who received physical therapy interventions between October 2023 and April 2026.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Adult neurocritical ICU patients who presented at least one adverse event (e.g., hypotension, hypertension, tachycardia, bradycardia, oxygen desaturation, increased ICP, decreased CPP, acute neurological deterioration) during the physical therapy intervention.
Other: Physical Therapy Intervention
Adult neurocritical ICU patients who underwent physical therapy intervention without experiencing any adverse events during the session.
Other: Physical Therapy Intervention
Physical therapy and mobilization procedures administered to neurocritical patients during their ICU stay as recorded in medical, nursing, and physical therapy notes. Retrospective data collection evaluates baseline clinical-pathological risk profile and monitoring parameters (hemodynamics, neurological, respiratory).
Incidence of Adverse Events During Physical Therapy
Presence or absence of any adverse event (binary variable: Yes/No) occurring during or immediately following a physical therapy session in adult neurocritical ICU patients. Adverse events include: hypotension (drop in SBP \> 20 mmHg), hypertension, tachycardia, bradycardia, oxygen desaturation, acute neurological deterioration, increase in intracranial pressure (ICP), or decrease in cerebral perfusion pressure (CPP) requiring therapy session suspension.
Time frame: During the physical therapy session (from initiation up to immediate post-session evaluation, up to 1 hour per session).
Clinical and Physiological Predictors of Adverse Events
Association between baseline clinical-pathological variables and the occurrence of adverse events during physical therapy. Evaluated parameters include: Glasgow Coma Scale (GCS), Mean Arterial Pressure (MAP), Richmond Agitation-Sedation Scale (RASS), vasopressor dependence, SpO2/FiO2 ratio (SAFI), external ventricular drain presence, and decompressive procedure history.
Time frame: Baseline assessment immediately prior to each physical therapy session.
Frequency and Specific Types of Adverse Events
Distribution and frequency of specific types of adverse events recorded during therapy sessions, categorized into hemodynamic (hypotension, hypertension, tachycardia, bradycardia), respiratory (oxygen desaturation), and neurological (acute deterioration, ICP increase, CPP decrease).
Time frame: During each physical therapy session throughout the ICU stay (retrospectively evaluated from October 2023 to April 2026).
Comparative Analysis of Hemodynamic versus Respiratory Variables
Statistical comparison using Student's t-test to evaluate whether hemodynamic variables show significantly higher association with adverse events compared to respiratory variables.
Time frame: Retrospective evaluation spanning the total ICU stay for each patient record (October 2023 to April 2026).
Started Sep 2026 (actual). Primary completion is estimated for Oct 2026, 1 month after the start.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is active, not recruiting, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
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Hospital H+ Queretaro