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Active, not recruitingNCT00692471Updated Oct 8, 2025

Sleep Actigraphy in Postural Tachycardia Syndrome (POTS)

An observational study in Postural Tachycardia Syndrome, Orthostatic Intolerance and Sleep Disorders, sponsored by Satish R. Raj. Active, not recruiting at 1 site in United States. Open to participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-10-08.

Sponsored by Satish R. Raj · Observational

Study type
Observational
Model
Case-control
Time perspective
Prospective
Enrollment
100
Ages
18 Years to 65 Years
Sex
All
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Study summary

We propose to use actigraphy (measured by activity watches) as a tool to quantify sleep disturbances in patients with orthostatic intolerance compared with healthy control subjects. In this pilot study, we will test the null hypothesis (Ho) that there are no differences in the sleep quality between patients with orthostatic intolerance and healthy control subjects.

Read the detailed description

We propose to use actigraphy (measured by activity watches) as a tool to quantify sleep disturbances in patients with orthostatic intolerance compared with healthy control subjects. In this pilot study, we will test the null hypothesis (Ho) that there are no differences in the sleep quality between patients with orthostatic intolerance and healthy control subjects.

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Conditions studied

  • Postural Tachycardia Syndrome
  • Orthostatic Intolerance
  • Sleep Disorders

Keywords

  • Sleep
  • Orthostatic tachycardia
  • POTS
03

In context

Postural Orthostatic Tachycardia Syndrome

131 studies on the registry are indexed under Postural Orthostatic Tachycardia Syndrome; 44 are open to participants now.

This study's planned enrollment of 100 is close to the median of 100 across 31 observational studies indexed under Postural Orthostatic Tachycardia Syndrome.

Browse Postural Orthostatic Tachycardia Syndrome studies →

Lead sponsor

Satish R. Raj is the lead sponsor of 7 studies on the registry; none are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years to 65 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

Patients diagnosed with the Postural Tachycardia Syndrome. The criteria include:

  • an increase in heart rate on standing (from supine) of >30 bpm
  • in the setting of symptoms of cerebral hypoperfusion that are worse with standing and better when recumbent
  • the symptoms are daily or almost daily
  • the symptoms are chronic (lasting greater than 6 motnsh)

Inclusion criteria

  • Diagnosed with orthostatic intolerance by the Vanderbilt Autonomic Dysfunction Center
  • Control subjects will be free of orthostatic intolerance and other major medical problems, free of medications during the study
  • Age between 18-65 years
  • Male and female subjects are eligible.
  • Able and willing to provide informed consent

Exclusion criteria

Exclusion Criteria:

  • Overt cause for postural tachycardia (such as acute dehydration)
  • Self-report of pregnancy
  • Inability to give, or withdrawal of, informed consent
  • Other factors which in the investigator's opinion would prevent the subject from completing the protocol
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Study design

Observational model
Case-control
Time perspective
Prospective
Enrollment
100 participants (estimated)

Groups and cohorts

  • 1

    Patients meeting the diagnostic criteria for the Postural Tachycardia Syndrome, a form of Orthostatic Intolerance

    Device: Actigraphy Watch (motion sensors) with light sensors - ActiWatch from Minimitter

  • 2

    Healthy control subjects who do not meet the criteria for the Postural Tachycardia Syndrome

    Device: Actigraphy Watch (motion sensors) with light sensors - ActiWatch from Minimitter

Interventions

  • DeviceActigraphy Watch (motion sensors) with light sensors - ActiWatch from Minimitter

    Watch to be worn on wrist for 7 days (except in water) that will measure activity/movement.

    Also known as: ActiWatch from Minimitter

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What researchers measure

Primary outcomes

  1. Sleep Latency

    Time frame: 1 week

Secondary outcomes

  1. Sleep Efficiency

    Time frame: 1 week

  2. Wake After Sleep Onset

    Time frame: 1 week

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Study locations

1 site
  • Vanderbilt University
    Nashville, Tennessee 37232-2195, United States
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References and documents

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Oct 8, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT00692471
Lead sponsor
Satish R. Raj
Collaborators
National Center for Research Resources (NCRR)
Responsible party
Satish R. Raj (Assistant Professor of Medicine & Pharmacology, Vanderbilt University Medical Center) — Sponsor-investigator
First posted
Jun 6, 2008
Start date
Jun 2008
Primary completion
Dec 2029 (estimated)
Completion
Dec 2029 (estimated)
Last update
Oct 8, 2025

Study contacts

Satish R Raj, MD MSCI
principal investigator · Vanderbilt University Medical Center

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is active, not recruiting, as verified in Oct 2025. You cannot join it, but the record below documents what was studied.

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