Hypotension, Orthostatic clinical trials
The registry lists 159 studies for Hypotension, Orthostatic across more than 10 countries. 35 are recruiting or about to start. 91 of them are mainly about Hypotension, Orthostatic (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-23.
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Status
Who runs them
Vanderbilt University Medical Center (10) · James J. Peters Veterans Affairs Medical Center (8) · Chelsea Therapeutics (6) · Shire (5) · VA Office of Research and Development (5) · Vanderbilt University (5) · University of British Columbia (5) · Kessler Foundation (4)
What is being tested here
Drugs under test in Hypotension, Orthostatic studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Droxidopa | 2 | 7 | 14 |
| Midodrine | 0 | 2 | 14 |
| Yohimbine | 0 | 0 | 4 |
| Pyridostigmine | 0 | 0 | 3 |
| Ampreloxetine | 0 | 2 | 3 |
| Atomoxetine | 0 | 0 | 2 |
| Trimethaphan | 0 | 0 | 1 |
| Enalaprilat | 0 | 0 | 1 |
| Phenylephrine | 0 | 0 | 1 |
| Isoproterenol | 0 | 0 | 1 |
Drug classes tested here Cholinesterase inhibitors 4
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest
- Nov 2026Cardiovascular Function and Response to Stimulation Within the First Year After Spinal Cord Injury · Kessler Foundation
- Nov 2026Overnight Trials With Heat Stress in Autonomic Failure Patients With Supine Hypertension · Vanderbilt University Medical Center
- Dec 2026Reduction in Splanchnic Capacitance Contributes to Sympathetically Dependent Hypertension in Autonomic · Vanderbilt University
- Dec 2026Speed of Robotic Leg Movements and Orthostatic Hypotension in Subacute SCI · Methodist Rehabilitation Center
- Dec 2026Autonomic Regulation of Blood Pressure and Heart Rate During Orthostasis and Exercise in Healthy and Hypertensive Individuals · University Medical Centre Ljubljana
- Dec 2026The Value of Near-infrared Spectroscopy and Blood Pressure Measurements in Estimating Future Fall Risk in Older Adults · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
- Dec 2026Blood Pressure Effects on Cognition and Brain Blood Flow in PD · University of California, San Diego
- Dec 2026Cardiovascular Autonomic Function After Resistance Training · Pusan National University Yangsan Hospital
- Mar 2027CPAP for the Treatment of Supine Hypertension · Vanderbilt University Medical Center
- Apr 2027The Effect of Water Carbonation on Orthostatic Tolerance · Simon Fraser University
Who these studies take
Of the 23 Hypotension, Orthostatic studies recruiting now, 8 (35%) set no upper age limit and 8 (35%) stop at 75 or younger. 1 (4%) take children under 18. 1 (4%) are for women only and 0 (0%) for men only; 4 (17%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 1 (4%) | 1 (4%) |
| 18 | 12 (52%) | 12 (52%) |
| 30 | 16 (70%) | 15 (65%) |
| 40 | 18 (78%) | 18 (78%) |
| 50 | 20 (87%) | 20 (87%) |
| 65 | 19 (83%) | 19 (83%) |
| 75 | 18 (78%) | 18 (78%) |
| 85 | 12 (52%) | 12 (52%) |
Across all 159 studies, recruiting or not: 23% stop at 75 or younger and 14% at 65; 5% take children; 2% are for women only and 2% for men only; 18% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Hypotension, Orthostatic studies take
Of 34 interventional studies with no phase under Hypotension, Orthostatic, half reached primary completion within 54 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 54 mo32–70 · 34 studies | — | — |
| Observational | 39 mo7–56 · 21 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Stopped1
- Effects of Midodrine and Droxidopa on Splanchnic Capacitance in Autonomic FailureTerminatedOct 23, 2026NCT02897063
Studies
Recruiting first, then most recently updated. Showing 50 of 159. Browse all 159 → or search them.
- Spinal Cord Stimulation for Neurogenic Orthostatic HypotensionNot yet recruitingNCT07879391Not applicable
- Fainting Detection And Early Warning In Syncope Evaluation Study (ARISE)RecruitingNCT075025991 country
- NORTHERA (DROXIDOPA) for Dysautonomia in Pediatric Survivors of Menkes DiseaseRecruitingNCT07398508Phase 1/21 country
- Ceasing Alpha-blockers Early After Resection of the Prostate (The CLEAR Trial)Not yet recruitingNCT07846579Phase 4
- Cardiovascular Autonomic Function After Resistance TrainingNot yet recruitingNCT07725952Not applicable1 country
- Blood Pressure Effects on Cognition and Brain Blood Flow in PDRecruitingNCT05400174Not applicable1 country
- State of Knowledge Among Nurses Regarding the Screening for Orthostatic Hypotension in Elderly Individuals in Acute Geriatric Medicine and Medical and Rehabilitation ServicesNot yet recruitingNCT077386661 country
- Droxidopa / Pyridostigmine in Orthostatic HypotensionEnrolling by invitationNCT01370512Phase 21 country
- Epidural Electrical Stimulation to Support Hemodynamic Management in Individuals With Parkinson's DiseaseRecruitingNCT06920134Not applicable1 country
- Use of Accelerometer for Quantification of Neurogenic Orthostatic Hypotension SymptomsRecruitingNCT04782830Not applicable1 country
- Cardiovascular Function and Response to Stimulation Within the First Year After Spinal Cord InjuryRecruitingNCT06841198Not applicable1 country
- Impact of Transcutaneous Spinal Stimulation on Blood Pressure and Orthostasis in Spinal Cord InjuryNot yet recruitingNCT07674511Not applicable1 country
- Effects of Breathing Retraining Exercises in Pregnant Females With Postural Orthostatic Tachycardia Syndrome.RecruitingNCT07579026Not applicable1 country
- Hypercapnia in Orthostatic HypotensionRecruitingNCT05295810Not applicable1 country
- The Effect of Water Carbonation on Orthostatic ToleranceRecruitingNCT05621460Not applicable1 country
- CPAP for the Treatment of Supine HypertensionRecruitingNCT05489575Not applicable1 country
- Orthostatic And Postprandial Hypotension In Hospitalized Older Adults (HOPE65)Not yet recruitingNCT074859981 country
- Autonomic Regulation of Blood Pressure and Heart Rate During Orthostasis and Exercise in Healthy and Hypertensive IndividualsRecruitingNCT074824621 country
- Overnight Trials With Heat Stress in Autonomic Failure Patients With Supine HypertensionRecruitingNCT03042988Not applicable1 country
- Research, Development, and Application of Intelligent Diagnostic System for Orthostatic HypotensionNot yet recruitingNCT073096661 country
- Non-invasive Spinal Cord Stimulation for Recovery of Autonomic Function After Spinal Cord InjuryRecruitingNCT05369520Not applicable1 country
- POLish Registry of CArdioneuroablation and CArdioneuromodulationRecruitingNCT071963971 country
- Spinal Cord Transcutaneous Stimulation Effect on Blood Pressure in Acute Spinal Cord Injury (SCI)RecruitingNCT05731986Not applicable1 country
- The Effect of Transcutaneous Stimulation on Blood Pressure in Spinal Cord Injury (SCI)RecruitingNCT05725499Not applicable1 country
- Deciphering the Mechanisms of Central BP Regulation in Patients With PD Associated With Orthostatic HypotensionNot yet recruitingNCT071397561 country
- Transcutaneous Spinal Cord Stimulation Home StudyRecruitingNCT06838637Not applicable1 country
- Controlled CO2 Inhalation in NOHNot yet recruitingNCT06751888Not applicable1 country
- The Value of Near-infrared Spectroscopy and Blood Pressure Measurements in Estimating Future Fall Risk in Older AdultsRecruitingNCT067145651 country
- Cardiopulmonary Changes Following Spinal Cord Stimulation in Individuals With Spinal Cord InjuryNot yet recruitingNCT06379711Not applicable1 country
- The Effect of Rehabilitation Training on Orthostatic Hypotension in Parkinson's PatientsNot yet recruitingNCT06328335Not applicable
- The Effect of Rehabilitation Training on Orthostatic Hypotension in Parkinson's PatientsRecruitingNCT06255717Not applicable1 country
- A Novel Device for the Treatment of Postural Hypotension - a Signal of Effectiveness Study.RecruitingNCT06039410Not applicable1 country
- Efficacy, Safety and Response Predictors of Adjuvant Astragalus for Cognition in Orthostatic HypotensionRecruitingNCT05647473Phase 21 country
- ARC Therapy to Restore Hemodynamic Stability and Trunk Control in People With Spinal Cord InjuryRecruitingNCT05941819Not applicable1 country
- Efficacy and Tolerance of Flucortac in Patients With Orthostatic Neurogenic HypotensionRecruitingNCT04128137Phase 41 country
- Effects of Midodrine and Droxidopa on Splanchnic Capacitance in Autonomic FailureTerminatedNCT02897063Phase 11 country
- A Study in Subjects With Neurogenic Orthostatic HypotensionActive, not recruitingNCT07089043Phase 21 country
- Water and the Gastropressor Response - Diurnal VariabilityActive, not recruitingNCT00581373Not applicable1 country
- Water and the Gastropressor Response - TachyphylaxisActive, not recruitingNCT00580996Not applicable1 country
- Deciphering Preserved Autonomic Function After Spinal Cord InjuryCompletedNCT04493372Not applicable1 country
- Autonomic Effects of Stimulation in SCICompletedNCT05664646Not applicable1 country
- Autonomic Effects of Spinal Cord Stimulation in Spinal Cord InjuryActive, not recruitingNCT05960448Not applicable1 country
- SalT Supplementation in Older Adults With Orthostatic Intolerance DisordersActive, not recruitingNCT06188663Phase 21 country
- Automated Abdominal Binder for Orthostatic HypotensionCompletedNCT03482297Phase 1/21 country
- Hemodynamic Mechanisms of Abdominal Compression in the Treatment of Orthostatic Hypotension in Autonomic FailureCompletedNCT02429557Phase 11 country
- Efficacy of L-threo DOPS on Orthostatic Hypotension Symptoms and Other Non-motor Symptoms in Patients With MSACompletedNCT02071459Phase 2/31 country
- Evaluation of the Contribution of Lower Limb and/or Abdominal Compression on Orthostatic HypotensionCompletedNCT06694688Not applicable1 country
- Reduction in Splanchnic Capacitance Contributes to Sympathetically Dependent Hypertension in AutonomicActive, not recruitingNCT02726711Phase 11 country
- Evaluation of the ORTHO-LBNP SystemCompletedNCT03354234Not applicable1 country
- Transcutaneous Stimulation in Spinal Cord InjuryCompletedNCT05180227Not applicable1 country