Postural Orthostatic Tachycardia Syndrome clinical trials

The registry lists 136 studies for Postural Orthostatic Tachycardia Syndrome across more than 10 countries. 42 are recruiting or about to start. 95 of them are mainly about Postural Orthostatic Tachycardia Syndrome (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12.

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Status

Completed: 53
Recruiting: 29
Active, not recruiting: 25
Not yet recruiting: 12
Terminated: 8
Status unknown: 5

Phase

Phase 2: 21
Phase 1: 9
Early Phase 1: 7
Phase 3: 4
Phase 4: 4

Where

United States: 92
Canada: 12
Germany: 4
Sweden: 4
Italy: 3
Switzerland: 2

Who runs them

Vanderbilt University Medical Center (18) · Vanderbilt University (12) · University of Calgary (9) · New York Medical College (6) · Mayo Clinic (5) · Satish R. Raj (4) · Virginia Commonwealth University (3) · Karolinska Institutet (3)

What is being tested here

Drugs under test in Postural Orthostatic Tachycardia Syndrome studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted

Drug	Open	Phase 3	All
Propranolol	1	0	5
Pyridostigmine	1	0	5
Sodium Chloride	1	0	2
Mirabegron	1	0	2
Guanfacine	1	0	1
Cromolyn	1	0	1
Naltrexone	1	0	1
Ropivacaine	1	0	1
Ivabradine	0	1	3
Phenylephrine	0	0	2

Drug classes tested here Beta blockers 1 open · Cholinesterase inhibitors 1 open

Coming up

0phase 3 studies under way

17studies finish main data collection within a year

Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.

The 10 nearest

Nov 2026Breathing Device in Postural Orthostatic Tachycardia Syndrome (POTS) · Alfredo Gamboa
Dec 2026Restoring Iron Deficiency in POTS · Vanderbilt University Medical Center
Dec 2026Modafinil and Cognitive Function in POTS · Vanderbilt University Medical Center
Dec 2026Aldosterone & Sodium Regulation in Postural Tachycardia Syndrome - Screening · Vanderbilt University
Dec 2026Periaqueductal Gray-vagus Nerve Interface Malfunction Explain the Natural History With Its Numerous Co-morbidities? · Virginia Commonwealth University
Dec 2026Tragus Stimulation for POTS Treatment · Aristotle University Of Thessaloniki
Dec 2026Compression Garments in the Community With POTS · University of Calgary
Dec 2026Auricular Vagal Nerve Stimulation for Hypermobile Ehlers-Danlos Syndrome · Medical College of Wisconsin
Feb 2027Autoimmune Basis for Postural Tachycardia Syndrome · Vanderbilt University Medical Center
Feb 2027A Study of Pyridostigmine in Postural Tachycardia Syndrome · Mayo Clinic

Who these studies take

Of the 29 Postural Orthostatic Tachycardia Syndrome studies recruiting now, 9 (31%) set no upper age limit and 16 (55%) stop at 75 or younger. 9 (31%) take children under 18. 4 (14%) are for women only and 0 (0%) for men only; 10 (34%) take healthy volunteers.

Recruiting studies that take each age, of 29
Age	Women	Men
10	4 (14%)	4 (14%)
18	28 (97%)	25 (86%)
30	24 (83%)	22 (76%)
40	22 (76%)	22 (76%)
50	22 (76%)	22 (76%)
65	13 (45%)	13 (45%)
75	13 (45%)	13 (45%)
85	10 (34%)	10 (34%)

Across all 136 studies, recruiting or not: 60% stop at 75 or younger and 57% at 65; 25% take children; 10% are for women only and 1% for men only; 43% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.

How long Postural Orthostatic Tachycardia Syndrome studies take

Of 44 interventional studies with no phase under Postural Orthostatic Tachycardia Syndrome, half reached primary completion within 46 months of starting, counting those still running.

Start to primary completion	Every sponsor	Industry	Non-industry
Interventional, no phase	46 mo20–61 · 44 studies	—	46 mo20–61 · 44 studies

Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out

What changed recently

From the registry's own updates since Oct 16, 2026.

Started recruiting1

Ultrasound Guided Stellate Ganglion Block in Postural Tachycardia SyndromeOct 28, 2026NCT06953661

Studies

Recruiting first, then most recently updated. Showing 50 of 136. Browse all 136 → or search them.