Malaria clinical trials
The registry lists 1,298 studies for Malaria across more than 10 countries. 85 are recruiting or about to start. Per ClinicalTrials.gov, last updated 2026-09-25.
Status
- Completed
- 984
- Status unknown
- 103
- Recruiting
- 54
- Terminated
- 52
- Withdrawn
- 38
- Active, not recruiting
- 30
Phase
- Phase 1
- 298
- Phase 2
- 234
- Phase 3
- 198
- Phase 4
- 194
- Early Phase 1
- 8
Where
- United States
- 116
- Kenya
- 108
- Burkina Faso
- 106
- Uganda
- 98
- Mali
- 92
- Tanzania
- 90
Who runs them
National Institute of Allergy and Infectious Diseases (NIAID) (118) · University of Oxford (112) · London School of Hygiene and Tropical Medicine (109) · Medicines for Malaria Venture (57) · GlaxoSmithKline (47) · U.S. Army Medical Research and Development Command (36) · Centers for Disease Control and Prevention (36) · University of California, San Francisco (31)
Studies
Recruiting first, then most recently updated. Showing 50 of 1,298 — search for more.
- Safety and Immunogenicity of the Recombinant Malaria Vaccines in Healthy Adults Aged 18-50 YearsNot yet recruitingNCT07831226Phase 11 country
- Induced Blood-Stage Malaria in Healthy Malaria-Naive Adults to Assess the Safety and Infectivity of Plasmodium Vivax Challenge Agent and Evaluate Transmission in Mosquito Feeding AssaysRecruitingNCT06607003Phase 11 country
- Safety, Tolerability, Pharmacokinetics, and Mosquitocidal Activity of Lotilaner in Healthy Participants in Mali.RecruitingNCT07758985Phase 11 country
- Evaluation, Treatment and Monitoring of Patients With a Known or Suspected Parasitic InfectionRecruitingNCT000016451 country
- Intermittent Preventive Treatment of Malaria in School-age Children to Decrease Community TransmissionNot yet recruitingNCT07246525Phase 41 country
- Platelet-Directed Whole Blood Transfusion Strategy for MalariaRecruitingNCT05711485Not applicable2 countries
- Collection of Human Biospecimens for Basic and Clinical Research Into Globin VariantsRecruitingNCT039378171 country
- Non-invasive Malaria Diagnostic Data Collection in EthiopiaRecruitingNCT074569691 country
- OPTIMAL LEAP: Optimizing Dihydroartemisinin-Piperaquine IPTsc Intervals to Advance Learning, Executive Function, Attendance, and Antimalarial Resistance Surveillance in Kenyan SchoolchildrenNot yet recruitingNCT07798583Phase 3
- Screening of Healthy Volunteers for Investigational Antimalarial Drugs, Malaria Vaccines, and Controlled Human Malaria ChallengeRecruitingNCT026392991 country
- Host and Parasite Factors That Influence Susceptibility to Malaria Infection and Disease During Pregnancy and Early Childhood in Ouelessebougou and Bamako, MaliRecruitingNCT011682711 country
- Insecticide-Treated Baby Wraps for the Prevention of MalariaNot yet recruitingNCT07773350Not applicable1 country
- Community-Based Cohort Study of Hidden Malaria Infections, Diagnostic Gaps, & Mosquito Vector Dynamics in Odisha, IndiaRecruitingNCT077700481 country
- Focal Mass Drug Administration for the Prevention of Malaria in PregnancyRecruitingNCT07021430Early Phase 11 country
- Post-discharge Malaria Chemoprevention Implementation Trial in BeninRecruitingNCT06601712Phase 41 country
- Laboratory Evaluation of Pregnancy Malaria Vaccine Candidates/In-vitro Testing of Pregnancy Malaria Vaccine CandidatesRecruitingNCT024713781 country
- Assessing Vaccine Effectiveness of R21/Matrix-M Across Malaria Transmission Settings (AVERT)RecruitingNCT077499112 countries
- A Clinical Study of Piperaquine, Pyronaridine, and Artesunate Administered in Combination in Healthy AdultsNot yet recruitingNCT07470424Phase 11 country
- R21/MM Dosing, Presentations, and PreservativesNot yet recruitingNCT07194668Phase 41 country
- This is a Clinical Study to Assess Whether the Combination of SJ733 and Tafenoquine Will be a Safe and Rapidly Acting Anti-malarial for the Radical Cure of P. Vivax MalariaNot yet recruitingNCT07430592Phase 21 country
- Surveillance of AMR in DRCRecruitingNCT068212821 country
- PfSPZ-LARC2 Vaccine in Women of Child-bearing Potential (WOCBP) in MaliRecruitingNCT07675785Phase 21 country
- Integrating the Guardian Spatial Emanator Within AVENIR IINot yet recruitingNCT07712263Not applicable1 country
- Study to Assess Safety and Clinical Responses With Coartem® Baby Dispersible Tablets in Paediatric Patients Weighing 2 to <5 kg With Uncomplicated MalariaNot yet recruitingNCT07713602Phase 4
- A Phase 2A Study of a Novel Antimalarial Pyrrolidinamide in Adult Patients With Uncomplicated P. Falciparum MalariaNot yet recruitingNCT07545681Phase 2
- DON in Pediatric Cerebral MalariaRecruitingNCT05478720Phase 1/21 country
- Safety, Tolerability and Efficacy of PfSPZ-LARC2 Vaccine Against CHMI in Malaria-Naïve AdultsRecruitingNCT06862453Phase 11 country
- Single Ascending Dose Study to Assess the Safety, Tolerability and Pharmacokinetics of LAI MMV055 Alone and in Combination With MMV371 in Healthy ParticipantsRecruitingNCT07011511Phase 11 country
- First-in-Human Dose-escalation of GSK4425689A: Safety, Tolerability, and PK in Healthy AdultsNot yet recruitingNCT07646353Phase 1
- FocaL Mass Drug Administration for Vivax Malaria EliminationRecruitingNCT05690841Phase 31 country
- Field Trial of PfSPZ-LARC2 Vaccine in Burkinabe AdultsRecruitingNCT07385287Phase 21 country
- Safety and PK of MMV371 LAI in Healthy Adults and Adolescents in RwandaNot yet recruitingNCT07548021Phase 11 country
- Comparison of Two Strategies for Administering the R21-Matrix M Vaccine in a Context of Seasonal Malaria Transmission in ChadRecruitingNCT07038837Phase 41 country
- Xpert® Tropical Fever Test on GeneXpert® Edge X SystemEnrolling by invitationNCT075202791 country
- Clinical Study to Assess Minimum Mosquito Bites for P. Vivax Infection in Thai AdultsRecruitingNCT07257965Not applicable1 country
- Pregnancy Registry in MaliRecruitingNCT064683191 country
- An Ultra-short Course of Primaquine for the Radical Cure of Vivax MalariaNot yet recruitingNCT07468526Phase 34 countries
- Effectiveness of Malaria Vaccines in Reducing the Risk of Invasive Non-typhoidal Salmonella DiseaseRecruitingNCT074164611 country
- Assessing the Feasibility of Combining Dihydroartemisinin Piperaquine and Primaquine for Malaria Mass Drug Administration in High Endemic Communities in the Eastern Region of GhanaRecruitingNCT07389057Not applicable1 country
- Long-acting Spatial Emanators / Repellents (LASER)Not yet recruitingNCT07387341Not applicable1 country
- OPTImizing Malaria And HIV Treatment in a Shifting Landscape in AfricaRecruitingNCT06967519Phase 41 country
- Severe Malaria in Remote Areas- Closing the Evidence GapEnrolling by invitationNCT068069562 countries
- Risk Assessment of Community Spread of Multiple Endemic Infectious Diseases in a One Health PerspectiveRecruitingNCT073589101 country
- Clinical Aspects, Management and Surveillance of Febrile Illnesses in DRCRecruitingNCT073452861 country
- The Effects of Iron Treatment on Malaria and Measles Vaccine Response in Kenyan Infants With Iron DeficiencyNot yet recruitingNCT06816524Not applicable
- Introduction of Polymerase Chain Reaction (PCR) in Microbiology and ParasitologyRecruitingNCT072693141 country
- Testing a Biometric Identification System to Improve Malaria Vaccine CompletionRecruitingNCT07261280Not applicable1 country
- PDMC Implementation Trial in KenyaRecruitingNCT06624631Phase 41 country
- Safety of Antimalarials in the FIRst trimEsterRecruitingNCT06962319Phase 33 countries
- A Study to Assess the Safety and Immunogenicity of a Vaccine Against Malaria in Healthy Children Aged 5-60 MonthsRecruitingNCT07036159Phase 21 country