London School of Hygiene and Tropical Medicine: Malaria trials

The registry lists 109 Malaria studies with London School of Hygiene and Tropical Medicine as lead sponsor. 3 are open to participants now and 4 have results posted.

Phase 1 5Phase 2 18Phase 3 49Phase 4 16No phase 35(a study in two phases counts in both)

Studies

Page 1 of 2. Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Community-Based Cohort Study of Hidden Malaria Infections, Diagnostic Gaps, & Mosquito Vector Dynamics in Odisha, IndiaRecruitingNCT07770048
• Seasonal R21 Mass Vaccination for Malaria EliminationRecruitingNCT06578572Phase 3
• Effectiveness and Cost-effectiveness of Integrated Model for Malaria and Helminth ControlNot yet recruitingNCT06182176Not applicable
• Seasonal Malaria Vaccination (RTS,S/AS01) and Seasonal Malaria Chemoprevention (SP/AQ) Extension StudyCompletedNCT04319380Phase 3Results posted
• Seasonal Malaria Vaccination (RTS,S/AS01) and Seasonal Malaria Chemoprevention (SP/AQ)CompletedNCT03143218Phase 3Results posted
• Intermittent Preventive Treatment of Malaria in SchoolchildrenCompletedNCT00852371Phase 3Results posted
• Artemisinin-Based Combination Therapy: Clinical Trials in CameroonCompletedNCT00297882Phase 3Results posted
• Parasite Clearance and Protection from Infection (PCPI) in CameroonCompletedNCT06173206Phase 3
• Parasite Clearance and Protection From Infection (PCPI) in ZambiaCompletedNCT06166498Phase 3
• Perennial Malaria Chemoprevention (PMC) in CameroonCompletedNCT05889052
• Understanding and Maximizing the Community Impact of Antimalarial Treatment (INDIE-SMC)CompletedNCT05878366Not applicable
• Perennial Malaria Chemoprevention (PMC) in Côte d'IvoireCompletedNCT05856357
• Net Transition Initiative: Efficacy of Two Next-generation Nets for Control of Malaria in Cote d'IvoireActive, not recruitingNCT05796193Not applicable
• Feasibility and Safety of Combining Anti-malarial With Deworming Drugs in African ChildrenStatus unknownNCT05354258Not applicable
• Adjunctive Ivermectin Mass Drug Administration for Malaria ControlStatus unknownNCT04844905Phase 3
• The ASPIRE Trial - Aiming for Safe Pregnancies by Reducing Malaria and Infections of the Reproductive TractCompletedNCT04189744Phase 3
• P. Falciparum Infection Dynamics and Transmission to Inform EliminationStatus unknownNCT04053907Not applicable
• Efficacy of Two Dual Active Ingredient Long Lasting Insecticidal Nets for Control of Malaria Transmitted by Pyrethroid Resistant Vectors in BeninCompletedNCT03931473Not applicable
• P. Falciparum Infection Dynamics and Transmission to Inform Elimination (INDIE-1a)CompletedNCT03705624Not applicable
• Mass Drug Administration of Ivermectin and Dihydroartemisinin-piperaquine as an Additional Intervention for Malaria EliminationCompletedNCT03576313Phase 3
• Efficacy of Three Novel Bi-treated Long Lasting Insecticidal NetsCompletedNCT03554616Not applicable
• Susceptibility of Gambian Adults to PfSPZ-Challenge Infection in the Controlled Human Malaria Infection ModelCompletedNCT03496454Not applicable
• Cardiac Safety of Dihydroartemisinin-Piperaquine Amongst Pregnant Women in TanzaniaCompletedNCT02909712Phase 2
• RHOST-cRCT, Reactive Household-based Self-administered Treatment Against Residual Malaria TransmissionCompletedNCT02878200Not applicable
• Feasibility of the Vapor Nanobubble Technology for Malaria Diagnostics (MalariaSense)CompletedNCT02672228Not applicable
• Evaluation of the Safety of Primaquine in Combination With Dihydroartemisinin-piperaquine in G6PD Deficient Males in The GambiaTerminatedNCT02654730Phase 2/3
• Targeted Indoor Residual Spraying Against MalariaCompletedNCT02556242Phase 4
• Artemisinin-based Combination Therapy for Treatment of Plasmodium Falciparum Malaria in North Sumatera, IndonesiaCompletedNCT02325180Phase 4
• Evaluation of a Novel Long Lasting Insecticidal Net and Indoor Residual Spray ProductCompletedNCT02288637Not applicable
• Dihydroartemisinin-piperaquine With Low Dose Primaquine to Reduce Malaria TransmissionCompletedNCT02259426Phase 3
• School-based Programme of Malaria Diagnosis and Treatment in Southern MalawiCompletedNCT02213211Not applicable
• A Trial of Seasonal Malaria Chemoprevention Plus Azithromycin in African ChildrenCompletedNCT02211729Phase 3
• Safety of Primaquine + Artemether-lumefantrine in G6PD Deficient Males With an Asymptomatic Malaria Infection (SAFEPRIM)CompletedNCT02174900Phase 2/3
• School-Based Treatment With ACT to Reduce TransmissionCompletedNCT02009215Phase 4
• Adherence to Antimalarial Drugs in Sierra LeoneCompletedNCT01967472Not applicable
• Treatment Efficacy and Malaria TRANSmission After Artemisinin Combination Therapy 2 (TRANSACT2)CompletedNCT01939886Phase 3
• Low Dose Primaquine for Clearance of GametocytesCompletedNCT01935882Phase 2/3
• Primaquine's Gametocytocidal Efficacy in Malaria Asymptomatic CarriersCompletedNCT01838902Phase 3
• Impact of Insecticide Resistance on Vector ControlStatus unknownNCT01713517Phase 4
• The Combined Use of Indoor Residual Spraying (IRS) and Long-lasting Insecticidal Nets (LLINs) for Malaria PreventionStatus unknownNCT01697852Phase 4
• Impact of Repeated Anthelmintic Treatment on the Risk of Malaria in Kenyan School ChildrenCompletedNCT01658774Not applicable
• Trial of Artemether-Lumefantrine Alone and in Combination With Ivermectin to Reduce Post-Treatment Malaria TransmissionCompletedNCT01603251Phase 1/2
• Intermittent Parasite Clearance (IPC) in Schools: Impact on Malaria, Anaemia and CognitionCompletedNCT01454752Not applicable
• Cluster Randomised Trial of Malaria RDTs Used by CHWs in AfghanistanCompletedNCT01403350Phase 4
• Evaluation of the Gametocytocidal Efficacy and Safety of Primaquine in Uncomplicated Falciparum Malaria in UgandaCompletedNCT01365598Phase 3
• Research on the Economics of Artemisinin Combination Therapy (ACTs) for the Treatment of MalariaCompletedNCT01350752Not applicable
• Pharmacokinetics of Sulfadoxine-pyrimethamine Plus Amodiaquine for Intermittent Preventive Treatment in Children (IPTc)CompletedNCT01328990Phase 1/2
• Intermittent Preventive Treatment for Malaria in Patient With Sickle Cell DiseaseCompletedNCT01319448Phase 1/2
• Prenatal Iron and Malaria StudyCompletedNCT01308112Phase 4
• A Cluster-randomised Trial of Interventions to Improve Antimalarial Prescribing With Malaria TestsCompletedNCT01292707Not applicable
• IMPACT2: Monitoring Interventions to Improve Artemisinin-based Combination Therapy (ACT) Access and TargetingStatus unknownNCT01130155
• Intermittent Preventive Treatment Versus Scheduled Screening and Treatment of Malaria in PregnancyCompletedNCT01084213Phase 4
• Extended-dose Chloroquine (ECQ) for Resistant Falciparum Malaria Among Afghan Refugees in PakistanCompletedNCT01019408Phase 4
• Trial of Artesunate Combination Therapy in PakistanCompletedNCT00959517Phase 2
• Intermittent Preventive Treatment (IPTc) and Home Based Management of Malaria (HMM)in The GambiaCompletedNCT00944840Phase 3
• Dihydroartemisinin (DHA)-Piperaquine for IPT to Prevent Malaria in Children in Burkina FasoCompletedNCT00941785Phase 2/3
• Clinical Evaluation of Insect Repellent and Insecticide Treated Nets in Lao PDRStatus unknownNCT00938379Phase 3
• Examination of ACT Implementation in a Vivax / Falciparum Co-endemic AreaCompletedNCT00935688Phase 4
• Impact of School-based Delivery of Long Lasting Insecticide NetsCompletedNCT00878397Not applicable
• Impact of Malaria Prevention on Health and Education in Kenyan SchoolchildrenCompletedNCT00878007Not applicable
• Intermittent Preventive Treatment for Malaria in Infants in Navrongo GhanaCompletedNCT00857077Not applicable
• A Trial of the Combined Impact of Intermittent Preventive Treatment and Insecticide Treated Bednets in Reducing Morbidity From Malaria in African ChildrenCompletedNCT00738946Not applicable
• Evaluation of the Public Health Impact of Seasonal Intermittent Preventive Treatment (IPT) in Children in SenegalStatus unknownNCT00712374Phase 4
• Azithromycin + Artesunate v Artemether-lumefantrine in Uncomplicated Malaria.CompletedNCT00694694Phase 3
• Evaluation of Local Mechanisms for Staff Motivation to Reduce Hospital MortalityCompletedNCT00673166Not applicable
• Comparison of Three Drug Combinations for Intermittent Treatment of Malaria in ChildrenCompletedNCT00561899Phase 2/3
• Three Alternative Drug Regimens for Malaria Seasonal Preventive Treatment in SenegalCompletedNCT00529620Phase 3
• The Effect of Malaria on Disease Progression of HIV/AIDSCompletedNCT00499876Not applicable
• Trial of Rapid Diagnostic Tests in Rural GhanaCompletedNCT00493922Phase 4
• Artesunate Plus Sulfadoxine-Pyrimethamine Versus Chloroquine for Vivax MalariaCompletedNCT00486694Phase 2
• Tolerability and Efficacy of CD+A Compared to AQ+SP for the Treatment of P.Falciparum Malaria in Rwandan ChildrenCompletedNCT00461578Not applicable
• Clinical Evaluation of Mosquito Coils to Control Malaria in ChinaStatus unknownNCT00442442Phase 3
• Intermittent Preventive Treatment (IPTp) Versus Rapid Diagnostic Testing (RDT) and Treatment of Malaria in PregnancyCompletedNCT00432367Phase 3
• Comparison of Two Strategies for the Delivery of IPTcCompletedNCT00376155Phase 4
• IPT and Efficacy of Sulphadoxine/Pyrimethamine and Chlorproguanil/Dapsone in 6-59 Month Old Children With Malaria.TerminatedNCT00361114Phase 3
• Randomized Trial of Two Antimalarial Treatments for Clearing Low Density P.Falciparum Parasitaemia in SudanCompletedNCT00330902Phase 3
• Effect of Antimalarial Treatment on Gametocyte Carriage in Asymptomatic P. FalciparumCompletedNCT00289250Phase 3
• Cluster Randomized Trial of Peer Health Education in Malaria in The GambiaCompletedNCT00269178Phase 3
• A Stitch in Time May Save Lives: Turning Poor Bednets Into Good OnesCompletedNCT00169117Not applicable
• Impact of Insecticide-treated Curtains on Antimalarial Drug ResistanceCompletedNCT00169078Not applicable
• Eight Week Primaquine Regimen for the Treatment of Vivax MalariaCompletedNCT00158587Phase 3
• Kilimanjaro IPTi Drug Options TrialCompletedNCT00158574Phase 2/3
• Chlorproguanil/Dapsone Compared With Chloroquine and SP for Vivax MalariaCompletedNCT00158561Phase 3
• ACT With Chloroquine, Amodiaquine & Sulphadoxine-pyrimethamine in PakistanCompletedNCT00158548Phase 3
• A Randomised Trial of Rapid Diagnostic Tests in the Diagnosis of Malaria in TanzaniaCompletedNCT00146796Phase 4
• Navrongo Drug Options for IPT in Pregnancy TrialCompletedNCT00146783Phase 2/3
• A Trial of Antimalarial Drugs Used in Pregnancy in TanzaniaCompletedNCT00146731Phase 3
• Anti-Malarial Drug Resistance in CameroonCompletedNCT00146718Phase 2/3
• A Trial of Improved Financial Access to Healthcare in GhanaCompletedNCT00146692Phase 4
• Evaluation of Combined Use of ITN's and Insect Repellents Against MalariaCompletedNCT00144716Phase 3
• Study of the Impact of Intermittent Preventive Treatment in Schools on Malaria, Anaemia and Education.CompletedNCT00142246Phase 3
• Preventing Malaria During Pregnancy in Epidemic-prone Areas.CompletedNCT00142207Phase 3
• Relationships Between the Use of Antimalarial Drugs in Pregnancy and Plasmodium Falciparum ResistanceCompletedNCT00140517Not applicable
• A Trial of Intermittent Treatment in the Prevention of Malaria in Senegalese ChildrenCompletedNCT00132561Phase 2/3
• A Trial of Four Drug Regimens for the Prevention of Malaria in Senegalese ChildrenCompletedNCT00132548Phase 3
• Influence of Chloroquine on HIV Viral Load Among Pregnant Women in UgandaCompletedNCT00132535Not applicable
• Bacillus Calmette-Guerin (BCG) Vaccine and Morbidity From MalariaCompletedNCT00131794Phase 3
• Efficacy and Safety of Sulphadoxine-pyrimethamine and Amodiaquine in Ghanaian Pregnant WomenCompletedNCT00131703Phase 3
• Malaria Infection Diagnosed by Polymerase Chain Reaction (PCR) as a Means of Evaluating Pre-erythrocytic Candidate Malaria VaccinesCompletedNCT00121823Phase 1/2
• Malaria Candidate Vaccines FP9 Circumsporozoite (CS) and MVA CS in Adult Gambian MenCompletedNCT00121771Phase 1