National Institute of Allergy and Infectious Diseases (NIAID): Malaria trials

The registry lists 120 Malaria studies with National Institute of Allergy and Infectious Diseases (NIAID) as lead sponsor. 8 are open to participants now and 19 have results posted.

Phase 1 52Phase 2 12Phase 3 3Phase 4 2No phase 53(a study in two phases counts in both)

Studies

Page 1 of 2. Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Positron Emission Tomography and Organ-Specific Changes in Participants Co-Enrolled in NIH Studies of Plasmodium Vivax Controlled Human Malaria InfectionNot yet recruitingNCT07859800Not applicable
• Induced Blood-Stage Malaria in Healthy Malaria-Naive Adults to Assess the Safety and Infectivity of Plasmodium Vivax Challenge Agent and Evaluate Transmission in Mosquito Feeding AssaysRecruitingNCT06607003Phase 1
• Pregnancy Registry in MaliRecruitingNCT06468319
• Collection of Human Biospecimens for Basic and Clinical Research Into Globin VariantsRecruitingNCT03937817
• Screening of Healthy Volunteers for Investigational Antimalarial Drugs, Malaria Vaccines, and Controlled Human Malaria ChallengeRecruitingNCT02639299
• Laboratory Evaluation of Pregnancy Malaria Vaccine Candidates/In-vitro Testing of Pregnancy Malaria Vaccine CandidatesRecruitingNCT02471378
• Host and Parasite Factors That Influence Susceptibility to Malaria Infection and Disease During Pregnancy and Early Childhood in Ouelessebougou and Bamako, MaliRecruitingNCT01168271
• Evaluation, Treatment and Monitoring of Patients With a Known or Suspected Parasitic InfectionRecruitingNCT00001645
• L9LS MAb in Malian InfantsCompletedNCT06461026Phase 1Results posted
• L9LS MAb in Malian AdultsCompletedNCT05816330Phase 2Results posted
• Pharmacokinetic Study of IV Artesunate to Treat Children With Severe MalariaCompletedNCT05750459Phase 4Results posted
• Anti-malaria MAb in Kenyan ChildrenCompletedNCT05400655Phase 2Results posted
• Anti-malaria MAb in Malian ChildrenCompletedNCT05304611Phase 2Results posted
• Study of the Transmission-Blocking Vaccine Pfs230D1-EPA/Matrix-M Against Malaria in Adults in MaliCompletedNCT05135273Phase 1Results posted
• Blood-Stage Plasmodium Vivax Cell BankCompletedNCT05095272Phase 1Results posted
• Trial to Evaluate L9LS in Healthy AdultsCompletedNCT05019729Phase 1Results posted
• Safety and Efficacy of CIS43LS Anti-malaria mAb in MaliCompletedNCT04329104Phase 2Results posted
• Trial to Evaluate CIS43LS in Healthy AdultsCompletedNCT04206332Phase 1Results posted
• Safety, Immunogenicity, and Protective Efficacy of Radiation Attenuated Plasmodium Falciparum NF54 Sporozoites (PfSPZ Vaccine) During Malaria Transmission Season in Healthy African Adult Women of Childbearing Potential in MaliCompletedNCT03989102Phase 2Results posted
• Sanaria PfSPZ Challenge With Pyrimethamine or Chloroquine Chemoprophylaxis Vaccination (PfSPZ-CVac Approach): A Randomized Double Blind Placebo Controlled Phase I/II Trial to Determine Safety and Protective Efficacy Against Natural Plasmodium Falcipa...CompletedNCT03952650Phase 1/2Results posted
• Pfs230D1M-EPA/AS01 Vaccine, a Transmission Blocking Vaccine Against Plasmodium Falciparum, in an Age De-Escalation Trial of Children and a Family Compound Trial in MaliCompletedNCT03917654Phase 2Results posted
• Safety, Immunogenicity, and Protective Efficacy of Two Regimens of Radiation Attenuated Plasmodium Falciparum NF54 Sporozoites (PfSPZ Vaccine) During Natural Transmission Season in Healthy African Adults in MaliCompletedNCT03510481Phase 1Results posted
• Dose Escalation PfSPZ-CVacCompletedNCT03083847Phase 1Results posted
• Safety and Immunogenicity of Pfs25M-EPA/AS01 and Pfs230D1M-EPA/AS01 Vaccines, Transmission Blocking Vaccines Against Plasmodium Falciparum, at Full and Fractional Dosing in Adults in MaliCompletedNCT02942277Phase 1Results posted
• Evaluation of Oral Activated Charcoal on Antimalarial Drug's Ability to Kill Parasites in Malian Children With MalariaCompletedNCT01955382Phase 2Results posted
• Chloroquine for Malaria in PregnancyCompletedNCT01443130Phase 3Results posted
• Chloroquine Alone or in Combination for Malaria in Children in MalawiCompletedNCT00379821Phase 3Results posted
• L9LS-R21 InteractionWithdrawnNCT07208760Phase 2
• L9LS in Women of Childbearing Potential in MaliCompletedNCT07060508Phase 2
• First-in-Human PfSPZ-LARC2 Vaccination/CHMICompletedNCT06735209Phase 1
• Study of the Plasmodium Vivax Transmission-blocking Vaccine Pvs230D1-EPA/Matrix-M to Assess Safety, Immunogenicity, and Transmission-blocking Activity in Healthy Malaria-naive AdultsCompletedNCT05913973Phase 1
• Safety Evaluation of PfSPZ Vaccine in Pregnant Women in Mali (MalVIP1)WithdrawnNCT05652504Phase 1
• Community Dynamics of Malaria Transmission in Humans and Mosquitoes at Maferinyah Sub-Prefecture, GuineaCompletedNCT04969913
• Community Dynamics of Malaria Transmission in Humans and Mosquitoes in Fleh-la and Marshansue, Salala District, Bong County, LiberiaActive, not recruitingNCT04704674
• Malaria Transmission in Humans and Mosquitoes at the Area of Sabou, Burkina FasoCompletedNCT04650815
• Malaria Prevalence Around Maferinyah, GuineaCompletedNCT04105855
• Plasmodium and Other Parasites in Pregnant Women and Children Around Margibi and Montserrado Counties, LiberiaCompletedNCT03719599
• rCSP/AP10-602 [GLA-LSQ] Vaccine TrialCompletedNCT03589794Phase 1
• Safety and Pharmacokinetics Study of DM1157 to Treat MalariaTerminatedNCT03490162Phase 1
• Community Dynamics of Malaria Transmission and Mosquito Feeding in Bancoumana, MaliCompletedNCT03304704
• Molecular Basis of Erythrocyte Invasion by Plasmodium Vivax Into Duffy-Negative Erythrocytes in MaliCompletedNCT03304691
• Trial to Evaluate the Safety, Immunogenicity and Protective Efficacy of Three or Five Administrations of GAP3KO SporozoitesCompletedNCT03168854Phase 1
• A Systems Biology Approach to Malaria ImmunityCompletedNCT03014258Phase 1
• Safety and Efficacy of Sanaria's PfSPZ-CVac in Malian AdultsCompletedNCT02996695Phase 1
• Impact of Malaria on Pregnant Women in Ouelessebougou, MaliCompletedNCT02974608
• PfSPZ Challenge in Non-immune Adults in Baltimore, USACompletedNCT02780154Phase 1
• PfSPZ Challenge in Healthy Malaria-Naïve Adults in the United StatesCompletedNCT02773979Phase 1
• Safety and Immunogenicity of Sanaria's Irradiated Sporozoite Vaccine (PfSPZ Vaccine) in Malaria-Experienced Adults in Burkina FasoCompletedNCT02663700Phase 1
• Impact of Antimalarial Treatment on Measures of T Cell Suppression/Regulation in Healthy Adults From Doneguebougou, MaliCompletedNCT02659566
• Artemether-lumefantrine Resistance Monitoring in Children With Uncomplicated Plasmodium Falciparum Malaria in MaliCompletedNCT02645604
• Safety, Immunogenicity, and Protective Efficacy of Radiation Attenuated Plasmodium Falciparum NF54 Sporozoites in Healthy African Adults in MaliCompletedNCT02627456Phase 1
• Efficacy, Safety, and Tolerability of Dihydroartemisinin-piperaquine + Mefloquine Compared to Dihydroartemisinin-piperaquine or Artesunate-mefloquine in Patients With Uncomplicated Falciparum Malaria in CambodiaCompletedNCT02612545Phase 1
• Markers of T Cell Suppression: Antimalarial Treatment and Vaccine Responses in Healthy Malian AdultsCompletedNCT02544048
• Sanaria PfSPZ Challenge With Pyrimethamine Chemoprophylaxis (PfSPZ-CVac Approach): Phase 1 Trial to Determine Safety and Protective Efficacy of Sanaria PfSPZ Challenge With Concurrent Pyrimethamine Treatment That Inhibits Development of Asexual B...CompletedNCT02511054Phase 1
• Markers of T Cell Suppression: Associations With Malaria Infection and Antimalarial Treatment in Malian ChildrenCompletedNCT02504918
• Study of the Safety and Immunogenicity of Pfs230D1M-EPA/Alhydrogel and Pfs25M-EPA/Alhydrogel , a Transmission Blocking Vaccine Against Plasmodium Falciparum Malaria, in Adults in the U.S. and MaliCompletedNCT02334462Phase 1
• Assessing Human-to-Mosquito Transmission in Volunteers Participating in Malaria Vaccine Candidate Trials in MaliCompletedNCT02206451
• Longitudinal Analysis of Plasmodium Falciparum-Specific Immunity in Travelers and Immigrants From Malaria Endemic Areas to the United StatesTerminatedNCT02153996
• Impact of TMP-SMX Prophylaxis on Malaria Infection and Immunity in Children in UgandaCompletedNCT02094508
• Study of Controlled Human Malaria Infections to Evaluate Protection After Intravenous or Intramuscular Administration of PfSPZ Vaccine in Malaria-Naive AdultsCompletedNCT02015091Phase 1
• Study of Safety and Effectiveness of Intravenous Immunization With PfSPZ Vaccine in Healthy African AdultsCompletedNCT01988636Phase 1
• Testing Pfs25-EPA/Alhydrogel as a Potential Malaria Transmission Blocking VaccineCompletedNCT01867463Phase 1
• Collection of Biological Material From Pregnant Women in a Malarial RegionTerminatedNCT01862783
• Malaria Transmission Studies in MaliCompletedNCT01829737
• Artemisinin-resistant Malaria in CambodiaCompletedNCT01736319
• Sanaria™ PfSPZ Challenge VaccineCompletedNCT01546389Phase 1
• Apheresis to Obtain Plasma and White Blood Cells in MaliesWithdrawnNCT01511601
• Experimental PfSPZ Vaccine in Adults Without MalariaCompletedNCT01441167Phase 1
• Initial Study of Malaria Vaccine Pfs25-EPA/Alhydrogel(Registered Trademark)CompletedNCT01434381Phase 1
• Preventing the Spread of Malaria in MaliCompletedNCT01360112
• A Longitudinal Systems Biological Analysis of Naturally Acquired Malaria Immunity in MaliCompletedNCT01322581
• Malaria Surveillance in Rakai, UgandaCompletedNCT01265407
• Plasmodium Falciparum Clearance Rates in Response to Artesunate in Eastern CambodiaCompletedNCT01240603
• EP1300 Polyepitope DNA Vaccine Against Plasmodium Falciparum MalariaCompletedNCT01169077Phase 1
• Pilot Study to Estimate the Burden and Distribution of Plasmodium Falciparum Malaria in Kalifabougou, Mali in Preparation for a Prospective Cohort Study of Naturally-Acquired Malaria ImmunityCompletedNCT01160562
• EBA-175 RII-NG Malaria Vaccine Administered Intramuscularly in Semi-immune AdultsCompletedNCT01026246Phase 1
• Adenovirus Type 35 Based Circumsporozoite Malaria Vaccine in Burkina FasoCompletedNCT01018459Phase 1
• Phase I Study of the Safety and Immunogenicity of BSAM-2/Alhydrogel +CPG 7909, an Asexual Blood Stage Vaccine for Plasmodium Falciparum Malaria in Adults in the US and MaliCompletedNCT00889616Phase 1
• Estivation of Malaria Vector Mosquitoes in the Sahelian Region of MaliCompletedNCT00863408
• Immune Parameters in the Cord Blood of Newborns Exposed to Malaria in the WombCompletedNCT00772642
• Malaria Challenge With NF54 StrainCompletedNCT00744133Phase 1
• Malaria Vaccine for Children in MaliCompletedNCT00740090Phase 1
• Innate and Acquired Resistance to Plasmodium Falciparum Malaria in MaliCompletedNCT00669084
• Malaria Studies in CambodiaCompletedNCT00663546
• ICC-1132 - Candidate Vaccine Against P Falciparum MalariaCompletedNCT00587249Phase 1
• Malaria Incidence in Infants in Bancoumana, MaliCompletedNCT00508417
• Phase 1 Study of the Safety, Reactogenicity, and Immunogenicity of AMA1-C1/ISA 720: Blood Stage Vaccine for Plasmodium FalciparumCompletedNCT00487916Phase 1
• Medical Implications of Coinfection With Malaria and Filariasis ParasitesCompletedNCT00471666
• Normal Immunological Parameters Among Healthy Volunteers in Kambila, MaliCompletedNCT00471302
• Plasmodium Resistance in A. GambiaeCompletedNCT00466557
• Phase I Study of AMA1-C1/Alhydrogel® (Registered Trademark) + CPG 7909 Malaria VaccineCompletedNCT00427167Phase 1
• Phase I Study of Safety and Immunogenicity of AMA1-C1Alhydrogel + CPG 7909 Vaccine for MalariaCompletedNCT00414336Phase 1
• Malaria Transmission and Immunity in Highland KenyaCompletedNCT00393757
• Congenital and Neonatal Malaria in MaliCompletedNCT00384267
• CS DNA MVA Trial in Mampong, GhanaWithdrawnNCT00377494Phase 1
• Adenovirus Vaccine for MalariaCompletedNCT00371189Phase 1
• Study of Factors Involved in Resistance to Severe MalariaCompletedNCT00368810
• Relationship Between HIV and Malaria in Ugandan ChildrenCompletedNCT00356824
• Safety and Immunogenicity of EBA-175 RII-NG Malaria Vaccine Administered IntramuscularlyCompletedNCT00347555Phase 1
• Analysis of the Immune Response to the Malaria Parasite in Mali, West AfricaCompletedNCT00346346