Malaria, Vivax clinical trials
The registry lists 123 studies for Malaria, Vivax across more than 10 countries. 19 are recruiting or about to start. 95 of them are mainly about Malaria, Vivax (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-22.
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Who runs them
University of Oxford (23) · Menzies School of Health Research (11) · GlaxoSmithKline (9) · Medicines for Malaria Venture (5) · Malaria Vaccine and Drug Development Center (5) · London School of Hygiene and Tropical Medicine (5) · Centers for Disease Control and Prevention (4) · Fundação de Medicina Tropical Dr. Heitor Vieira Dourado (4)
What is being tested here
Drugs under test in Malaria, Vivax studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 9, phase 3 first
- Nov 2026Plasmodium Immunotherapy for Advanced Ovarian Cancer · Phase 3 · CAS Lamvac (Guangzhou) Biomedical Technology Co., Ltd.
- Dec 2026Postpartum 8-aminoquinoline Breast Milk Study · Phase 3 · Curtin University
- Mar 2027A Revised Tafenoquine Dose to Improve Radical Cure for Vivax Malaria · Phase 3 · Menzies School of Health Research
- Apr 2027Serological Testing and Treatment for Plasmodium Vivax Malaria: a Trial in Ethiopia and Madagascar · Phase 3 · London School of Hygiene and Tropical Medicine
- May 2027FocaL Mass Drug Administration for Vivax Malaria Elimination · Phase 3 · University of California, San Francisco
- May 2027An Interventional Study to Compare the Efficacy and Safety of Tafenoquine (TQ) and Primaquine (PQ) When Either Are Taken Together With Chloroquine (CQ) for the Treatment of P. Vivax Malaria in Indian Participants Aged 2 Years and Older · Phase 3 · GlaxoSmithKline
- Dec 2026Investigating the Pharmacology of Tafenoquine in Papua New Guinean Children With Uncomplicated Malaria · Curtin University
- Jul 2027Phase IIa/b Trial of PvCS/Montanide ISA-51 Malaria Vaccine in Adults in Chocó, Colombia · Malaria Vaccine and Drug Development Center
- Oct 2027Southeast Asia Dose Optimization of Tafenoquine · University of Oxford
Who these studies take
Of the 9 Malaria, Vivax studies recruiting now, 6 (67%) set no upper age limit and 3 (33%) stop at 75 or younger. 5 (56%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 2 (22%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 5 (56%) | 5 (56%) |
| 18 | 8 (89%) | 8 (89%) |
| 30 | 8 (89%) | 8 (89%) |
| 40 | 8 (89%) | 8 (89%) |
| 50 | 8 (89%) | 8 (89%) |
| 65 | 7 (78%) | 7 (78%) |
| 75 | 6 (67%) | 6 (67%) |
| 85 | 6 (67%) | 6 (67%) |
Across all 123 studies, recruiting or not: 42% stop at 75 or younger and 38% at 65; 59% take children; 5% are for women only and 2% for men only; 33% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Malaria, Vivax studies take
Of 14 interventional studies with no phase under Malaria, Vivax, half reached primary completion within 26 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 26 mo16–56 · 14 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
Studies
Recruiting first, then most recently updated. Showing 50 of 123. Browse all 123 → or search them.
- Safety and Immunogenicity of the Recombinant Malaria Vaccines in Healthy Adults Aged 18-50 YearsNot yet recruitingNCT07831226Phase 11 country
- This is a Clinical Study to Assess Whether the Combination of SJ733 and Tafenoquine Will be a Safe and Rapidly Acting Anti-malarial for the Radical Cure of P. Vivax MalariaNot yet recruitingNCT07430592Phase 21 country
- Southeast Asia Dose Optimization of TafenoquineRecruitingNCT04704999Phase 45 countries
- An Interventional Study to Compare the Efficacy and Safety of Tafenoquine (TQ) and Primaquine (PQ) When Either Are Taken Together With Chloroquine (CQ) for the Treatment of P. Vivax Malaria in Indian Participants Aged 2 Years and OlderRecruitingNCT06666491Phase 31 country
- Tafenoquine Drug Levels in Small ChildrenNot yet recruitingNCT07835321Phase 22 countries
- Serological Testing and Treatment for Plasmodium Vivax Malaria: a Trial in Ethiopia and MadagascarRecruitingNCT06923592Phase 32 countries
- FocaL Mass Drug Administration for Vivax Malaria EliminationRecruitingNCT05690841Phase 31 country
- Tafenoquine Combinations for Improved Radical Cure Efficacy of Plasmodium VivaxNot yet recruitingNCT07533136Not applicable1 country
- Tafenoquine and ACTs (TADORE- Plus)Not yet recruitingNCT07060794Phase 4
- Postpartum 8-aminoquinoline Breast Milk StudyNot yet recruitingNCT07060404Phase 2/31 country
- Investigating the Pharmacokinetics of Tafenoquine in Healthy Papua New Guinean ChildrenRecruitingNCT07052162Phase 41 country
- Primaquine for Vivax Malaria in G6PD Intermediate and Deficient Cases.RecruitingNCT07468513Phase 43 countries
- Investigating the Pharmacology of Tafenoquine in Papua New Guinean Children With Uncomplicated MalariaNot yet recruitingNCT07403643Phase 41 country
- Phase IIa/b Trial of PvCS/Montanide ISA-51 Malaria Vaccine in Adults in Chocó, ColombiaNot yet recruitingNCT07373301Phase 21 country
- Clinical Trial to Evaluate the Safety and Immunogenicity of the Vivaxin Vaccine for Malaria Caused by Plasmodium Vivax."Not yet recruitingNCT07172724Phase 11 country
- A Revised Tafenoquine Dose to Improve Radical Cure for Vivax MalariaRecruitingNCT06148792Phase 34 countries
- ACT vs CQ With Tafenoquine for P. Vivax Mono-infectionRecruitingNCT05788094Phase 41 country
- Plasmodium Immunotherapy for Advanced Ovarian CancerNot yet recruitingNCT05924776Phase 2/31 country
- Plasmodium Immunotherapy for Lung CancerRecruitingNCT02786589Phase 1/21 country
- Short Course Primaquine for the Radical Cure of P. Vivax - Papua New GuineaCompletedNCT05874271Not applicable1 country
- Efficacy of Chloroquine-Primaquine Treatment for Uncomplicated Plasmodium Vivax MalariaCompletedNCT07753967Not applicable1 country
- Rigorous Assessment of P. Vivax Relapses and Primaquine Efficacy for Radical CureCompletedNCT04706130Phase 41 country
- Targeting High Risk Populations With Enhanced Reactive Case Detection in Southern Lao Peoples Democratic RepublicWithdrawnNCT04416945Not applicable1 country
- Targeting High Risk Populations With Enhanced Reactive Focal Mass Drug Administration in ThailandCompletedNCT05052502Not applicable1 country
- Radical Cure (RC) With Tafenoquine or Primaquine After Semi-quantitative G6PD Testing: A Feasibility Study in PeruCompletedNCT053614861 country
- Safety and Immunogenicity of Pvs25-IMX313/Matrix-M1 VaccineTerminatedNCT05270265Early Phase 11 country
- Short Course Primaquine for the Radical Cure of P. Vivax Malaria - IndonesiaCompletedNCT05879224Not applicable1 country
- Vivax Elimination With Tafenoquine (VET) StudyCompletedNCT06575647Phase 41 country
- Radical CUREfor MAlaria Among Highly Mobile and Hard-to-reach Populations in the Guyanese ShieldCompletedNCT05540470Not applicable2 countries
- VAC069: A Study of Blood-stage Controlled Human P. Vivax InfectionCompletedNCT03797989Early Phase 11 country
- Study to Evaluate Primaquine for Radical Cure of Uncomplicated Plasmodium Vivax Malaria in ChildrenCompletedNCT05044637Phase 21 country
- Safety and Efficacy of Different Regimens of Primaquine on Vivax Malaria Treatment in G6PD Deficient PatientsCompletedNCT03529396Phase 21 country
- Safety, Immunogenicity and Efficacy of the Blood-stage Plasmodium Vivax Malaria Vaccine Candidate PvDBPII in Matrix M1CompletedNCT04201431Phase 1/21 country
- Effectiveness of Novel Approaches to Radical Cure With Tafenoquine and PrimaquineCompletedNCT04411836Phase 34 countries
- Short Course Radical Cure of P. Vivax Malaria in NepalCompletedNCT04079621Phase 41 country
- Efficacy of Focal Primaquine Mass Administration for Eliminating Plasmodium Vivax Malaria in Northern MyanmarActive, not recruitingNCT06392152Not applicable1 country
- VAC071: A Study to Assess Efficacy of the ChAd63/MVA PvDBP VaccinesCompletedNCT04009096Phase 21 country
- Tafenoquine and Primaquine in Colostrum and Breast MilkWithdrawnNCT04984759Phase 41 country
- Efficacy of SJ733 in Adults With Uncomplicated Plasmodium Falciparum or Vivax MalariaCompletedNCT04709692Phase 21 country
- Reducing the Risk of P. Vivax After Falciparum Infections in Co-endemic AreasCompletedNCT03916003Phase 43 countries
- Phenotyping and Genotyping of Duffy AntigenCompletedNCT055271191 country
- Operational Feasibility of Appropriate Plasmodium Vivax Radical Cure After G6PD Testing in ThailandCompletedNCT057531501 country
- Therapeutic Efficacy of Chloroquine Plus Primaquine in the Treatment of Uncomplicated Plasmodium VivaxCompletedNCT06044805Phase 41 country
- Combination Momordica Charantia Extract and Primaquine Againts Plasmodium Falciparum Uncomplicated and Plasmodium Vivax Uncomplicated Treatment in Manokwari, West PapuaCompletedNCT06036030Phase 21 country
- TES of Chloroquine for Pv in the Philippines in 2016CompletedNCT05958797
- TES of Artemether-lumefantrine for Pf and Chloroquine for Pv in the Philippines From 2013-2014CompletedNCT04222088
- Study of Controlled Human Plasmodium Vivax InfectionCompletedNCT03377296Not applicable1 country
- Operational Feasibility of Appropriate Radical Cure of Plasmodium Vivax With Tafenoquine or Primaquine After Quantitative G6PD Testing in BrazilActive, not recruitingNCT050967021 country
- DHA-PQP vs Chloroquine and Primaquine for Radical Cure of Vivax Malaria in BrazilCompletedNCT03208907Phase 31 country
- Primaquine Double Dose for Radical Cure of Plasmodium Vivax in ColombiaWithdrawnNCT05232227Phase 2/3