U.S. Army Medical Research and Development Command: Malaria trials

The registry lists 37 Malaria studies with U.S. Army Medical Research and Development Command as lead sponsor. 0 are open to participants now and 18 have results posted.

Early Phase 1 1Phase 1 25Phase 2 17No phase 2(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Evaluate the Infectivity Equivalence of Current and New Lots of Plasmodium Falciparum Strain NF54CompletedNCT03882528Phase 1Results posted
• Evaluate the Safety and Efficacy of Plasmodium Falciparum Malaria Protein 010 (FMP010) Administered With Adjuvant AS01BCompletedNCT02458092Phase 1Results posted
• Trial of a Falciparum Malaria Protein (FMP012), E. Coli-expressed PfCelTOS, in Healthy Malaria-Naive AdultsCompletedNCT01540474Phase 1Results posted
• Study to Evaluate the Efficacy and Safety of Tafenoquine for the Treatment of Plasmodium Vivax in AdultsTerminatedNCT01290601Phase 2Results posted
• Study of VMP001 and AS01B (Adjuvant Formulation) in Healthy Malaria-Naïve AdultsCompletedNCT01157897Phase 1/2Results posted
• Weekly Dosing of Malarone ® for Prevention of MalariaCompletedNCT00984256Phase 2Results posted
• Phase II AMA-1 Malaria Vaccine FMP2.1/AS02A Trial in MaliCompletedNCT00460525Phase 2Results posted
• NMRC-M3V-Ad-PfCA Vaccine - Clinical Trial 1CompletedNCT00392015Phase 1/2Results posted
• Phase I Pediatric FMP2.1/AS02A Trial in MaliCompletedNCT00358332Phase 1Results posted
• FMP2.1/AS02A: Rabies Vaccine Malaria-Experienced Adults in Bandiagara, MaliCompletedNCT00349713Phase 1Results posted
• Phase 1 Trial of a Malaria Vaccine in Young Kenyan ChildrenCompletedNCT00317473Phase 1Results posted
• Phase I/II Trial of a Malaria Vaccine in Adults Living in the United States of AmericaCompletedNCT00312702Phase 1/2Results posted
• Phase I/II Trial of a Malaria Vaccine in Adults Living in the United States of AmericaCompletedNCT00312663Phase 1/2Results posted
• Safety Study of Candidate Malaria Vaccine FMP1/AS02A in Healthy Adults in Bandiagara, MaliCompletedNCT00308061Phase 1Results posted
• Safety and Efficacy Study of IV Artesunate to Treat MalariaCompletedNCT00298610Phase 2Results posted
• Study of the Safety of Intravenous ArtesunateCompletedNCT00292942Phase 1Results posted
• Double-blind, Randomized, Controlled Study of Safety, Immunogenicity and Efficacy of a Candidate Malaria VaccineCompletedNCT00223990Phase 2Results posted
• Safety, Immunogenicity of RTS,S/AS02A, and RTS,S/AS01B Malaria Vaccines in Malaria-experienced Adults.CompletedNCT00197054Phase 2Results posted
• A Trial For The Study of Falciparum Malaria Protein 014 Administered Via Intramuscular Injection in Healthy AdultsStatus unknownNCT04296279Phase 1
• A Trial For The Study of Falciparum Malaria Protein 013 Administered Via Intramuscular Injection in Healthy AdultsStatus unknownNCT04268420Phase 1
• A Clinical Trial to Evaluate Plasmodium Falciparum 7G8 and NF54 Challenge Strains (PfSPZ) in a Head-to-head Comparative Study - (ECG-CHMI)WithdrawnNCT04203186Not applicable
• Study Assessing Pharmacokinetics and Bioavailability of Three Novel Triazine CompoundsCompletedNCT03436160Early Phase 1
• Trial to Evaluate the Safety, Immunogenicity, and Efficacy of Malaria Infection in Malaria Naïve AdultsCompletedNCT03341754Phase 1
• Chloroquine (CQ) and Azithromycin (AZ) Combination for Malaria ProphylaxisWithdrawnNCT03278808Phase 2
• Evaluation of Weekly TafenoquineCompletedNCT02491606Phase 2
• A Randomized, Double-blind, Placebo-controlled Evaluation of Increasing Doses of Weekly Tafenoquine for Chemosuppression of Plasmodium FalciparumCompletedNCT02488902Phase 2
• Phase 1 Clinical Trial With Controlled Human Malaria Infection (CHMI) to Evaluate the Safety and Efficacy of the Plasmodium Falciparum Vaccine Candidate FMP012 Administered Intramuscularly With AS01B Adjuvant System in Healthy Malaria-Naïve AdultsCompletedNCT02174978Phase 1
• Immunization Via Mosquito Bite With Radiation-attenuated SporozoitesCompletedNCT01994525Phase 1
• A Phase I Clinical Trial Immunizing Healthy Adults With the NMRC-M3V-Ad-PfCA Vaccine to Generate Biologic ReagentsWithdrawnNCT01843491Phase 1
• Safety and Preliminary Efficacy of the Malaria Vaccine Candidates Falciparum Merozoite Protein-1 (FMP1) and SmithKlineBeecham (SKBB) Candidate Malaria Vaccine RTS,SCompletedNCT01556945Phase 1/2
• Clinical Trial for the Development of a Safe Malaria Challenge Model That Can be Reproduced in HumansCompletedNCT00935623Phase 1
• Clinical Trial for Malaria Vaccines to Test for Safety, Immune Response and Protection Against MalariaCompletedNCT00870987Phase 1/2
• Merozoite Surface Protein 1 Antibody Response in Asymptomatic Human Malaria InfectionCompletedNCT00761020Not applicable
• A Study to Determine the Effects of an Investigational Malaria Vaccine Given to Adults Living in the United States and Thereafter to Adults Living in KenyaCompletedNCT00666380Phase 1
• A Study to Determine Whether 2 Investigational Malaria Vaccines Are Safe, Protective Against Malaria in AdultsCompletedNCT00385047Phase 1/2
• Study of the Safety of Intravenous ArtesunateCompletedNCT00292929Phase 1
• Safety and Efficacy Study of RTS,S AS02A/AS01B Vaccine to Prevent MalariaCompletedNCT00075049Phase 1/2