Hypothyroidism clinical trials
The registry lists 217 studies for Hypothyroidism across more than 10 countries. 50 are recruiting or about to start. 156 of them are mainly about Hypothyroidism (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-09. Counting its narrower condition Congenital Hypothyroidism too: 242 studies, 58 open.
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· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
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Who runs them
Assiut University (13) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (6) · Seoul National University Bundang Hospital (4) · Sohag University (4) · University of Pennsylvania (3) · HaEmek Medical Center, Israel (3) · Cairo University (3) · Newcastle-upon-Tyne Hospitals NHS Trust (2)
What is being tested here
Drugs under test in Hypothyroidism studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Sep 2027A Study to Assess the Safety and Efficacy of Oral Armour Thyroid Compared to Synthetic T4 for the Treatment of Primary Hypothyroidism in Adult Participants · Phase 3 · AbbVie
- Nov 2027An Open-Label, Single-Arm Study to Investigate the Efficacy and Safety of North Star Desiccated Porcine Thyroid Extract Tablets. · Phase 3 · Neuvosyn Laboratories, LLC
- Nov 2026Study of Chronic Fatigue, Depression, and Anxiety Among Hypothyroid Patients Attending Assuit University Hospitals · Assiut University
- Nov 2026Effect of Medication Adherence-Based Digital Intervention on Fatigue Severity, Weight, and Thyroid Hormone Regulation · University of Baghdad
- Dec 2026Comparison of Two Timings of Levothyroxine Intake in Hypothyroid Patients: A Cross-over Randomized Control Trial · Elyes Kamoun
- Dec 2026Patient-centered Dosage of Levothyroxine · University Hospital of North Norway
- Dec 2026Impact of Subclinical Hypothyroidism on Liver Enzymes and Lipid Profile · Assiut University
- Dec 2026Infants With Primary Congenital Hypothyroidism and Development · Nigde Omer Halisdemir University
- Dec 2026Evaluation of Levothyroxine Replacement Therapy After Total Thyroidectomy Using a Smart Wristband · Yeditepe University Hospital
- Dec 2026Comorbidities Resolution After MGB Surgery and Change in Body Composition · All India Institute of Medical Sciences, Bhubaneswar
Who these studies take
Of the 32 Hypothyroidism studies recruiting now, 14 (44%) set no upper age limit and 11 (34%) stop at 75 or younger. 9 (28%) take children under 18. 2 (6%) are for women only and 1 (3%) for men only; 3 (9%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 6 (19%) | 7 (22%) |
| 18 | 23 (72%) | 23 (72%) |
| 30 | 25 (78%) | 25 (78%) |
| 40 | 26 (81%) | 25 (78%) |
| 50 | 25 (78%) | 25 (78%) |
| 65 | 24 (75%) | 24 (75%) |
| 75 | 23 (72%) | 23 (72%) |
| 85 | 19 (59%) | 18 (56%) |
Across all 217 studies, recruiting or not: 50% stop at 75 or younger and 35% at 65; 19% take children; 18% are for women only and 2% for men only; 20% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Hypothyroidism studies take
Of 42 observational studies under Hypothyroidism, half reached primary completion within 31 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 29 mo11–… · 27 studies | — | — |
| Observational | 31 mo15–47 · 42 studies | — | 28 mo15–47 · 38 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 12, 2026.
Newly registered3
- Validation of Uzbek SARC-F and IPAQ-SF Questionnaires in Adults With and Without HypothyroidismNov 6, 2026NCT07923136
- Comparison of Two Timings of Levothyroxine Intake in Hypothyroid Patients: A Cross-over Randomized Control TrialOct 28, 2026NCT07900737
- Prevalence and Associated Factors of High BMI and Periodontitis in Thai Adults Aged Under 60 YearsOct 19, 2026NCT07880717
Studies
Recruiting first, then most recently updated. Showing 50 of 217. Browse all 217 → or search them.
- Clinical and Basic Investigations Into Known and Suspected Congenital Disorders of GlycosylationRecruitingNCT020897891 country
- Natural History of Thyroid Function DisordersRecruitingNCT000011591 country
- Validation of Uzbek SARC-F and IPAQ-SF Questionnaires in Adults With and Without HypothyroidismNot yet recruitingNCT07923136
- Prevalence and Associated Factors of High BMI and Periodontitis in Thai Adults Aged Under 60 YearsRecruitingNCT078807171 country
- Evaluation of Levothyroxine Replacement Therapy After Total Thyroidectomy Using a Smart WristbandRecruitingNCT07733375Not applicable1 country
- Impact of Overt and Subclinical Hypothyroidism on Liver Fibrosis in Patients With MASLDNot yet recruitingNCT07827430
- Optimizing Care for Older Adults Through Thyroid Hormone DeprescribingRecruitingNCT06629272Not applicable1 country
- Internal Organ and Musculoskeletal Assessment in Hypothyroidism (HYPOMORPH)RecruitingNCT077078301 country
- Hypothyroidism and Liver Fibrosis Severity in MASLDNot yet recruitingNCT07793279
- Discontinuation of Low-Dose Levothyroxine in Older Adults With Subclinical HypothyroidismNot yet recruitingNCT07787585Phase 41 country
- Vitamin E Add-On Therapy, Thyroid Function & Oxidative Stress in Levothyroxine-Treated HypothyroidismEnrolling by invitationNCT07781514Not applicable1 country
- T4/T3 Therapy in HypothyroidismNot yet recruitingNCT07424183Phase 21 country
- An Open-Label, Single-Arm Study to Investigate the Efficacy and Safety of North Star Desiccated Porcine Thyroid Extract Tablets.RecruitingNCT07747103Phase 31 country
- Natural History of Sphingosine Phosphate Lyase Insufficiency Syndrome (SPLIS)RecruitingNCT066699491 country
- Effect of Medication Adherence-Based Digital Intervention on Fatigue Severity, Weight, and Thyroid Hormone RegulationNot yet recruitingNCT07636681Not applicable1 country
- Association Between Overt and Sub-clinical Primary Hypothyroidism and Metabolic Dysfunction-Associated Steatoic Liver Disease in Non-Diabetic PatientsRecruitingNCT076038171 country
- ThyMoves: Screening and Exercise to Improve Muscle, Enhance Quality of Life, and Reduce Fall Risk in Thyroid DiseaseEnrolling by invitationNCT06960005Not applicable1 country
- Novel Approaches to the Treatment of HypothyroidismRecruitingNCT06731764Phase 2/31 country
- Physical Activity, Fatigue, Social Support, and Psychological Well-Being in Women With Primary HypothyroidismRecruitingNCT074087651 country
- Dosing of LT4 in Older IndividualsRecruitingNCT06073665Phase 41 country
- SNUH Immune Checkpoint Inhibitor-induced Hypothyroidism Recovery TrialRecruitingNCT07421869Not applicable1 country
- Comorbidities Resolution After MGB Surgery and Change in Body CompositionRecruitingNCT060156201 country
- Infants With Primary Congenital Hypothyroidism and DevelopmentRecruitingNCT072801041 country
- Levothyroxine Treatment on Cardiac Function in Children With Subclinical HypothyroidismRecruitingNCT07393165Not applicable1 country
- Thyroid Hormone Replacement After Coronary Artery Bypass Grafting for Patients With Subclinical HypothyroidismRecruitingNCT07380854Not applicable1 country
- Ayurvedic Diet in MyxedemaRecruitingNCT07323706Not applicable1 country
- Impact of Subclinical Hypothyroidism on Liver Enzymes and Lipid ProfileNot yet recruitingNCT072366971 country
- Walking for Hypothyroidism Trial (WHT)Not yet recruitingNCT07205042Not applicable1 country
- Improvement of Laboratory Diagnostics in Hypothyroid Patients Using LevothyroxineRecruitingNCT060836361 country
- Periodization Resistance Training on Quality of Life in Females With HypothyroidismRecruitingNCT06757712Not applicable1 country
- Patient-centered Dosage of LevothyroxineRecruitingNCT06455371Not applicable1 country
- A Randomized Controlled Trial of Thyroid Hormone Supplementation in Hemodialysis PatientsRecruitingNCT03977207Not applicable1 country
- Thyroid Function and Structure in Klinefelter SyndromeRecruitingNCT055811471 country
- Study of Chronic Fatigue, Depression, and Anxiety Among Hypothyroid Patients Attending Assuit University HospitalsEnrolling by invitationNCT066608881 country
- Evaluation of Different Diagnostic Therapeutic Strategies in Patients with Thyroid PathologyRecruitingNCT067797471 country
- Hypothyroidism After the TAVI Procedure in Elderly PatientsRecruitingNCT04831957Not applicable1 country
- Quest to Analyze One Thousand Humans MeditatingEnrolling by invitationNCT065833951 country
- Register for Patients With Thyroid Hormone Resistance.RecruitingNCT065660661 country
- Recovery Rate in Secondary HypothyroidismRecruitingNCT052768561 country
- Efficacy and Safety of Catheter Ablation of Atrial Fibrillation in Patients With Thyroid Hormone StabilizationEnrolling by invitationNCT064528231 country
- The Protection of Thyroid Function in IMRT for Nasopharyngeal CarcinomaRecruitingNCT06268600Not applicable1 country
- Throid Dysfunction in Liver Failure and Its Eddects Upon OutcomeRecruitingNCT061793681 country
- Effect of Vitamin C Supplementation in Patients With Primary HypothyroidismRecruitingNCT05733078Phase 21 country
- TSH Suppression During Radiotherapy on Thyroid Site to Prevent Iatrogenic Hypothyroidism in Pediatric Cancer PatientsRecruitingNCT05316922Phase 31 country
- Effect of Life Style Modification and Metformin on Hypothyroidism With Insulin ResistanceNot yet recruitingNCT06096454Phase 4
- Factors Affecting Timing of Hypothyroidism Following Radioactive Iodine Therapy Patients With Graves DiseaseRecruitingNCT056433651 country
- The Effects of an Anti-inflammatory Diet With or Without Curcumin Supplementation on Anthropometric Measurements, Concentrations of Thyroid Hormones, Anti-TPO, and Systemic Inflammation in Plasma and NFK-B in Peripheral Blood Mononuclear Cells in Patients With HashimatoNot yet recruitingNCT05975866Not applicable1 country
- Awareness of Osteoporosis in Patients With HypothyroidismNot yet recruitingNCT05760131
- Screening of Subclinical Hypothyroidism in Pregnant WomenNot yet recruitingNCT05801822
- Early Detection of Endolymphatic Hydrops in Hypothyroid PatientsNot yet recruitingNCT05334771