ClinicalTrials.gg
Not yet recruitingNCT07636681Updated Jun 9, 2026

Effect of Medication Adherence-Based Digital Intervention on Fatigue Severity, Weight, and Thyroid Hormone Regulation

An interventional study of medication adherence based digital intervention in Hypothyroidism, sponsored by University of Baghdad. Not yet recruiting at 1 site in Iraq. Open to participants aged 18 Years to 60 Years. Per ClinicalTrials.gov, last updated 2026-06-09.

Sponsored by University of Baghdad · Not applicable, Interventional, and Supportive care

Phase
Not applicable
Study type
Interventional
Enrollment
80
Allocation
Randomized
Ages
18 Years to 60 Years
Sex
All
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Study summary

  1. To evaluate the effect of a medication adherence-based digital intervention on fatigue severity in patients with hypothyroidism.
  2. To assess the effect of a medication adherence-based digital intervention on weight in patients with hypothyroidism.
  3. To investigate the effect of a medication adherence-based digital intervention on thyroid hormone regulation in patients with hypothyroidism.
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Conditions studied

  • Hypothyroidism

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03

In context

Hypothyroidism

217 studies on the registry are indexed under Hypothyroidism; 50 are open to participants now.

This study's planned enrollment of 80 is above the median of 70 across 109 interventional studies indexed under Hypothyroidism.

Browse Hypothyroidism studies →

Lead sponsor

University of Baghdad is the lead sponsor of 170 studies on the registry; 69 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years to 60 Years
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Adults (≥18 years) with primary hypothyroidism.
  • On stable levothyroxine therapy for at least 3 months.
  • Able to read, understand study instructions
  • capable of using basic mobile applications
  • poor medication adherence, fatigue, documented weight fluctuations and abnormal thyroid hormone

Exclusion criteria

Exclusion Criteria:

  • Secondary hypothyroidism or recent thyroidectomy/radioactive iodine therapy.
  • Pregnancy or breastfeeding woman.
  • Severe psychiatric disorders or cognitive impairment
  • significant visual or hearing deficits
  • Serious comorbidities affecting medication adherence (e.g., chronic disease, renal, or hepatic disease).
  • take dietary supplements or medications that interfere with levothyroxine absorption.
Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Clinically significant

Judged by the study doctor to matter for your health or for the study. It is a doctor’s decision, so ask the study team if you are unsure whether something counts.

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Study design

Phase
Not applicable
Primary purpose
Supportive care
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Participant)
Enrollment
80 participants (estimated)

Study arms

  • No intervention
    Control Group

    receive routine care

  • Experimental
    Intervention Group

    participants in the intervention group will receive digital support aimed at improving their adherence to prescribed medications. This support will include a smartphone application developed specifically for the study, as well as reminder messages via WhatsApp to prompt participants to take their levothyroxine at the scheduled times

    Other: medication adherence based digital intervention

Interventions

  • Othermedication adherence based digital intervention

    participants in the intervention group will receive digital support aimed at improving their adherence to prescribed medications. This support will include a smartphone application developed specifically for the study, as well as reminder messages via WhatsApp to prompt participants to take their levothyroxine at the scheduled times

    Also known as: intervntion group

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What researchers measure

Primary outcomes

  1. Change in Fatigue Severity Score

    Assessment of the effectiveness of a medication adherence-based digital intervention on fatigue severity by using the Fatigue Severity Scale (FSS).

    Time frame: Baseline and 3 months after intervention

  2. Change in Body Weight

    Assessment of the effectiveness of a medication adherence-based digital intervention on weight by assessment of changes in Body Mass Index (BMI), calculated as weight in kilograms divided by height in meters squared (kg/m²).

    Time frame: Baseline and 3 months after intervention.

  3. Change in Thyroid Hormone Levels

    Assessment of the effectiveness of a medication adherence-based digital intervention on Thyroid Hormone Levels by assessment of serum Thyroid Stimulating Hormone (TSH) and Free Thyroxine (FT4) levels.

    Time frame: Baseline and 3 months after intervention.

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Study locations

1 site
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References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jun 9, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT07636681
Responsible party
Shahad Sabah Khudhair (PhD Student, University of Baghdad) — Principal investigator
First posted
Jun 9, 2026
Start date
Jun 1, 2026 (estimated)
Primary completion
Nov 30, 2026 (estimated)
Completion
Dec 30, 2026 (estimated)
Last update
Jun 9, 2026

Study contacts

Shahad Sabah Khudhair
Contact
shahed.sabbah1202a@conursing.uobaghdad.edu.iq
9647737721360

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is not yet recruiting, as verified in May 2026. You cannot join it, but the record below documents what was studied.

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