Drug
Thyroxine clinical trials
Also written Synthroid, Levothyroxin and Euthyrox.
- studies test it
- 114
- open now
- 20
- in phase 3
- 20
- first study started
- 2002
Keep track of what changes. Save the Thyroxine studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Development codes
Other names
- T4
- 1
Studies by the year they started
114 studies that test it; most in 2015 (9)
| Year | Studies |
|---|---|
| 2002 | 1 |
| 2003 | 6 |
| 2004 | 4 |
| 2005 | 4 |
| 2006 | 4 |
| 2007 | 3 |
| 2008 | 1 |
| 2009 | 2 |
| 2010 | 2 |
| 2011 | 5 |
| 2012 | 4 |
| 2013 | 6 |
| 2014 | 8 |
| 2015 | 9 |
| 2016 | 6 |
| 2017 | 4 |
| 2018 | 2 |
| 2019 | 4 |
| 2020 | 5 |
| 2021 | 8 |
| 2022 | 6 |
| 2023 | 3 |
| 2024 | 7 |
| 2025 | 7 |
| 2026 | 3 |
By phase
A phase 1/2 study counts in both.
- Early Phase 1
- 2
- Phase 1
- 17
- Phase 2
- 13
- Phase 3
- 20
- Phase 4
- 36
- No phase
- 33
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 16 · Other 98
Insel Gruppe AG, University Hospital Bern (6) · Mylan Pharmaceuticals Inc (4) · Ain Shams University (3) · Shandong Provincial Hospital (3) · VA Office of Research and Development (2) · Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany (2) · IBSA Institut Biochimique SA (2) · University of Pennsylvania (2)
Often tested with
Tested in the same studies.
Triiodothyronine (8) · Thyroid (USP) (2) · MK-0616 (1) · Methylprednisolone (1) · Glyburide (1) · Digoxin (1) · Colesevelam (1) · Semaglutide (1)
Studies
Open first, then newest update. How each study uses Thyroxine is read from its arms, and is right about nine times in ten.
Testing it · 114
- Effect of HCQ Combined With LT4 on LBR in Euthyroid Women With URPL and TPO-AbRecruitingNot applicableSun Yat-Sen Memorial Hospital of Sun Yat-Sen UniversityNCT06652113Written as hydroxychloroquine and levothyroxine
- Levothyroxine Supplementation for Heart Transplant RecipientsRecruitingPhase 1University of California, San FranciscoNCT06428097Written as Levothyroxine
- Thyroxine Supplementation in Small for Gestational Age (SGA) Infants With Birth Weight <1500g and TSH 6-20 mIU/mlNot yet recruitingNot applicableShandong Provincial HospitalNCT07625722Written as Levothyroxine Sodium (LT4) Tablets
- Impact of Medically Supervised Performance-Enhancing Substances (PES) on Elite AthletesEnrolling by invitationNot applicableEnhanced Emirates LimitedNCT07568574Written as Levothyroxine
- Thyroid Hormone for Treatment of Nonalcoholic Steatohepatitis in VeteransRecruitingPhase 2VA Office of Research and DevelopmentNCT05526144Written as Synthroid
- Dosing of LT4 in Older IndividualsRecruitingPhase 4University of PennsylvaniaNCT06073665Written as Levothyroxine Sodium
- COACH - Comparing Two Different Methods to Suppress Thyrotropin in Patients With Advanced Thyroid CancerNot yet recruitingPhase 2AHS Cancer Control AlbertaNCT06790589Written as Levothyroxine Oral Tablet [Synthroid]
- Levothyroxine Treatment on Cardiac Function in Children With Subclinical HypothyroidismRecruitingNot applicableTanta UniversityNCT07393165Written as L-thyroxine
- Thyroid Hormone Replacement After Coronary Artery Bypass Grafting for Patients With Subclinical HypothyroidismRecruitingNot applicableSeoul National University Bundang HospitalNCT07380854Written as levothyroxine
- Levothyroxine as Adjuvant to a Hypocaloric Diet for the Treatment of Obesity.RecruitingPhase 3Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y SaludNCT07332273Written as Levothyroxine
- Desiccated Thyroid Extract Combined With Levothyroxine for TSH Suppression Therapy in DTCNot yet recruitingPhase 3West China HospitalNCT07239674Written as desiccated thyroid extract (DTE)+levothyroxine (L-T4)
- A Randomized Controlled Trial of Thyroid Hormone Supplementation in Hemodialysis PatientsRecruitingNot applicableUniversity of California, IrvineNCT03977207Written as Levothyroxine Sodium
- Best Treatment for Women With Both (Polycystic Ovary Syndrome) PCOS and Subclinical HypothyroidismRecruitingNot applicableMuhamed Ahmed Abdelmoaty Muhamed AlhagrasyNCT06041204Written as Levothyroxine 25 Mcg (0.025 Mg) Oral Tablet
- A Clinical Trial of Adjunctive Thyroxine for Avolition in SchizophreniaNot yet recruitingEarly Phase 1Peking UniversityNCT07011953Written as Antipsychotics plus Levothyroxine Sodium
- LIGHT Trial: Levothyroxine for Gestational Hypothyroidism in Recurrent Pregnancy LossNot yet recruitingPhase 3Women's Hospital School Of Medicine Zhejiang UniversityNCT06999278Written as Levothyroxin
- Necessity of TSH Suppression Therapy in Active Surveillance for Thyroid Cancer Patients.Not yet recruitingNot applicableNational Cancer Center, KoreaNCT06971965Written as Levothyroxin
- Levothyroxine Intervention in Pregnant Women with TSH （2.5 MIU/L-upper Limit of Reference Range） and Negative Thyroid Peroxidase AntibodyNot yet recruitingPhase 4Yang ZHANGNCT06653907Written as Levothyroxine Sodium (LT4) Tablets
- Efficacy of Thyroid Hormone Replacement for Secondary Hypothyroidism Following Intracerebral HemorrhageRecruitingNot applicablePeking Union Medical College HospitalNCT06353555Written as Euthyrox
- TSH Suppression During Radiotherapy on Thyroid Site to Prevent Iatrogenic Hypothyroidism in Pediatric Cancer PatientsRecruitingPhase 3Fondazione IRCCS Istituto Nazionale dei Tumori, MilanoNCT05316922Written as Levothyroxine
- Thyroxine Replacement Therapy After Lobectomy for Low-risk Papillary Thyroid CarcinomaRecruitingPhase 2Cancer Institute and Hospital, Chinese Academy of Medical SciencesNCT06087068Written as Thyroxine
See all 114 studies that test Thyroxine →
Given in every arm · 11 — Thyroxine is usual care beside what is tested
- T4/T3 Therapy in HypothyroidismNot yet recruitingPhase 2University of PennsylvaniaNCT07424183Written as Levothyroxine Sodium (LT4) Tablets
- Novel Approaches to the Treatment of HypothyroidismRecruitingPhase 2/3UConn HealthNCT06731764Written as Levothyroxine
- MASLD in Primary Hypothyroidism and Efficacy of DapaglifozinActive, not recruitingEarly Phase 1Post Graduate Institute of Medical Education and Research, ChandigarhNCT06373523Written as Levothyroxine Replacement daily
- Sunitinib or Cediranib for Alveolar Soft Part SarcomaCompletedPhase 2National Cancer Institute (NCI)NCT01391962Written as Levothyroxine
- Vitamin D & Levothyroxine Combination Versus Levothyroxine on Lipid Profile in HypothyroidismCompletedPhase 3King Edward Medical UniversityNCT06276205Written as Levothyroxin
- Energy Metabolism in Thyroidectomized PatientsCompletedPhase 2Virginia Commonwealth UniversityNCT04782856Written as Levothyroxine
- Combined Replacement Therapy With Levothyroxine and Liothyronine in Thyroidectomized PatientsCompletedPhase 2/3Azienda USL ModenaNCT03053115Written as Levothyroxin
- Effect of Acupuncture and Low Caloric Diet on Primary Hypothyroidism and Irregular Menstruation in Infertile WomenCompletedPhase 2Cairo UniversityNCT05804149Written as Thyroxine
- Interaction Between Levothyroxine and Probiotics in Hypothyroid PatientsCompletedNot applicableAzienda USL ModenaNCT03095963Written as levothyroxin
- Adjuvant Treatment of Graves´ Ophthalmopathy With NSAID (aGO Study)CompletedPhase 4Mikael LantzNCT01458600Written as L-thyroxin
- Thyroxine Replacement in Organ DonorsCompletedPhase 1/2London Health Sciences Centre Research Institute and Lawson Research Institute of St. Joseph'sNCT00238030Written as L-thryoxine
As the comparator · 7 — what is tested is compared with Thyroxine
- A Study Evaluation the Safety and Efficacy of Hormone Replacement Therapy With North Star Compared to Levothyroxine in Patients With Primary HypothyroidismCompletedPhase 2Neuvosyn Laboratories, LLCNCT05712421Written as Levothyroxine
- The Role of Immunomodulatory Treatment in Success of ICSI in Patients With Autoimmune ThyroiditisCompletedPhase 2Aljazeera HospitalNCT03289403Written as Thyroxine
- A Study Evaluating the Safety and Efficacy of Hormone Replacement Therapy With ST-1891 Compared to Levothyroxine in Patients With Primary HypothyroidismCompletedPhase 2Sention Therapeutics, LLCNCT05412979Written as Levothyroxine
- A Study of Armour® Thyroid Compared to Synthetic T4 (Levothyroxine) in Previously Hypothyroid ParticipantsCompletedPhase 2AllerganNCT04124705Written as Levothyroxine
- Effects of Liothyronine on Energy Expenditure and Cardiovascular FunctionCompletedPhase 1/2Virginia Commonwealth UniversityNCT03098433Written as Levothyroxine
- Identification of Non-responders to Levothyroxine TherapyCompletedPhase 2Oslo University HospitalNCT03627611Written as Levothyroxin
- Thyroxine Replacement in Organ DonorsCompletedPhase 1/2London Health Sciences Centre Research Institute and Lawson Research Institute of St. Joseph'sNCT00238030Written as L-thryoxine
Codes
What other systems call Thyroxine · ClinicalTrials.gg INT008325
- MeSH (NLM) D013974ThyroxineConfirmed ClinicalTrials.gov, NLM
- UNII (FDA) Q51BO43MG4LEVOTHYROXINEConfirmed FDA, NLM, Wikidata
- RxNorm 10582Confirmed FDA, Wikidata
- Wikidata Q106345689L-thyroxine zwitterionConfirmed FDA, NLM, Wikidata
- Wikidata Q773449L-thyroxineConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C62080LevothyroxineOne source FDA
- DrugBank DB00451One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D013974 | Thyroxine | Confirmed ClinicalTrials.gov, NLM |
| UNII (FDA) | Q51BO43MG4 | LEVOTHYROXINE | Confirmed FDA, NLM, Wikidata |
| RxNorm | 10582 | — | Confirmed FDA, Wikidata |
| Wikidata | Q106345689 | L-thyroxine zwitterion | Confirmed FDA, NLM, Wikidata |
| Wikidata | Q773449 | L-thyroxine | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C62080 | Levothyroxine | One source FDA |
| DrugBank | DB00451 | — | One source Wikidata |
Also registered as levothyroxine sodium (UNII 9J765S329G · RxNorm 40144).
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.