Hyperthermia clinical trials
The registry lists 256 studies for Hyperthermia across more than 10 countries. 73 are recruiting or about to start. 93 of them are mainly about Hyperthermia (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-03.
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Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
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Status
Who runs them
University of Ottawa (16) · University of Texas Southwestern Medical Center (11) · State University of New York at Buffalo (10) · University of Connecticut (7) · Medtronic Surgical Technologies (7) · National Cancer Institute (NCI) (6) · First Hospital of China Medical University (5) · Clinical Laserthermia Systems AB (5)
What is being tested here
Drugs under test in Hyperthermia studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Hydrogen Peroxide | 2 | 0 | 2 |
| Cisplatin | 1 | 0 | 4 |
| Doxorubicin | 1 | 0 | 1 |
| Ifosfamide | 1 | 0 | 1 |
| Dacarbazine | 1 | 0 | 1 |
| Miltefosine | 0 | 2 | 2 |
| Lyso-Thermosensitive Liposome Doxorubicin | 0 | 0 | 2 |
| Misoprostol | 0 | 1 | 2 |
| Melphalan | 0 | 0 | 2 |
| Cocaine | 0 | 0 | 1 |
Drug classes tested here Alkylating agents 1 open · Antimetabolites 3
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest
- Dec 2026The Sarah Nanotechnology System for Treatment of Advanced Metastatic Solid Tumors Using Hyperthermia. · New Phase Ltd.
- Dec 2026Acute Sauna Session and Glucose Control · University of Prince Edward Island
- Dec 2026Intratumoral Targeted Hyperthermia Therapy (THT) for Cutaneous Metastatic Melanoma · Sona Nanotech Inc
- Dec 2026Randomized Controlled Clinical Trial of Hyperthermia and Hydrogen Peroxide 3% in the Treatment of Cutaneous Warts · First Hospital of China Medical University
- Dec 2026Leg Heat Therapy in Peripheral Artery Disease · Indiana University
- Dec 2026Working in the Heat at Simulated Altitude: Effects of Normobaric Hypoxia on Physiological Strain · University of Ottawa
- Jan 2027Heat Therapy During Reduced Physical Activity · Brigham Young University
- Jan 2027Heat Waves and the Elderly - Cooling Modalities · University of Texas Southwestern Medical Center
- Feb 2027Postoperative Re-irradiaTion With and Without HYPERthermia, or Surgery Only: Toxicity, Quality of Life and Survival in Patients With Locoregional Recurrent Breast Cancer · Amsterdam UMC, location VUmc
- Feb 2027NanoTherm In Adjuvant Therapy of Glioblastoma Multiforme · Poznan University of Medical Sciences
Who these studies take
Of the 50 Hyperthermia studies recruiting now, 25 (50%) set no upper age limit and 19 (38%) stop at 75 or younger. 7 (14%) take children under 18. 4 (8%) are for women only and 3 (6%) for men only; 14 (28%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 4 (8%) | 3 (6%) |
| 18 | 34 (68%) | 32 (64%) |
| 30 | 35 (70%) | 33 (66%) |
| 40 | 34 (68%) | 32 (64%) |
| 50 | 36 (72%) | 36 (72%) |
| 65 | 36 (72%) | 37 (74%) |
| 75 | 30 (60%) | 30 (60%) |
| 85 | 30 (60%) | 29 (58%) |
Across all 256 studies, recruiting or not: 46% stop at 75 or younger and 36% at 65; 15% take children; 14% are for women only and 7% for men only; 37% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Hyperthermia studies take
Of 108 interventional studies with no phase under Hyperthermia, half reached primary completion within 18 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 18 mo7–30 · 108 studies | — | 18 mo7–30 · 103 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 11, 2026.
Started recruiting1
- Thermal Therapies in the Treatment of Muscle InjuriesOct 28, 2026NCT07045129
Newly registered1
- Electrosurgical Patterns and Learning Curve in Elective Laparoscopic CholecystectomyOct 22, 2026NCT07888491
Studies
Recruiting first, then most recently updated. Showing 50 of 256. Browse all 256 → or search them.
- Rapid Cool: Heat Stroke TreatmentNot yet recruitingNCT07743619Not applicable
- Thermal Therapies in the Treatment of Muscle InjuriesRecruitingNCT07045129Not applicable1 country
- Electrosurgical Patterns and Learning Curve in Elective Laparoscopic CholecystectomyRecruitingNCT078884911 country
- Feasibility of Integrating Thermotherapy for Treatment of Cutaneous Leishmaniasis in Primary Health Care SetupRecruitingNCT06746350Not applicable1 country
- Hyperthermia With Chemoradiotherapy in Rectal CancerRecruitingNCT06831981Not applicable1 country
- Multi-site Feasibility of an Integrated Treatment for the Biology and Experience of Depression: The MULTIBED StudyNot yet recruitingNCT07596914Not applicable1 country
- Consecutive Occupational Heat Exposure With and Without Overnight CoolingRecruitingNCT07656519Not applicable1 country
- Hyperthermia in Patients With Chronic Primary Pain - Effects on Thermoregulation, Somatosensory System and Movement Evoked PainNot yet recruitingNCT07101978Not applicable1 country
- Heat Therapy During Reduced Physical ActivityRecruitingNCT07847424Not applicable1 country
- Progressive Heat Exposure and Physiological StrainNot yet recruitingNCT07847437Not applicable1 country
- Heat thErapy And mobiLity in COVID-19 SurvivorsRecruitingNCT06928116Not applicable1 country
- More Representative Vaginal Temperature Measurements With a Hyperthermia Pelotte During Hyperthermia Treatments for Gynaecological Cancer.RecruitingNCT07235540Not applicable1 country
- A Prospective Study of Concurrent Hyperthermia, Chemotherapy and Radiotherapy in Borderline and Locally Advanced Pancreatic Cancer (PANHEAT)Not yet recruitingNCT07839676Not applicable1 country
- Temperature Optimization in Afebrile Septic PatienTsRecruitingNCT07831057Not applicable1 country
- Hyperthermia Safety Study Uses Temperature Management System to Gently Raise Participant's Body Temperature to a Fever-range Level in a Controlled Setting.Enrolling by invitationNCT07564440Not applicable1 country
- TECAR Therapy in Chronic Back PainNot yet recruitingNCT07821021Not applicable
- Heat Waves and the Elderly - Cooling ModalitiesRecruitingNCT05484739Not applicable1 country
- Thermotherapy for Head and Neck Cancer PatientsRecruitingNCT07690618Phase 11 country
- IEEM- Work:Rest Cycles in Burn Survivors- HumidityRecruitingNCT069663361 country
- Randomized Controlled Clinical Trial of Hyperthermia and Hydrogen Peroxide 3% in the Treatment of Cutaneous WartsRecruitingNCT06812065Not applicable1 country
- Leg Heat Therapy in Peripheral Artery DiseaseRecruitingNCT05465070Not applicable1 country
- A Study Comparing Whole-Body Heat Treatment Plus Systemic Therapy to Systemic Therapy Alone, for Advanced Pancreatic CancerNot yet recruitingNCT07711067Phase 2/32 countries
- Postoperative Re-irradiaTion With and Without HYPERthermia, or Surgery Only: Toxicity, Quality of Life and Survival in Patients With Locoregional Recurrent Breast CancerRecruitingNCT064524851 country
- Working in the Heat at Simulated Altitude: Effects of Normobaric Hypoxia on Physiological StrainRecruitingNCT07664462Not applicable1 country
- Work Design Interventions for Heat ResilienceNot yet recruitingNCT06599788Not applicable
- Work Design Interventions for Older Workers During Consecutive Days in the HeatNot yet recruitingNCT07046026Not applicable
- Suitability of a 26 °C Indoor Environment for Mitigating Heat Strain in Young AdultsRecruitingNCT07267598Not applicable1 country
- Laboratory Heat Biomarker and Cooling InterventionsNot yet recruitingNCT07617649Not applicable1 country
- IEEM-Heat and Heart FailureRecruitingNCT06961929Not applicable1 country
- The Sarah Nanotechnology System for Treatment of Advanced Metastatic Solid Tumors Using Hyperthermia.RecruitingNCT07224464Not applicable1 country
- Home-Based Heat Therapy in Spinal Cord Injury to Improve Cardiovascular HealthRecruitingNCT07317843Not applicable1 country
- Local Hyperthermia Combined With Topical 3% Hydrogen Peroxide for Refractory Viral WartsRecruitingNCT07565350Not applicable1 country
- Healing Efficacy of Diode Laser in Lingual FrenectomyRecruitingNCT07557875Not applicable1 country
- Intratumoral Targeted Hyperthermia Therapy (THT) for Cutaneous Metastatic MelanomaNot yet recruitingNCT06870994Not applicable
- Heat Stress in Individuals With SchizophreniaRecruitingNCT07383324Not applicable1 country
- Suitability of the 26 °C Indoor Temperature Upper Limit for Older Adults: Impacts of Clothing and Daily ActivityRecruitingNCT07189507Not applicable1 country
- Impact of Indoor Overheating on Physiological Strain in ChildrenRecruitingNCT07261202Not applicable1 country
- Leg Heating in Pregnant Women With ObesityRecruitingNCT06932250Not applicable1 country
- Acute Sauna Session and Glucose ControlRecruitingNCT07520929Not applicable1 country
- Title: ICARUS - Psycho-physiological Profiling of Low and High Heat-resilient IndividualsRecruitingNCT07510061Not applicable2 countries
- Repeated Far Infrared Sauna Bathing in Adults With ObesityRecruitingNCT07158047Not applicable1 country
- The Effectiveness of Emergency Room Protocols for Treating HyperthermiaRecruitingNCT07433036Not applicable1 country
- Modulated Electro-Hyperthermia in Combination With Multimodal Therapy for Locally Advanced Rectal CancerRecruitingNCT07372300Phase 31 country
- Predicting Responses to Exhausting, Prolonged, And Repeated Exercise Demands (PREPARED) for HeatRecruitingNCT06475339Not applicable1 country
- Feasibility of Total Neoadjuvant Treatment With HYPErthermia in Patients With High-risk Extremity and Trunk Soft Tissue Sarcoma (TNT-HYPE)RecruitingNCT06835049Phase 21 country
- Cold and Heat Investigation to Lower Levels of DepressionRecruitingNCT06263738Not applicable1 country
- Hyperthermia Combined With Immune Checkpoint Inhibitors in the Treatment of Advanced Gastrointestinal Malignancies With Liver MetastasesNot yet recruitingNCT07118566Phase 2
- Analysis of Hyperthermia as an Adjunctive Treatment to Evidence-based Clinical Intervention in Subjects With Plantar Fasciitis: a Double-blind Randomized Clinical TrialNot yet recruitingNCT07103226Not applicable
- Analysis of Hyperthermia as an Adjunctive Treatment to Evidence-based Clinical Intervention in Subjects With Bursitis: a Double-blind Randomized Clinical TrialNot yet recruitingNCT07099573Not applicable
- Influence of Indoor Humidity on Physiological Strain in Older Adults During a Simulated Heat WaveRecruitingNCT06842953Not applicable1 country