An interventional study of An infrared hyperthermia device and Hydrogen Peroxide 3 % Topical Solution in Refactory Warts, sponsored by First Hospital of China Medical University. Recruiting at 2 sites in China. Per ClinicalTrials.gov, last updated 2026-05-04.
Sponsored by First Hospital of China Medical University · Not applicable, Interventional, and Treatment
Current Treatment Status Thermotherapy (44°C ± 2°C, 30 minutes per session): Studies have demonstrated that it can stimulate the activation of local immune cells (such as Langerhans cells), thereby enhancing antiviral immune responses.
Hydrogen peroxide: It possesses antibacterial properties and promotes tissue repair. In keratinocytes, it can induce thermally induced pyroptosis, thereby enhancing the efficacy of antiviral treatment.
256 studies on the registry are indexed under Hyperthermia; 73 are open to participants now.
This study's planned enrollment of 80 is above the median of 40 across 232 interventional studies indexed under Hyperthermia.
Browse Hyperthermia studies →First Hospital of China Medical University is the lead sponsor of 62 studies on the registry; 34 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
- 1: Patients with a disease course of ≥2 years who have failed to respond to ≥2 treatment methods (such as topical ointments, cryotherapy, laser therapy, etc.)
2: The subject or their legal guardian is able to understand and sign the form/agree to participate in the study.
Exclusion Criteria:
1: The subject or their legal guardian is unable to understand and refuses to sign the form / refuses to participate in the study
2: Individuals allergic to local hyperthermia or hydrogen peroxide;
3: Subjects with tumors or other serious diseases are unable to complete this clinical study;
4: Due to personal or other objective reasons, it is not possible to ensure timely treatment and follow-up.
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Local hyperthermia combined with hydrogen peroxide
Device: An infrared hyperthermia device · Drug: Hydrogen Peroxide 3 % Topical Solution
Local hyperthermia combined with normal saline
Device: An infrared hyperthermia device · Drug: Normal Saline (NS)
(Patent No: ZL 200820231952.4, Model: YY-WRY-V01, Liaoning Yanyang Medical Instrument Co., Ltd., China) An infrared hyperthermia device was used to apply local hyperthermia at 44°C to the target warts(largest and most severe warts).The device includes a heating source, an infrared temperature monitor, an adjusting arm, a control circuit for temperature stabilization, and a display. It uses a tungsten-halogen lamp (wavelength: 760-2300 nm, peak at 1200 nm) to maintain the temperature of a 0.5\*0.5 cm skin area within ±0.1°C using a non-contact infrared feedback system.Hyperthermia: Conduct 44-degree Celsius, 30-minute sessions. Do it daily for the first 3 days, then 2 sessions every 7 days for 24 weeks.
Dressing: Dress with a cotton ball soaked in 3% hydrogen peroxide one hour prior to each hyperthermia session. Local Hyperthermia treats the target warts(largest and most severe warts), while medication addresses all warts.
The control group used normal saline as the placebo for wet compress, and the hyperthermia treatment was the same as that of the trial group.
Complete clearance rate of warts within 6 months
The complete clearance rate was defined as the proportion of patients with lesions that completely disappeared within 6 months of completing all treatments.
Time frame: 6 months after the first time of treatment.
Recurrence rate of warts
Recurrence was the proportion of patients with recurrence of lesions at the cured lesion site within 6 and 12 months after treatment.
Time frame: recurrence was the proportion of patients with reappearance of lesions at previously cleared sites within 6,12 months after treatment.
Complete clearance rate of warts within 3 months
The complete clearance rate was defined as the proportion of patients with lesions that completely disappeared within 3 months of completing all treatments.
Time frame: 3 months after the first time of treatment.
HPV genotyping
Collect the tissue sample from the wart for HPV gene testing.
Time frame: Pre-treatment and 3,6 months after the first time of treatment
Pathogenic Gene Screening Analysis
Collecting patient blood samples for pathogenic gene screening
Time frame: Pre-treatment
Immune-related cytokines
Collecting the patient's blood samples to test immune-related cytokines
Time frame: Pre-treatment and 3,6 months after the first time of treatment
Changes in the size and number of warts at different points in time
Changes in the size and number of warts at different time points (1 week, 2 weeks, 3 weeks, 4 weeks, 12 weeks, 24 weeks)
Time frame: At 1 week, 2 weeks, 3 weeks, 4 weeks, 12 weeks, 24 weeks follow-up
Curative effect of different types of warts
The cure of different types of warts (common warts, plantar warts, condyloma acuminatum) was followed up at 6 months.
Time frame: followed up at 6 months.
Occurrence of adverse events
occurrence of adverse events (short - and long-term adverse reactions) (e.g. blisters, erythema, nail changes, ulcers/scars, hyperpigmentation, hypopigmentation, erosion)
Time frame: During treatment and follow-up
Treatment-related pain intensity
Pain assessed by Visual Analog Scale (VAS) ranging from 0 (no pain) to 10 (worst imaginable pain)
Time frame: During each treatment session (Day 1, 2, 3, 10, 11, 18, 19, 26, ....180)
Patient satisfaction score
Self-reported satisfaction on a 5-point Likert scale (0=very dissatisfied, 5=very satisfied)
Time frame: At 6-month follow-up
Plan to share: No
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Studies of the drug tested here: Hydrogen Peroxide
First Hospital of China Medical University