An interventional study of Passive cooling and Cooling packs in Hyperthermia, sponsored by University of Colorado, Colorado Springs. Recruiting at 1 site in United States. Open to participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-02-25.
Sponsored by University of Colorado, Colorado Springs · Not applicable, Interventional, and Treatment
This study will help us as scientists and clinicians understand how effective commonly used cooling protocols in emergency departments are and which of the protocols is the most effective.
It consists of a single, approximately 1 hour preliminary session and five, approximately 3 hour experimental sessions, equaling an approximate 16 hour total time commitment.
The purpose of this research is to test the effectiveness of three cooling protocols.
Additionally, a negative control (passive cooling in air-conditioned room) and a positive control (cold water immersion).
256 studies on the registry are indexed under Hyperthermia; 73 are open to participants now.
This study's planned enrollment of 50 is above the median of 40 across 232 interventional studies indexed under Hyperthermia.
Browse Hyperthermia studies →University of Colorado, Colorado Springs is the lead sponsor of 18 studies on the registry; 5 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Participant lies supine in an air-conditioned room
Procedure: Passive cooling
During recovery, cooling packs are applied on either side of the neck, both underarms, and both sides of the groin
Procedure: Cooling packs
During recovery, participants lie supine and are wrapped in bed sheets that have been soaked in ice water, then have a fan directed towards them while cooling
Procedure: Ice sheets
During recovery, participants are zipped into a body bag that is full of ice
Procedure: Body bag cooling
During recovery, participants are submerged to the neck in a cold water bath
Procedure: Cold water immersion
During recovery, participants lie supine in an air-conditioned room
During recovery, participants lie supine while ice packs are applied to both sides of the neck, both arm pits, and both sides of the groin
Also known as: Ice packs
During recovery, participants are wrapped in bed sheets that have been soaked in ice water, while an electric fan blows air across their body
During recovery, participants are placed in a body bag full of ice, and then have ice placed on top of their body, followed by zipping the body bag closed.
Also known as: Ice bag
During recovery, participants are submerged in a bath, up to their neck, in cold water water with ice
Also known as: Ice water immersion
Rectal temperature cooling rate
Following termination of the exercise protocol, at a core temperature above 39 degrees Celcius, participants will be cooled until they reach a core temperature of 38 degrees Celcius. The cooling rate in degrees Celcius per minute, is the primary outcome.
Time frame: The measurement occurs immediately upon completion of the exercise protocol. Time itself is part of the outcome variable and will vary between participants (~3 to 40 min post exercise protocol).
PDFs hosted by the registry, ClinicalTrials.gov.
Plan to share: No
Started Jul 2025 (actual). Primary completion is estimated for Dec 2027, 29 months after the start.
Of 103 non-industry interventional studies with no phase under Hyperthermia, half reached primary completion within 18 months of starting (the median), counting those still running; a quarter within 7 and three quarters within 30. This study's planned 29 months is above that.
Counting every sponsor, half of 108 studies reached it within 18 months; a quarter within 7 and three quarters within 30.
How these figures are worked out, and which studies are left out of them.
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University of Colorado, Colorado Springs