Dental Pulp Necrosis clinical trials
The registry lists 157 studies for Dental Pulp Necrosis across more than 10 countries. 44 are recruiting or about to start. 131 of them are mainly about Dental Pulp Necrosis (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12.
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Status
Who runs them
Cairo University (37) · Mansoura University (8) · Ain Shams University (5) · Future University in Egypt (4) · Suez Canal University (3) · The University of Texas Health Science Center at San Antonio (3) · Minia University (3) · Kahramanmaras Sutcu Imam University (2)
What is being tested here
Drugs under test in Dental Pulp Necrosis studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest
- Nov 2026Professional Practices Regarding Treatment of Non-vital Primary Teeth Among Dental Surgeons in France · University Hospital, Strasbourg, France
- Nov 2026Comparing Amla (Emblica Officinalis) and 3% Sodium Hypochlorite Against Enterococcus Faecalis in Root Canal Treatment. · Postgraduate Medical Institute, Lahore
- Nov 2026Effect of Apical Patency on Periapical Lesion Healing · Recep Tayyip Erdogan University
- Dec 2026Regenerative Root Canal Treatment of Immature Teeth Using Omega-3 Fatty Acids · Mansoura University
- Dec 2026Maximum Occlusal Bite Force of Necrotic Permanent Teeth Treated by Regenerative Technique: Randomized Clinical Trial · Lama Awawdeh
- Dec 2026Lesion Sterilization and Tissue Repair Antibiotic Paste Versus Zinc Oxide and Eugenol Pulpectomy for Treatment of Primary Molars With Pulp Necrosis · University of Faisalabad
- Dec 2026Evaluation of Pulpotomy Versus Pulpectomy in Primary Molars With Irreversible Pulpitis or Necrotic Pulp · Ajman University
- Jan 2027Comparison of Post-operative Pain and Levels of MMP -9 Following Root Canal Irrigation With Sodium Hypochlorite Versus Cold Atmospheric Plasma in Patient With Necrotic Single Rooted Teeth: Randomized Clinical Trial · Ahmed Hesham Abdelmohaimen Rezk
- Jan 2027Conventional and Nano-Metronidazole Irrigation With/Without Activation in Necrotic Teeth With Apical Periodontitis · October 6 University
- Jan 2027Evaluation of Post-operative Pain and Bacterial Load Reduction After Application of Three Intra-canal Medications (Cocoa Husk Versus Calcium Hydroxide With and Without Cocoa) in Necrotic Mandibular First Molar. · Future University in Egypt
Who these studies take
Of the 15 Dental Pulp Necrosis studies recruiting now, 6 (40%) set no upper age limit and 7 (47%) stop at 75 or younger. 4 (27%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 5 (33%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 2 (13%) | 2 (13%) |
| 18 | 10 (67%) | 10 (67%) |
| 30 | 11 (73%) | 11 (73%) |
| 40 | 11 (73%) | 11 (73%) |
| 50 | 10 (67%) | 10 (67%) |
| 65 | 8 (53%) | 8 (53%) |
| 75 | 8 (53%) | 8 (53%) |
| 85 | 8 (53%) | 8 (53%) |
Across all 157 studies, recruiting or not: 82% stop at 75 or younger and 80% at 65; 46% take children; 0% are for women only and 0% for men only; 55% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Dental Pulp Necrosis studies take
Of 67 interventional studies with no phase under Dental Pulp Necrosis, half reached primary completion within 15 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 15 mo9–31 · 67 studies | — | 16 mo9–35 · 66 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Newly registered7
- Bioceramic Versus Epoxy Resin-Based Root Canal Sealer and Postoperative Pain After Warm Vertical CompactionNov 12, 2026NCT07930533
- Post-operative Pain and Clinical Outcome After Single-cone Obturation With a Calcium Silicate-based Versus Epoxy Resin SealerNov 6, 2026NCT07923110
- Calcium Hydroxide Versus Triple Antibiotic Paste for Pain After Root Canal TreatmentNov 6, 2026NCT07923422
- PRP-Assisted Regenerative Endodontics Versus Conventional Root Canal Treatment in Mature Necrotic TeethNov 5, 2026NCT07918664
- Clinical and Inflammatory Outcomes of Regenerative Endodontic Treatment Using Injectable Platelet-Rich Fibrin in Mature Necrotic Teeth With Chronic Apical Periodontitis.Nov 3, 2026NCT07913399
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Studies
Recruiting first, then most recently updated. Showing 50 of 157. Browse all 157 → or search them.
- Bioceramic Versus Epoxy Resin-Based Root Canal Sealer and Postoperative Pain After Warm Vertical CompactionNot yet recruitingNCT07930533Not applicable
- Post-operative Pain and Clinical Outcome After Single-cone Obturation With a Calcium Silicate-based Versus Epoxy Resin SealerNot yet recruitingNCT07923110Not applicable1 country
- PRP-Assisted Regenerative Endodontics Versus Conventional Root Canal Treatment in Mature Necrotic TeethNot yet recruitingNCT07918664Not applicable1 country
- Clinical and Inflammatory Outcomes of Regenerative Endodontic Treatment Using Injectable Platelet-Rich Fibrin in Mature Necrotic Teeth With Chronic Apical Periodontitis.Not yet recruitingNCT07913399Not applicable
- Conventional and Nano-Metronidazole Irrigation With/Without Activation in Necrotic Teeth With Apical PeriodontitisRecruitingNCT07897591Not applicable1 country
- The Effect of Bitewing Radiography on Outcomes and Costs of Treating Caries in Permanent TeethNot yet recruitingNCT07882693Not applicable1 country
- One vs Two Visits Root Canal Treatments in Infected TeethRecruitingNCT04605445Not applicable1 country
- Evaluation of Different Medicaments in the Management of Necrotic Primary Molars by Lesion Sterilization and Tissue RepairEnrolling by invitationNCT06926322Not applicable1 country
- Efficiency of Asiaticoside as Intracanal Medication in Revascularization ProcessRecruitingNCT07802340Not applicable1 country
- Comparing Amla (Emblica Officinalis) and 3% Sodium Hypochlorite Against Enterococcus Faecalis in Root Canal Treatment.Not yet recruitingNCT07688005Not applicable1 country
- Frankincense Versus Sodium Hypochlorite for Root Canal DisinfectionNot yet recruitingNCT07823868Early Phase 11 country
- Bacterial Reduction After Supplementary Disinfection Procedures in Infected Root CanalsRecruitingNCT06569329Not applicable1 country
- Clinical and Radiographic Success of Calcium Hydroxide-Iodoform Paste Versus Modified Triple Antibiotic Paste for Necrotic Primary Molars in ChildrenNot yet recruitingNCT07773805Not applicable
- Comparison of Post-operative Pain and Levels of MMP -9 Following Root Canal Irrigation With Sodium Hypochlorite Versus Cold Atmospheric Plasma in Patient With Necrotic Single Rooted Teeth: Randomized Clinical TrialNot yet recruitingNCT07747753Not applicable1 country
- The Effect of Different Intra-canal Medications on Postoperative PainRecruitingNCT07603934Early Phase 11 country
- Chloramphenicol, Tetracycline, Zinc Oxide and Eugenol Paste (CTZ Paste) for Emergency Dental Treatment in Public Health Settings: A Randomized TrialNot yet recruitingNCT07542639Early Phase 1
- Metagenomic Analysis and Postoperative Pain in Infected Root Canals Using Different Irrigation ProtocolsNot yet recruitingNCT07546773Not applicable1 country
- Evaluation of Postoperative Pain and Success Rate Between Lateral Condensation and Warm Vertical Obturation TechniquesRecruitingNCT07310212Not applicable1 country
- Lesion Sterilization and Tissue Repair Antibiotic Paste Versus Zinc Oxide and Eugenol Pulpectomy for Treatment of Primary Molars With Pulp NecrosisNot yet recruitingNCT07475364Phase 1/2
- Triple Antibiotic Paste vs Simvastatin for Lesion Sterilization and Tissue Repair in Primary Molars.RecruitingNCT07264842Phase 21 country
- Professional Practices Regarding Treatment of Non-vital Primary Teeth Among Dental Surgeons in FranceRecruitingNCT072978361 country
- Antibacterial Effect and Postoperative Pain After Triton Irrigation Protocol in Necrotic Mandibular MolarNot yet recruitingNCT07435883Not applicable1 country
- Antibacterial Effect of Two Different Intracanal Medicaments and Their Effect on Post-operative PainNot yet recruitingNCT07388888Phase 41 country
- This Study Compares Two Different Ways of Cleaning and Shaping Root Canals During Root-canal Treatment: the Step-down Technique and the Step-back Technique. Iu Want to Find Out Which Method Causes Less Pain After the Procedure. Patients Will be Randomly Placed Into One of the Two Groups, Treated WitNot yet recruitingNCT07290192Not applicable1 country
- Influence of Maintaining Apical Patency on Post-Endodontic Pain in MolarsNot yet recruitingNCT07239752Not applicable
- Evaluation of Pulpotomy Versus Pulpectomy in Primary Molars With Irreversible Pulpitis or Necrotic PulpNot yet recruitingNCT07230717Not applicable
- Evaluation of Regenerative Endodontic Treatment for Immature TeethRecruitingNCT07210359Not applicable1 country
- Using Platelet-rich Fibrin in Regenerative Endodontic Treatment in Mature Permanent TeethNot yet recruitingNCT07192289Not applicable1 country
- Bacterial Load Reduction by GentleWave and EdgePro Irrigation Systems in Mandibular Necrotic MolarsRecruitingNCT06554366Not applicable1 country
- Bite Force MeasurementsRecruitingNCT068435251 country
- Chitosan Irrigation in Premolar Root Canal Therapy (Randomized Trial)RecruitingNCT07048028Not applicable1 country
- Moringa Oleifera vs Sodium Hypochlorite for Root Canal Irrigation in Nonvital Primary MolarsNot yet recruitingNCT06971055Not applicable1 country
- Antibacterial Efficacy and Outcomes of Root Canal Irrigation MethodsEnrolling by invitationNCT06959602Not applicable1 country
- Maximum Occlusal Bite Force of Necrotic Permanent Teeth Treated by Regenerative Technique: Randomized Clinical TrialEnrolling by invitationNCT06934317Not applicable1 country
- Clinical and Radiographic Evaluation of Zinc Oxide Modified 3Mixtatin Versus Zical in Root Canal Treatment of Necrotic Primary Molars.RecruitingNCT06752889Not applicable1 country
- Efficacy of Integrated Nano-technology in Revascularization of Immature Necrotic TeethNot yet recruitingNCT06631885Not applicable
- Effectiveness of Asiaticoside as Intracanal Medication on Infectious/Inflammatory Contents in Teeth With Apical PeriodontitisRecruitingNCT06566508Phase 2/31 country
- Investigation of the Effect of Low Torque and Speed on Post-Operative Pain After Root Canal TreatmentNot yet recruitingNCT06309095Not applicable1 country
- Effect of Commiphora Myrrh Solution as a Root Canal Irrigant on Post Operative Pain and Bacterial Load Reduction in Necrotic ToothNot yet recruitingNCT06310044Not applicable
- Influence of Moment of Restoration in Pain After a Root Canal TreatmentRecruitingNCT06142799Not applicable1 country
- Effect of Vachellia Nilotica Versus Sodium Hypochlorite as Root Canal Irrigant on Postoperative Pain and Bacterial Load Reduction in Mandibular Premolar Teeth With Necrotic PulpNot yet recruitingNCT06116214Phase 4
- Single and Two-visit Pulpectomy in Primary MolarsNot yet recruitingNCT06071663Not applicable
- The Efficacy and Safety of Pulp Regeneration Induced by SHED PolymerizationNot yet recruitingNCT05728346Not applicable
- Efficacy of Guedes-Pinto Paste and CTZ Paste in the Non-instrumental Endodontic Treatment of Primary TeethNot yet recruitingNCT04587089Phase 1/2
- Calcium Hydroxide Versus Triple Antibiotic Paste for Pain After Root Canal TreatmentCompletedNCT07923422Phase 41 country
- Effect of Apical Patency on Periapical Lesion HealingActive, not recruitingNCT07867314Not applicable1 country
- Lesion Sterilization Tissue Repair and Conventional Pulpectomy in Primary MolarsActive, not recruitingNCT068116361 country
- CLINICAL AND RADIOGRAPHIC SUCCESS OF MODIFIED LSTR TECHNIQUES IN PRIMARY SECOND MOLARSCompletedNCT07836686Not applicable1 country
- Cryotherapy and Intracanal Medicaments for Postoperative Pain in Apical PeriodontitisCompletedNCT07437612Not applicable1 country
- Antimicrobial Photodynamic Therapy in the Endodontic Treatment of Anterior Primary Teeth With Pulp NecrosisCompletedNCT02485210Not applicable1 country