A Phase 4 interventional study of Vachellia Nelotica and sodium hypochlorite in Necrotic Pulp and Post Operative Pain, sponsored by Cairo University. Not yet recruiting. Open to participants aged 20 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-11-03.
Sponsored by Cairo University · Phase 4, Interventional, and Treatment
Among 37 studies in Dental Pulp Necrosis by Cairo University — 5 open to participants now, 5 under way, none of them phase 3. Dental Pulp Necrosis · Cairo University.
Among the 37 studies in Dental Pulp Necrosis by Cairo University, this one is the 12th largest by planned enrollment, is one of 4 that started in 2023, is one of 2 in phase 4, and was the 33rd registered.
157 studies on the registry are indexed under Dental Pulp Necrosis; 44 are open to participants now.
Browse Dental Pulp Necrosis studies →5 of the 37 studies in Dental Pulp Necrosis by Cairo University are open now, in 1 country. Recruiting first, the newest first:
Cairo University · Sites in Egypt
Ages 18–40 · Healthy volunteers
Cairo University
Ages 4–7
Cairo University · Sites in Egypt
Ages 4–7 · Healthy volunteers
Cairo University
Ages 20–40 · Healthy volunteers
By country, each count listing its studies:
Of the 15 Dental Pulp Necrosis studies recruiting now, 6 (40%) set no upper age limit and 7 (47%) stop at 75 or younger; 4 take children under 18; 5 take healthy volunteers.
This study: 20 Years to 40 Years · all sexes · healthy volunteers too.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
37 studies; the count open now beside each. This study's row is marked.
A study in two phases is counted once above. Listed by phase, each with its combined phases: Phase 1 4 · Phase 2 3 · Phase 3 4 · Phase 4 2
First in 2011; this study’s year is marked. 4 started in 2023.
By drug class, each counting the studies that test any of its medicines:
This study's planned enrollment of 46 is close to the median of 45 across 148 interventional studies indexed under Dental Pulp Necrosis.
Median enrollment 42 across the 37 interventional studies. Of the 10 that completed or were terminated, 1 (10%) have results posted.
This tab as a report to print or save as PDF → With an account.
Cairo University is the lead sponsor of 4,941 studies on the registry; 1,457 are open to participants now.
Of its 37 completed or terminated interventional studies of FDA-regulated products, 5 (14%) have results posted.
1 of the studies in Dental Pulp Necrosis by Cairo University that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07603934Cairo UniversityThe Effect of Different Intra-canal Medications on Postoperative Pain | 2027-02-15 |
Add it to your calendar (.ics) → With an account.
Among the 37 studies in Dental Pulp Necrosis by Cairo University, from their registry updates:
Nothing recorded among them since 2026-09-25.
This tab as a report to print or save as PDF → With an account.
The aim of this study is to assess the effect of V. nilotica extract solution versus 2.5% NaOCl on the intensity of postoperative pain and the amount of bacterial load reduction.
Clinical compare the effect of V. nilotica extract solution versus 2.5% NaOCl on the intensity of postoperative pain and the amount of bacterial load reduction when used as root canal irrigant in necrotic pulp. The post operative pain will be recorded using Numerical rating scale, and the bacterial load reduction will be measured by Bacterial counting using agar culture technique.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Mandibular single rooted premolars having the following criteria:
Exclusion criteria:
Teeth with:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
A weakened immune system. It can come from an illness, such as HIV or some blood cancers, or from medicines that turn the immune system down, for example after an organ transplant or for an autoimmune disease; steroids at higher doses count.
Read whether the line is about a condition or about medicines, and which medicines and doses it means.
ASA physical status
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Immunosuppression
A weakened immune system. It can come from an illness, such as HIV or some blood cancers, or from medicines that turn the immune system down, for example after an organ transplant or for an autoimmune disease; steroids at higher doses count.
Read whether the line is about a condition or about medicines, and which medicines and doses it means.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
in this group the teeth will be irrigated with 2.5% Sodium Hypochlorite (gold standard)
Other: sodium hypochlorite
in this group the teeth will be irrigated with 10% V. Nelotica (Herbal irrigant)
Other: Vachellia Nelotica
As a root canal irrigant (herbal)
Also known as: Babul
As a root canal irrigant
post operative pain.
non=0, mild=1-3, moderate4-6, sever=7-10. Measured and reported by Numerical Rating Scale (NRS). Minimum value=0, maximum value=10, the higher score or value mean a worse outcome.
Time frame: At 6, 12, 24, and 48 hours postoperatively (post instrumentation and post obturation)
Bacterial load reduction
Bacterial counting using agar culture technique.
Time frame: 1 hour. First sample (S1) will be taken pre-intervention (before chemo-mechanical preparation) and the second sample (S2) will be taken immediately after the intervention (after completion of chemo-mechanical preparation) on the same visit.
No study locations are listed for this record.
Plan to share: No — Not chosen yet
No publications or documents are linked to this record.
Start is estimated for Nov 2023; primary completion for Feb 2024, 3 months later.
How these figures are worked out, and which studies are left out of them.
This study is not yet recruiting, as verified in Nov 2023. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.