Drug
Nitrofurantoin clinical trials
Also written Macrodantin.
- studies test it
- 29
- open now
- 9
- in phase 3
- 0
- first study started
- 2002
Keep track of what changes. Save the Nitrofurantoin studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Studies by the year they started
29 studies that test it; most in 2025 (5)
| Year | Studies |
|---|---|
| 2002 | 1 |
| 2003 | 1 |
| 2007 | 1 |
| 2008 | 2 |
| 2011 | 1 |
| 2013 | 2 |
| 2015 | 1 |
| 2016 | 4 |
| 2017 | 2 |
| 2020 | 1 |
| 2021 | 3 |
| 2022 | 3 |
| 2024 | 1 |
| 2025 | 5 |
| 2026 | 1 |
By phase
A phase 1/2 study counts in both.
- Early Phase 1
- 4
- Phase 1
- 1
- Phase 2
- 2
- Phase 4
- 18
- No phase
- 5
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 2 · Other 27
Altamash Institute of Dental Medicine (3) · University of California, San Diego (2) · Cairo University (2) · Roswell Park Cancer Institute (1) · Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina (1) · Wake Forest University Health Sciences (1) · Halina M Zyczynski, MD (1) · Newcastle-upon-Tyne Hospitals NHS Trust (1)
Often tested with
Tested in the same studies.
Fosfomycin (3) · Gentamicins (2) · Trimethoprim, Sulfamethoxazole Drug Combination (1) · Amdinocillin Pivoxil (1) · Chlorhexidine (1) · Potassium Citrate (1) · Ibuprofen (1) · Amoxicillin-Potassium Clavulanate Combination (1)
Studies
Open first, then newest update. How each study uses Nitrofurantoin is read from its arms, and is right about nine times in ten.
Testing it · 29
- Self-Start Triage Model for Post-Botox® Lower Urinary Tract SymptomsRecruitingEarly Phase 1The Cleveland ClinicNCT07648290Written as Macrobid® Capsules 100 mg
- The Effect of Different Intra-canal Medications on Postoperative PainRecruitingEarly Phase 1Cairo UniversityNCT07603934Written as Nitrofurantoin
- Urine Alkalinization for UTI in Women: RCTNot yet recruitingNot applicableAssiut UniversityNCT07202832Written as Nitrofurantoin
- Comparison of Inter-appointment Pain Reduction During Root Canal Treatment in Symptomatic Apical Periodontitis by Using Intracanal Medicaments; Chlorhexidine Gel and Single Antibiotic Paste NitrofurantoinEnrolling by invitationPhase 1/2Altamash Institute of Dental MedicineNCT07198919Written as Nitrofurantoin 100 MG
- Bladder Botox UTI Antibiotic ProphylaxisRecruitingPhase 4Walter Reed National Military Medical CenterNCT06387329Written as Nitrofurantoin 100 MG
- Clinical Trial Testing Whether Targeted Antibiotic Prophylaxis Can Reduce Infections After Cystectomy Compared to Empiric ProphylaxisRecruitingPhase 4Rigshospitalet, DenmarkNCT06709196Written as Nitrofurantoin
- Gag Therapy for Recurrent Urinary Tract Infection Assessing Comparability to International Nitrofurantoin Gold Standard StudyRecruitingPhase 4Radboud University Medical CenterNCT05652374Written as Nitrofurantoin
- COMPARISON OF NITROFURANTOIN WITH FOSFOMYCIN in TREATING CYSTITIS IN WOMENNot yet recruitingPhase 4Shalamar Institute of Health SciencesNCT06518291Written as Nitrofurantoin 100 MG
- Use of Prophylactic Antibiotics Prior to OnabotulinumtoxinARecruitingPhase 4Atlantic Health SystemNCT05519072Written as Nitrofurantoin
- Prophylactic Antibiotics for Urinary Tract Infections After Robot-Assisted Radical CystectomyCompletedPhase 4Roswell Park Cancer InstituteNCT04502095Written as Nitrofurantoin
- Clinical Effectiveness and Bacteriological Eradication of 4 Short-course Antibiotics for Uncomplicated UTIs in Women.CompletedPhase 4Fundacio d'Investigacio en Atencio Primaria Jordi Gol i GurinaNCT04959331Written as Nitrofurantoin
- Endourology Disease Group Excellence (EDGE) Consortium: Antibiotics (Abx) for Percutaneous Nephrolithotomy (PCNL) Part 2CompletedNot applicableUniversity of California, San DiegoNCT02829060Written as Nitrofurantoin 100 MG, 7d
- The Effectiveness of Single Antibiotic Paste Nitrofurantoin Versus Double Antibiotic PasteCompletedPhase 4Altamash Institute of Dental MedicineNCT05600023Written as Nitrofurantoin
- Nitrofurantoin Administration for the Prevention of Short-Term Catheter Associated Urinary Tract Infection After Pelvic SurgeryCompletedPhase 4Wake Forest University Health SciencesNCT03287089Written as Nitrofurantoin 100 MG
- Effect of Nitrofurantion Used as an Intracanal MedicamentStatus unknownEarly Phase 1Cairo UniversityNCT05074628Written as Nitrofurantoin capsules
- Comparison of Nitrofurantoin and Calcium Hydroxide as Intracanal Medicaments in Alleviating Post-operative PainCompletedPhase 4Altamash Institute of Dental MedicineNCT04900571Written as Nitrofurantoin 100 MG
- The Preventive Infection Role of One Week Antibiotics Before Minimally Invasive Upper Tract LithotomyStatus unknownEarly Phase 1Xinhua Hospital, Shanghai Jiao Tong University School of MedicineNCT02789579Written as Nitrofurantoin
- A Randomized Trial of Preoperative Prophylactic Antibiotics Prior to Kidney Stone Surgery (Percutaneous Nephrolithotomy [PCNL])CompletedPhase 4University of California, San DiegoNCT02384200Written as nitrofurantoin monohydrate/macrocrystalline capsules
- INtravesical Antimicrobial Agents v STANDard Oral Antibiotics for the Treatment of Acute UTI in Women With rUTIWithdrawnPhase 4Mayo ClinicNCT03299387Written as Nitrofurantoin
- Nitrofurantoin Prophylaxis During Catheter-managed Acute Urinary Retention After Pelvic Reconstructive SurgeryCompletedPhase 4Halina M Zyczynski, MDNCT02727322Written as Nitrofurantoin
See all 29 studies that test Nitrofurantoin →
Given in every arm · 1 — Nitrofurantoin is usual care beside what is tested
As the comparator · 15 — what is tested is compared with Nitrofurantoin
- A Study to Investigate Pivmecillinam Versus Nitrofurantoin in Female Adolescents 12 to Less Than 18 Years of Age With Uncomplicated Urinary Tract InfectionNot yet recruitingPhase 2Alembic TherapeuticsNCT07871968Written as Nitrofurantoin 100 mg (nitrofurantoin monohydrate/macrocrystalline capsule)
- Microbiome-Modulating Prophylaxis RCT: Antibiotic vs Gynoflor in Postmenopausal Women With Recurrent CystitisRecruitingPhase 4Mahidol UniversityNCT07186465Written as Nitrofurantoin
- An Open Clinical Trial of the Safety and Efficacy of the Drug Fluorothiazinone, 300 Mg Tablets with the Participation of Adult Patients with Chronic Bacterial Cystitis"Not yet recruitingPhase 3Gamaleya Research Institute of Epidemiology and Microbiology, Health Ministry of the Russian FederationNCT06815549Written as Nitrofurantoin 100 MG
- Intravesical Gentamicin to Prevent Recurrent UTICompletedPhase 4Women and Infants Hospital of Rhode IslandNCT06332781Written as Nitrofurantoin
- Safety, Tolerability, Pharmacokinetic and Microbiological Investigation of GSK3882347 in Female Participants With Urinary Tract InfectionsCompletedPhase 1GlaxoSmithKlineNCT05138822Written as Nitrofurantoin
- Role of Prophylactic Postoperative Antibiotics in HoLEPWithdrawnPhase 4Baylor Research InstituteNCT05274672Written as Nitrofurantoin
- A Study to Investigate the Efficacy and Safety With Gepotidacin in Japanese Female Participants With Uncomplicated Urinary Tract Infection (Acute Cystitis)CompletedPhase 3GlaxoSmithKlineNCT05630833Written as Nitrofurantoin
- Food Study of Nitrofurantoin Macrocrystals 100 mg Capsules and Macrodantin® 100 mgCompletedPhase 1Mylan Pharmaceuticals IncNCT00649506Written as Macrodantin® 100 mg Capsules
- Food Study of Nitrofurantoin Monohydrate/Macrocrystals Capsules 100 mg and Macrobid® Capsules 100 mgCompletedPhase 1Mylan Pharmaceuticals IncNCT00649285Written as Macrobid® Capsules 100 mg
- Fed Study of Mylan Nitrofurantoin Monohydrate/Macrocrystals Capsules 100 mg and Macrobid® Capsules 100 mgCompletedPhase 1Mylan Pharmaceuticals IncNCT01018342Written as Macrobid® Capsules 100 mg
- Antibiotic Prophylaxis and Renal Damage In Congenital Abnormalities of the Kidney and Urinary TractActive, not recruitingPhase 3Fondazione IRCCS Ca' Granda, Ospedale Maggiore PoliclinicoNCT02021006Written as nitrofurantoin
- Comparative Study to Evaluate Efficacy and Safety of Gepotidacin to Nitrofurantoin in Treatment of Uncomplicated Urinary Tract Infection (UTI)CompletedPhase 3GlaxoSmithKlineNCT04187144Written as Nitrofurantoin
- A Study to Evaluate Efficacy and Safety of Gepotidacin in the Treatment of Uncomplicated Urinary Tract Infection (UTI)CompletedPhase 3GlaxoSmithKlineNCT04020341Written as Nitrofurantoin
- EXtended Use of FOsfomycin for the Treatment of CYstitis in Primary CareTerminatedPhase 3MJM BontenNCT05254808Written as Nitrofurantoin
- Oral Omadacycline vs. Oral Nitrofurantoin for the Treatment of CystitisCompletedPhase 2Paratek Pharmaceuticals IncNCT03425396Written as Nitrofurantoin capsules
Codes
What other systems call Nitrofurantoin · ClinicalTrials.gg INT007901
- MeSH (NLM) D009582NitrofurantoinConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) 927AH8112LNITROFURANTOINConfirmed FDA, NLM, Wikidata
- RxNorm 7454Confirmed FDA, Wikidata
- Wikidata Q422669nitrofurantoinConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C29293NitrofurantoinConfirmed FDA, Wikidata
- DrugBank DB00698One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D009582 | Nitrofurantoin | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | 927AH8112L | NITROFURANTOIN | Confirmed FDA, NLM, Wikidata |
| RxNorm | 7454 | — | Confirmed FDA, Wikidata |
| Wikidata | Q422669 | nitrofurantoin | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C29293 | Nitrofurantoin | Confirmed FDA, Wikidata |
| DrugBank | DB00698 | — | One source Wikidata |
Also registered as nitrofurantoin monohydrate (UNII E1QI2CQQ1I · RxNorm 221129).
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.