An interventional study of 3Mix-MP Antibiotic Paste and 3Mix-NS Antibiotic Paste in Pulp Necrosis and Irreversible Pulpitis, sponsored by Uşak University. Completed at 1 site in Turkey (Türkiye). Open to participants aged 4 Years to 11 Years. Per ClinicalTrials.gov, last updated 2026-09-29.
Sponsored by Uşak University · Not applicable, Interventional, and Treatment
Among 20 studies in Dental Pulp Necrosis with a site in Turkey — 3 open to participants now, 5 under way, none of them phase 3. Dental Pulp Necrosis · Turkey.
Among the 20 studies in Dental Pulp Necrosis with a site in Turkey, this one is the 8th largest by enrollment of the 15 interventional ones that give a count, is one of 8 that started in 2024, is one of 14 with no phase, and was the 18th registered.
157 studies on the registry are indexed under Dental Pulp Necrosis; 44 are open to participants now.
Browse Dental Pulp Necrosis studies →3 of the 20 studies in Dental Pulp Necrosis with a site in Turkey are open now. Recruiting first, the newest first:
ESRA DAĞCI · Sites in Turkey
Ages 18+ · Healthy volunteers
TC Erciyes University · Sites in Turkey
Ages 18–45
Afyonkarahisar Health Sciences University · Sites in Turkey
Ages 18–65 · Healthy volunteers
A study can be open while its sites in Turkey have not opened yet or have stopped. Only those recruiting at a site in Turkey →
Of the 15 Dental Pulp Necrosis studies recruiting now, 6 (40%) set no upper age limit and 7 (47%) stop at 75 or younger; 4 take children under 18; 5 take healthy volunteers.
This study: 4 Years to 11 Years · all sexes · no healthy volunteers.
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20 studies; the count open now beside each. This study's row is marked.
First in 2017; this study’s year is marked. 8 started in 2024.
This study's enrollment of 64 is above the median of 45 across 148 interventional studies indexed under Dental Pulp Necrosis.
Median enrollment 64 across the 15 interventional studies, 60 across the 5 observational. Of the 14 that completed or were terminated, 0 (0%) have results posted.
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None of the 20 has an industry lead sponsor. The 10 most frequent:
Uşak University is the lead sponsor of 80 studies on the registry; 10 are open to participants now.
Uşak University has 1 study filed under Dental Pulp Necrosis — fewer than ten, so there is no comparison to draw.
1 of the studies in Dental Pulp Necrosis with a site in Turkey that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07867314Recep Tayyip Erdogan UniversityEffect of Apical Patency on Periapical Lesion Healing | 2026-11-27 |
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Among the 20 studies in Dental Pulp Necrosis with a site in Turkey, from their registry updates:
This tab as a report to print or save as PDF → With an account.
This study aimed to evaluate and compare the clinical and radiographic success of different antibiotic and vehicle modifications of the Lesion Sterilization and Tissue Repair (LSTR) technique in infected mandibular primary second molars. The study included systemically healthy children aged 4-11 years. Participants were assigned to four treatment groups according to the antibiotic combination (3Mix or 2Mix) and vehicle used [Macrogol-Propylene Glycol (MP) or normal saline (NS)]: 3Mix-MP, 3Mix-NS, 2Mix-MP, and 2Mix-NS. Clinical outcomes were evaluated at 3, 6, and 12 months after treatment, and radiographic outcomes were evaluated at 6 and 12 months. The clinical and radiographic success of the four LSTR modifications was compared over the 12-month follow-up period.
This study was conducted to evaluate and compare the clinical and radiographic success of different antibiotic and vehicle modifications of the Lesion Sterilization and Tissue Repair (LSTR) technique in infected mandibular primary second molars.
A total of 64 systemically healthy children aged 4-11 years were included in the study. The cases were assigned to four treatment groups according to the antibiotic combination (3Mix or 2Mix) and the vehicle used [Macrogol-Propylene Glycol (MP) or Normal saline (NS)]. The four treatment groups were 3Mix-MP, 3Mix-NS, 2Mix-MP, and 2Mix-NS.
Following LSTR treatment, clinical evaluations were performed at 3, 6, and 12 months, while radiographic evaluations were performed at 6 and 12 months. Clinical and radiographic findings were assessed at the specified follow-up periods to determine treatment success and to compare the outcomes of the four LSTR modifications over a 12-month follow-up period.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Participants in this arm received LSTR treatment using the 3Mix antibiotic combination with Macrogol-Propylene Glycol (MP) as the vehicle.
Drug: 3Mix-MP Antibiotic Paste
Participants in this arm received LSTR treatment using the 3Mix antibiotic combination with normal saline (NS) as the vehicle.
Drug: 3Mix-NS Antibiotic Paste
Participants in this arm received LSTR treatment using the 2Mix antibiotic combination with Macrogol-Propylene Glycol (MP) as the vehicle.
Drug: 2Mix-MP Antibiotic Paste
Participants in this arm received LSTR treatment using the 2Mix antibiotic combination with normal saline (NS) as the vehicle.
Drug: 2Mix-NS Antibiotic Paste
The 3Mix antibiotic powder consisted of metronidazole, ciprofloxacin, and clindamycin mixed in a 1:1:1 ratio. Macrogol and propylene glycol were mixed in a 1:1 ratio to prepare the vehicle. Immediately before application, the antibiotic powder and the vehicle were combined at a 7:1 ratio to form a homogeneous paste, which was used as part of the LSTR treatment.
The 3Mix antibiotic powder consisted of metronidazole, ciprofloxacin, and clindamycin mixed in a 1:1:1 ratio. Normal saline (NS) was used as the vehicle. Immediately before application, the antibiotic powder and normal saline were combined at a 7:1 ratio to form a homogeneous paste, which was used as part of the LSTR treatment.
The 2Mix antibiotic powder consisted of metronidazole and ciprofloxacin mixed in a 1:1 ratio. Macrogol and propylene glycol were mixed in a 1:1 ratio to prepare the vehicle. Immediately before application, the antibiotic powder and the vehicle were combined at a 7:1 ratio to form a homogeneous paste, which was used as part of the LSTR treatment.
The 2Mix antibiotic powder consisted of metronidazole and ciprofloxacin mixed in a 1:1 ratio. Normal saline (NS) was used as the vehicle. Immediately before application, the antibiotic powder and normal saline were combined at a 7:1 ratio to form a homogeneous paste, which was used as part of the LSTR treatment.
Clinical Success of LSTR Treatment
Clinical success was defined as the absence of pain or tenderness, swelling or fistula, pathological mobility, and tenderness to percussion. The presence of any of these signs or symptoms was considered clinical failure
Time frame: 3, 6, and 12 months after treatment
Radiographic Success of LSTR Treatment
Radiographic success was defined as stabilization, reduction, or complete resolution of existing interradicular and periradicular radiolucency, with no development of new radiographic lesions. Failure to meet any of these criteria was considered radiographic failure.
Time frame: 6 and 12 months after treatment
Overall Success of LSTR Treatment
Overall treatment success was defined as fulfillment of both the clinical and radiographic success criteria. A case was considered unsuccessful if either the clinical or radiographic success criteria were not met.
Time frame: 6 and 12 months after treatment
Plan to share: No
No publications or documents are linked to this record.
Ran from Nov 2024 to primary completion in Mar 2026, 15 months.
Of 66 non-industry interventional studies with no phase under Dental Pulp Necrosis, half reached primary completion within 16 months of starting (the median), counting those still running; a quarter within 9 and three quarters within 35. This study's 15 months is close to that.
Counting every sponsor, half of 67 studies reached it within 15 months; a quarter within 9 and three quarters within 31.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is completed, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
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Uşak University