An interventional study of regenerative endodontic procedure using blood clot according to AAE and regenerative endodontic procedure using photo activated nanochitosan 2% in Immature Teeth and Necrotic Pulp, sponsored by Minia University. Not yet recruiting. Per ClinicalTrials.gov, last updated 2024-10-08.
Sponsored by Minia University · Not applicable, Interventional, and Treatment
This trial aims to study the effect of photoactivated disinfection using Diod laser (810 nm) to activate photosensitive nanoparticle chitosan as an endodontic irrigant versus sodium hypochlorite followed by saline and then EDTA 17% on 1) postoperative pain and 2) the success of revascularization in patients with necrotic immature maxillary anterior teeth using a randomized clinical trial design.
randomized clinical trial will be conducted to investigate and compare the efficacy of photosensitized nano-chitosan 2% as an endodontic disinfectant during revascularization versus sodium hypochlorite, followed by EDTA 17% according to the standardized protocol of the American Association of endodontics.
Twenty individuals with necrotic, immature permanent anterior teeth will be recruited. They will be randomly assigned into two groups according to the received intervention: control group and test group.
pain will be evaluated as a primary outcome at 24 hours and one week post-intervention using numerical rating scale (NRS). In addition, the root development in terms of change in root length and apical foramen diameter and periapical bone healing will be evaluated as secondary outcomes using cone beam tomography.
157 studies on the registry are indexed under Dental Pulp Necrosis; 44 are open to participants now.
This study's planned enrollment of 20 is below the median of 45 across 148 interventional studies indexed under Dental Pulp Necrosis.
Browse Dental Pulp Necrosis studies →Minia University is the lead sponsor of 370 studies on the registry; 117 are open to participants now.
Of its 6 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
o Immature necrotic maxillary incisor with open apex greater than 1 mm.
Exclusion Criteria:
o Non-restorable teeth.
revascularization using blood clot according to the standardized protocol of the American association of endodontics
Procedure: regenerative endodontic procedure using blood clot according to AAE
diode laser will be used to activate photosensitized nano chitosan 2% for canal disinfection instead of NaOCl in the first visit of revascularization protocol
Procedure: regenerative endodontic procedure using photo activated nanochitosan 2%
regenerative endodontic procedure using blood clot to replace the necrotic pulp tissues in immature teeth with a pulp like to tissue to complete root development. using AAE protocol
regenerative endodontic procedure using blood clot to replace the necrotic pulp tissues in immature teeth with a pulp like to tissue to complete root development. using photosensitized nanochitosan for root canal disinfection
pain intensity assessed by numerical rating scale
postoperative pain using numerical rating scale
Time frame: 24 hours and 1 week after completion of the procedure
root development
change of root length
Time frame: 6 months, 1 year postoperative
Apical foramen closure
change in apical foramen diameter
Time frame: 6 months, 1 year postoperative
periapical bone healing
change in the area of periapical lesion
Time frame: 6 months, 1 year postoperative
No study locations are listed for this record.
Plan to share: No
No publications or documents are linked to this record.
Start is estimated for Oct 2024; primary completion for Nov 2024, 1 month later.
Of 66 non-industry interventional studies with no phase under Dental Pulp Necrosis, half reached primary completion within 16 months of starting (the median), counting those still running; a quarter within 9 and three quarters within 35. This study's planned 1 month is below that.
Counting every sponsor, half of 67 studies reached it within 15 months; a quarter within 9 and three quarters within 31.
How these figures are worked out, and which studies are left out of them.
This study is not yet recruiting, as verified in Oct 2024. You cannot join it, but the record below documents what was studied.
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