An interventional study of Sodium hypochlorite and Moringa Oleifera Leaf Extract in Dental Caries, Pulp Necrosis and Primary Tooth Pulpectomy, sponsored by Cairo University. Not yet recruiting at 1 site in Egypt. Open to participants aged 4 Years to 7 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-06-03.
Sponsored by Cairo University · Not applicable, Interventional, and Treatment
Among 151 studies in Dental Caries by Cairo University — 41 open to participants now, 43 under way, none of them phase 3. Dental Caries · Cairo University.
Among the 151 studies in Dental Caries by Cairo University, this one is the 73rd largest by planned enrollment of the 120 interventional ones that give a count, is one of 17 that started in 2025, is one of 101 with no phase, reaches primary completion later than 15 of the 42 other live ones, and was the 135th registered.
1,171 studies on the registry are indexed under Dental Caries; 209 are open to participants now.
Browse Dental Caries studies →41 of the 151 studies in Dental Caries by Cairo University are open now, in 1 country. Recruiting first, the newest first:
Cairo University · Sites in Egypt
Ages 35–44 · Healthy volunteers
Cairo University · Sites in Egypt
Ages 4–8 · Healthy volunteers
Cairo University · Sites in Egypt
Cairo University · Sites in Egypt
Ages 25–45 · Healthy volunteers
Cairo University
Ages 45–55
By country, each count listing its studies:
Of the 86 Dental Caries studies recruiting now, 18 (21%) set no upper age limit and 66 (77%) stop at 75 or younger; 60 take children under 18; 53 take healthy volunteers.
This study: 4 Years to 7 Years · all sexes · healthy volunteers too.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
151 studies; the count open now beside each. This study's row is marked.
A study in two phases is counted once above. Listed by phase, each with its combined phases: Phase 1 6 · Phase 2 4 · Phase 3 5 · Phase 4 6
First in 2015; this study’s year is marked. 17 started in 2025.
By drug class, each counting the studies that test any of its medicines:
This study's planned enrollment of 38 is below the median of 60 across 967 interventional studies indexed under Dental Caries.
Median enrollment 46 across the 120 interventional studies, 250 across the 31 observational. Of the 40 that completed or were terminated, 1 (3%) have results posted.
This tab as a report to print or save as PDF → With an account.
Cairo University is the lead sponsor of 4,941 studies on the registry; 1,457 are open to participants now.
Of its 37 completed or terminated interventional studies of FDA-regulated products, 5 (14%) have results posted.
13 of the studies in Dental Caries by Cairo University that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07612540Cairo UniversityRetention and Caries Prevention of Giomer Sealant With or Without Diode Laser Pre-treatment: A Randomized Controlled Trial | 2026-12-01 |
| NCT07171775Cairo UniversityThis Study Aims to Clinically Assess and Radiographically Measure the Formed Dentin Bridge Over the Pulp, Utilizing Three-dimensional Imaging Following the Application of a Bioactive Restorative System Versus a Conventional Restorative System After Selective Caries Removal to Soft Dentin Over 2 | 2026-12-01 |
| NCT06780527Cairo UniversityClinical Performance of Resin Composite Restoration After Dentin Biomodification by Grape Seed Extract in Deep Carious Lesions. | 2026-12-01 |
| NCT06497231Cairo UniversityEvaluation of Bioactive Giomer Material Versus Nanohybrid Resin Composite in Deep Marginal Elevation | 2026-12-01 |
| NCT06901453Cairo UniversityThe Effectiveness RMGI and Giomer, Individually and Combined Anterior Cervical Caries | 2026-12-31 |
Add all 13 to your calendar (.ics) → With an account.
Among the 151 studies in Dental Caries by Cairo University, from their registry updates:
This tab as a report to print or save as PDF → With an account.
This randomized clinical trial aims to evaluate and compare the antimicrobial efficacy of Moringa Oleifera leaf extract versus sodium hypochlorite as root canal irrigants in pulpectomy of nonvital primary molars in pediatric patients. The study will assess bacterial reduction using blood agar
This randomized clinical trial is designed to compare the antimicrobial efficacy of Moringa Oleifera leaf extract and sodium hypochlorite when used as root canal irrigants in the pulpectomy of nonvital primary molars in children aged 4 to 7 years. Root canal disinfection in pediatric endodontics is essential due to the complex anatomy of primary teeth and the potential systemic implications of untreated infections.
Sodium hypochlorite (NaOCl) is widely used due to its strong antimicrobial and tissue-dissolving properties but is associated with cytotoxic effects and safety concerns in children. Moringa Oleifera, a plant rich in bioactive compounds such as flavonoids and isothiocyanates, has demonstrated antimicrobial, anti-inflammatory, and antioxidant properties, offering a potentially safer and natural alternative.
A total of 38 participants will be randomly assigned to two equal groups. Group 1 will receive root canal irrigation with 2.5% NaOCl, while Group 2 will be irrigated using an ethanol extract of Moringa Oleifera leaves. The primary outcome will be the diameter of the inhibition zone against Coagulase-Negative Staphylococci measured using a blood agar. The secondary outcome will be the diameter of the inhibition zone against Enterococcus Faecalis measured using a blood agar
The study will be conducted at the outpatient clinics of the Pediatric Dentistry and Dental Public Health Department at the Faculty of Dentistry, Cairo University. All procedures will be performed by a single operator (the principal investigator) using a standardized protocol. Data collection will be blinded at the laboratory and statistical analysis levels to minimize bias.
The results of this study aim to determine whether Moringa Oleifera extract can be a safe, effective, and biocompatible alternative to sodium hypochlorite in pediatric root canal irrigation, ultimately enhancing clinical outcomes and patient experience
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Participants in this group will receive root canal irrigation using sodium hypochlorite during pulpectomy of nonvital primary molars. A 3 mL solution will be used per canal following standard clinical procedures.
Drug: Sodium hypochlorite
extract of Moringa oleifera leaves prepared as a solution, used as a natural antimicrobial root canal irrigant.
Biological: Moringa Oleifera Leaf Extract
sodium hypochlorite solution will be used as a root canal irrigant during pulpectomy in primary molars. A volume of 3 mL will be delivered into each canal using a syringe with a side-vented needle. Irrigation will be followed by microbial sampling for blood agar
extract of Moringa oleifera leaves will be used as an intracanal irrigant during pulpectomy. A volume of 3 mL will be used per canal, and post-irrigation microbial samples will be analyzed using the same methods as the control group.
Zone of inhibition against Coagulase-Negative Staphylococci
"Primary Outcome: The antimicrobial efficacy of both types of irrigants... based on the diameter of the zone of inhibition
Time frame: "Day 1 (Pre- and post-irrigation samples collected during the same visit)"
Plan to share: No
No publications or documents are linked to this record.
Start is estimated for Jul 2025; primary completion for Sep 2025, 1 month later.
Of 469 non-industry interventional studies with no phase under Dental Caries, half reached primary completion within 15 months of starting (the median), counting those still running; a quarter within 7 and three quarters within 30. This study's planned 1 month is below that.
Counting every sponsor, half of 502 studies reached it within 15 months; a quarter within 7 and three quarters within 29.
How these figures are worked out, and which studies are left out of them.
This study is not yet recruiting, as verified in May 2025. You cannot join it, but the record below documents what was studied.
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Studies of the drugs tested here: Sodium Hypochlorite · Moringa oleifera leaf