An interventional study of Root canal treatment with intracanal medication by calcium hydroxide for one week. and Root canal treatment with intracanal medication by cocoa husk for one week in Pulp Necrosis and Postoperative Pain, sponsored by Future University in Egypt. Active, not recruiting at 1 site in Egypt. Open to participants aged 18 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-08-27.
Sponsored by Future University in Egypt · Not applicable, Interventional, and Other
Among 43 studies in Dental Pulp Necrosis with a site in Egypt — 12 open to participants now, 16 under way, 1 of them phase 3. Dental Pulp Necrosis · Egypt.
Among the 43 studies in Dental Pulp Necrosis with a site in Egypt, this one is the 25th largest by planned enrollment, is one of 7 that started in 2026, is one of 31 with no phase, reaches primary completion later than 8 of the 15 other live ones, and was the 41st registered.
157 studies on the registry are indexed under Dental Pulp Necrosis; 44 are open to participants now.
Browse Dental Pulp Necrosis studies →12 of the 43 studies in Dental Pulp Necrosis with a site in Egypt are open now. Recruiting first, the newest first:
Mansoura University · Sites in Egypt
Ages 8–18
October 6 University · Sites in Egypt
Ages 21–50
Cairo University · Sites in Egypt
Ages 18–40 · Healthy volunteers
Kafrelsheikh University · Sites in Egypt
Ages 9–15 · Healthy volunteers
Ain Shams University · Sites in Egypt
Ages 5–7 · Healthy volunteers
A study can be open while its sites in Egypt have not opened yet or have stopped. Only those recruiting at a site in Egypt →
Of the 15 Dental Pulp Necrosis studies recruiting now, 6 (40%) set no upper age limit and 7 (47%) stop at 75 or younger; 4 take children under 18; 5 take healthy volunteers.
This study: 18 Years to 40 Years · all sexes · healthy volunteers too.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
43 studies; the count open now beside each. This study's row is marked.
A study in two phases is counted once above. Listed by phase, each with its combined phases: Phase 1 2 · Phase 2 6 · Phase 3 1 · Phase 4 4
First in 2016; this study’s year is marked. 7 started in 2026.
By drug class, each counting the studies that test any of its medicines:
This study's planned enrollment of 36 is below the median of 45 across 148 interventional studies indexed under Dental Pulp Necrosis.
Median enrollment 40 across the 43 interventional studies. Of the 22 that completed or were terminated, 1 (5%) have results posted.
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None of the 43 has an industry lead sponsor. The 10 most frequent:
Future University in Egypt is the lead sponsor of 105 studies on the registry; 32 are open to participants now.
Future University in Egypt has 4 studies filed under Dental Pulp Necrosis — fewer than ten, so there is no comparison to draw.
9 of the studies in Dental Pulp Necrosis with a site in Egypt that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07371416Mansoura UniversityRegenerative Root Canal Treatment of Immature Teeth Using Omega-3 Fatty Acids | 2026-12 |
| NCT07747753Ahmed Hesham Abdelmohaimen RezkComparison of Post-operative Pain and Levels of MMP -9 Following Root Canal Irrigation With Sodium Hypochlorite Versus Cold Atmospheric Plasma in Patient With Necrotic Single Rooted Teeth: Randomized Clinical Trial | 2027-01 |
| NCT07897591October 6 UniversityConventional and Nano-Metronidazole Irrigation With/Without Activation in Necrotic Teeth With Apical Periodontitis | 2027-01 |
| NCT07790796Future University in EgyptEvaluation of Post-operative Pain and Bacterial Load Reduction After Application of Three Intra-canal Medications (Cocoa Husk Versus Calcium Hydroxide With and Without Cocoa) in Necrotic Mandibular First Molar. | 2027-01-06 |
| NCT07388888Ain Shams UniversityAntibacterial Effect of Two Different Intracanal Medicaments and Their Effect on Post-operative Pain | 2027-02 |
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Among the 43 studies in Dental Pulp Necrosis with a site in Egypt, from their registry updates:
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The study will aim to evaluate the postoperative pain and bacterial load after application of two intracanal medications in mandibular first molar teeth with necrotic pulp.
Methods (Participants, Interventions, and Outcomes)
Study Setting:
This randomized clinical trial will include 36 patients, equally allocated into three groups (12 patients each). Participants will be recruited from the Outpatient Clinic of the Endodontic Department, Faculty of Oral and Dental Medicine, Future University in Egypt. All treatments will be performed by a postgraduate master's degree candidate using a Ritter dental unit (Germany) and Sirona digital intraoral radiography (Nanopix, size 2).
Eligibility Criteria:
Eligible participants will be 18-40 years old with necrotic pulp and symptomatic apical periodontitis in restorable mandibular first molars (Type III mesial and distal canals) and willing to participate. Exclusion criteria include pregnancy, systemic diseases, recent use of analgesics or antibiotics, bruxism or clenching, severe traumatic malocclusion, and teeth with periapical radiolucency, root resorption, pulp stones/calcifications, or previous endodontic treatment.
Inclusion Criteria:1. Patients with an age range between 18 to 40. 2. Patients with necrotic pulp. 3. Restorable teeth. 4. Positive patient acceptance for participating in the study. 5. Type III distal and mesial canal of the first mandibular molar. 6. Patients have necrotic pulp with symptomatic apical periodontitis in mandibular first molars.
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Exclusion Criteria:1. Pregnant females 2. Medically compromised patients. 3. Patients having analgesics before the treatment 4. If antibiotics have been administered during the past two weeks pre-operatively.
5. Patients having bruxism or clenching 6. Patients have severe malocclusion associated with traumatic occlusion. 7. Teeth that have:
a. Peri-apical radiolucency b. Root resorption. c. Pulp stones or calcifications. d. Previous endodontic treatment
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Drug: Root canal treatment with intracanal medication by calcium hydroxide for one week.
Drug: Root canal treatment with intracanal medication by cocoa husk for one week
Drug: Root canal treatment with intracanal medication by calcium hydroxide with cocoa husk for one week.
Following cleaning and shaping of the root canal, calcium hydroxide paste will be used as an intracanal medicament for one week to reduce bacterial load before the final root canal
Root canal treatment with intracanal medication by cocoa husk for one week
Following cleaning and shaping, no intracanal medicament will be used. The root canal will be obturated according to the study protocol.
postoperative pain
Time frame: 6,12,24,48,and 72hours after root canal treatment by numerical rate scale (NRS)
bacterial load reduction
Time frame: S1: after access cavity and before RCT. S2: after mechanical instrumentation S3: after intracanal medicament removal By Colony Forming Unit analysis18 CFU/ml (%)
Plan to share: Yes
Supporting information: Study protocol
No publications or documents are linked to this record.
Started Jan 2026 (actual). Primary completion is estimated for Jan 2027, 12 months after the start.
Of 66 non-industry interventional studies with no phase under Dental Pulp Necrosis, half reached primary completion within 16 months of starting (the median), counting those still running; a quarter within 9 and three quarters within 35. This study's planned 12 months is below that.
Counting every sponsor, half of 67 studies reached it within 15 months; a quarter within 9 and three quarters within 31.
How these figures are worked out, and which studies are left out of them.
This study is active, not recruiting, as verified in Jan 2026. You cannot join it, but the record below documents what was studied.
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