An interventional study of Root canal treatment with intracanal medication by calcium hydroxide for one week. and Root canal treatment with intracanal medication by cocoa husk for one week in Pulp Necrosis and Postoperative Pain, sponsored by Future University in Egypt. Active, not recruiting at 1 site in Egypt. Open to participants aged 18 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-08-27.
Sponsored by Future University in Egypt · Not applicable, Interventional, and Other
The study will aim to evaluate the postoperative pain and bacterial load after application of two intracanal medications in mandibular first molar teeth with necrotic pulp.
Methods (Participants, Interventions, and Outcomes)
Study Setting:
This randomized clinical trial will include 36 patients, equally allocated into three groups (12 patients each). Participants will be recruited from the Outpatient Clinic of the Endodontic Department, Faculty of Oral and Dental Medicine, Future University in Egypt. All treatments will be performed by a postgraduate master's degree candidate using a Ritter dental unit (Germany) and Sirona digital intraoral radiography (Nanopix, size 2).
Eligibility Criteria:
Eligible participants will be 18-40 years old with necrotic pulp and symptomatic apical periodontitis in restorable mandibular first molars (Type III mesial and distal canals) and willing to participate. Exclusion criteria include pregnancy, systemic diseases, recent use of analgesics or antibiotics, bruxism or clenching, severe traumatic malocclusion, and teeth with periapical radiolucency, root resorption, pulp stones/calcifications, or previous endodontic treatment.
Inclusion Criteria:1. Patients with an age range between 18 to 40. 2. Patients with necrotic pulp. 3. Restorable teeth. 4. Positive patient acceptance for participating in the study. 5. Type III distal and mesial canal of the first mandibular molar. 6. Patients have necrotic pulp with symptomatic apical periodontitis in mandibular first molars.
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Exclusion Criteria:1. Pregnant females 2. Medically compromised patients. 3. Patients having analgesics before the treatment 4. If antibiotics have been administered during the past two weeks pre-operatively.
5. Patients having bruxism or clenching 6. Patients have severe malocclusion associated with traumatic occlusion. 7. Teeth that have:
a. Peri-apical radiolucency b. Root resorption. c. Pulp stones or calcifications. d. Previous endodontic treatment
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Drug: Root canal treatment with intracanal medication by calcium hydroxide for one week.
Drug: Root canal treatment with intracanal medication by cocoa husk for one week
Drug: Root canal treatment with intracanal medication by calcium hydroxide with cocoa husk for one week.
Following cleaning and shaping of the root canal, calcium hydroxide paste will be used as an intracanal medicament for one week to reduce bacterial load before the final root canal
Root canal treatment with intracanal medication by cocoa husk for one week
Following cleaning and shaping, no intracanal medicament will be used. The root canal will be obturated according to the study protocol.
postoperative pain
Time frame: 6,12,24,48,and 72hours after root canal treatment by numerical rate scale (NRS)
bacterial load reduction
Time frame: S1: after access cavity and before RCT. S2: after mechanical instrumentation S3: after intracanal medicament removal By Colony Forming Unit analysis18 CFU/ml (%)
Plan to share: Yes
Supporting information: Study protocol
No publications or documents are linked to this record.
This study is active, not recruiting, as verified in Jan 2026. You cannot join it, but the record below documents what was studied.
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Future University in Egypt